scholarly journals Effects of Lactococcus lactis on the Intestinal Functions in Weaning Piglets

2021 ◽  
Vol 8 ◽  
Author(s):  
Dongming Yu ◽  
Yaoyao Xia ◽  
Liangpeng Ge ◽  
Bie Tan ◽  
Shuai Chen
Keyword(s):  
Gene Expression ◽  
Amino Acid ◽  
Gut Microbiota ◽  
Growth Performance ◽  
Lactococcus Lactis ◽  
Primary Response ◽  
Interleukin 17 ◽  
Intestinal Immunity ◽  
Pathogen Infection ◽  
Weaning Piglets

Post-weaning diarrhea of piglets is associated with gut microbiota dysbiosis and intestinal pathogen infection. Recent studies have shown that Lactococcus lactis (L.lactis) could help suppress pathogen infection. This study aimed to investigate the effects of L.lactis on various factors related to growth and immunity in weaning piglets. The results showed that L.lactis improved the growth performance, regulated the amino acid profile (for example, increasing serum tryptophan and ileal mucosal cystine) and the intestinal GABAergic system (including inhibiting ileal gene expression of SLC6A13, GABAAρ1, π, θ, and γ1, and promoting ileal GABAAα5 expression). L.lactis also modulated intestinal immunity by promoting jejunal interleukin 17, 18, 22, ileal toll-like receptor 2, 5, 6, and myeloid differentiation primary response protein 88 gene expression while inhibiting jejunal interferon-γ and ileal interleukin 22 expressions. L.lactis highly affected the intestinal microbiota by improving the beta diversity of gut microbiota and the relative abundance of Halomonas and Shewanella. In conclusion, L.lactis improved the growth performance and regulated amino acid profiles, intestinal immunity and microbiota in weaning piglets.

Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets

2019 ◽  
Vol 10 (1) ◽  
pp. 366-378 ◽  
Author(s):  
Shuai Chen ◽  
Bie Tan ◽  
Yaoyao Xia ◽  
Simeng Liao ◽  
Meiwei Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Growth Performance ◽  
Aminobutyric Acid ◽  
Gut Microflora ◽  
Gamma Aminobutyric Acid ◽  
Intestinal Immunity ◽  
Weaned Piglets ◽  
Amino Acid Profiles ◽  
Intestinal Functions ◽  
Weaning Piglets

This study aims to investigate the effects of dietary gamma-aminobutyric acid (GABA) supplementation on the growth performance, intestinal immunity, intestinal GABAergic system, amino acid profiles and gut microflora of the weaned piglets.

Effects of dietary gamma-aminobutyric acid supplementation on amino acid profile, intestinal immunity, and microbiota in ETEC-challenged piglets

2020 ◽  
Vol 11 (10) ◽  
pp. 9067-9074
Author(s):  
Shuai Chen ◽  
Xin Wu ◽  
Yaoyao Xia ◽  
Meiwei Wang ◽  
Simeng Liao ◽  
...  
Keyword(s):  
Amino Acid ◽  
Gut Microbiota ◽  
Growth Performance ◽  
Amino Acid Profile ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Intestinal Immunity ◽  
Acid Supplementation

GABA improves growth performance, regulates the serum amino acid profile, intestinal immunity, and gut microbiota in ETEC-challenged piglets.

Effect of fish meal substitution with fermented soy pulp on growth performance, digestive enzyme, amino acid profile, and immune-related gene expression of African catfish (Clarias gariepinus)

Aquaculture ◽  
2022 ◽  
Vol 546 ◽  
pp. 737418
Author(s):  
Zulhisyam Abdul Kari ◽  
Muhammad Anamul Kabir ◽  
Mahmoud A.O. Dawood ◽  
Mohammad Khairul Azhar Abdul Razab ◽  
Nik Shahman Nik Ahmad Ariff ◽  
...  
Keyword(s):  
Gene Expression ◽  
Amino Acid ◽  
Growth Performance ◽  
Fish Meal ◽  
Digestive Enzyme ◽  
Clarias Gariepinus ◽  
Amino Acid Profile ◽  
African Catfish ◽  
Related Gene ◽  
Immune Related Gene

Effects of ornithine α-ketoglutarate on growth performance and gut microbiota in a chronic oxidative stress pig model induced by d-galactose

