scholarly journals Decreased Serum Maresin 1 Concentration Is Associated With Postmenopausal Osteoporosis: A Cross-Sectional Study

2022 ◽  
Vol 8 ◽  
Author(s):  
Jing Wu ◽  
Xin-Yue Li ◽  
Xia Fang ◽  
Fang-Yuan Teng ◽  
Yong Xu
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Postmenopausal Osteoporosis ◽  
Cross Sectional Study ◽  
Normal Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Amino Terminal ◽  
Maresin 1

Background: Maresin 1 plays a role in the regulation of inflammation and metabolic diseases in vivo. An increasing number of studies have reported that postmenopausal osteoporosis (PMOP) is associated with inflammation. However, the potential relationship between the serum Maresin 1 content and PMOP is unclear.Aims: 1) To evaluate the Maresin 1 content in postmenopausal women with osteopenia, osteoporosis, or without these conditions (normal group) and 2) to analyze the correlations between Maresin 1 concentrations and bone mineral density (BMD) and bone turnover markers.Methods: In this cross-sectional study, we measured serum Maresin 1 concentrations, serum biochemical parameters, markers of bone metabolism, and BMD of the femoral neck, lumbar spine, and hip in 141 postmenopausal women.Results: We found that serum Maresin 1 in the osteopenia (140.09 ± 30.54 pg/ml) and PMOP (124.68 ± 31.35 pg/ml) groups were significantly lower than those in the normal group (167.38 ± 24.85 pg/ml) (P < 0.05 and P < 0.001). Serum Maresin 1 levels were positively correlated with femoral neck, lumbar spine, and hip BMD (P < 0.001). Meanwhile, Maresin 1 concentrations were positively associated with 25-hydroxyvitamin D [25(OH)D] levels (P < 0.001), but negatively correlated with β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide (β-CTX) (P = 0.002), procollagen type I amino-terminal propeptide (PINP) (P = 0.004), tartrate-resistant acid phosphatase 5b (TRAP-5b) (P = 0.005), and osteocalcin (OC) levels (P = 0.001). Multivariate logistic regression analysis showed that a decrease in Maresin 1 concentration was still associated with osteopenia (P = 0.035) or PMOP (P = 0.016). Maresin 1 levels had a maximum area under curve of 0.820 for osteopenia and 0.746 for PMOP (P < 0.001). Our results showed that the serum Maresin 1 levels were reduced in osteopenia and PMOP patients compared with that in normal subjects, and were the lowest in the PMOP subjects. The results suggest that Maresin 1 may serve as a new non-invasive diagnostic biomarker for PMOP.

scholarly journals Association between carotid intima-media thickness and bone mineral density: a cross-sectional study in Vietnamese men and women aged 50 years and older

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e028603
Author(s):  
Lich T Nguyen ◽  
Vinh N Pham ◽  
Phuong M N Chau ◽  
Lan T Ho-Pham ◽  
Tuan V Nguyen
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Media Thickness

ObjectivesThe association between osteoporosis and atherosclerosis remains controversial. We sought to define the relationship between carotid intima-media thickness and bone mineral density (BMD) in individuals of Vietnamese background.Design and settingCross-sectional study in Ho Chi Minh City, Vietnam.ParticipantsThe study involved 1460 individuals (559 men) aged 50 years and older (average age 59 years) who were randomly recruited from the community.Outcome measuresBMD at the femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (Hologic, Waltham, Massachusetts, USA). Carotid intima-media thickness (cIMT) was measured using a Philips Ultrasonography (HD7XE). The presence of atherosclerotic plaque was ascertained for each individual. The association between cIMT and BMD was analysed by a multiple linear regression model.ResultsIn unadjusted analysis, cIMT was positively associated with femoral neck BMD in men (p=0.005), but not in women (p=0.242). After adjusting for age, smoking, diabetes and hypertension, the association remained statistically significant in men (partial R2=0.005; p=0.015) but not in women (partial R2=0.008; p=0.369). When the analysis was limited to individuals aged 60 years and older, the association between cIMT and BMD was no longer statistically significant. There was no statistically significant association between cIMT and lumbar spine BMD in either men or women.ConclusionsIn Vietnamese individuals aged 50 years and older, there is a clinically non-significant but statistically significant association between carotid intima-media thickness and BMD in men, not in women.

