scholarly journals Cognitive and Behavioral Inhibition Deficits in Parkinson’s Disease: The Hayling Test as a Reliable Marker

2021 ◽  
Vol 12 ◽  
Author(s):  
Antònia Siquier ◽  
Pilar Andrés
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Short Form ◽  
Behavioral Assessment ◽  
Behavioral Approach ◽  
Neuropsychological Measures ◽  
Sf 36 ◽  
Behavior Rating Inventory ◽  
Neuropsychological Tasks ◽  
Reliable Marker

ObjectiveThe present study seeks to provide an overview of executive (inhibition and flexibility) deficits in Parkinson’s disease (PD) by combining a cognitive and behavioral approach.MethodsFifteen PD patients and 15 healthy controls underwent a neuropsychological and behavioral assessment including the Hayling and Trails Tests, the Questionnaire for Impulsive–Compulsive Disorders in Parkinson’s Disease (QUIP-RS), the Behavior Rating Inventory of Executive Function (BRIEF-A), and the Short Form-36 Health Survey (SF-36). The level of awareness of executive functioning was also analyzed. We finally explored how these neuropsychological and clinical outcomes could relate to each other.ResultsPD patients performed significantly worse in both neuropsychological tasks designed to evaluate inhibition abilities. They also reported more inhibition difficulties in everyday life and poorer quality of life. Associations between neuropsychological measures and self-reports were found. Moreover, as indicated by the discrepancy score, PD patients were as accurate as their relatives in self-reporting their executive daily difficulties.ConclusionInhibition and cognitive flexibility impairments assessed by the neuropsychological tests (Hayling and Trails tests) seem to capture daily life executive problems in PD. Furthermore, our study provides a deeper understanding of PD patients’ and their relatives’ experience of these executive dysfunctions.

scholarly journals Validating the Parkinson’s disease caregiver burden questionnaire (PDCB) in German caregivers of advanced Parkinson’s disease patients

2019 ◽  
Vol 31 (12) ◽  
pp. 1791-1800 ◽  
Author(s):  
M. Klietz ◽  
L. Rippena ◽  
F. Lange ◽  
A. Tulke ◽  
L. Paracka ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Caregiver Burden ◽  
Short Form ◽  
Assessment Tools ◽  
Life Questionnaire ◽  
German Version ◽  
Advanced Parkinson’S Disease ◽  
Adequate Measure ◽  
Sf 36

ABSTRACTBackground:Advanced Parkinson’s disease (PD) may place a high burden on patients and their caregivers. Understanding the determinants of caregiver burden is of critical importance. This understanding requires the availability of adequate assessment tools. Recently, the Parkinson’s disease caregiver burden questionnaire (PDCB) has been developed as a PD-specific measure of caregiver burden. However, the PDCB has only been evaluated in a sample of Australian caregivers of patients at a less advanced stage of the disease.Objective:We tested whether a German translation of the PDCB qualifies as an adequate measure of caregiver burden in a German sample of caregivers of advanced patients with PD.Methods:We collected PDCB data from 65 caregivers of advanced patients with PD. Reliability of the scale was assessed and compared against the original version. To validate the German version of the PDCB, we examined the correlations with the caregiver burden inventory (CBI), the short form 36 health survey (SF-36), the Parkinson’s disease quality of life questionnaire 39 (PDQ-39), disease duration, and the amount of caregiving time.Results:The total PDCB score proved to be reliable and to be significantly related to CBI and SF-36 scores. PDCB scores also increased with increasing amounts of caregiving time.Conclusions:The German version of the PDCB appears to be an adequate measure of caregiver burden in caregivers of advanced PD patients.

scholarly journals Is Depression or Apathy Playing a Key Role in Predicting Financial Capacity in Parkinson’s Disease with Dementia and Frontotemporal Dementia?

2021 ◽  
Vol 11 (6) ◽  
pp. 785
Author(s):  
Vaitsa Giannouli ◽  
Magda Tsolaki
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Frontotemporal Dementia ◽  
Cognitive Abilities ◽  
Short Form ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Decisive Role ◽  
Financial Capacity ◽  
Capacity Performance

