scholarly journals Case Report: Noninvasive Clinical Intervention of REBACIN® on Histologic Regression of High Grade Cervical Intraepithelial Neoplasia

2021 ◽  
Vol 8 ◽  
Author(s):  
Fan Wang ◽  
Rong Liu ◽  
Yan Ma ◽  
Dai-Fei Wu ◽  
Liu-Hong Deng ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Clinical Intervention ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Non Invasive ◽  
Future Fertility ◽  
Intraepithelial Lesion ◽  
High Risk Hpv

High-risk human papillomavirus (hrHPV) persistent infection is the major cause of cervical cancer. Clinical intervention of hrHPV-associated high-grade squamous intraepithelial lesion (HSIL) is critical to prevent cervical cancer, and current treatment is surgery (an invasive therapy). However, some patients refuse to do so for an afraid of potential adverse effects on future fertility or other concerns which creates a critical need for development of non-invasive therapeutic strategies. Here, we report for the first time the cases of non-invasive intervention with REBACIN®, a proprietary antiviral biologics, in clinical treatment of HSIL. From 12,958 visiting patients assessed for eligibility, 18 HSIL-patients with cervical intraepithelial neoplasia-grade 2, positive of both diffused overexpression of p16 and high-risk HPV were enrolled in this non-invasive clinical intervention mainly due to concerns of future fertility. REBACIN® was administered intravaginally every other day for 3 months (one-course) except during menstrual period, and were followed up for 6-36 months for the examination of high-risk HPV DNA, cervical cytology, and histopathology. After one to three course treatments, most cases (16/18) displayed both the regression from HSIL (CIN2) to normal cervical cytology and clearance of high-risk HPV infection. Further studies demonstrated REBACIN® significantly suppressed HPV16 E7 oncoprotein expression in a human cervical cancer cell line, which is consistent with previous finding that REBACIN® inhibits the growth of tumors induced by expression of E6/E7 oncogenes of either HPV16 or HPV18. This report indicates REBACIN® as a novel effective non-invasive clinical intervention for HSIL-patients as well for high-risk HPV persistent infection, providing a new clinical option for the non-invasive treatment of hrHPV-associated high-grade squamous intraepithelial lesion, which is worthy of further research on clinical validation and application.

scholarly journals High-risk HPV genotypes and cervical lesions association in postmenopausal women

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Ana Rita Fernandes Miranda da Costa ◽  
Cláudia Sousa ◽  
Erica Isidoro ◽  
Regina Silva ◽  
Cristiana Mourato
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Postmenopausal Women ◽  
Age Groups ◽  
Low Grade ◽  
High Grade ◽  
Cervical Lesions ◽  
Intraepithelial Lesion ◽  
The Bethesda System ◽  
High Risk Hpv

Abstract Background Persistent infection by high-risk Human Papillomavirus (hrHPV) are the major cause of cervical cancer. Studies report disparities in the incidence of infection and the various genotypes of this virus in different age groups, suggesting a higher frequency of hrHPV in young women and low-risk subtypes being predominant in older women. This study aimed to investigate the incidence and distribution of hrHPV genotypes in postmenopausal women as well as the correlation with the cytological findings. Methods 16 859 women, aged 50–64 years, performed cervical cancer screening test in Friuri Venezia Giulia region, Italy. The infection was evaluated by the Polymerase Chain Reaction methodology and the positive samples were evaluated by Liquid Based Cytology according to the Bethesda System from 2014. A statistical analysis was performed to study the molecular and cytological data of this population. Results hrHPV infection were found in 5.8% of the women and 78.3% of these were caused by hrHPV other than HPV16 and HPV18 (). Also, 65.7% of the positive samples were negative for intraepithelial lesion or malignancy while low grade squamous intraepithelial lesion was the most frequent (22.4%). There was an increase in the number of high-grade intraepithelial lesions in the presence of HPV16 compared to that recorded when this genotype was absent (20.8% vs. 8.5%). No cervical cancers were detected. Conclusions Infection with hrHPV is uncommon in postmenopausal women and it is mostly caused by subtypes less associated with the development of cervical cancer. Yet, HPV16 infection triggers the development of high-grade lesions.

scholarly journals High-Grade Squamous Intraepithelial Lesion of the Gastroesophageal Junction Secondary to High-Risk Human Papillomavirus