scholarly journals Bone health in elite Norwegian endurance cyclists and runners: a cross-sectional study

2018 ◽  
Vol 4 (1) ◽  
pp. e000449 ◽  
Author(s):  
Oddbjørn Klomsten Andersen ◽  
Benjamin Clarsen ◽  
Ina Garthe ◽  
Morten Mørland ◽  
Trine Stensrud
Keyword(s):  
Lumbar Spine ◽  
Resistance Training ◽  
Femoral Neck ◽  
Bone Health ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Long Distance ◽  
Cross Sectional ◽  
Heavy Resistance Training ◽  
Road Cyclists

BackgroundAthletes who compete in non-weight-bearing activities such as swimming and cycling are at risk of developing low bone mineral density (BMD). Athletes in long-distance running are at risk of low BMD.Objective (1) To evaluate the bone health in Norwegian male and female national elite road cyclists and middle-distance and long-distance runners, and to identify cases of low BMD. (2) To identify possible risk factors associated with low BMD.MethodsTwenty-one runners (11 females and 10 males) and 19 road cyclists (7 females and 12 males) were enrolled in this cross-sectional study. Dual-energy X-ray absorptiometry measurement of BMD in total body, femoral neck and lumbar spine was measured. Participants completed a questionnaire regarding training, injuries, calcium intake and health variables.ResultsThe cyclists had lower BMD for all measured sites compared with the runners (p≤0.05). Ten of 19 cyclists were classified as having low BMD according to American College of Sports Medicine criteria (Z-score ≤−1), despite reporting to train heavy resistance training on the lower extremities. Low BMD was site specific having occurred in the lumbar spine and the femoral neck and was not confined to females. Type of sport was the only factor significantly associated with low BMD.ConclusionNational elite Norwegian road cyclists had lower BMD compared with runners, and a large proportion was classified as having low BMD, despite having performed heavy resistance training. Interventions to increase BMD in this population should be considered.

Bone Mass Assessment in a Cohort of Adults With Down Syndrome: A Cross-Sectional Study

2017 ◽  
Vol 55 (5) ◽  
pp. 315-324 ◽  
Author(s):  
Ramón Costa ◽  
Rosa De Miguel ◽  
Clara García ◽  
Diego Real de Asúa ◽  
Santos Castañeda ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Lumbar Spine ◽  
General Population ◽  
Femoral Neck ◽  
Bone Mass ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional

Abstract Differences in bone mineral density (BMD) have been observed between adults with Down syndrome (DS) and the general population. The purpose of this article is to describe the prevalence of bone mass disorders in a cohort of adults with DS and their predisposing factors. We performed a cross-sectional study of 104 consecutively recruited adults with DS from an outpatient clinic of a tertiary care hospital in Madrid, Spain. We recorded epidemiological and anthropometric data, nutritional variables, coexisting clinical conditions, and laboratory variables. BMD was measured at the lumbar spine, total hip, and femoral neck using dual-energy X-ray absorptiometry. The prevalence of osteopenia ranged from 48% to 52%, and that of osteoporosis ranged from 19% to 22% depending on the site of measurement (femoral neck or lumbar spine, respectively). Age was the greatest risk factor associated for lower BMD, with similar bone mass accrual curve but with lower peak of BMD than the general population. We conclude that low bone mass is an extremely prevalent condition in adult patients with DS.

