Synthesis of Recommendations From 25 Countries and 31 Oncology Societies: How to Navigate Through Covid-19 Labyrinth

IntroductionPandemic COVID-19 is an unexpected challenge for the oncological community, indicating potential detrimental effects on cancer patients. Our aim was to summarize the converging key points providing a general guidance in order to support decision making, pertaining to the oncologic care in the middle of a global outbreak.MethodsWe did an international online search in twenty five countries that have managed a surge in cancer patient numbers. We collected the recommendations from thirty one medical oncology societies.ResultsBy synthesizing guidelines for a) oncology service delivery adjustments, b) general and specific treatment adaptations, and c) discrepancies from guidelines comparison, we present a clinical synopsis with the forty more crucial statements. A Covid-19 risk stratification base was also created in order to obtain a quick, objective patient assessment and a risk-benefit evaluation on a case-by-case basis.ConclusionsIn an attempt to face these complex needs and due to limited understanding of COVID-19, a variability of recommendations based on general epidemiological and infectious disease principles rather than definite cancer-related evidence has evolved. Additionally, the absence of an effective treatment or vaccine requires the development of cancer management guidance, capitalizing on comprehensive COVID-19 oncology experience globally.

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Understanding new records management guidance

Practice Management ◽

10.12968/prma.2021.31.10.36 ◽

2021 ◽

Vol 31 (10) ◽

pp. 36-40

Author(s):

Ceylan Simsek

Keyword(s):

New Records ◽

Case Manager ◽

The Body ◽

Record Management ◽

Records Management ◽

Key Points ◽

Management Guidance

NHSX, the body responsible for NHS technology, digital and data, has released new guidance on record management. Ceylan Simsek, Case Manager at Medical Protection, explains the key points

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Treatment of B-cell disorder improves renal outcome of patients with monoclonal gammopathy–associated C3 glomerulopathy

Blood ◽

10.1182/blood-2016-08-737163 ◽

2017 ◽

Vol 129 (11) ◽

pp. 1437-1447 ◽

Cited By ~ 57

Author(s):

Sophie Chauvet ◽

Véronique Frémeaux-Bacchi ◽

Florent Petitprez ◽

Alexandre Karras ◽

Laurent Daniel ◽

...

Keyword(s):

B Cell ◽

Monoclonal Gammopathy ◽

Cell Clone ◽

Specific Treatment ◽

Renal Outcome ◽

C3 Glomerulopathy ◽

Renal Survival ◽

Key Points ◽

Cell Disorder

Key Points Monoclonal gammopathy is associated with C3 glomerulopathy. Specific treatment of the underlying B-cell clone improves renal survival.

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Incorporating PSMA-Targeting Theranostics Into Personalized Prostate Cancer Treatment: a Multidisciplinary Perspective

Frontiers in Oncology ◽

10.3389/fonc.2021.722277 ◽

2021 ◽

Vol 11 ◽

Author(s):

Thomas S. C. Ng ◽

Xin Gao ◽

Keyan Salari ◽

Dimitar V. Zlatev ◽

Pedram Heidari ◽

...

Keyword(s):

Prostate Cancer ◽

Medical Oncology ◽

Advanced Treatment ◽

Prostate Cancer Treatment ◽

Cancer Management ◽

Recent Developments ◽

Localized Disease ◽

Multidisciplinary Perspective ◽

Specific Membrane ◽

Prostate Cancer Management

Recent developments in prostate-specific membrane antigen (PSMA) targeted diagnostic imaging and therapeutics (theranostics) promise to advance the management of primary, biochemically recurrent, and metastatic prostate cancer. In order to maximize the clinical impact of PSMA-targeted theranostics, a coordinated approach between the clinical stakeholders involved in prostate cancer management is required. Here, we present a vision for multidisciplinary use of PSMA theranostics from the viewpoints of nuclear radiology, medical oncology, urology, and radiation oncology. We review the currently available and forthcoming PSMA-based imaging and therapeutics and examine current and potential impacts on prostate cancer management from early localized disease to advanced treatment-refractory disease. Finally, we highlight the clinical and research opportunities related to PSMA-targeted theranostics and describe the importance of multidisciplinary collaboration in this space.