2019 ◽  
Vol 152 (3) ◽  
pp. 359-364
Author(s):  
Edward B Stelow ◽  
Erik A Dill ◽  
Jonathan J Davick ◽  
Michael B McCabe ◽  
Vanessa M Shami
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Squamous Cell ◽  
Gastroesophageal Junction ◽  
Squamous Cell Carcinomas ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
History Of ◽  
Intraepithelial Lesion ◽  
High Risk Hpv

ABSTRACT Objectives Although the role of human papillomavirus (HPV) in the development of some carcinomas (eg, anogenital and oropharyngeal squamous cell carcinomas) is nondebatable, there is still significant controversy regarding the relationship of HPV and esophageal squamous cell carcinomas (SCCs). Methods All cases were sampled at or near the gastroesophageal junctions in patients with reflux and/or known Barrett esophagus and appear to have been initially sampled “incidentally.” Patients were all men, aged 56 to 80 years. None had a known history of other HPV-related disease. Results We present four cases of high-grade squamous intraepithelial lesion of the gastroesophageal junction secondary to high-risk HPV that have identical histologic features to similar lesions of the anogenital tract. Conclusions Whether such lesions are at risk for developing into invasive SCC remains unclear.

High grade squamous intraepithelial lesion on high-risk HPV negative patients: Why we still need the Pap test

2018 ◽  
Vol 46 (11) ◽  
pp. 908-913 ◽  
Author(s):  
Hongxia Sun ◽  
Ramya P. Masand ◽  
Shobhanaben Jagdishbhai Patel ◽  
Vijayalakshmi Padmanabhan
Keyword(s):  
High Risk ◽  
Pap Test ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Intraepithelial Lesion ◽  
High Risk Hpv

scholarly journals Research of the Potential Vaginal Microbiome Biomarkers for High-Grade Squamous Intraepithelial Lesion

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiaopei Chao ◽  
Lan Wang ◽  
Shu Wang ◽  
Jinghe Lang ◽  
Xianjie Tan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Relative Abundance ◽  
Hpv Infection ◽  
High Grade ◽  
Vaginal Microbiome ◽  
Squamous Intraepithelial Lesion ◽  
Cervical Neoplasm ◽  
Intraepithelial Lesion

Vaginal microbiome may have a role in HPV infection and cervical neoplasm. To explore potential vaginal microbiome biomarkers for high-grade squamous intraepithelial lesion (HSIL), and to find the best scheme to facilitate the current cervical cancer screening strategy. This study enrolled 272 women, including 83 confirmed with HSIL, 86 with HPV infection but without cervical neoplasm, and 103 without HPV infection as controls. Vaginal microbiome composition was determined by sequencing of barcoded 16S rDNA gene fragments (V4) on Illumina HiSeq2500. The relative increasing abundance of Stenotrophomonas, Streptococcus, and Pseudomonas, and a concomitant paucity of Dialister, unidentified Prevotellaceae, Faecalibacterium, Bifidobacterium, and Bacteroides, were related with HSIL, which can be used to predict the development of HISL in high-risk HPV infected patients. The relative abundance of Stenotrophomonas being over 0.0090387%, or Faecalibacterium being under 0.01420015%, or Bifidobacterium being under 0.0116183% maybe a good predictor for HSIL for those infected with HPV 16 and/or 18. The relative abundance of Stenotrophomonas being over 0.01549105%, or Streptococcus being over 0.48409585%, or Bacteroides being under 0.0296912% maybe a good predictor for HSIL for those infected with the 12 other high-risk types of HPV with concurrent abnormal TCT results. This study revealed that potential vaginal microbiome biomarkers may relate to HSIL, and can facilitate the cervical cancer screening.

scholarly journals High Risk HPV E6/E7 Oncoprotein Expression in Women with High Grade Squamous Intraepithelial Lesion

2016 ◽  
Vol 38 (03) ◽  
pp. 154-159 ◽  
Author(s):  
Ana Gonçalves ◽  
Ismael Guerreiro da Silva ◽  
José Eleutério Junior ◽  
Terezinha Tenório da Silva ◽  
Danyelly Bruneska ◽  
...  
Keyword(s):  
High Risk ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
E7 Oncoprotein ◽  
Hpv E6 ◽  
Intraepithelial Lesion ◽  
High Risk Hpv

scholarly journals Kanker serviks dan gen Fas-promoter-670

2019 ◽  
Vol 2 (3) ◽  
pp. 90-91
Author(s):  
ML Edy Parwanto
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cervical Intraepithelial Neoplasia ◽  
Incidence Rate ◽  
Invasive Cervical Cancer ◽  
Intraepithelial Neoplasia ◽  
Low Grade ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Intraepithelial Lesion