scholarly journals Osteoporosis is associated with varus deformity in postmenopausal women with knee osteoarthritis: a cross-sectional study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Cheng Zhang ◽  
Zhikun Zhuang ◽  
Xiaojun Chen ◽  
Keda Li ◽  
Tianye Lin ◽  
...  
Keyword(s):  
Risk Factor ◽  
Femoral Neck ◽  
Knee Osteoarthritis ◽  
Postmenopausal Women ◽  
Varus Deformity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Limb Alignment ◽  
Cross Sectional ◽  
The Relationship

Abstract Background Varus deformity of the knee is a common pathological characteristic in knee osteoarthritis (KOA), and not enough attention has been given to the relationship between knee varus deformity and the state of systemic bone mass. The purpose of this study was to evaluate the potential relationship between bone mineral density (BMD) and varus deformity in postmenopausal women with KOA. Methods A total of 202 postmenopausal women with KOA(KL grade ≥ 2)in our department from January 2018 to June 2020 were reviewed in this cross-sectional study. The hip-knee-ankle angle of the lower extremity (HKA), medial distal femoral angle (MDFA), medial proximal tibial angle (MPTA), and the angle of the joint line (JLCA) were measured in all patients. According to the HKA Angle, these participants were divided into the varus deformity group (HKA < 175.3°) and the normal limb alignment group (175.3°≤ HKA ≤ 180.3°). The BMD of the lumbar (L1-L4), left femoral neck, and left hip were measured by dual-energy X-ray absorptiometry in all patients. The difference in BMD between the knee varus deformity group and the normal limb alignment group was compared, and the relationship between the different angles of limb alignment and the BMD values at different sites was evaluated. Results There were 144 cases (71.3 %) in the varus deformity group and 58 cases (28.7 %) in the normal limb alignment group. BMD at different joint sites within the knee varus deformity group was lower than of the normal limb alignment group, and the prevalence of osteoporosis was higher. After adjusting for confounding factors such as age, BMI, pain duration, and affected side, binary logistic regression showed that osteoporosis was an independent risk factor for varus deformity of KOA, and multiple linear regression showed that the BMD of spine, femoral neck, and hip was significantly associated with varus deformity of KOA. Pearson correlation analysis showed that BMD of the lumbar spine (L1-L4), left femoral neck and left hip joint were positively correlated with the HKA, but negatively correlated with JLCA. MPTA was positively correlated with the left femoral neck and left hip joint BMD, but not correlated with lumbar bone density. Furthermore, in the normal limb alignment group, the HKA was only negatively correlated with JLCA, but not significantly correlated with MDFA and MPTA. In the varus deformity group, the HKA was not only negatively correlated with JLCA but also positively correlated with MDFA and MPTA. Conclusions Osteoporosis should be a major risk factor for varus deformity in postmenopausal women with KOA. The progression of varus deformity of the knee should be concerned in postmenopausal women who simultaneously has KOA and osteoporosis.

Morphometric Parameters of the Proximal Femur in Nepalese Population: A Cross-sectional Study

2020 ◽  
Vol 3 (2) ◽  
pp. 8-12
Author(s):  
Bishnu Pokharel ◽  
Ashok Raj Pant ◽  
Pashupati Chaudhary ◽  
Guru Prasad Khanal
Keyword(s):  
Femoral Neck ◽  
Proximal Femur ◽  
Cross Sectional Study ◽  
Morphometric Parameters ◽  
Radiographic Measurement ◽  
Sectional Study ◽  
Cross Sectional ◽  
Neck Width ◽  
Femur Fractures ◽  
Femoral Neck Width

