scholarly journals Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning

2018 ◽  
Vol 9 ◽  
Author(s):  
Elisabeth Zechendorf ◽  
Phillip Vaßen ◽  
Jieyi Zhang ◽  
Ahmed Hallawa ◽  
Antons Martincuks ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cell Culture ◽  
Heparan Sulfate ◽  
In Silico ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Receptor Interaction ◽  
Small Data ◽  
Data Set

Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis are linked to trauma- or sepsis-associated cardiomyopathy. However, the underling causative factors are still debatable. Heparan sulfate (HS) fragments belong to the class of danger/damage-associated molecular patterns liberated from endothelial-bound proteoglycans by heparanase during tissue injury associated with trauma or sepsis. We hypothesized that HS induces apoptosis or necroptosis in murine cardiomyocytes. By using a novel Medical-In silico approach that combines conventional cell culture experiments with machine learning algorithms, we aimed to reduce a significant part of the expensive and time-consuming cell culture experiments and data generation by using computational intelligence (refinement and replacement). Cardiomyocytes exposed to HS showed an activation of the intrinsic apoptosis signal pathway via cytochrome C and the activation of caspase 3 (both p < 0.001). Notably, the exposure of HS resulted in the induction of necroptosis by tumor necrosis factor α and receptor interaction protein 3 (p < 0.05; p < 0.01) and, hence, an increased level of necrotic cardiomyocytes. In conclusion, using this novel Medical-In silico approach, our data suggest (i) that HS induces necroptosis in cardiomyocytes by phosphorylation (activation) of receptor-interacting protein 3, (ii) that HS is a therapeutic target in trauma- or sepsis-associated cardiomyopathy, and (iii) indicate that this proof-of-concept is a first step toward simulating the extent of activated components in the pro-apoptotic pathway induced by HS with only a small data set gained from the in vitro experiments by using machine learning algorithms.

scholarly journals Computational Models Using Multiple Machine Learning Algorithms for Predicting Drug Hepatotoxicity with the DILIrank Dataset

2020 ◽  
Author(s):  
Robert Ancuceanu ◽  
Marilena Viorica Hovanet ◽  
Adriana Iuliana Anghel ◽  
Florentina Furtunescu ◽  
Monica Neagu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Liver Injury ◽  
Computational Models ◽  
Liver Toxicity ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Drug Induced ◽  
Reference Drug ◽  
Drug Induced Liver Injury

Drug induced liver injury (DILI) remains one of the challenges in the safety profile of both authorized drugs and candidate drugs and predicting hepatotoxicity from the chemical structure of a substance remains a challenge worth pursuing, being also coherent with the current tendency for replacing non-clinical tests with in vitro or in silico alternatives. In 2016 a group of researchers from FDA published an improved annotated list of drugs with respect to their DILI risk, constituting “the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans”, DILIrank. This paper is one of the few attempting to predict liver toxicity using the DILIrank dataset. Molecular descriptors were computed with the Dragon 7.0 software, and a variety of feature selection and machine learning algorithms were implemented in the R computing environment. Nested (double) cross-validation was used to externally validate the models selected. A number of 78 models with reasonable performance have been selected and stacked through several approaches, including the building of multiple meta-models. The performance of the stacked models was slightly superior to other models published. The models were applied in a virtual screening exercise on over 100,000 compounds from the ZINC database and about 20% of them were predicted to be non-hepatotoxic.

scholarly journals PERFORMANCE COMPARISON OF MACHINE LEARNING ALGORITHMS FOR PREDICTIVE MAINTENANCE

2020 ◽  
Vol 10 (3) ◽  
pp. 32-35
Author(s):  
Jakub Gęca
Keyword(s):  
Machine Learning ◽  
Learning Algorithms ◽  
Performance Comparison ◽  
Machine Learning Algorithms ◽  
Predictive Maintenance ◽  
Model Parameters ◽  
Data Set ◽  
Reduction Techniques ◽  
Machine Reliability ◽  
Dimensionality Reduction Techniques

