scholarly journals Jidong Restless Legs Syndrome Cohort Study: Objectives, Design, and Baseline Screening

2021 ◽  
Vol 12 ◽  
Author(s):  
Shu-Hong Wang ◽  
Xue-Yu Chen ◽  
Xiao-Ping Wang
Keyword(s):  
Cohort Study ◽  
Restless Legs Syndrome ◽  
Scientific Evidence ◽  
Vascular Diseases ◽  
Cardiovascular Risks ◽  
Negative Effects ◽  
Restless Legs ◽  
Cerebrovascular Events ◽  
Increased Risk ◽  
China National Petroleum Corporation

Background: Restless legs syndrome (RLS) is a common neurological disorder with unpleasant leg sensations and serious negative effects on mental and physical health. Many observational studies showed that people with RLS had a high risk of vascular diseases, including cerebrovascular and cardiovascular diseases (CVD), but the findings were conflicting. The Jidong RLS Cohort Study is a prospective cohort study designed to mainly examine whether or not RLS is associated with an increased risk of CVD.Methods and Design: The study recruited 8,867 healthy participants older than 18 years from October 2014 to December 2015. Participants received a physical examination in the Staff Hospital, Jidong Oilfield Branch, China National Petroleum Corporation. Baseline data and blood samples were collected. Restless legs syndrome was assessed using the international RLS diagnostic criteria. All of subjects would be followed up until December 2025. Major cardiovascular/cerebrovascular events including cardiac death, myocardial infarction, ischemic heart disease, heart failure, atrial fibrillation, ischemic, and hemorrhagic stroke will be the primary outcomes. Secondary outcomes include all-cause mortality, the decline in quality of life, cognitive impairment, and depression.Discussion: This study will contribute to the scientific evidence on the association between RLS and cardiovascular risks and also provide an unprecedented opportunity for early detection and prevention of CVD.

Susceptible genes of restless legs syndrome in migraine

Cephalalgia ◽  
2016 ◽  
Vol 36 (11) ◽  
pp. 1028-1037 ◽  
Author(s):  
Jong-Ling Fuh ◽  
Ming-Yi Chung ◽  
Shu-Chih Yao ◽  
Ping-Kun Chen ◽  
Yi-Chu Liao ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Genetic Variants ◽  
Multivariate Regression ◽  
Iron Homeostasis ◽  
Nucleotide Polymorphisms ◽  
Regression Analyses ◽  
Single Nucleotide ◽  
Association Analyses ◽  
Restless Legs ◽  
Increased Risk

Objective Several genetic variants have been found to increase the risk of restless legs syndrome (RLS). The aim of the present study was to determine if these genetic variants were also associated with the comorbidity of RLS and migraine in patients. Methods Thirteen single-nucleotide polymorphisms (SNPs) at six RLS risk loci ( MEIS1, BTBD9, MAP2K5, PTPRD, TOX3, and an intergenic region on chromosome 2p14) were genotyped in 211 migraine patients with RLS and 781 migraine patients without RLS. Association analyses were performed for the overall cohort, as well as for the subgroups of patients who experienced migraines with and without aura and episodic migraines (EMs) vs. chronic migraines (CMs). In order to verify which genetic markers were potentially related to the incidence of RLS in migraine patients, multivariate regression analyses were also performed. Results Among the six tested loci, only MEIS1 was significantly associated with RLS. The most significant SNP of MEIS1, rs2300478, increased the risk of RLS by 1.42-fold in the overall cohort ( p = 0.0047). In the subgroup analyses, MEIS1 augmented the risk of RLS only in the patients who experienced EMs (odds ratio (OR) = 1.99, p = 0.0004) and not those experiencing CMs. Multivariate regression analyses further showed that rs2300478 in MEIS1 (OR = 1.39, p = 0.018), a CM diagnosis (OR = 1.52, p = 0.022), and depression (OR = 1.86, p = 0.005) were independent predictors of RLS in migraine. Conclusions MEIS1 variants were associated with an increased risk of RLS in migraine patients. It is possible that an imbalance in iron homeostasis and the dopaminergic system may represent a link between RLS incidence and migraines.