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RANCANG BANGUN SISTEM ADMINISTRASI KERJA PRAKTEK DAN TUGAS AKHIR BERBASIS WEB MENGGUNAKAN FRAMEWORK CODEIGNITER

GEMA TEKNOLOGI ◽

10.14710/gt.v19i4.19147 ◽

2018 ◽

Vol 19 (4) ◽

pp. 1

Author(s):

Arkhan Subari ◽

Dista Yoel Tadeus ◽

Heru Winarno ◽

Teguh Yuwono

Keyword(s):

Information System ◽

Web Application ◽

Great Accuracy ◽

Application Framework ◽

Complex Needs ◽

Mvc Model ◽

Model View Controller ◽

The Many ◽

Model View ◽

Support Decision Making

Information system is a set of components that interconnect, collect, process, store, and distribute information to support decision making and supervision within an organization. Today the information system can not be separated with computer technology that feels growing rapidly along with our increasingly complex needs. These developments can be seen from the many organizations or institutions in various fields that use computerized systems to perform various jobs quickly and with great accuracy. The use of computerized systems is expected to minimize errors made by humans thereby reducing large losses. And can mengefisienkan time in completing the work quickly and accurately. One concept of building a computerized information system is dengfan MVC model. Model-View-Controller (MVC) is a concept introduced by the inventor of Smalltalk (Trygve Reenskaug) to encapsulate data along with processing (model), isolate from the process of manipulation (controller) and view to be represented on a user interface . The MVC architecture has the benefit of separating between model and view allowing multiple views using the same model. As a result, an application model component is easier to implement, test, and maintain, because all access to the model runs through this component. One of the frameworks that works based on the MVC concept is Codeigniter. Codeigniter is an open source web application framework that is used to build dynamic php applications. The main purpose of Codeigniter development is to help developers to work on applications faster than writing all the code from scratch. Because of the superiority of codeigniter that the system of practical work administration and the final task is built using the framework..

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Single umbilical cord blood with or without CD34+ cells from a third-party donor in adults with leukemia

Blood Advances ◽

10.1182/bloodadvances.2017006999 ◽

2017 ◽

Vol 1 (15) ◽

pp. 1047-1055 ◽

Cited By ~ 5

Author(s):

Jaime Sanz ◽

Mi Kwon ◽

Guiomar Bautista ◽

Miguel A. Sanz ◽

Pascual Balsalobre ◽

...

Keyword(s):

Cord Blood ◽

Umbilical Cord Blood ◽

Specific Treatment ◽

Third Party ◽

Effective Strategy ◽

Long Term Outcomes ◽

Platelet Recovery ◽

Cd34 Cells ◽

Key Points

Key Points Haplo-Cord is an effective strategy to quicken neutrophil and platelet recovery. In specific treatment platforms, sUCBT and Haplo-Cord offer similar long-term outcomes.

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Starting an Adolescent and Young Adult Program: Some Success Stories and Some Obstacles to Overcome

Journal of Clinical Oncology ◽

10.1200/jco.2009.23.8097 ◽

2010 ◽

Vol 28 (32) ◽

pp. 4850-4857 ◽

Cited By ~ 126

Author(s):

Andrea Ferrari ◽

David Thomas ◽

Anna R.K. Franklin ◽

Brandon M. Hayes-Lattin ◽

Maurizio Mascarin ◽

...

