scholarly journals Associations Between Sleep Quality and Health Span: A Prospective Cohort Study Based on 328,850 UK Biobank Participants

2021 ◽  
Vol 12 ◽  
Author(s):  
Muhammed Lamin Sambou ◽  
Xiaoyu Zhao ◽  
Tongtong Hong ◽  
Jingyi Fan ◽  
Til Bahadur Basnet ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sleep Quality ◽  
Prospective Cohort ◽  
Population Attributable Risk ◽  
Chronic Obstructive ◽  
Poor Sleep ◽  
Uk Biobank ◽  
Health Span ◽  
Sleep Behavior ◽  
Reduced Risk

ObjectiveTo examine the associations between sleep quality and health span using a prospective cohort design based on the UK Biobank (UKB).Materials and MethodsThis longitudinal cohort study enrolled 328,850 participants aged between 37 and 73 years from UKB to examine the associations between sleep quality and risk of terminated health span. End of health span was defined by eight events strongly associated with longevity (cancer, death, congestive heart failure, myocardial infarction, chronic obstructive pulmonary disease, stroke, dementia, and diabetes), and a sleep score was generated according to five sleep behavioral factors (sleep duration, chronotype, sleeplessness, daytime sleepiness, and snoring) to characterize sleep quality. The hazard ratio (HR) and 95% confidence intervals (CIs) were calculated by multivariate-adjusted Cox proportional hazards model. Moreover, we calculated population attributable risk percentage (PAR%) to reflect the public health significance of healthy sleep quality.ResultsCompared with poor sleep quality, participants with healthy sleep quality had a 15% (HR: 0.85, 95% CI: 0.81–0.88) reduced risk of terminated health span, and those of less-healthy sleep quality had a 12% (HR: 0.88, 95% CI: 0.85–0.92) reduced risk. Linear trend results indicated that the risk of terminated health span decreased by 4% for every additional sleep score. Nearly 15% health span termination events in this cohort would have been prevented if a healthy sleep behavior pattern was adhered to (PAR%: 15.30, 95% CI: 12.58–17.93).ConclusionHealthy sleep quality was associated with a reduced risk of premature end of health span, suggesting healthy sleep behavior may extend health span. However, further studies are suggested for confirmation of causality and potential mechanism.

scholarly journals Associations with covid-19 hospitalisation amongst 406,793 adults: the UK Biobank prospective cohort study

2020 ◽  
Author(s):  
Anthony P Khawaja ◽  
Alasdair N Warwick ◽  
Pirro G Hysi ◽  
Alan Kastner ◽  
Andrew Dick ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Antihypertensive Medication ◽  
Severe Disease ◽  
Chronic Obstructive ◽  
Uk Biobank ◽  
Antihypertensive Medications ◽  
Asian Ethnicity ◽  
Increased Risk

ABSTRACTOBJECTIVESTo identify the sociodemographic, lifestyle, comorbidity and antihypertensive medication associations with the development of hospitalisation with covid-19 in an English population.DESIGNProspective cohort studySETTINGThe population-based UK Biobank study was linked to English covid-19 test results.PARTICIPANTSIndividuals resident in England and alive in 2020.MAIN OUTCOME MEASURESCases (n=605) were defined by a positive covid-19 test result conducted between 16th March and 16th April 2020, during a restricted testing policy for hospitalised individuals with severe disease.RESULTSA total of 406,793 participants were included. Mean age on 1st January 2020 was 68 years (range 48 to 85 years). 55% were women. In multivariable models, major independent risk factors for hospitalisation with covid-19 were male sex (odds ratio 1.52; 95% confidence interval 1.28 to 1.81; P<0.001), South Asian ethnicity (2.02; 1.28 to 3.17; P=0.002) or black ethnicity (3.09; 2.18 to 4.38; P<0.001) compared to white ethnicity, greater residential deprivation (1.92 for most deprived quartile compared to least deprived quartile; 1.50 to 2.47; P<0.001), higher BMI (2.04 for BMI >35 compared to <25 Kg/m2; 1.50 to 2.77; P<0.001), former smoking (1.39 compared to never smoked; 1.16 to 1.66; P<0.001), and comorbidities hypertension (1.28; 1.06 to 1.53; P=0.009) and chronic obstructive pulmonary disease (1.81; 1.34 to 2.44; P<0.001). Increased risk was observed with increasing number of antihypertensive medications used rather than any individual class.CONCLUSIONUnderstanding why these factors confer increased risk of severe covid-19 in the population may help elucidate the underlying mechanisms as well as inform strategy and policy to prevent this disease and its consequences. We found no evidence of increased risk with specific classes of antihypertensive medication.

