scholarly journals Clinical Prescription-Protein-Small Molecule-Disease Strategy (CPSD), A New Strategy for Chinese Medicine Development: A Case Study in Cardiovascular Diseases

2020 ◽  
Vol 10 ◽  
Author(s):  
Yong-Zhi Guo ◽  
Ying-Nan Jiang ◽  
Yi-Fang Li ◽  
Hiroshi Kurihara ◽  
Yi Dai ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Cardiovascular Diseases ◽  
Small Molecule ◽  
Medicine Development ◽  
New Strategy

Narrative Scientific Data Visualization in an Immersive Environment

2021 ◽  
Author(s):  
Richen Liu ◽  
Hailong Wang ◽  
Chuyu Zhang ◽  
Xiaojian Chen ◽  
Lijun Wang ◽  
...  
Keyword(s):  
Data Visualization ◽  
Domain Knowledge ◽  
User Study ◽  
Scientific Visualization ◽  
Scientific Data ◽  
Immersive Environments ◽  
Related Information ◽  
New Strategy ◽  
Scientific Data Visualization

Abstract Motivation Narrative visualization for scientific data explorations can help users better understand the domain knowledge, because narrative visualizations often present a sequence of facts and observations linked together by a unifying theme or argument. Narrative visualization in immersive environments can provide users with an intuitive experience to interactively explore the scientific data, because immersive environments provide a brand new strategy for interactive scientific data visualization and exploration. However, it is challenging to develop narrative scientific visualization in immersive environments. In this paper, we propose an immersive narrative visualization tool to create and customize scientific data explorations for ordinary users with little knowledge about programming on scientific visualization, They are allowed to define POIs (point of interests) conveniently by the handler of an immersive device. Results Automatic exploration animations with narrative annotations can be generated by the gradual transitions between consecutive POI pairs. Besides, interactive slicing can be also controlled by device handler. Evaluations including user study and case study are designed and conducted to show the usability and effectiveness of the proposed tool. Availability Related information can be accessed at: https://dabigtou.github.io/richenliu/

A comprehensive review of pharmacokinetic and pharmacodynamic in animals: exploration of interaction with antibiotics of Shuang-Huang-Lian preparations

2021 ◽  
Vol 21 ◽  
Author(s):  
Liuyi Liang ◽  
Xin Jin ◽  
Jinjing Li ◽  
Rong Li ◽  
Xinyi Jiao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Pharmacokinetic Interaction ◽  
Pharmacological Action ◽  
New Strategy ◽  
System Review ◽  
Tract Infections ◽  
Important Significance

: As a traditional Chinese medicine, Shuang-Huang-Lian (SHL) has been widely used for treating infectious diseases of the respiratory tract such as encephalitis, pneumonia and asthma. During the past few decades, considerable research has focused on the pharmacological action, pharmacokinetic interaction with antibiotics and clinical applications of SHL. A huge and more recent body of pharmacokinetic study supports the combination of SHL and antibiotics has different effects such as antagonism and synergism. SHL has been one of the best-selling traditional Chinese medicine (TCM) products. However, there is no system review of SHL preparations, ranging from protection against respiratory tract infections to interaction with antibiotics. Since their important significance in clinical therapy, the pharmacodynamic, pharmacokinetic, and interactions with antibiotics of SHL were reviewed and discussed. In addition, this review attempts to explore the possible potential mechanism of SHL preparations in prevention and treatment of COVID-19. We are concerned about what is known of the effects of SHL against virus, bacterium, and its interactions with antibiotics, providing a new strategy for expanding the clinical research and medication of SHL preparations.