The Relevance of Supplemental Vitamin D in Malignancies

2021 ◽  
Vol 21 ◽  
Author(s):  
Delia Nica-Badea ◽  
Aurelian Udristioiu
Keyword(s):  
Vitamin D ◽  
Health Care Providers ◽  
Anticancer Agents ◽  
Scientific Evidence ◽  
Sun Exposure ◽  
Care Providers ◽  
Negative Effects ◽  
Antitumor Effects ◽  
Increased Risk ◽  
Vdr Polymorphisms

Background: Vitamin D has a widely acknowledged role in regulating the metabolism of calcium and phosphate, both essential to bone remodeling. However, numerous studies in recent decades have emphasized the association between low sun exposure and vitamin D deficiency, and an increased risk of extra-skeletal disorders such as cancer. Objective: This mini-review of literature aims to present an objective overview of several recent studies and meta-analyses evaluating the role of vitamin D in cancer prevention, its potential to improve cancer treatment outcomes, as well as the negative effects of vitamin D deficiencies. Methods: The antitumor effects of calcitriol and analogs in the treatment of cancer, either as single agents or in combination with other anticancer agents, are based on several mechanisms: inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis, all recorded in a number of preclinical studies of several cancer types Results: The importance of VDR polymorphisms for individual malignancies remains a topic of debate. Contradictory effects have been recorded in recent studies, the results of which include positive associations of VDR when cumulated with other risk factors, both an increase and a decrease in cancer risks, as well as no correlation between VDR polymorphisms and individual malignancies.. Conclusion: The scientific evidence reviewed in this paper suggests that health care providers and individuals should consider increasing concentrations of 25 (OH) D through sensitive sun exposure and / or by supplementing with vitamin D to reduce cancer risk and, in combination with standard care, to treat cancer.

scholarly journals Lifestyle Factors and Risk of Restless Legs Syndrome: Prospective Cohort Study

2016 ◽  
Vol 12 (02) ◽  
pp. 187-194 ◽  
Author(s):  
Salma Batool-Anwar ◽  
Yanping Li ◽  
Katerina De Vito ◽  
Atul Malhotra ◽  
John Winkelman ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Restless Legs Syndrome ◽  
Prospective Cohort ◽  
Lifestyle Factors ◽  
Restless Legs

Restless legs syndrome is associated with cardio/cerebrovascular events and mortality in end-stage renal disease

2014 ◽  
Vol 22 (1) ◽  
pp. 142-149 ◽  
Author(s):  
C.-H. Lin ◽  
H.-N. Sy ◽  
H.-W. Chang ◽  
H.-H. Liou ◽  
C.-Y. Lin ◽  
...  
Keyword(s):  
Renal Disease ◽  
Restless Legs Syndrome ◽  
End Stage Renal Disease ◽  
Restless Legs ◽  
Cerebrovascular Events ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Restless legs syndrome: literature review

2010 ◽  
Vol 128 (3) ◽  
pp. 167-170 ◽  
Author(s):  
Emmanouil Symvoulakis ◽  
Dimitrios Anyfantakis ◽  
Christos Lionis
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
Negative Effects ◽  
Restless Legs ◽  
Care Services ◽  
Primary Care Settings ◽  
Inappropriate Treatment ◽  
Occupational Life ◽  
Distressing Condition

Restless legs syndrome is a distressing condition, with negative effects on sleep and daytime activities that affect personal, family and occupational life. The overall impact of restless legs syndrome on quality of life is comparable to that of chronic and frustrating conditions such as depression and diabetes. Misdiagnosis and inappropriate treatment may increase patients' suffering in terms of uncertainty, overuse or misuse of care services and lack of trust. Presenting a synthesis of the main topics in the literature on restless legs syndrome facilitates for a better understanding and its management in primary care settings.

scholarly journals Restless legs syndrome and risk of incident cardiovascular disease in women and men: prospective cohort study

BMJ Open ◽  
2012 ◽  
Vol 2 (2) ◽  
pp. e000866 ◽  
Author(s):  
Anke C Winter ◽  
Markus Schürks ◽  
Robert J Glynn ◽  
Julie E Buring ◽  
J Michael Gaziano ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Restless Legs Syndrome ◽  
Prospective Cohort ◽  
Restless Legs ◽  
Cardiovascular Disease In Women ◽  
Incident Cardiovascular Disease

Prenatal stress and its role in children's pathology: historical aspects and the current status of the question (review of literature)

2020 ◽  
Vol 24 (3) ◽  
pp. 28-41
Author(s):  
A. A. Vyalkova ◽  
B. A. Frolov ◽  
E. V. Savelyeva ◽  
S. A. Chesnokova
Keyword(s):  
Oxidative Stress ◽  
Kidney Diseases ◽  
Scientific Evidence ◽  
Current Status ◽  
Stress Reactions ◽  
Metabolic Disturbances ◽  
Negative Effects ◽  
Adaptation Mechanism ◽  
Increased Risk