Investigation of the Relationships Between Sleep Behaviors and Risk of Health Lifespan Termination: A Prospective Cohort Study Based on 323,373 UK-Biobank Participants

2021 ◽  
Author(s):  
Muhammed Lamin Sambou ◽  
Xiaoyu Zhao ◽  
Tongtong Hong ◽  
Alima Sambou ◽  
EL HAFA FADOUA ◽  
...  
Keyword(s):  
Daytime Sleepiness ◽  
Prospective Cohort ◽  
Population Attributable Risk ◽  
Cox Proportional Hazards ◽  
Low Risk ◽  
Outcome Variable ◽  
Uk Biobank ◽  
Sleep Behavior ◽  
Increased Risk ◽  
Sleep Behaviors

Abstract Objectives: To examine the associations between insomnia, napping, daytime sleepiness, and getting up from bed with the risk of health lifespan termination using a prospective cohort design based on the UK-Biobank (UKB) database. Methods: Our study population consisted of 323,373 UKB participants enrolled in the UKB study from 2006 to 2010 and followed up to 2016. The outcome variable was health lifespan that was characterized by eight events strongly associated with ageing. Multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for risk of terminated health lifespan were computed in Cox proportional hazards models. Furthermore, we collapsed each of the four sleep behavior factors into binary categories (high vs. low-risk groups) to explore the Population Attributable Risk percentages (PAR%).Results: Participants in the high-risk subgroups of the four sleep behaviors had a significantly higher risk of terminated health lifespan; that is, 'usually insomnia' (HR=1.05, 95% CI: 1.03-1.07; P<0.001), 'usually napping' (HR=1.22, 95% CI: 1.18-1.26; P<0.01), 'excessive daytime sleepiness' (HR=1.25, 95% CI: 1.19-1.32; P<0.001), and 'difficult getting up from bed' (HR=1.08, 95% CI: 1.05-1.10; P<0.001). The corresponding PAR% indicated that about 7% of the terminated health lifespan events in this cohort would have been eliminated if all people were in the low-risk sleep groups.Conclusion: We observed that frequent insomnia, napping, daytime sleepiness, and 'difficult getting up from bed' are associated with increased risk of terminated health lifespan. Therefore adherence to healthy sleep behavior is significant for healthy lifespan.

scholarly journals Sleep behavior of infants with infantile hemangioma treated with propranolol—a cohort study

2021 ◽  
Author(s):  
Martin Theiler ◽  
Nicole Knöpfel ◽  
Susanne von der Heydt ◽  
Agnes Schwieger-Briel ◽  
Isabelle Luchsinger ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sleep Quality ◽  
Outcome Measures ◽  
Negative Impact ◽  
Behavioral Development ◽  
Sleep Efficiency ◽  
Sleep Pattern ◽  
Control Group ◽  
Infant Sleep ◽  
Sleep Behavior

AbstractSleep problems are frequently reported in infants treated with propranolol for infantile hemangiomas, possibly serving as a marker for a negative impact on central nervous system function. In this cohort study, we objectively investigate the sleep behavior of infants with infantile hemangiomas on propranolol compared to a healthy, untreated control group. Sleep of propranolol-treated infants and controls was investigated using ankle actigraphy and a 24-h diary for 7–10 days at ages 3 and 6 months. The main outcome measures were the Number of Nighttime Awakenings and Sleep Efficiency. The main secondary outcome measures included 24-hour Total Sleep, daytime sleep behavior, and parent-rated infant sleep quality and behavioral development based on the Brief Infant Sleep Questionnaire (BISQ) and the age-appropriate Ages-and-Stages Questionnaire (ASQ), respectively. Fifty-four term-born infants were included in each cohort. No group difference in any investigated parameter was seen at age 3 months. At age 6 months, the propranolol group exhibited a decrease in Sleep Efficiency and a trend towards an increased Number of Nighttime Awakenings compared to the control group. Treated infants at 6 months also had shorter daytime waking periods. 24-hour Total Sleep was unaffected by propranolol. No negative impact of propranolol on subjective sleep quality and behavioral development was noted.Conclusion: Propranolol exerts a measurable yet mild impact on objectively assessed infants’ sleep measures. Behavioral developmental scores were unaffected. Our results support propranolol as first-line therapy for complicated infantile hemangiomas. What is Known:• Sleep disorders are frequently reported in infants with infantile hemangiomas treated with propranolol and often lead to treatment discontinuation.• Investigations of the sleep pattern in this patient group using objective measures are lacking. What is New:• The sleep pattern of propranolol-treated infants is assessed using actigraphy and a 24-h sleep diary and compared to healthy, untreated controls.• Propranolol leads to a decreased sleep efficiency at night and an increased demand of daytime sleep, yet effects are mild overall.

scholarly journals Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants

Diabetologia ◽  
2021 ◽  
Author(s):  
Ziyi Zhou ◽  
John Macpherson ◽  
Stuart R. Gray ◽  
Jason M. R. Gill ◽  
Paul Welsh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Respiratory Diseases ◽  
Population Based ◽  
Incident Diabetes ◽  
Uk Biobank ◽  
Metabolically Healthy Obesity ◽  
Wide Range ◽  
Metabolically Healthy

