Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age

Objective: To investigate the rate and stability of impairments in children born preterm by assessing (1) early and school-age outcome in four developmental domains and (2) individual changes in outcome at both timepoints.Design: Prospective, longitudinal cohort study in children born in 2006–2007, <32 weeks' gestation. Follow-up at 2 and 10 years of age included standardized neurological, motor, cognitive and behavioral assessments. Children were categorized as having no, mild or moderate-severe impairment in these four domains. A composite impairment score was composed and the number of domains with impairments counted. For each child, individual outcomes at both timepoints were compared.Results: Follow-up at both time-points was available in 71/113(63%) children. At group level, there were no significant changes in the severity of impairments per domain. However, at individual level, there were less children with a mild abnormal composite score at 10 years of age (44 vs. 20%; p = 0.006), and more with a moderate-severe abnormal composite score (12 vs. 35%; p = 0.001). Especially children with normal/mild outcome at 2 years were likely to shift to other outcome categories over time.Conclusions: Children with early severe impairment are likely experiencing impairments later on, but early normal/mild abnormal outcomes should be interpreted with care, considering the large individual shifts over time. Long-term follow-up in all children born very preterm should therefore be continued to at least school-age.

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The natural course of DSM-IV somatoform disorders and syndromes among adolescents and young adults: a prospective-longitudinal community study

European Psychiatry ◽

10.1016/s0924-9338(02)00686-7 ◽

2002 ◽

Vol 17 (6) ◽

pp. 321-331 ◽

Cited By ~ 81

Author(s):

Roselind Lieb ◽

Petra Zimmermann ◽

Robert H Friis ◽

Michael Höfler ◽

Sven Tholen ◽

...

Keyword(s):

Risk Factors ◽

Substance Use ◽

Young Adults ◽

Somatoform Disorders ◽

Epidemiologic Study ◽

Natural Course ◽

Adolescents And Young Adults ◽

Prospective Longitudinal ◽

Over Time

SummaryObjective.Although somatoform disorders are assumed to be chronic clinical conditions, epidemiological knowledge on their natural course based on representative samples is not available.Method.Data come from a prospective epidemiologic study of adolescents and young adults in Munich, Germany. Respondents’ diagnoses (N = 2548) at baseline and follow-up on average 42 months later are considered. The follow-up incidence, stability as well as selected baseline risk factors (sociodemographics, psychopathology, trauma exposure) for the incidence and stability of somatoform disorders and syndromes are prospectively examined. Diagnostic information was assessed by using the standardized Munich-Composite International Diagnostic Interview (M-CIDI).Results.Over the follow-up period, incidence rate for any of the covered somatoform diagnoses was 25.7%. Stability for the overall group of any somatoform disorder/syndrome was 48%. Female gender, lower social class, the experience of any substance use, anxiety and affective disorder as well as the experience of traumatic sexual and physical threat events predicted new onsets of somatoform conditions, while stability was predicted by being female, prior existing substance use, affective and eating disorders as well as the experience of a serious accident.Conclusions.At least for a substantial proportion of individuals, the overall picture of somatization seems to be relatively stable, but with fluctuation in the symptom picture over time. Being female, the experience of substance use as well as anxiety disorder seem to constitute risk factors for the onset of new somatoform conditions as well as for a stable course over time.

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Methods of conduct and reporting of living systematic reviews: a protocol for a living methodological survey

F1000Research ◽

10.12688/f1000research.18005.2 ◽

2019 ◽

Vol 8 ◽

pp. 221 ◽

Cited By ~ 3

Author(s):