Background: Most of the proximal femur fractures are managed surgically by internal fiation with a variety of implants. Improperly designed or ill-fited implant may lead to a failure of fiation, breakage of implant and nonunion, thus increasing the morbidity and the cost of treatment. This study was conducted to evaluate the radiographic morphometry of the proximal femur which may be helpful in designing the implants for the Nepalese population. Methods: In this cross-sectional study, 84 patients aged 18 years and above with traumatic unilateral hip fracture were enrolled. Anthropometric measurements were recorded. The postoperative check X-ray in the antero-posterior view of the pelvis and bilateral hip were assessed. Various morphometric parameters of the proximal femur were measured and recorded in the radiograph of the unaffcted limb using a digital caliper. Results: Out of 84 patients, 47 were male. The mean ± SD femoral neck width, femoral neck length, femoral axis length, cervico-diaphyseal angle, acetabular tear-drop distance, and great trochanter-pubic symphysis distance were 36.10 ± 5.67 mm, 28.29 ± 4.18 mm, 104.51 ± 9.56 mm, 130.35 ± 8.67°, 32.56 ± 11.05 mm, and 163.07 ± 10.71 mm respectively. The femoral neck width was found to be signifiantly larger in males (39.08 ± 3.06 mm) than in females (32.32 ± 5.99 mm, p < 0.001). Conclusion: This study determined the radiographic measurement of the proximal femur and found that the femoral neck width of the males was larger than that of the females.

scholarly journals BMD status of Postmenopausal Women in relation with BMI: A study with 93 cases

2016 ◽  
Vol 17 (2) ◽  
pp. 138-141
Author(s):  
Samira Sharmin ◽  
Mabubul Haque ◽  
Syedur Rahman Miah ◽  
Md Mahbub Ur Rahman ◽  
Jasmine Ara Haque ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Lumbar Vertebrae ◽  
The Body ◽  
Mineral Density ◽  
Cross Sectional ◽  
T Score ◽  
Minimal Trauma ◽  
The Mean

Objectives: Low bone mass is a common disorder in elderly population which predisposes to fracture with minimal trauma. This study was performed to find out the association between the Body Mass Index (BMI) and Bone Mineral Density (BMD) in postmenopausal women.Materials and Methods: This cross sectional study was carried out at Institute of Nuclear Medicine and Allied Sciences Comilla and Mitford, Dhaka over a period of 12 months from January 2013 to December 2013. A total 93 postmenopausal women were enrolled for this study. All postmenopausal women underwent a BMD scan of femoral neck and lumbar vertebrae using a Dual Energy X-ray Absorptiometry (DEXA). Participants were categorized into three groups according to their age and BMI. BMD were expressed base on T-score according to WHO criteria. The relation among BMI, age and BMD were assessed.Results: The results of this study showed that the mean age of the study group was 57.13±7.49 years with range of 46 to 75 years. The most postmenopausal women were in age group 55-65years. The mean BMI of the study subjects were 24.18±5.08 kg/m2 with a range of 15.62 to 36.20 kg/m2. Among 93 subjects osteopenia was greater at lumbar spine (45.2%) with T-score mean±SD-1.83±0.33 and osteoporosis at femoral neck (51.6%) with T-score mean ±SD-3.36±-0.67. Pearson’s correlation coefficient test showed inverse relationship between age and BMD both lumbar spine (r = -0.301, p = 0.003) and femoral neck (r = -0.303, p=0.003) whereas the positive relation between BMI and BMD both at lumbar spine (r=0.338, p=0.001) and femoral neck (r =0.343, p=0.001). These showed that with advancing age, BMD decreases and the risk of osteoporosis increases and with increasing BMI, BMD increases and risk of osteoporosis decreases.Conclusion: The findings of this study portrait that aging and low BMI are risk factors associated with bone loss. So preventive measure should be taken for high risk post menopausal women.Bangladesh J. Nuclear Med. 17(2): 138-141, July 2014

scholarly journals Depression and Quality of Life among Postmenopausal Women in Bangladesh: A Cross-sectional Study

2017 ◽  
Vol 23 (3) ◽  
pp. 172 ◽  
Author(s):  
Mamun Ibn Bashar ◽  
Kawsar Ahmed ◽  
Muhammad Shahin Uddin ◽  
Farzana Ahmed ◽  
Abdullah-Al Emran ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Postmenopausal Women ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional
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