Keyword(s):

Young Adult ◽

Medical Oncology ◽

Models Of Care ◽

Adolescent And Young Adult ◽

Complex Needs ◽

Success Stories ◽

Medical Oncologists ◽

Challenges And Opportunities ◽

Successful Establishment ◽

No Man's Land

Adolescent and young adult (AYA) patients seem to be in a sort of no-man's land, halfway between the two different worlds of pediatric and adult medical oncology and bearing the brunt, in terms of inclusion in clinical trials and quality of professional care, of the lack of integration between these two worlds. This article discusses the different organization models of care used in pediatric oncology (mainly family-focused) and in adult medical oncology (disease-focused). There is a growing awareness that these models are not ideally suited to the complex needs of AYA patients, which require a different, new, patient-focused multidisciplinary approach. A comprehensive, multipronged effort is required to bridge the gap in the care of AYA patients, with the ultimate challenge of creating a new discipline, AYA oncology. In this article, we review the experiences of AYA oncology programs in Europe, North America, and Australia, focusing on similarities and differences in strategy, as well as the major challenges and opportunities faced by these programs. Among the most important factors for the successful establishment of an AYA oncology service are the degree of engagement of both pediatric and adult medical oncologists, the philanthropic support of powerful charities, and the role of dedicated professionals across a range of disciplines in driving the development of services for AYA patients.

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COVID-19 infection in children and adolescents

British Journal of Hospital Medicine ◽

10.12968/hmed.2020.0321 ◽

2020 ◽

Vol 81 (8) ◽

pp. 1-10

Author(s):

Meena Naja ◽

Lucy Wedderburn ◽

Coziana Ciurtin

Keyword(s):

Children And Adolescents ◽

Adult Population ◽

Clinical Manifestations ◽

Specific Treatment ◽

Intensive Care Admission ◽

The Uk ◽

Inflammatory Syndrome ◽

Case Basis ◽

Index Cases ◽

Paediatric Disease

The COVID-19 pandemic has predominantly affected the adult population. The disease is less well-defined in children (≤18 years). This review summarises the current understanding of the epidemiology, clinical manifestations, and management of COVID-19 in children and adolescents. The prevalence of COVID-19 is significantly lower in children than adults, but paediatric disease is likely underdiagnosed as a result of the high numbers of asymptomatic or mild cases. Children are vulnerable to family cluster outbreaks, but are unlikely to be index cases within a household. Vertical transmission or breast milk transmission are yet to be proven. Between 10 and 90% of paediatric COVID-19 cases are asymptomatic. Symptomatic cases typically present with mild symptoms, including cough, fever and sore throat. Intensive care admission and mortality are rare. Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 is a rare, but severe, newly emerging phenotype. At present, there is no specific treatment for COVID-19 in adults or children; management is usually supportive. For severe or critical disease, including paediatric multisystem inflammatory syndrome temporally associated with COVID-19, the decision to start antiviral or immunomodulatory therapy should be on a case-by-case basis; in the UK, this should be done within a clinical trial. Further research is needed into both the disease course and treatment of paediatric COVID-19.

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FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation

Blood ◽

10.1182/blood-2014-06-585216 ◽

2015 ◽

Vol 125 (12) ◽

pp. 1936-1947 ◽

Cited By ~ 33

Author(s):

Thomas Oellerich ◽

Sebastian Mohr ◽

Jasmin Corso ◽

Julia Beck ◽

Carmen Döbele ◽

...

Keyword(s):

Tyrosine Kinase ◽

Cell Survival ◽

Treatment Strategies ◽

Specific Treatment ◽

Oncogenic Signaling ◽

Flt3 Inhibitor ◽

Key Points ◽

Bruton Tyrosine Kinase ◽

Cell Survival And Proliferation

Key Points Two novel transducer modules consisting of BTK in combination with either FLT3-ITD or TLR9 induce distinct oncogenic signaling programs. This study suggests subtype-specific treatment strategies, including BTK/FLT3 inhibitor combinations, and shows how TLR9 affects AML biology.