Abstract Aims/hypothesis People with obesity and a normal metabolic profile are sometimes referred to as having ‘metabolically healthy obesity’ (MHO). However, whether this group of individuals are actually ‘healthy’ is uncertain. This study aims to examine the associations of MHO with a wide range of obesity-related outcomes. Methods This is a population-based prospective cohort study of 381,363 UK Biobank participants with a median follow-up of 11.2 years. MHO was defined as having a BMI ≥ 30 kg/m2 and at least four of the six metabolically healthy criteria. Outcomes included incident diabetes and incident and fatal atherosclerotic CVD (ASCVD), heart failure (HF) and respiratory diseases. Results Compared with people who were not obese at baseline, those with MHO had higher incident HF (HR 1.60; 95% CI 1.45, 1.75) and respiratory disease (HR 1.20; 95% CI 1.16, 1.25) rates, but not higher ASCVD. The associations of MHO were generally weaker for fatal outcomes and only significant for all-cause (HR 1.12; 95% CI 1.04, 1.21) and HF mortality rates (HR 1.44; 95% CI 1.09, 1.89). However, when compared with people who were metabolically healthy without obesity, participants with MHO had higher rates of incident diabetes (HR 4.32; 95% CI 3.83, 4.89), ASCVD (HR 1.18; 95% CI 1.10, 1.27), HF (HR 1.76; 95% CI 1.61, 1.92), respiratory diseases (HR 1.28; 95% CI 1.24, 1.33) and all-cause mortality (HR 1.22; 95% CI 1.14, 1.31). The results with a 5 year landmark analysis were similar. Conclusions/interpretation Weight management should be recommended to all people with obesity, irrespective of their metabolic status, to lower risk of diabetes, ASCVD, HF and respiratory diseases. The term ‘MHO’ should be avoided as it is misleading and different strategies for risk stratification should be explored. Graphical abstract

Workaholism and Sleep Quality Among Japanese Employees: A Prospective Cohort Study

2012 ◽  
Vol 21 (1) ◽  
pp. 66-76 ◽  
Author(s):  
Kazumi Kubota ◽  
Akihito Shimazu ◽  
Norito Kawakami ◽  
Masaya Takahashi
Keyword(s):  
Cohort Study ◽  
Sleep Quality ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Japanese Employees

scholarly journals Hormonal and reproductive factors and risk of upper gastrointestinal cancers in men: A prospective cohort study within the UK Biobank

2018 ◽  
Vol 143 (4) ◽  
pp. 831-841
Author(s):  
Úna C. Mc Menamin ◽  
Andrew T. Kunzmann ◽  
Michael B. Cook ◽  
Brian T. Johnston ◽  
Liam J. Murray ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Reproductive Factors ◽  
Uk Biobank ◽  
Gastrointestinal Cancers ◽  
The Uk ◽  
Upper Gastrointestinal

scholarly journals Predicting the risk of atherosclerosis in patients with cystic fibrosis – rationale and design of a prospective cohort study

2015 ◽  
Vol 84 (2) ◽  
pp. 126-128
Author(s):  
Edyta Mądry ◽  
Jan Nowak ◽  
Andrzej Wykrętowicz ◽  
Ewa Wenska-Chyży ◽  
Anna Miśkiewicz-Chotnicka ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Cohort Study ◽  
Heart Disease ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Metabolic Diseases ◽  
Chronic Obstructive ◽  
Science Center ◽  
Obstructive Pulmonary Disease ◽  
Endogenous Factors

The project “Risk of atherosclerosis in cystic fibrosis in relation to the exogenous and endogenous factors that influence the course of the disease” ranked first in the OPUS2 Competition, as announced in May 2012 by the Polish National Science Center. The total value of the grant is 198,580 PLN (ca. 50,000 EUR). The grant was awarded jointly to the Department of Pediatric Gastroenterology and Metabolic Diseases and to the Department of Cardiac Intensive Care at Poznan University of Medical Sciences, Poland. The project will be focused on conducting a prospective cohort study in patients with cystic fibrosis (CF) and healthy controls. Cases of symptomatic and asymptomatic forms of coronary heart disease in patients with CF were reported [1, 2]; however, no data on the epidemiology of atherosclerosis in patients with CF were published so far. In the past, cardiovascular disease in patients with CF used to be limited to pulmonary heart disease as a consequence of end-stage chronic obstructive pulmonary disease [3]. Although hypertension has not yet been officially recognized as a major problem in this population [4], there are reports indicating that it is found in 20% of patients in adult CF care centers [5]. The project is innovative in nature and necessitates close co-operation between cardiology and basic science units.

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