scholarly journals The Architecture of Contemporary Care Networks for Rare Movement Disorders: Leveraging the ParkinsonNet Experience

2021 ◽  
Vol 12 ◽  
Author(s):  
Bart P. van de Warrenburg ◽  
Mark Tiemessen ◽  
Marten Munneke ◽  
Bastiaan R. Bloem

In this paper, we present a universal model for implementing network care for persons living with chronic diseases, specifically those with rare movement disorders. Building on our longstanding experience with ParkinsonNet, an integrated care network for persons living with Parkinson's disease or a form of atypical parkinsonism, we provide a series of generic, supportive building blocks to (re)design comparable care networks. We discuss the specific challenges related to rare movement disorders and how these challenges can inform a tailored implementation strategy, using the basic building blocks to offer practical guidance. Lastly, we identify three main priorities to facilitate network development for these rare diseases. These include the clustering of different types of rare movement disorders at the network level, the implementation of supportive technology, and the development of interdisciplinary guidelines.

2021 ◽  
Vol 13 (10) ◽  
pp. 5516
Author(s):  
Maro Vlachopoulou ◽  
Christos Ziakis ◽  
Kostas Vergidis ◽  
Michael Madas

The agribusiness sector shows tremendous growth and sustainability prospects by exploiting the challenges of “AgriFood-Tech” business models in the digital environment, by encouraging innovation, accelerating institutional and structural change, enhancing productivity, and introducing new products and services to the market. The purpose of this study is to investigate different types of “AgriFood-Tech” digital models and analyze their role in the agribusiness and AgriFood sector. Based on relevant literature research, the authors present and discuss five indicative examples of “AgriFood-Tech” models, using the Business Model Canvas (BMC) framework. The methodology included the analysis of the components of innovative AgriFood innovative business models paradigms, such as distribution channels, key partnerships, customer selection and relationships, financial viability, and value proposition. The goal was to explore their building blocks and the required decisions that create, deliver, and capture value. Our findings highlight the importance of specific features of the models, including online sharing of information between the stakeholders, online searches of agri-products, and logistics services in the agribusiness sector.


Synthese ◽  
2021 ◽  
Author(s):  
Matti Sarkia

AbstractThis paper analyzes three contrasting strategies for modeling intentional agency in contemporary analytic philosophy of mind and action, and draws parallels between them and similar strategies of scientific model-construction. Gricean modeling involves identifying primitive building blocks of intentional agency, and building up from such building blocks to prototypically agential behaviors. Analogical modeling is based on picking out an exemplary type of intentional agency, which is used as a model for other agential types. Theoretical modeling involves reasoning about intentional agency in terms of some domain-general framework of lawlike regularities, which involves no detailed reference to particular building blocks or exemplars of intentional agency (although it may involve coarse-grained or heuristic reference to some of them). Given the contrasting procedural approaches that they employ and the different types of knowledge that they embody, the three strategies are argued to provide mutually complementary perspectives on intentional agency.


Entropy ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. 492
Author(s):  
Valentina Y. Guleva ◽  
Polina O. Andreeva ◽  
Danila A. Vaganov

Finding the building blocks of real-world networks contributes to the understanding of their formation process and related dynamical processes, which is related to prediction and control tasks. We explore different types of social networks, demonstrating high structural variability, and aim to extract and see their minimal building blocks, which are able to reproduce supergraph structural and dynamical properties, so as to be appropriate for diffusion prediction for the whole graph on the base of its small subgraph. For this purpose, we determine topological and functional formal criteria and explore sampling techniques. Using the method that provides the best correspondence to both criteria, we explore the building blocks of interest networks. The best sampling method allows one to extract subgraphs of optimal 30 nodes, which reproduce path lengths, clustering, and degree particularities of an initial graph. The extracted subgraphs are different for the considered interest networks, and provide interesting material for the global dynamics exploration on the mesoscale base.


2022 ◽  
pp. 1-15
Author(s):  
David Danks

There are growing calls for more digital ethics, largely in response to the many problems that have occurred with digital technologies. However, there has been less clarity about exactly what this might mean. This chapter argues first that ethical decisions and considerations are ubiquitous within the creation of digital technology. Ethical analyses cannot be treated as a secondary or optional aspect of technology creation. This argument does not specify the content of digital ethics, though, and so further research is needed. This chapter then argues that this research must take the form of translational ethics: a robust, multi-disciplinary effort to translate the abstract results of ethical research into practical guidance for technology creators. Examples are provided of this kind of translation from principles to different types of practices.


1998 ◽  
Vol 51 (3) ◽  
pp. 327-335 ◽  
Author(s):  
Thomas Bell ◽  
Michael O'Connor ◽  
V. K. Jones ◽  
Andrew Rekow ◽  
Gabriel Elkaim ◽  
...  