2020 ◽  
Vol 11 (1) ◽  
pp. 472-482 ◽  
Author(s):  
Yuying Li ◽  
Peng Wang ◽  
Jie Yin ◽  
Shunshun Jin ◽  
Wenxuan Su ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acid ◽  
Gut Microbiota ◽  
Growth Performance ◽  
Growth Suppression ◽  
Pig Model ◽  
Positive Effects ◽  
Chronic Oxidative Stress ◽  
Gut Microbe

d-Galactose induced chronic oxidative stress and also proved the positive effects of 0.5% ornithine α-ketoglutarate on altering the pig gut microbe, restoring serum amino acid and alleviating the growth-suppression induced by d-galactose chronic oxidative stress.

scholarly journals The Effects of Dietary Glycine on the Acetic Acid-Induced Mouse Model of Colitis

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Xin Wu ◽  
Yongmin Zheng ◽  
Jie Ma ◽  
Jie Yin ◽  
Shuai Chen
Keyword(s):  
Gene Expression ◽  
Amino Acids ◽  
Acetic Acid ◽  
Amino Acid ◽  
Mouse Model ◽  
Intestinal Microbiota ◽  
Intestinal Inflammation ◽  
Serum Concentrations ◽  
Intestinal Immunity ◽  
Chronic Intestinal Inflammation

Inflammatory bowel disease, a gut disease that is prevalent worldwide, is characterized by chronic intestinal inflammation, such as colitis, and disorder of the gut microbiome. Glycine (Gly) is the simplest amino acid and functions as an anti-inflammatory immune-nutrient and intestinal microbiota regulator. This study aimed at investigating the effect of Gly on colitis induced in mice by intrarectal administration of 5% acetic acid (AA). Bodyweight and survival rates were monitored, and colonic length and weight, serum amino acid concentrations, intestinal inflammation-related gene expression, and colonic microbiota abundances were analyzed. The results showed that Gly dietary supplementation had no effect on the survival rate or the ratio of colonic length to weight. However, Gly supplementation reversed the AA-induced increase in serum concentrations of amino acids such as glutamate, leucine, isoleucine, and valine. Furthermore, Gly inhibited colonic gene expression of interleukin- (IL-) 1β and promoted IL-10 expression in colitis mice. Gly supplementation also reversed the AA-induced reduction in the abundance of bacteria such as Clostridia, Ruminococcaceae, and Clostridiales. This change in the intestinal microbiota was possibly attributable to the changes in colonic IL-10 expression and serum concentrations of valine and leucine. In sum, Gly supplementation regulated the serum concentrations of amino acids, the levels of colonic immune-associated gene expression, and the intestinal microbiota in a mouse model of colitis. These findings enhance our understanding of the role of Gly in regulating metabolism, intestinal immunity, and the gut microbiota in animals afflicted with colitis.

scholarly journals Impacts of increasing challenge with Eimeria maxima on the growth performance and gene expression of biomarkers associated with intestinal integrity and nutrient transporters

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Po-Yun Teng ◽  
Janghan Choi ◽  
Yuguo Tompkins ◽  
Hyun Lillehoj ◽  
Woo Kim
Keyword(s):  
Gene Expression ◽  
Amino Acid ◽  
Tight Junction ◽  
Growth Performance ◽  
Broiler Chickens ◽  
Nutrient Transporters ◽  
Tight Junction Proteins ◽  
Intestinal Integrity ◽  
Eimeria Maxima ◽  
Junction Proteins

AbstractThis study was conducted to investigate the impacts of graded severity of Eimeria maxima infection on the growth performance and intestine health of broiler chickens. Four different levels of E. maxima-challenged treatments were used, including a non-challenged control group, a low challenge (12 500 oocysts), a medium challenge (25 000 oocysts), and a high challenge dose (50 000 oocysts). There were eight replicate cages per treatment, with 12 birds in each cage, and chickens in the challenged groups orally received sporulated oocysts on day 14. Gastrointestinal permeability was measured by fluorescein isothiocyanate dextran at 5 days post-infection (dpi), whereas intestinal morphology and gene expression of nutrient transporters and tight junction proteins were determined at 6 dpi. The results demonstrate a linear reduction in growth performance, jejunal villus height, and jejunal integrity with graded challenge doses of E. maxima (P < 0.01). Moreover, linear regulation of nutrient transporters and tight junction proteins was a consequence of increasing Eimeria infection levels (P < 0.01). The linear increase of Claudin 1, cationic amino acid transporter, glucose transporter 1, and L-type amino acid transporter genes was associated with increased severity of coccidiosis (P < 0.01). Furthermore, expression of nutrient transporters located at the brush border membrane were down-regulated (P < 0.01) with increasing E. maxima inoculation dose. In conclusion, growth performance and key intestinal integrity biomarkers in broiler chickens were adversely influenced in a dose-dependent manner by E. maxima infection.

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