(1) Background: Depression and apathy both affect cognitive abilities, such as thinking, concentration and making decisions in young and old individuals. Although apathy is claimed to be a “core” feature of Parkinson’s disease (PD) and frontotemporal dementia (FTD), it may occur in the absence of depression and vice versa. Thus, the aim of this study is to explore whether depression or apathy better predict financial capacity performance in PD and FTD as well as in nondemented participants. (2) Methods: Eighty-eight participants divided into three groups (PD, FTD and non-demented participants) were examined with the Mini-Mental State Examination (MMSE) and the Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS)—Full and short form. The Geriatric Depression Scale informant version (GDS-15) and the Irritability-Apathy Scale (IAS) we completed by caregivers. (3) Results: The results indicated that both PD and FTD patients’ general cognitive functioning and financial capacity performance is negatively influenced by apathy and not by depression. (4) Conclusions: Differences in financial capacity performance indicate that apathy should not be disregarded in clinical assessments. Further studies on larger PD and FTD populations are necessary in order to investigate the decisive role of mood factors on financial capacity impairment.

scholarly journals Karakteristik dan Kualitas Hidup Pasien Penyakit Parkinson dengan Probabel Gangguan Perilaku Tidur Fase Gerak Mata Cepat di Manado

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Grisheila M. Koleangan ◽  
Arthur H. P. Mawuntu ◽  
Mieke A. H. M. Kembuan
Keyword(s):  
Quality Of Life ◽  
High School ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Movement ◽  
Junior High School ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Sf 36

Abstract: Rapid eye movement sleep behavior disorder (RBD) often occurs in patients with Parkinson's disease (PD) and it could reduce their quality of life (QoL). This study was aimed to obtain the characteristics and QoL of PD patients with pRBD in Manado. This was a descriptive study with a cross-sectional design. Subjects were PD patients with pRBD at Prof. Dr. R. D. Kandou Hospital from October to November 2019. The QoL was measured by using the SF-36 QoL questionnaire. The results obtained 48 eligible subjects. Male patients were more common than females (52.1% vs 47.9%). Most of the subjects were 60-69 years (54.1%), had senior high school and junior high school education (each of 29.1%), and unemployed (41.7%). Moreover, 62.5% of patients had been diagnosed as PD since 1-5 years ago. The mean score of the physical and mental component of the subjects were 46.5 and 60.8 subsequently. In conclusion, the majority of patients with Parkinson's disease and pRBD were 60-69 years, senior or junior high school educated, unemployed, and had been diagnosed as PD since 1-5 years ago. Their quality of life in physical component was below norm-based score but in mental component was still good.Keywords: Parkinson's disease, probable RBD, quality of life, SF-36 Abstrak: Gangguan perilaku tidur fase gerak mata cepat (rapid eye movement sleep behaviour disorder/RBD) sering terjadi pada pasien penyakit Parkinson (PD) yang mungkin menurunkan kualitas hidup mereka. Penelitian ini bertujuan untuk mengetahui karakteristik dan kualitas hidup pasien PD dengan probabel RBD (pRBD) di Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang terhadap pasien PD dengan pRBD yang datang ke RSUP Prof. Dr. R. D. Kandou Manado bulan Oktober-November 2019. Kualitas hidup diukur menggu-nakan kuesioner kualitas hidup SF-36. Hasil penelitian mendapatkan 48 pasien yang meme-nuhi kriteria penelitian. Pasien berjenis kelamin laki-laki lebih banyak daripada perempuan (52,1% vs 47,9%). Sebagian besar pasien berada pada kelompok usia 60-69 tahun (54,1%), tingkat pendidikan terakhir SMA/Sederajat dan SMP sama banyak (29,1%), dan tidak bekerja (41,7%). Sebanyak 62,5% subjek telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Skor rerata komponen fisik dan komponen mental kualitas hidup SF-36 ialah 46,5 dan 60,8. Sim-pulan penelitian ini ialah mayoritas pasien penyakit Parkinson dengan pRBD berusia 60-69 tahun, pendidikan SMA/sederajat atau SMP, tidak bekerja, dan telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Kualitas hidup pasien penyakit Parkinson dengan pRBD pada komponen fisik secara umum berada di bawah skor normatif tetapi komponen mental masih baik.Kata kunci: penyakit Parkinson, probabel RBD, kualitas hidup, SF-36

scholarly journals Impact of stimulating cognitive-motor training on neuropsychological status and quality of life in patients with Parkinson's disease

2018 ◽  
Vol 10 (4) ◽  
pp. 65-71
Author(s):  
Yu. N. Bykov ◽  
T. B. Bender ◽  
Yu. N. Vasiliev ◽  
A. N. Kalyagin ◽  
Т. М. Maksikova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Combination Therapy ◽  
Mobile Devices ◽  
Physical Functioning ◽  
Motor Training ◽  
Neuropsychological Status ◽  
Sf 36

