scholarly journals Celebrex Adjuvant Therapy on Coronavirus Disease 2019: An Experimental Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Wenxin Hong ◽  
Yan Chen ◽  
Kai You ◽  
Shenglin Tan ◽  
Feima Wu ◽  
...  
Keyword(s):  
Clinical Study ◽  
Vital Signs ◽  
Mean Value ◽  
Urine Samples ◽  
Adjunctive Treatment ◽  
Control Group ◽  
Prospective Clinical Study ◽  
Prostaglandin E ◽  
Full Dose ◽  
Half Dose

Background: The pandemic of coronavirus disease 2019 (COVID-19) resulted in grave morbidity and mortality worldwide. There is currently no effective drug to cure COVID-19. Based on analyses of available data, we deduced that excessive prostaglandin E2 (PGE2) produced by cyclooxygenase-2 was a key pathological event of COVID-19.Methods: A prospective clinical study was conducted in one hospital for COVID-19 treatment with Celebrex to suppress the excessive PGE2 production. A total of 44 COVID-19 cases were enrolled, 37 cases in the experimental group received Celebrex as adjuvant (full dose: 0.2 g, bid; half dose: 0.2 g, qd) for 7–14 days, and the dosage and duration was adjusted for individuals, while seven cases in the control group received the standard therapy. The clinical outcomes were evaluated by measuring the urine PGE2 levels, lab tests, CT scans, vital signs, and other clinical data. The urine PGE2 levels were measured by mass spectrometry. The study was registered and can be accessed at http://www.chictr.org.cn/showproj.aspx?proj=50474.Results: The concentrations of PGE2 in urine samples of COVID-19 patients were significantly higher than those of PGE2 in urine samples of healthy individuals (mean value: 170 ng/ml vs 18.8 ng/ml, p < 0.01) and positively correlated with the progression of COVID-19. Among those 37 experimental cases, there were 10 cases with age over 60 years (27%, 10/37) and 13 cases (35%, 13/37) with preexisting conditions including cancer, atherosclerosis, and diabetes. Twenty-five cases had full dose, 11 cases with half dose of Celebrex, and one case with ibuprofen. The remission rates in midterm were 100%, 82%, and 57% of the full dose, half dose, and control group, respectively, and the discharged rate was 100% at the endpoint with Celebrex treatment. Celebrex significantly reduced the PGE2 levels and promoted recovery of ordinary and severe COVID-19. Furthermore, more complications, severity, and death rate were widely observed and reported in the COVID-19 group of elders and with comorbidities; however, this phenomenon did not appear in this particular Celebrex adjunctive treatment study.Conclusion: This clinical study indicates that Celebrex adjuvant treatment promotes the recovery of all types of COVID-19 and further reduces the mortality rate of elderly and those with comorbidities.

scholarly journals Celebrex adjuvant therapy on COVID-19: An experimental study

2020 ◽  
Author(s):  
Wenxin Hong ◽  
Yan Chen ◽  
Kai You ◽  
Shenglin Tan ◽  
Feima Wu ◽  
...  
Keyword(s):  
Experimental Study ◽  
Adjuvant Therapy ◽  
Remission Rate ◽  
Vital Signs ◽  
Mean Value ◽  
Control Group ◽  
Full Dose ◽  
Half Dose ◽  
And Control ◽  
Experimental Group

AbstractBackgroundThe world is under serious threat with the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). However, there is no effective drug for the treatment of COVID-19. Based on analyses of available data, we deduced that the excessive prostaglandins E2 (PGE2) accumulation mediated by cyclooxygenase-2 (COX-2) was the key pathological basis of COVID-19.MethodsThe urine PGE2 levels were measured by mass spectrometry. An experimental study about Celebrex to treat COVID-19 was conducted based on routine treatment. A total of 44 confirmed COVID-19 patients were enrolled (Experimental group n=37, Control group n=7). Patients in experimental group were given Celebrex once or twice a day (0.2 g/time) for 7–14 days. The dosage or duration was modified for individuals. Clinical outcomes of Celebrex adjuvant therapy were evaluated by vital signs, laboratory tests, and computed tomography upon the discontinuance of Celebrex.ResultsWe found that the concentrations of PGE2 in urine samples of COVID-19 patients were significantly higher than that of healthy individuals (mean value is 170 ng/ml vs 18.8 ng/ml, p<0.01) and positively correlated with the progression of COVID-19. Among the experimental group (ordinary n=29, severe n=7, critical n=1), 25 cases were treated with full dose and 11 cases with half dose of Celebrex, and 1 case with Ibuprofen. The remission rate were 100%, 82% and 57% in full dose, half dose and control group respectively. Celebrex significantly reduced the PGE2 levels and promoted recovery of ordinary or severe COVID-19.ConclusionOur study suggests that Celebrex adjuvant treatment may be helpful for the therapy of COVID-19.

scholarly journals Effect of almond consumption on the serum fatty acid profile: a dose–response study