Reconsidering azobenzene as a component of small-molecule hypoxia-mediated cancer drugs: A theranostic case study

Biomaterials ◽  
2017 ◽  
Vol 115 ◽  
pp. 104-114 ◽  
Author(s):  
Peter Verwilst ◽  
Jiyou Han ◽  
Jiyeong Lee ◽  
Sora Mun ◽  
Hee-Gyoo Kang ◽  
...  
Keyword(s):  
Small Molecule ◽  
Cancer Drugs

scholarly journals Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications

Antibodies ◽  
2018 ◽  
Vol 7 (4) ◽  
pp. 40
Author(s):  
Thomas Linz ◽  
Dominick Yeo ◽  
Qiuting Hong ◽  
Wesley Zmolek ◽  
Jesse McFarland ◽  
...  
Keyword(s):  
Small Molecule ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Liquid Chromatography Tandem Mass ◽  
Molecular Components ◽  
Mass Shifts ◽  
Composition Changes ◽  
Antibody Drug

We hypothesized that systematic liquid chromatography-tandem mass spectrometry investigations of an antibody–drug conjugate (ADC), its small and large molecular components, and surrogate small-molecule conjugates might comprise a simple and efficient approach for the extended characterization of ADCs. Furthermore, we envisioned that results from this work might allow us to assign specific composition changes in the ADC based on monoisotopic mass shifts of conjugatable modifications as detected in the surrogate small-molecule conjugates. We tested our hypothesis with a case study using an aldehyde-tag-based ADC conjugated to a noncleavable linker bearing a maytansine payload. Nearly quantitative bioconversion from cysteine to formylglycine was observed in the monoclonal antibody, and bioorthogonal conjugation was detected only on the formylglycine residues in the ADC. Using our method, both conjugatable and nonconjugatable modifications were discovered in the linker/payload; however, only conjugatable modifications were observed on the ADC. Based on these results, we anticipate that our approach to systematic mass spectrometric investigations can be successfully applied to other ADCs and therapeutic bioconjugates for investigational new drug (IND)-enabling extended characterization.

scholarly journals LINKING ISLAMIC COMMERCIAL AND SOCIAL FINANCE WITH SPECIAL REFERENCE TO CASH-WAQF AS NEW STRATEGY OF INTEREST-FREE MICRO-CREDIT FOR FAMILY EMPOWERMENT OF THE POOR TOWARDS ESTABLISHING WORLD SOCIAL BANK: A CASE STUDY APPROACH

2018 ◽  
Vol 3 ◽  
pp. 1-32
Author(s):  
Muhammad Abdul Mannan
Keyword(s):  
Special Reference ◽  
Case Study Approach ◽  
Study Approach ◽  
Family Empowerment ◽  
The Poor ◽  
New Strategy ◽  
Micro Credit

Linking Islamic Commercial and Social Finance with Special Reference to Cash-Waqf as New Strategy of Interest-Free Micro-Credit for Family Empowerment of the Poor Towards Establishing World Social Bank: A Case Study Approach

scholarly journals A CASE STUDY ON ESSENTIAL HYPERTENSION MANAGING THROUGH AYURVEDA W.S.R. RAKTAGATA VYAN VAISHAMYA

2021 ◽  
Vol p5 (4) ◽  
pp. 2965-2968
Author(s):  
Ruhi Zahir ◽  
Iqbal Khan
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Risk Factor ◽  
Essential Hypertension ◽  
Cardiovascular Diseases ◽  
High Blood Pressure ◽  
Direct Reference ◽  
Major Risk Factor ◽  
End Stage

Essential hypertension is high blood pressure that doesn't have any known etiopathology. Most of sufferers (85%) are asymptomatic and as per available reports, in more than 95% cases of hypertension under lying cause is not found. It is estimated that 600 million people are affected worldwide. Hypertension is a major risk factor for the development of cardiovascular diseases (CVD). Its impact is greatest on stroke, MI and end stage is renal failure as it’s known as a Silent Killer. Hence there is no direct reference of hypertension in Ayurvedic classics by name as well as by its path physiological views. Many works have been carried out on hypertension to evaluate the perfect diagnosis and mode of treatment on the basis of Different nomenclatures also have been adopted by Ayurveda experts like Raktagata Vata, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Raktavrita Vata, Siragata Vata etc. Keywords: Essential hypertension, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Cardiovascular diseases, Silent Killer.

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