scholarly journals Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria

2020 ◽  
Vol 11 ◽  
Author(s):  
Ting Su ◽  
Ye Qiu ◽  
Xuesi Hua ◽  
Bi Ye ◽  
Haoming Luo ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Resistant Bacteria ◽  
Antibiotics Resistance ◽  
Active Components ◽  
Antibiotic Resistant Bacteria ◽  
Antimicrobial Drugs ◽  
Antibiotic Resistant ◽  
Potential Activity

Antibiotic resistance is becoming significantly prominent and urgent in clinical practice with the increasing and wide application of antibacterial drugs. However, developing and synthesizing new antimicrobial drugs is costly and time-consuming. Recently, researchers shifted their sights to traditional Chinese medicine (TCM). Here, we summarized the inhibitory mechanism of TCM herbs and their active ingredients on bacteria, discussed the regulatory mechanism of TCM on antibiotic-resistant bacteria, and revealed preclinical results of TCM herbs and their active components against antibiotic-resistant bacteria in mouse models. Those data suggest that TCM herbs and their effective constituents exhibit potential blockage ability on antibiotic-resistant bacteria, providing novel therapeutic ideas for reversing antibiotic resistance.

scholarly journals Antibiotics resistance in pathogenic bacteria isolated from water and sediment around the floating fish farms in the Nha Trang bay

2021 ◽  
Vol 20 (4A) ◽  
pp. 199-209
Author(s):  
Nguyen Kim Hanh ◽  
Nguyen Trinh Duc Hieu ◽  
Nguyen Minh Hieu ◽  
Vo Hai Thi ◽  
Pham Thi Mien ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Pathogenic Bacteria ◽  
Water Environment ◽  
Resistant Bacteria ◽  
Antibiotics Resistance ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Water And Sediment ◽  
Nha Trang Bay ◽  
The Impact

To assess the impact of antibiotic use in aquaculture in Nha Trang bay, we conducted this study with the aim of assessing antibiotic resistance of opportunistic pathogenic bacteria isolated from water and sediment around shrimp/fish cages in the Nha Trang bay. 109 strains of Vibrio, Salmonella-Shigella and Aeromonas groups were isolated in the surrounding environment of farming areas in Dam Bay and Hon Mieu. Antimicrobial resistance test of these 109 strains showed that in the water environment in Dam Bay, TET (96.6%) and NIT (92.5%) were the two antibiotics with the highest rates of resistant bacteria while no bacteria were resistant to RIF. All 5 types of antibiotics had a statistically insignificant percentage of antibiotic-resistant bacteria in water samples at Hon Mieu, ranging from 33.3% to 68.9%. Also in the water environment, the rate of antibiotic-resistant bacteria in Dam Bay was not influenced by the distance to the cages (42.5–66.6%). Meanwhile, in Hon Mieu, the highest rate of resistant bacteria was observed at the distance of 200 m (100%) away from cages and the lowest rate at the distance of 100 m (20%). In the sediment environment around the cages, both the Dam Bay and Hon Mieu farming areas showed the highest rates of antibiotic-resistant bacteria against TET, NIF and RIF had the lowest rate of resistant bacteria. Among the total of 109 strains tested for antibiotic resistance, 2 strains labeled TCBS_HM200 m and SS_HM200 m were found to be resistant to all 5 tested antibiotics. These two strains were respectively identified as Vibrio harveyi and Oceanimonas sp.

scholarly journals Comparison of Antibiotic Resistance Profile of Escherichia coli between Pristine and Human-Impacted Sites in a River

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 575
Author(s):  
Emi Nishimura ◽  
Masateru Nishiyama ◽  
Kei Nukazawa ◽  
Yoshihiro Suzuki
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Resistant Bacteria ◽  
Downstream Site ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Upstream Site ◽  
Resistance Profile ◽  
Antibiotic Resistance Profile ◽  
Significant Difference

Information on the actual existence of antibiotic-resistant bacteria in rivers where sewage, urban wastewater, and livestock wastewater do not load is essential to prevent the spread of antibiotic-resistant bacteria in water environments. This study compared the antibiotic resistance profile of Escherichia coli upstream and downstream of human habitation. The survey was conducted in the summer, winter, and spring seasons. Resistance to one or more antibiotics at upstream and downstream sites was on average 18% and 20%, respectively, and no significant difference was observed between the survey sites. The resistance rates at the upstream site (total of 98 isolated strains) to each antibiotic were cefazolin 17%, tetracycline 12%, and ampicillin 8%, in descending order. Conversely, for the downstream site (total of 89 isolated strains), the rates were ampicillin 16%, cefazolin 16%, and tetracycline 1% in descending order. The resistance rate of tetracycline in the downstream site was significantly lower than that of the upstream site. Furthermore, phylogenetic analysis revealed that many strains showed different resistance profiles even in the same cluster of the Pulsed-Field Gel Electrophoresis (PFGE) pattern. Moreover, the resistance profiles differed in the same cluster of the upstream and the downstream sites. In flowing from the upstream to the downstream site, it is plausible that E. coli transmitted or lacked the antibiotic resistance gene.

scholarly journals Antibiotic-Resistant Bacteria in Green Turtle (Chelonia mydas) Rearing Seawater

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1841
Author(s):  
Thanaporn Chuen-Im ◽  
Korapan Sawetsuwannakun ◽  
Pimmnapar Neesanant ◽  
Nakarin Kitkumthorn
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infection ◽  
High Mortality ◽  
Mortality Rates ◽  
Sea Turtle ◽  
Resistant Isolate ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Increased Risk

Antibiotic resistance of microorganisms is a serious health problem for both humans and animals. Infection of these bacteria may result in therapy failure, leading to high mortality rates. During an early intervention program process, the Sea Turtle Conservation Center of Thailand (STCCT) has faced high mortality rates due to bacterial infection. Previously, investigation of juvenile turtle carcasses found etiological agents in tissue lesions. Further determination of sea water in the turtle holding tanks revealed a prevalence of these causative agents in water samples, implying association of bacterial isolates in rearing water and infection in captive turtles. In this study, we examined the antibiotic resistance of bacteria in seawater from the turtle holding tank for a management plan of juvenile turtles with bacterial infection. The examination was carried out in three periods: 2015 to 2016, 2018, and 2019. The highest isolate numbers were resistant to beta-lactam, whilst low aminoglycoside resistance rates were observed. No gentamicin-resistant isolate was detected. Seventy-nine isolates (71.17%) were resistant to at least one antibiotic. Consideration of resistant bacterial and antibiotic numbers over three sampling periods indicated increased risk of antibiotic-resistant bacteria to sea turtle health. Essentially, this study emphasizes the importance of antibiotic-resistant bacterial assessment in rearing seawater for sea turtle husbandry.

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