Assem M. Khamis ◽

Lara A. Kahale ◽

Hector Pardo-Hernandez ◽

Holger J. Schünemann ◽

Elie A. Akl

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Evidence Synthesis ◽

Cochrane Library ◽

Cross Sectional Survey ◽

Systematic Review Methodology ◽

Cross Sectional ◽

Prospective Longitudinal ◽

Over Time

Background: The living systematic review (LSR) is an emerging approach for improved evidence synthesis that uses continual updating to include relevant new evidence as soon as it is published. The objectives of this study are to: 1) assess the methods of conduct and reporting of living systematic reviews using a living study approach; and 2) describe the life cycle of living systematic reviews, i.e., describe the changes over time to their methods and findings. Methods: For objective 1, we will begin by conducting a cross-sectional survey and then update its findings every 6 months by including newly published LSRs. For objective 2, we will conduct a prospective longitudinal follow-up of the cohort of included LSRs. To identify LSRs, we will continually search the following electronic databases: Medline, EMBASE and the Cochrane library. We will also contact groups conducting LSRs to identify eligible studies that we might have missed. We will follow the standard systematic review methodology for study selection and data abstraction. For each LSR update, we will abstract information on the following: 1) general characteristics, 2) systematic review methodology, 3) living approach methodology, 4) results, and 5) editorial and publication processes. We will update the findings of both the surveys and the longitudinal follow-up of included LSRs every 6 months. In addition, we will identify articles addressing LSR methods to be included in an ‘LSR methods repository’. Conclusion: The proposed living methodological survey will allow us to monitor how the methods of conduct, and reporting as well as the findings of LSRs change over time. Ultimately this should help with ensuring the quality and transparency of LSRs.

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Changes in self-rated health and quality of life among Syrian refugees migrating to Norway: a prospective longitudinal study

International Journal for Equity in Health ◽

10.1186/s12939-020-01300-6 ◽

2020 ◽

Vol 19 (1) ◽

Author(s):

Jasmin Haj-Younes ◽

Elisabeth Marie Strømme ◽

Jannicke Igland ◽

Bernadette Kumar ◽

Eirik Abildsnes ◽

...

Keyword(s):

Quality Of Life ◽

Longitudinal Study ◽

Syrian Refugees ◽

Prospective Longitudinal Study ◽

Mean Values ◽

Self Rated Health ◽

Prospective Longitudinal ◽

Over Time

Abstract Background Forced migrants can be exposed to various stressors that can impact their health and wellbeing. How the different stages in the migration process impacts health is however poorly explored. The aim of this study was to examine changes in self-rated health (SRH) and quality of life (QoL) among a cohort of adult Syrian refugees before and after resettlement in Norway. Method We used a prospective longitudinal study design with two assessment points to examine changes in health among adult Syrian resettlement refugees in Lebanon accepted for resettlement in Norway. We gathered baseline data in 2017/2018 in Lebanon and subsequently at follow-up one year after arrival. The main outcomes were good SRH measured by a single validated item and QoL measured by WHOQOL-BREF. We used generalized estimating equations to investigate changes in outcomes over time and incorporated interaction terms in the models to evaluate effect modifications. Results In total, 353 subjects participated in the study. The percentage of participants reporting good SRH showed a non-significant increase from 58 to 63% RR, 95%CI: 1.1 (1.0, 1.2) from baseline to follow-up while mean values of all four QoL domains increased significantly from baseline to follow-up; the physical domain from 13.7 to 15.7 B, 95%CI: 1.9 (1.6, 2.3), the psychological domain from 12.8 to 14.5 B, 95%CI: 1.7 (1.3, 2.0), social relationships from 13.7 to 15.3 B, 95%CI: 1.6 (1.2, 2.0) and the environmental domain from 9.0 to 14.0 5.1 B, 95%CI: (4.7, 5.4). Positive effect modifiers for improvement in SRH and QoL over time include male gender, younger age, low level of social support and illegal status in transit country. Conclusion Our results show that good SRH remain stable while all four QoL domains improve, most pronounced in the environment domain. Understanding the dynamics of migration and health is a fundamental step in reaching health equity.

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Prospective longitudinal characterisation of the relationship between diabetes and cardiac remodeling

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jeab090.043 ◽

2021 ◽

Vol 22 (Supplement_2) ◽

Author(s):

A Chowdhary ◽

N Jex ◽

S Thirunavukarasu ◽

T Craven ◽

A Das ◽

...