2014 ◽  
Vol 112 (7) ◽  
pp. 1137-1146 ◽  
Author(s):  
Stephanie Nishi ◽  
Cyril W. C. Kendall ◽  
Ana-Maria Gascoyne ◽  
Richard P. Bazinet ◽  
Balachandran Bashyam ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Risk Score ◽  
Percentage Change ◽  
Control Group ◽  
Dependent Manner ◽  
Serum Fatty Acid ◽  
Full Dose ◽  
Fa Composition ◽  
Chd Risk ◽  
Half Dose

Consumption of almonds has been shown to be associated with a decreased risk of CHD, which may be related to their fatty acid (FA) composition. However, the effect of almond consumption on the serum FA composition is not known. Therefore, in the present study, we investigated whether almond consumption would alter the serum FA profile and risk of CHD, as calculated using Framingham's 10-year risk score, in a dose-dependent manner in hyperlipidaemic individuals when compared with a higher-carbohydrate control group using dietary interventions incorporating almonds. A total of twenty-seven hyperlipidaemic individuals consumed three isoenergetic (mean 1770 kJ/d) supplements during three 1-month dietary phases: (1) full-dose almonds (50–100 g/d); (2) half-dose almonds with half-dose muffins; (3) full-dose muffins. Fasting blood samples were obtained at weeks 0 and 4 for the determination of FA concentrations. Almond intake (g/d) was found to be inversely associated with the estimated Framingham 10-year CHD risk score (P= 0·026). In both the half-dose and full-dose almond groups, the proportions of oleic acid (OA) and MUFA in the TAG fraction (half-almond: OA P= 0·003; MUFA P= 0·004; full-almond: OA P< 0·001; MUFA P< 0·001) and in the NEFA fraction (half-almond: OA P= 0·01; MUFA P= 0·04; full-almond: OA P= 0·12; MUFA P= 0·06) increased. The estimated Framingham 10-year CHD risk score was inversely associated with the percentage change of OA (P= 0·011) and MUFA (P= 0·016) content in the TAG fraction. The proportions of MUFA in the TAG and NEFA fractions were positively associated with changes in HDL-cholesterol concentrations. Similarly, the estimated Framingham 10-year CHD risk score was inversely associated with the percentage change of OA (P= 0·069) and MUFA content in the NEFA fraction (P= 0·009). In conclusion, the results of the present study indicate that almond consumption increases OA and MUFA content in serum TAG and NEFA fractions, which are inversely associated with CHD lipid risk factors and overall estimated 10-year CHD risk.

Benefits of Early Prosthetic Management of Transtibial Amputees: A Prospective Clinical Study of a Prefabricated Prosthesis

2002 ◽  
Vol 23 (6) ◽  
pp. 509-514 ◽  
Author(s):  
Lew C. Schon ◽  
Kelly W. Short ◽  
Olga Soupiou ◽  
Kenneth Noll ◽  
John Rheinstein
Keyword(s):  
Clinical Study ◽  
Postoperative Complications ◽  
Patient Outcomes ◽  
Control Group ◽  
Prospective Clinical Study ◽  
Significant Difference ◽  
Historic Control ◽  
Student’S T ◽  
Transtibial Amputees ◽  
Student’S T Test

To evaluate the use of an immediate postoperative prosthesis (IPOP) for transtibial amputees, we compared patient outcomes from a prospective clinical study of 19 patients managed with an IPOP with those of a retrospective review of a matched historic control group of 23 patients managed with standard soft dressings. Data were analyzed with the Student's t-test, and significance was set at P=0.05. The IPOP patients had no surgical revisions, whereas the patients with standard soft dressings had 11. This was a significant difference. IPOP patients also had significantly fewer postoperative complications and shorter times to custom prosthesis than did controls.

Randomized Prospective Clinical Study of Spatz3® Adjustable Intragastric Balloon Treatment with a Control Group: a Large-Scale Brazilian Experiment

2020 ◽  
Author(s):  
Ricardo José Fittipaldi-Fernandez ◽  
Idiberto José Zotarelli-Filho ◽  
Cristina Fajardo Diestel ◽  
Márcia Regina Simas Torres Klein ◽  
Marcelo Falcão de Santana ◽  
...  
Keyword(s):  
Clinical Study ◽  
Intragastric Balloon ◽  
Large Scale ◽  
Control Group ◽  
Prospective Clinical Study ◽  
Group A

scholarly journals Apical surgery vs apical surgery with simultaneous orthograde retreatment: A prospective cohort clinical study of teeth affected by persistent periapical lesion

2018 ◽  
Vol 32 (1) ◽  
pp. 2-8 ◽  
Author(s):  
Carlo Prati ◽  
Arash Azizi ◽  
Chiara Pirani ◽  
Fausto Zamparini ◽  
Francesco Iacono ◽  
...  
Keyword(s):  
Clinical Study ◽  
Surgical Techniques ◽  
Drop Out ◽  
Control Group ◽  
Prospective Clinical Study ◽  
Simultaneous Treatment ◽  
Clinical Criteria ◽  
Periapical Lesions ◽  
Apical Surgery ◽  
Level Of Significance