Motor and non-motor symptoms are identified in the clinical picture of Parkinson's disease (PD). Among its non-motor manifestations, cognitive impairment (CI) and emotional disorders play a special role in PD. It is important to search for new forms and methods of cognitive therapy in patients with PD.Objective:to analyze neuropsychological status and quality of life (QOL) in PD patients and to evaluate the efficiency of personalized combination therapy with a stimulating cognitive motor training on computer and mobile devices in these patients.Patients and methods. The investigation enrolled 112 patients with PD. A study group included 56 PD patients who received a cycle of combination therapy with cognitive-motor training on PC and mobile devices; a control group consisted of 56 PD patients who had only a drug therapy cycle. To evaluate neuropsychological status and QOL, the investigators used the Montreal Cognitive Assessment (MoCA), the McNair and Kahn memory self-evaluation scale, the Hospital Anxiety and Depression Scale (HADS), and the 36-Item Short Form Health Survey (SF-36) questionnaire.Results and discussion. According to MoCA scores, CI of varying severity was diagnosed in the majority of patients: in 75 and 80.4% in the study and control groups, respectively. Depressive syndrome was detected in 53.6 and 64.3% in these groups, respectively. According to the SF-36, the physical status of patients had the greatest effect in reducing their QOL. There were treatment-induced statistically significant positive changes for the following domains: physical functioning (p<0.01), role-physical functioning (p<0.001), pain intensity (p<0.01), general health (p<0.01), role emotional (p<0.0001), and mental health (p<0.01).Conclusion.The investigation has shown the efficiency of personalized therapy including stimulating cognitive-motor training on computer and mobile devices, which improves neuropsychological status and QOL in patients with PD.

scholarly journals Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
N. Vila-Chã ◽  
S. Cavaco ◽  
A. Mendes ◽  
A. Gonçalves ◽  
I. Moreira ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Performance ◽  
Rating Scale ◽  
Short Form ◽  
Structured Interview ◽  
Smoking Habits ◽  
Addictive Behaviors ◽  
Study Results ◽  
Compulsive Behaviors

Introduction. Pain is a major nonmotor symptom of Parkinson’s disease (PD), and central parkinsonian pain is the core feature of the putative Park pain subtype of PD. This study aimed to explore the cognitive and behavioral profile of PD patients with central parkinsonian pain. Material and Methods. A structured interview was used to identify and characterize pain in a cohort of 260 consecutive PD patients. The Ford classification of pain was applied. The Dementia Rating Scale-2 (DRS-2) and the Impulse Control Disorders in Parkinson’s Disease Short Form (QUIP-S) were administered, and patients’ smoking habits were recorded. The Unified Parkinson’s Disease Rating Scale (UPDRS) was used to assess motor and nonmotor symptoms in off and on conditions. Results. One hundred and eighty-eight patients (68%) reported pain; and in 41 (22%) of them, the pain was classified as central parkinsonian pain. PD patients with central parkinsonian pain had better cognitive performance in DRS-2 Initiation/Perseveration and Conceptualization subscales but reported more other compulsive behaviors (e.g., hobbyism, punding, and walkabout) and had more current smoking habits than those without pain or with non-central parkinsonian pain. Multiple logistic regression analyses revealed that the DRS-2 Conceptualization subscale, other compulsive behaviors, and smoking habits remained statistically associated with central parkinsonian pain even when other significant covariates were considered. Only patients with pain, regardless of type, had a gambling disorder. Discussion. The study results provide further evidence that pain revealed that patients with central parkinsonian pain are more likely to present compulsive or addictive behaviors, despite having more preserved cognitive performance. Patients with central parkinsonian pain appear to have a distinct phenotype of PD.

Psychometric investigation of the affiliate stigma scale in Mexican Parkinson’s disease caregivers: Development of a short form

2021 ◽  
pp. 1-11
Author(s):  
Mickeal Pugh ◽  
Paul B. Perrin ◽  
Jack D. Watson ◽  
Duygu Kuzu ◽  
Carmen Tyler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Factor Structure ◽  
Convergent Validity ◽  
Short Form ◽  
Factor Analyses ◽  
Confirmatory Factor Analyses ◽  
Stigma Scale ◽  
Affiliate Stigma ◽  
Exploratory Factor Analyses