The consequences of failures and unscheduled maintenance are the reasons why engineers have been trying to increase the reliability of industrial equipment for years. In modern solutions, predictive maintenance is a frequently used method. It allows to forecast failures and alert about their possibility. This paper presents a summary of the machine learning algorithms that can be used in predictive maintenance and comparison of their performance. The analysis was made on the basis of data set from Microsoft Azure AI Gallery. The paper presents a comprehensive approach to the issue including feature engineering, preprocessing, dimensionality reduction techniques, as well as tuning of model parameters in order to obtain the highest possible performance. The conducted research allowed to conclude that in the analysed case , the best algorithm achieved 99.92% accuracy out of over 122 thousand test data records. In conclusion, predictive maintenance based on machine learning represents the future of machine reliability in industry.

scholarly journals Non-Invasive Risk Stratification of Hypertension: A Systematic Comparison of Machine Learning Algorithms

2020 ◽  
Vol 9 (3) ◽  
pp. 34
Author(s):  
Giovanna Sannino ◽  
Ivanoe De Falco ◽  
Giuseppe De Pietro
Keyword(s):  
Machine Learning ◽  
Blood Pressure ◽  
Risk Stratification ◽  
Learning Algorithms ◽  
Circulatory System ◽  
Machine Learning Algorithms ◽  
Learning Mechanisms ◽  
Data Set ◽  
Non Invasive ◽  
Blood Pressure Estimation

One of the most important physiological parameters of the cardiovascular circulatory system is Blood Pressure. Several diseases are related to long-term abnormal blood pressure, i.e., hypertension; therefore, the early detection and assessment of this condition are crucial. The identification of hypertension, and, even more the evaluation of its risk stratification, by using wearable monitoring devices are now more realistic thanks to the advancements in Internet of Things, the improvements of digital sensors that are becoming more and more miniaturized, and the development of new signal processing and machine learning algorithms. In this scenario, a suitable biomedical signal is represented by the PhotoPlethysmoGraphy (PPG) signal. It can be acquired by using a simple, cheap, and wearable device, and can be used to evaluate several aspects of the cardiovascular system, e.g., the detection of abnormal heart rate, respiration rate, blood pressure, oxygen saturation, and so on. In this paper, we take into account the Cuff-Less Blood Pressure Estimation Data Set that contains, among others, PPG signals coming from a set of subjects, as well as the Blood Pressure values of the latter that is the hypertension level. Our aim is to investigate whether or not machine learning methods applied to these PPG signals can provide better results for the non-invasive classification and evaluation of subjects’ hypertension levels. To this aim, we have availed ourselves of a wide set of machine learning algorithms, based on different learning mechanisms, and have compared their results in terms of the effectiveness of the classification obtained.

scholarly journals Computational Models Using Multiple Machine Learning Algorithms for Predicting Drug Hepatotoxicity with the DILIrank Dataset

2020 ◽  
Vol 21 (6) ◽  
pp. 2114
Author(s):  
Robert Ancuceanu ◽  
Marilena Viorica Hovanet ◽  
Adriana Iuliana Anghel ◽  
Florentina Furtunescu ◽  
Monica Neagu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Liver Injury ◽  
Computational Models ◽  
Liver Toxicity ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Drug Induced ◽  
Reference Drug ◽  
Drug Induced Liver Injury

Drug-induced liver injury (DILI) remains one of the challenges in the safety profile of both authorized and candidate drugs, and predicting hepatotoxicity from the chemical structure of a substance remains a task worth pursuing. Such an approach is coherent with the current tendency for replacing non-clinical tests with in vitro or in silico alternatives. In 2016, a group of researchers from the FDA published an improved annotated list of drugs with respect to their DILI risk, constituting “the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans” (DILIrank). This paper is one of the few attempting to predict liver toxicity using the DILIrank dataset. Molecular descriptors were computed with the Dragon 7.0 software, and a variety of feature selection and machine learning algorithms were implemented in the R computing environment. Nested (double) cross-validation was used to externally validate the models selected. A total of 78 models with reasonable performance were selected and stacked through several approaches, including the building of multiple meta-models. The performance of the stacked models was slightly superior to other models published. The models were applied in a virtual screening exercise on over 100,000 compounds from the ZINC database and about 20% of them were predicted to be non-hepatotoxic.