High-precision ‘autofarming’ makes possible farming techniques previously impractical using metre-level Differential GPS-based control systems: techniques such as tape irrigation, the elimination of guess rows, and precise contour farming. A Carrier-Phase Differential gps positioning and attitude system with centimetre-level and 0·1° accuracy was installed in a large farm tractor. Four types of trajectories (lines, arcs, spirals, and curves) were identified as basic building blocks necessary to generate a ‘global’ trajectory for a realistic autofarming path. Information about each trajectory type was translated into reference state specifications that a linear controller used to control the tractor over velocities between 0·7 and 2·8 m/s to within approximately 6 cm (1 σ) without implement and 10 cm (1 σ) with implement on sloped terrain using a previously developed tractor model. These results are a significant step towards a realistic autofarming system because they not only demonstrate accurate control over various realistic operating speeds but over different types of trajectories necessary for a commercial system.


2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Margot CW Joosen ◽  
Karlijn M van Beurden ◽  
Berend Terluin ◽  
Jaap van Weeghel ◽  
Evelien PM Brouwers ◽  
...  

Author(s):  
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Olga Makeeva ◽  
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Igor Tsarkov

The discovery of Critical Path Method (CPM) made breakdown of project management possible. In the result, project management consists of some knowledge areas like project time management, project cost management etc. But there is a problem: CPM couldn�t take into account resource constrains and costs. So there are a lot of models which include different types of constraints. But the vast majority of such models have serious problem: it�s impossible to scale them to universal model which could take into account time, cost and resources together. We suppose that this universal model could be developed on the base of genetic algorithms and it allow increasing efficiency and quality of project management. In this article we discuss the base principals and tools of such model and specific genetic algorithm is proposed


2016 ◽  
Vol 16 (9) ◽  
pp. 9862-9866
Author(s):  
Sung Ho Jung ◽  
Yubin Cha ◽  
Yeonweon Choi ◽  
Heekyoung Choi ◽  
Jong Hwa Jung

2009 ◽  
Vol 67 (4) ◽  
pp. 1133-1142 ◽  
Author(s):  
Hélio A.G. Teive

Spinocerebellar ataxias (SCAs) constitute a heterogeneous group of neurodegenerative diseases characterized by progressive cerebellar ataxia in association with some or all of the following conditions: ophthalmoplegia, pyramidal signs, movement disorders, pigmentary retinopathy, peripheral neuropathy, cognitive dysfunction and dementia. OBJECTIVE: To carry out a clinical and genetic review of the main types of SCA. METHOD: The review was based on a search of the PUBMED and OMIM databases. RESULTS: Thirty types of SCAs are currently known, and 16 genes associated with the disease have been identified. The most common types are SCA type 3, or Machado-Joseph disease, SCA type 10 and SCA types 7, 2, 1 and 6. SCAs are genotypically and phenotypically very heterogeneous. A clinical algorithm can be used to distinguish between the different types of SCAs. CONCLUSIONS: Detailed clinical neurological examination of SCA patients can be of great help when assessing them, and the information thus gained can be used in an algorithm to screen patients before molecular tests to investigate the correct etiology of the disease are requested.


2016 ◽  
Vol 13 (3) ◽  
pp. 278-302 ◽  
Author(s):  
Hanne Nørreklit ◽  
Lennart Nørreklit ◽  
Falconer Mitchell

Purpose The purpose of this paper is to enhance the relationship between research and practice. It addresses the question: How can practitioners’ use of generalisations be understood, with a view towards producing research-based generalisations that facilitate use in practice? Design/methodology/approach Language games are used to explore generalisation in practice, and the framework of pragmatic constructivism is adopted to characterise the generation of practice generalisation. Findings Practice is conceptualised as a complex set of clusters of organised actions run by a set of applied generalisations and driven by human intentions. Practice also encompasses reflective activities that aim to create the generalisations and reflect them into the specific circumstances to create functioning practice. Generalisations depend on underlying concepts. The formation and structure of concepts is explored and used to create the construction and use of different types of generalisation. Generalisations function as cognitive building blocks in constructing strings of interconnected functioning activities. Managers make their own functioning generalisations that, however, do not satisfy the research criteria for acceptable generalisations. The research/practice gap is shaped by the very different language games played. Research limitations/implications If research is to be useful to practice, the generalisations produced must methodologically articulate the types of generalisation that pervade the methods with which practitioners construct functioning activities. Further research has to give more insight into such processes. Originality/value The paper contributes insight into both the generalisation debate and the research/practice gap debate.


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