Kanker serviks merupakan keganasan pada serviks. Jenis kanker tersebut terjadi pada perempuan dan masih menjadi masalah di Indonesia. Indonesia merupakan negara urutan ke 4 di Asia Tenggara dengan insiden kanker serviks terbesar setelah Kamboja, Myanmar dan Thailand. Berdasar data statistik tahun 2012, tingkat insidensi (incidence rate) kanker serviks di Indonesia 17 per 100.000 perempuan per tahun.(1) Telah terbukti bahwa penyebab primer terjadinya kanker serviks yaitu virus papilloma atau yang lebih dikenal dengan istilah “human papillomavirus (HPV)”. Terdapat beberapa jenis serotype HPV, tetapi tidak semua jenis serotype bersifat progesif menjadikan kanker serviks. Salah satu serotype yang bersifat progesif menjadikan kanker serviks yaitu HPV serotype 16. HPV serotype 16 mampu mengubah sel epitel squamosa serviks (cervical-squamous-epithelial cells=CSEC) normal menjadi lesi intraepitelial squamosa tingkat rendah (low-grade squamous intraepithelial lesion=LSIL) atau neoplasia intraepitel serviks (cervical intraepithelial neoplasia=CIN) 1. Selanjutnya, LSIL atau CIN 1 berkembang menjadi lesi intraepitelial squamosa tingkat tinggi (high-grade squamous intraepithelial lesion=HSIL) atau CIN 2, dan akhirnya menjadi kanker serviks yang invasif (invasive cervical cancer=CIN3).(2)

scholarly journals Epidemiology of pre invasive and invasive lesions of the cervix at tertiary health centre in Punjab

2021 ◽  
Author(s):  
Garima Bhardwaj ◽  
Amritpal Kaur ◽  
Permeet Kaur Bagga
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Socioeconomic Status ◽  
High Risk ◽  
Cervical Intraepithelial Neoplasia ◽  
Pap Smear ◽  
Health Centre ◽  
Intraepithelial Neoplasia ◽  
Squamous Intraepithelial Lesion ◽  
Intraepithelial Lesion

Background: Cervical cancer is the fourth most frequent cancer in women globally, next to breast, colorectal and lung cancer and it is also the fourth most common cause of cancer death in women. According to the Indian council of medical research (ICMR), in India one woman dies of cervical cancer every 9 minutes. This study used PAP smear and histopathology to find out about the epidemiology of pre invasive and invasive lesions of the cervix at tertiary health centre in Punjab and their correlation with various social and demographic features.Methods: This prospective clinical study was carried out in the Department of Obstetrics and Gynaecology in Amritsar Medical College from May 2018 to April 2020, after taking approval from the Institutional Ethical Committee. The study selected 500 women randomly among the patients attending the Gynaecology OPD who met the inclusion criteria. Detailed history and PAP smear was taken at first visit followed by cervical biopsy amongst women with abnormal cytology report or with frank lesions of cervix.Results: Out of 500 women included in the study, majority of women (82.5%) were Negative for intraepithelial lesion or malignancy (NILM), 4% women had Atypical squamous cells of undetermined significance (ASCUS), 6.1% had low grade squamous intraepithelial lesion (LSIL) and 16 (3.2%) had High grade squamous intraepithelial lesion (HSIL). Amongst the histopathology reporting 15.62% patients had cervical intraepithelial neoplasia 1 (CIN I), 6.25% patients had cervical intraepithelial neoplasia II (CIN II), 3.12% patients had cervical intraepithelial neoplasia III (CIN III), 6.3% patients had squamous cell carcinoma and 3.1% patient had adenocarcinoma of cervix. Age, low level of education, poor socioeconomic status, early marriage and multiparity are the risk factors found to be associated with pre invasive and invasive lesions of the cervix. (p<0.001).Conclusions: Though infection with human papilloma virus (HPV) is essential for the development of the disease, there are other high-risk factors like age, poor education, low socioeconomic status, early age at marriage and high parity which are significantly associated with the occurrence of the disease. Therefore, our primary and secondary preventive measures must include the women who come under these high-risk categories. 

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