Keyword(s):

Cardiovascular Disease ◽

Ejection Fraction ◽

Event Rate ◽

Systolic Function ◽

Major Adverse Cardiovascular Event ◽

Left Ventricular ◽

Adverse Cardiovascular Event ◽

Prospective Longitudinal ◽

Over Time

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): British Heart Foundation Clinical Research Training Fellowship and Wellcome Trust Background Cardiovascular disease represents the primary cause of death in patients with type 2 diabetes (T2D). Heart failure (HF) is the commonest initial presentation of cardiovascular disease in T2D. Development of HF in patients with T2D is associated with a 4 to 6-fold increase in mortality, making the prevention of cardiac dysfunction an important goal. The long-term impact of T2D on cardiac function in the absence of cardiovascular disease is unknown. This is the first prospective longitudinal study utilising cardiovascular magnetic resonance (CMR) to evaluate the impact of T2D on cardiac remodeling. Objectives To determine longitudinal changes in the phenotypic expression of heart disease in diabetes over 6 years, and examine the association of baseline blood and imaging biomarkers with remodeling over time in patients who remained free of cardiovascular/clinical events, and to report clinical outcomes in the entire cohort. Methods 100 asymptomatic T2D patients with no history of cardiovascular disease or hypertension were previously studied. Biventricular volumes, function, and myocardial strain were assessed by CMR and blood biomarkers taken. 6-year follow-up CMR was repeated in those without interim cardiovascular events. Results Of the 100 patients, 78 could be contacted for follow-up. 29 participants experienced cardiovascular/clinical events over 6 years. 32 patients who were asymptomatic and without events received follow-up CMR. The major adverse cardiovascular event rate (MI, angina, revascularisation, stroke, death) during the 6-year follow-up period, including the patients with a silent MI, amounted to 25% in this study with an overall clinical event rate of 35%. There were no significant changes in BP, BMI or HBA1c between baseline and follow-up (Table 1). Left ventricular end-diastolic-volume(p = 0.005), mass (p = 0.01), ejection fraction (p = 0.0001), and right ventricular end-diastolic-volume(p = 0.03) and ejection fraction(p = 0.003) reduced over time (Figure 2 and Table 1). Baseline plasma high-sensitivity cardiac-troponin-T (hs-cTnT) (R=-0.44; p = 0.01) was significantly associated with change in left ventricular ejection fraction over time. Conclusions Even in the absence of overt clinical CAD, significant valvular disease, uncontrolled hypertension or change in BMI, T2D results in significant reductions in cardiac size and biventricular systolic function over time. The major adverse cardiovascular event rate (MI, angina, revascularisation, stroke, death) during the 6-year follow-up period was high in diabetes patients (25%). Plasma biomarker hs-cTnT measured at baseline was associated with change in LV systolic function over the 6-year follow-up period. hs-cTnT could potentially have a significant utility as a risk-predicting tool for cardiac dysfunction in T2D patients.

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Cohort studies

10.1093/med/9780198816805.003.0030 ◽

2021 ◽

pp. 85-100

Author(s):

Alvaro Muñoz ◽

F. Javier Nieto

Keyword(s):

Cohort Studies ◽

Individual Level ◽

Cohort Design ◽

Data Analyses ◽

Disease Occurrence ◽

Using Data ◽

The Individual ◽

Inference Methods ◽

Over Time

The simplest cohort design is to obtain exposure data at baseline and follow-up individuals to obtain data up to the point when the event of interest occurs. A richer design includes regularly scheduled visits at which data on exposures are updated. The exposures can be either fixed over time (e.g. race), change directly with time (e.g. age and calendar), or change at their own pace (e.g. biological markers). According to the scientific aims of a cohort study, disease occurrence can be measured as an event in person-time, time-to-endpoint of interest, or change in a biomarker repeatedly measured at follow-up visits. Analytical methods include survival analyses to handle censored observations and late entries due to incomplete observation of the development of events and origin, and longitudinal data analyses for the trajectories of markers of disease progression. Stratification, multivariate regression, and causal inference methods are key tools to accomplish comparability among exposed and unexposed groups. Identification of exposures and risk factors for disease provides a basis for prevention strategies. Data from cohort studies can be used to assess the effects of interventions by using data at the individual level to determine individual effectiveness or by comparing occurrence of disease in the population when typically none or only a few are intervened to determine population effectiveness.