Aim: This prospective clinical study analyzed the 24-month outcome of conventional apical surgery retro-filled with calcium-silicate cement versus apical surgery with simultaneous orthograde retreatment by means of clinical and radiographic criteria. Materials and methods: This study included 83 teeth affected by persistent periapical lesions in 68 patients. Mean age was 52 years (median = 51 years; range 19-81 years). Twenty-eight cases were treated with apical surgery, 16 cases with apical surgery with simultaneous orthograde retreatment and 39 cases with orthograde retreatment in previously treated teeth established as control group. Periapical index score (PAI) was used as radiographic criteria. Teeth were examined at 6 months, 1 and 2 years and classified as healed (without any symptoms and PAI 2), healing (without any symptoms and PAI = 3) or diseased (with symptoms or PAI 4 and not functional) on the basis of radiographic and clinical criteria. At 24 months evaluation, healed and healing were considered as success and diseased and fracture as failure. Multilevel GLM model and an ordered logistic regression as statistical analysis was made with level of significance set at p < 0.05. Results: Total drop-out was 7% (n = 6). After 6—9 months, 6 teeth (3 from apical surgery, 2 from simultaneous treatment and 1 from orthograde retreatment) were extracted for root fracture. Twenty-four-month success rate of apical surgery group was 78% (n = 17), apical surgery with simultaneous orthograde retreatment presented 81% (n = 10) and orthograde retreatment success was 80% (n = 24). There was no statistically difference between the groups at 24 months (p = 0.890). Conclusions: Both surgical techniques revealed a high percentage of healing, similar to that reported by previous studies. Apical surgery with simultaneous orthograde retreatment showed a faster healing after 12 months comparing to the control group.

scholarly journals The Connection between the Endometrial Thickness and the Risk of Endometrial Malignancy in Postmenopausal Women

2019 ◽  
Vol 7 (14) ◽  
pp. 2263-2266 ◽  
Author(s):  
Valentina Tofiloska ◽  
Vesna Velik-Stefanovska ◽  
Goran Dimitrov
Keyword(s):  
Endometrial Cancer ◽  
Clinical Study ◽  
Endometrial Thickness ◽  
Control Group ◽  
Prospective Clinical Study ◽  
Histopathological Analysis ◽  
Detailed History ◽  
Gynecology And Obstetrics ◽  
One Year ◽  
The University

BACKGROUND: Postmenopausis is a period that starts one year after the last menstruation. Late menopause, after 70 years, is called senile. AIM: To examine the correlation between endometrial thickness and the risk of endometrial malignancy in postmenopausal. MATERIAL AND METHODS: Prospective clinical study involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics – Skopje, divided into two groups: control and examination. The control group included 40 postmenopausal patients, hospitalised and operated due to urogenital pathology. The examined group consisted of 80 patients divided into three subgroups according to the ultrasound verified thickness of the endometrium: from 5-8 mm; > 8-11 mm and above 11 mm. A detailed history and intervention were taken in the patients from both groups, and the material was sent for histopathological analysis to determine eventual malignancy. RESULTS: The probability of endometrial malignancy significantly increased by 1.012 times in the group with a thickness of the endometrium from 5-8 mm, 1.769 times in the endometrial thickness group > 8-11 mm and 4.737-fold in the group over 11 mm compared to the control group. CONCLUSION: In postmenopausal patients, the likelihood of endometrial cancer significantly increases with the thickness of the endometrium.

Preventing Post-injury Hypothermia During Prolonged Prehospital Evacuation

2002 ◽  
Vol 17 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Hans Husum ◽  
Tone Olsen ◽  
Mudhafar Murad ◽  
Yang Van Heng ◽  
Torben Wisborg ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Hospital Admission ◽  
Penetrating Trauma ◽  
Mean Value ◽  
Control Group ◽  
Prospective Clinical Study ◽  
Trauma Patients ◽  
Post Injury ◽  
Northern Iraq ◽  
Care Protocol

AbstractIntroduction:Post-injury hypothermia is a risk predictor in trauma patients whose physiology is deranged. The aim of the present study was to examine the effect of simple, in-field, hypothermia prevention to victims of penetrating trauma during long prehospital evacuations.Methods:A total of 170 consecutively injured landmine victims were included in a prospective, clinical study in Northern Iraq and Cambodia. Thirty patients were provided with systematic prehospital hypothermia prevention, and for 140 patients, no preventive measures were provided.Results:The mean value for the time from injury to hospital admission was 6.6 hours (range: 0.2–72). The incidence of hypothermia (oral temperature <36°C) before prevention/rewarming was 21% (95% confidence interval: 15% to 28%). The Prevention Group had a statistically significant lower rate of hypothermia on hospital admission compared to the control group (95% confidence interval for difference: 6% to 24%).Conclusion:Simple, preventive, in-field measures help to prevent hypothermia during protracted evacuation, and should be part of the trauma care protocol in rural rescue systems.

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