BACKGROUND: Parkinson’s disease (PD) caregivers, particularly in Latin America, may experience high levels of affiliate stigma due to their association with a person having a disability. The most common measure used of this construct in the literature, the Affiliate Stigma Scale, was validated using non-standard and questionable methods. OBJECTIVE: The purpose of this study was to investigate the factor structure and psychometric properties of the Spanish version of the Affiliate Stigma Scale with PD caregivers in Mexico using more widely accepted psychometric approaches including confirmatory and exploratory factor analyses (confirmatory factor analyses (CFAs) and exploratory factor analyses (EFAs)). METHODS: A sample of 148 PD caregivers from Mexico completed this measure, as well as indices of caregiver burden and anxiety. RESULTS: Initial CFAs revealed that the data did not fit either the originally proposed one-factor or three-factor structures. An EFA was then conducted which was unable to discern any factor structure. Upon instituting a stepwise removal alpha-if-item-deleted process, a 5-item Affiliate Stigma Scale Spanish Short Form was retained with an adequate Cronbach’s alpha, good convergent validity, and a Short Form CFA generally indicating adequate fit. CONCLUSIONS: The new Spanish Affiliate Stigma Scale Short Form holds promise for more appropriately measuring affiliate stigma likely in general but particularly in Spanish and among PD caregivers. The Short Form can assist not only in assessing levels of caregiver affiliate stigma, but in creating novel interventions to help support caregivers and decrease stigma.

scholarly journals Evolution of impulsive–compulsive behaviors and cognition in Parkinson’s disease

2019 ◽  
Vol 267 (1) ◽  
pp. 259-266
Author(s):  
Aleksander H. Erga ◽  
Guido Alves ◽  
Ole Bjørn Tysnes ◽  
Kenn Freddy Pedersen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Short Form ◽  
Population Based ◽  
Self Report ◽  
Cognitive Changes ◽  
Compulsive Behaviors ◽  
Changes Over Time ◽  
Over Time

Abstract The longitudinal course of ICBs in patients with Parkinson’s disease (PwP) relative to controls has not been explored as of yet. The aim of this study is to determine the frequency, evolution and associated cognitive and clinical features of impulsive and compulsive behaviors (ICBs) over 4 years of prospective follow-up in a population-based cohort with early Parkinson’s disease (PD). We recruited 124 cognitively intact participants with early PD and 156 matched controls from the Norwegian ParkWest study. ICBs were assessed using the self-report short form version of the Questionnaire for Impulsive–Compulsive Disorders in PD. Cognitive changes were examined in PwP with and without ICBs who completed the 4-year follow-up. Generalized linear mixed modelling and mixed linear regression were used to analyze clinical factors and cognitive changes associated with ICBs in PwP over time. ICBs were more common in PwP than controls at all visits, with an age-adjusted odds ratio (OR) varying between 2.5 (95% CI 1.1–5.6; p = 0.022) and 5.1 (95% CI 2.4–11.0; p < 0.001). The 4-year cumulative frequency of ICBs in PwP was 46.8% and 23.3% developed incident ICBs during the study period, but the presence of ICBs was non-persistent in nearly 30%. ICBs were independently associated with younger age (OR 0.95, 95% CI 0.91–0.99: p = 0.008) and use of dopamine agonist (OR 4.1, 95% CI 1.56–10.69). Cognitive changes over time did not differ between patients with and without ICBs. In conclusion, ICBs are common in PwP, but are often non-persistent and not associated with greater cognitive impairment over time.

scholarly journals Cognitive Rehabilitation for Executive Dysfunction in Parkinson's Disease: Application and Current Directions

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jessica Calleo ◽  
Cristina Burrows ◽  
Harvey Levin ◽  
Laura Marsh ◽  
Eugene Lai ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Dysfunction ◽  
Cognitive Skills ◽  
Cognitive Rehabilitation ◽  
Small Sample ◽  
Behavioral Approach ◽  
Rehabilitation Programs

Cognitive dysfunction in Parkinson's disease contributes to disability, caregiver strain, and diminished quality of life. Cognitive rehabilitation, a behavioral approach to improve cognitive skills, has potential as a treatment option to improve and maintain cognitive skills and increase quality of life for those with Parkinson's disease-related cognitive dysfunction. Four cognitive rehabilitation programs in individuals with PD are identified from the literature. Characteristics of the programs and outcomes are reviewed and critiqued. Current studies on cognitive rehabilitation in PD demonstrate feasibility and acceptability of a cognitive rehabilitation program for patients with PD, but are limited by their small sample size and data regarding generalization of effects over the long term. Because PD involves progressive heterogeneous physical, neurological, and affective difficulties, future cognitive rehabilitation programs should aim for flexibility and individualization, according to each patient's strengths and deficits.

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