The article presents an analysis of fundamental data on the problem of stress and its role in the development of stressful diseases. Scientific evidence on the role of stress in childhood pathology indicates the extreme pathogenetic significance of stress. It is proved that stress has three interconnected faces: stress as a link in the adaptation mechanism, stress as a link in the pathogenesis of diseases and adaptation to stressful situations as a natural prevention of stressful diseases. The scientific substantiation of the main evolutionarily determined role of stress as an adaptation link indicates the possibility of acquiring some degree of resistance to stressful situations. Prevention of reducing the excess of stress reactions and reducing the possibility of its transformation into a link in the pathogenesis of diseases limits the complex of mechanisms designated as a stress-limiting system. Important information is the development and coordination of the stress response, which is provided by a complex set of mechanisms of neuroendocrine regulation, united by the concept of “stress-implementing system”. The most common forms of stress are fetal hypoxia, metabolic disturbances, and toxic effects leading to uncontrolled oxidative stress at the cellular and tissue levels with the development of pregnancy complications, intrauterine growth retardation syndrome (IUGR), persistent changes and pathological conditions. As the fetus grows, the flow of oxygen and nutrients from the mother through the placenta increases, which is accompanied by an increased risk of the formation of pathologies of the brain, heart, liver and kidneys with the development of a multi-organ pathology in the subsequent life. It has been proven that oxidative stress combined with stress of malnutrition in the prenatal period increases the risk of endocrinopathies, kidney diseases, and a number of other chronic diseases in the adult state. In practical terms, the negative effects of stress are of particular interest. Early detection of psychosocial and sympathomimetic factors causing stress is the basis for the prevention of childhood pathology.

Abstract P074: Restless Legs Syndrome and Carotid Intima-Media Thickness in Women

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Karen Jacobo ◽  
Adriana Monge ◽  
Eduardo Ortiz-Panozo ◽  
Elsa Yunes ◽  
Andres Catzin-Khulmann ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Mean Difference ◽  
Lower Limbs ◽  
Cross Sectional ◽  
Restless Legs ◽  
Media Thickness ◽  
Increased Risk

Introduction: Restless legs syndrome (RLS) is a common chronic disorder characterized by an irresistible need to move the lower limbs that is usually worse in the evening and is associated with sleep disturbances. RLS has been associated with hypertension and has been proposed as a marker for increased cardiovascular risk. Hypothesis: Individuals with RLS have an increased common carotid intima-media thickness (cIMT) relative to individuals without RLS. Methods: We evaluated cross-sectional relation of RLS and cIMT in 1,147 disease-free Mexican women of the Mexican Teachers’ Cohort. In 2011, participants responded to a follow-up questionnaire that included standardized questions addressing the four minimal diagnostic criteria of the International Restless Legs Study Group. Participants were asked: “Do you have unpleasant leg sensations (like crawling, loss of sensation or pain) combined with restlessness and an urge to move your legs?”, “Do these symptoms occur only at rest?”, “Does moving improve these symptoms?”, “Are these symptoms worse in the evening or at night compared with the morning?” Women who answered yes to all the four questions were defined as having RLS. Between 2012 and 2013, a subsample of participants were invited for a clinical visit where neurologists assessed cIMT with an ultrasound. cIMT measurements were found to be reproducible in a substudy in 52 participants (intra-class correlation=0.89). We defined subclinical atherosclerosis as a cIMT ≥0.8 mm or the presence of plaque. Results: Among women with a mean age of 48.2 (SD±4.3), the prevalence of RLS was 14.2% (cases, 163). The age-adjusted mean difference of cIMT comparing participants with RLS to those without RLS was 0.009mm (95%CI -0.004 to 0.023). After further adjustment for diabetes, hypercholesterolemia, migraine, oral contraceptive use, menopause, smoking, body mass index, physical activity and alcohol, the mean difference of cIMT comparing participants with and without RLS was not statistically different (0.007mm; 95%CI -0.007 to 0.021). The prevalence of subclinical atherosclerosis was 27% (n=44) in those with RLS and 21.9% (n=215) in those without RLS. The age-adjusted OR comparing women with RLS to those without RLS was 1.23 (95%CI 0.83-1.82). In the multivariable model the OR remained non-significant (1.16, 95%CI 0.77-1.74). Conclusions: In this cross-sectional study in middle-aged women, RLS was not associated to cIMT. Our results do not support the observation that individuals with RLS are at an increased risk for cardiovascular disease.

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