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Patients’ views on interactions with practitioners for type 2 diabetes: a longitudinal qualitative study in primary care over 10 years

British Journal of General Practice ◽

10.3399/bjgp17x693917 ◽

2017 ◽

Vol 68 (666) ◽

pp. e36-e43 ◽

Cited By ~ 3

Author(s):

Hajira Dambha-Miller ◽

Barbora Silarova ◽

Greg Irving ◽

Ann Louise Kinmonth ◽

Simon J Griffin

Keyword(s):

Type 2 Diabetes ◽

Primary Care ◽

Descriptive Analysis ◽

Free Text ◽

Individual Level ◽

Face To Face ◽

Relational Continuity ◽

Over Time

BackgroundIt has been suggested that interactions between patients and practitioners in primary care have the potential to delay progression of complications in type 2 diabetes. However, as primary care faces greater pressures, patient experiences of patient–practitioner interactions might be changing.AimTo explore the views of patients with type 2 diabetes on factors that are of significance to them in patient–practitioner interactions in primary care after diagnosis, and over the last 10 years of living with the disease.Design and settingA longitudinal qualitative analysis over 10 years in UK primary care.MethodThe study was part of a qualitative and quantitative examination of patient experience within the existing ADDITION-Cambridge and ADDITION-Plus trials from 2002 to 2016. The researchers conducted a qualitative descriptive analysis of free-text comments to an open-ended question within the CARE measure questionnaire at 1 and 10 years after diagnosis with diabetes. Data were analysed cross-sectionally at each time point, and at an individual level moving both backwards and forwards between time points to describe emergent topics.ResultsAt the 1-year follow-up, 311 out of 1106 (28%) participants had commented; 101 out of 380 (27%) participants commented at 10-year follow-up; and 46 participants commented at both times. Comments on preferences for face-to-face contact, more time with practitioners, and relational continuity of care were more common over time.ConclusionThis study highlights issues related to the wider context of interactions between patients and practitioners in the healthcare system over the last 10 years since diagnosis. Paradoxically, these same aspects of care that are valued over time from diagnosis are also increasingly unprotected in UK primary care.

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The Role of Pornography Use in Intimate Partner Violence in Different-Sex Couples: A Prospective Longitudinal Study

Journal of Interpersonal Violence ◽

10.1177/08862605211055145 ◽

2021 ◽

pp. 088626052110551

Author(s):

Katherine Jongsma ◽

Patti Timmons Fritz

Keyword(s):

Intimate Partner Violence ◽

Romantic Relationships ◽

Partner Violence ◽

Structural Equation ◽

Intimate Partner ◽

Prospective Longitudinal Study ◽

Pornography Use ◽

Prospective Longitudinal ◽

Over Time

Pornography use and intimate partner violence (IPV) are both prevalent in romantic relationships. However, information is lacking about whether pornography use predicts IPV. This study examined the relation between frequency of pornography use (FPU) and IPV across a span of 4 months in a sample of 132 different-sex couple dyads. At least one partner in each couple was attending a Canadian university. Participants ( N = 264) completed online measures of pornography use, IPV, and social desirability at baseline and at a 4-month follow-up. Two longitudinal actor–partner interdependence models using a structural equation framework to conduct path analyses demonstrated that (a) higher FPU among men at baseline predicted increases in IPV perpetration and victimization from baseline to 4-month follow-up for both men and women and (b) women’s baseline FPU did not predict change in IPV over time for themselves or their partners. These findings suggest that frequent pornography use among male partners in different-sex romantic relationships may represent an under-recognized risk factor for IPV, and further research is needed to identify latent factors that may be contributing to this relation. Although women’s baseline FPU did not predict changes in IPV over time, this may be because women used pornography less frequently than men.

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Methods of conduct and reporting of living systematic reviews: a protocol for a living methodological survey

F1000Research ◽

10.12688/f1000research.18005.1 ◽

2019 ◽

Vol 8 ◽

pp. 221

Author(s):

Assem M. Khamis ◽

Lara A. Kahale ◽

Hector Pardo-Hernandez ◽

Holger J. Schünemann ◽

Elie A. Akl

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Evidence Synthesis ◽

Cochrane Library ◽

Cross Sectional Survey ◽

Systematic Review Methodology ◽

Cross Sectional ◽

Prospective Longitudinal ◽

Over Time

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4102QT interval duration, long QT pattern and changes over time in children practicing sport

European Heart Journal ◽

10.1093/eurheartj/ehz745.0114 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

F D'Ascenzi ◽

F Anselmi ◽

F Graziano ◽

B Berti ◽

A Franchini ◽

...