scholarly journals Identification of Leukemia Subtypes from Microscopic Images Using Convolutional Neural Network

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 104 ◽  
Author(s):  
Ahmed ◽  
Yigit ◽  
Isik ◽  
Alpkocak
Keyword(s):  
Machine Learning ◽  
Data Augmentation ◽  
Nearest Neighbor ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Training Data ◽  
Support Vector ◽  
K Nearest Neighbor ◽  
Data Set ◽  
Leukemia Data

Leukemia is a fatal cancer and has two main types: Acute and chronic. Each type has two more subtypes: Lymphoid and myeloid. Hence, in total, there are four subtypes of leukemia. This study proposes a new approach for diagnosis of all subtypes of leukemia from microscopic blood cell images using convolutional neural networks (CNN), which requires a large training data set. Therefore, we also investigated the effects of data augmentation for an increasing number of training samples synthetically. We used two publicly available leukemia data sources: ALL-IDB and ASH Image Bank. Next, we applied seven different image transformation techniques as data augmentation. We designed a CNN architecture capable of recognizing all subtypes of leukemia. Besides, we also explored other well-known machine learning algorithms such as naive Bayes, support vector machine, k-nearest neighbor, and decision tree. To evaluate our approach, we set up a set of experiments and used 5-fold cross-validation. The results we obtained from experiments showed that our CNN model performance has 88.25% and 81.74% accuracy, in leukemia versus healthy and multiclass classification of all subtypes, respectively. Finally, we also showed that the CNN model has a better performance than other wellknown machine learning algorithms.

scholarly journals Prediction of Metabolic Syndrome in a Mexican Population Applying Machine Learning Algorithms

Symmetry ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 581
Author(s):  
Guadalupe Obdulia Gutiérrez-Esparza ◽  
Oscar Infante Vázquez ◽  
Maite Vallejo ◽  
José Hernández-Torruco
Keyword(s):  
Machine Learning ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Heart Diseases ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Mexican Population ◽  
World Health ◽  
Prognostic Variables ◽  
Data Set

Metabolic syndrome is a health condition that increases the risk of heart diseases, diabetes, and stroke. The prognostic variables that identify this syndrome have already been defined by the World Health Organization (WHO), the National Cholesterol Education Program Third Adult Treatment Panel (ATP III) as well as by the International Diabetes Federation. According to these guides, there is some symmetry among anthropometric prognostic variables to classify abdominal obesity in people with metabolic syndrome. However, some appear to be more sensitive than others, nevertheless, these proposed definitions have failed to appropriately classify a specific population or ethnic group. In this work, we used the ATP III criteria as the framework with the purpose to rank the health parameters (clinical and anthropometric measurements, lifestyle data, and blood tests) from a data set of 2942 participants of Mexico City Tlalpan 2020 cohort, applying machine learning algorithms. We aimed to find the most appropriate prognostic variables to classify Mexicans with metabolic syndrome. The criteria of sensitivity, specificity, and balanced accuracy were used for validation. The ATP III using Waist-to-Height-Ratio (WHtR) as an anthropometric index for the diagnosis of abdominal obesity achieved better performance in classification than waist or body mass index. Further work is needed to assess its precision as a classification tool for Metabolic Syndrome in a Mexican population.