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Consensus document of the Italian Association of Medical Oncology and the Italian Society of Palliative Care on early palliative care

Tumori Journal ◽

10.1177/0300891618792478 ◽

2018 ◽

Vol 105 (2) ◽

pp. 103-112 ◽

Cited By ~ 3

Author(s):

Domenico C. Corsi ◽

Adriana Turriziani ◽

Luigi Cavanna ◽

Piero Morino ◽

Angela S. Ribecco ◽

...

Keyword(s):

Palliative Care ◽

Medical Oncology ◽

Metastatic Cancer ◽

Italian Society ◽

Cancer Prognosis ◽

Early Palliative Care ◽

Cancer Management ◽

Consensus Document ◽

Palliative Care Consultation ◽

Practice Models

A consensus document on early palliative care was produced by a committed Working Group of the Italian Society of Medical Oncology and the Italian Society of Palliative Care to improve the early integration of palliative care in medical oncology and to stimulate and guide the choices of those who daily face the problems of advanced stage cancer patients. The simultaneous administration of antineoplastic treatments and early palliative care was shown to be beneficial in metastatic cancer pathway outcomes. Patients who could benefit from early palliative care are those with an advanced cancer at presentation, a compromised PS for cancer, and/or morbidities, and who are too frail to receive treatment. According to the Bruera practice models, in which the combination of cancer management with early palliative care can be offered, three groups of patients needing simultaneous care were identified and three different models of the delivery of palliative care were proposed. In patients with good prognosis and low need of simultaneous care, the solo practice model and the request for consultations were suggested, while in patients with poor prognosis disease with high need of simultaneous care and in conditions with high need of simultaneous care, regardless of cancer prognosis, the integrated care approach should be offered. Palliative care consultation services are seldom accessible in the majority of Italian hospitals; thus the application of various practice models depends on available resources, and a shared care model with the structures of palliative care operating in the area is often required.

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Prostate Cancer Management During the COVID-19 Pandemic

Asian Pacific Journal of Cancer Care ◽

10.31557/apjcc.2020.5.s1.231-233 ◽

2020 ◽

Vol 5 (S1) ◽

pp. 231-233

Author(s):

Kunhi Parambath Haresh ◽

Yousra Izzudeen ◽

Devangana Bora ◽

Subhash Gupta ◽

Goura Kishor Rath

Keyword(s):

Prostate Cancer ◽

Hormonal Therapy ◽

Specific Treatment ◽

Cell Types ◽

Response To Treatment ◽

Cancer Management ◽

Castration Resistant ◽

Hormone Sensitive ◽

Prompt Attention ◽

Prostate Cancer Management

The COVID-19 pandemic has derailed the management of many cancers. Prostate cancer although a disease known for good response to treatment has posed unique challenges in this pandemic in view of the co-morbidities associated with these elderly patients. A pandemic specific treatment approach following the RADS (Remote, Avoid, Defer, Shorten) principle is required while dealing with these patients. Very low, low and favourable intermediate risk cancers may be kept on active surveillance rather than active treatment. Unfavourable intermediate, high and very high risk cases may follow the ‘defer’ policy by initiating hormonal therapy for 6-8 months to defer radiotherapy. When radiation is planned for these patients extreme or moderate hypo fractionation may be used to follow the ‘shorten’ policy. Metastatic hormone sensitive cancers may be initiated on hormonal therapy avoiding antiandrogens like Abiraterone and chemotherapy upfront. In the castration resistant phase the antiandrogens like Abiraterone or Enzalutamide may be given preference over chemotherapy. In the post operative settings early salvage may be preferred over adjuvant that too, using hypofractionation. Symptomatic patients require prompt attention and radiation should not be delayed for palliation of impending spinal compression or fracture or for local symptoms. Aggressive histologies like small cell types also need prompt treatment. Other general measures like universal masking, hand hygiene, physical distancing, respiratory etiquettes, etc., must also be emphasised keeping in mind the vulnerability of these patients.

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