Keyword(s):

Qt Interval ◽

Paediatric Population ◽

P Value ◽

Interval Duration ◽

Long Qt ◽

Prospective Longitudinal Study ◽

Final Population ◽

Prospective Longitudinal ◽

Over Time

Abstract Background Twelve-lead electrocardiogram (ECG) is an established tool in the evaluation of adult athletes, providing information about life-threatening cardiovascular diseases such as long-QT syndrome. However, changes induced by development challenge the interpretation of ECG in the paediatric population, particularly for the repolarisation phase. The aim of this prospective, longitudinal study was to determinate the distribution of QT interval in children practicing sport and to evaluate changes in QT duration during preadolescence. Methods A final population of 1473 children practising sport (mean age: 12.0±1.8 years, interval 7–15 years) was analysed. Each athlete was evaluated at baseline, mid-term and end of the study with a mean follow-up of 3±1 years. QT interval was corrected with Bazett (B) and Fridericia (F) formulae. Results At baseline QTcB was 412±25ms and QTcF 387±21ms, with no changes during follow-up. Ten children (0.68%) had an abnormal QTc. In children with QTc ≥480ms confirmed both by Bazett and Fridericia formulae, QT duration persisted abnormal during the follow-up and children were disqualified. Conversely, children with borderline QTc intervals (>460 and <480ms) were not disqualified and we found a normalization of QT interval during the development. Mean difference in the calculation of QT between the two formulae was 25±11ms, p<0.0001. For HR values higher than 80 bpm, the QTcF resulted with low fluctuations around the mean was independent from HR values. Conversely, the QTcB revealed significant growing trend as the HR increased and showed higher variability than Fridericia correction. Dynamic changes in QT interval duration Baseline Mid-term FU Long-term FU p value Intervallo QT 343±25 345±24* 346±25* <0.0001 RR (ms) 599±111 711±111* 721±119*^ <0.0001 QTc Bazett (ms) 412±25 (371–449) 411±25 (367–449) 409±25 (367–446) 0.10 QTc Fredericia (ms) 387±21 (355–418) 387±20 (353–419) 387±20 (353–418) 0.59 FU, follow up; *p<0.0001 vs. baseline; §p<0.0001 vs. mid-term FU; ^p<0.05 vs. mid-term FU. Conclusions QT duration does not change over time in children with normal duration. A minority of children has a QT ≥480ms; in these subjects QT interval remains prolonged during the follow-up. Conversely, in children with borderline QT, mid-term follow-up is useful to identify a normalization during the growth. Clinicians should take into account that the use of Bazett and Fridericia correction formulae is not interchangeable and that Fridericia formula should be preferred when resting HR is higher than 80 bpm.

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The Influence of Adverse Childhood Experiences (ACEs) on the Functional Impairment of Justice-Involved Adolescents: A Comparison of Baseline to Follow-Up Reports of Adversity

Youth Violence and Juvenile Justice ◽

10.1177/15412040211016035 ◽

2021 ◽

pp. 154120402110160

Author(s):

Jacquelynn F. Duron ◽

Abigail Williams-Butler ◽

Feng-Yi Y. Liu ◽

Danielle Nesi ◽

Kathleen Pirozzolo Fay ◽

...

Keyword(s):

Functional Impairment ◽

Adverse Childhood Experiences ◽

Juvenile Justice System ◽

Global Functioning ◽

Childhood Experiences ◽

Individual Outcomes ◽

Adverse Childhood ◽

Trauma Informed ◽

Over Time

Adverse childhood experiences (ACEs) have long been recognized for negatively influencing individual outcomes such that each additional ACE exposure increases the risk for negative health and behavioral outcomes. Little is known, however, about how the more recent accumulation of ACEs occurring in follow-up periods influence global functioning considering the past accumulation of ACEs reported at baseline by justice-involved adolescents. Participants were 851 adolescents who completed the Northwestern Juvenile Project (NJP), a longitudinal survey. OLS regression models were used to examine the influence of follow-up and baseline ACEs on the functional impairment of youth. Results indicate that both follow-up and baseline ACEs were associated with worse functioning over time with baseline ACEs demonstrating a greater effect. This study highlights the importance of assessing accumulations of ACEs over time for adolescents in the juvenile justice system and considering how youth of different characteristics and experiences may differently encounter functional impairment. Implications for offering trauma-informed services to disrupt the effects of adversity on adolescents’ functioning are discussed.

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