A Surveillance on Machine Learning Algorithms and Its Applications

2020 ◽  
Vol 17 (9) ◽  
pp. 4294-4298
Author(s):  
B. R. Sunil Kumar ◽  
B. S. Siddhartha ◽  
S. N. Shwetha ◽  
K. Arpitha
Keyword(s):  
Machine Learning ◽  
Health Care ◽  
Sentiment Analysis ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Machine Learning Algorithm ◽  
Data Set ◽  
Pros And Cons ◽  
Primary Advantage

This paper intends to use distinct machine learning algorithms and exploring its multi-features. The primary advantage of machine learning is, a machine learning algorithm can predict its work automatically by learning what to do with information. This paper reveals the concept of machine learning and its algorithms which can be used for different applications such as health care, sentiment analysis and many more. Sometimes the programmers will get confused which algorithm to apply for their applications. This paper provides an idea related to the algorithm used on the basis of how accurately it fits. Based on the collected data, one of the algorithms can be selected based upon its pros and cons. By considering the data set, the base model is developed, trained and tested. Then the trained model is ready for prediction and can be deployed on the basis of feasibility.

scholarly journals Keystroke dynamics Based Technique to Enhance the Security in Smart Devices

2021 ◽  
Vol 4 (1) ◽  
pp. 14
Author(s):  
Farman Pirzado ◽  
Shahzad Memon ◽  
Lachman Das Dhomeja Dhomeja ◽  
Awais Ahmed
Keyword(s):  
Machine Learning ◽  
User Authentication ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Smart Devices ◽  
Mobile Banking ◽  
Alternative Technique ◽  
Keystroke Dynamics ◽  
Data Set ◽  
Proposed Model

Nowadays, smart devices have become a part of ourlives, hold our data, and are used for sensitive transactions likeinternet banking, mobile banking, etc. Therefore, it is crucial tosecure the data in these smart devices from theft or misplacement.The majority of the devices are secured with password/PINbaseduser authentication methods, which are already proveda less secure or easily guessable user authentication method.An alternative technique for securing smart devices is keystrokedynamics. Keystroke dynamics (KSD) is behavioral biometrics,which uses a natural typing pattern unique in every individualand difficult to fake or replicates that pattern. This paperproposes a user authentication model based on KSD as an additionalsecurity method for increasing the smart devices’ securitylevel. In order to analyze the proposed model, an android-basedapplication has been implemented for collecting data from fakeand genuine users. Six machine learning algorithms have beentested on the collected data set to study their suitability for usein the keystroke dynamics-based authentication model.

scholarly journals A Self-Supervised Machine Learning Approach for Objective Live Cell Segmentation and Analysis

2021 ◽  
Author(s):  
Marc Raphael ◽  
Michael Robitaille ◽  
Jeff Byers ◽  
Joseph Christodoulides
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Label Cell ◽  
Live Cell ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Supervised Machine Learning ◽  
Cell Segmentation ◽  
Data Set

Abstract Machine learning algorithms hold the promise of greatly improving live cell image analysis by way of (1) analyzing far more imagery than can be achieved by more traditional manual approaches and (2) by eliminating the subjective nature of researchers and diagnosticians selecting the cells or cell features to be included in the analyzed data set. Currently, however, even the most sophisticated model based or machine learning algorithms require user supervision, meaning the subjectivity problem is not removed but rather incorporated into the algorithm’s initial training steps and then repeatedly applied to the imagery. To address this roadblock, we have developed a self-supervised machine learning algorithm that recursively trains itself directly from the live cell imagery data, thus providing objective segmentation and quantification. The approach incorporates an optical flow algorithm component to self-label cell and background pixels for training, followed by the extraction of additional feature vectors for the automated generation of a cell/background classification model. Because it is self-trained, the software has no user-adjustable parameters and does not require curated training imagery. The algorithm was applied to automatically segment cells from their background for a variety of cell types and five commonly used imaging modalities - fluorescence, phase contrast, differential interference contrast (DIC), transmitted light and interference reflection microscopy (IRM). The approach is broadly applicable in that it enables completely automated cell segmentation for long-term live cell phenotyping applications, regardless of the input imagery’s optical modality, magnification or cell type.

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