scholarly journals Celebrex adjuvant therapy on COVID-19: An experimental study

2020 ◽  
Author(s):  
Wenxin Hong ◽  
Yan Chen ◽  
Kai You ◽  
Shenglin Tan ◽  
Feima Wu ◽  
...  
Keyword(s):  
Experimental Study ◽  
Adjuvant Therapy ◽  
Remission Rate ◽  
Vital Signs ◽  
Mean Value ◽  
Control Group ◽  
Full Dose ◽  
Half Dose ◽  
And Control ◽  
Experimental Group

AbstractBackgroundThe world is under serious threat with the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). However, there is no effective drug for the treatment of COVID-19. Based on analyses of available data, we deduced that the excessive prostaglandins E2 (PGE2) accumulation mediated by cyclooxygenase-2 (COX-2) was the key pathological basis of COVID-19.MethodsThe urine PGE2 levels were measured by mass spectrometry. An experimental study about Celebrex to treat COVID-19 was conducted based on routine treatment. A total of 44 confirmed COVID-19 patients were enrolled (Experimental group n=37, Control group n=7). Patients in experimental group were given Celebrex once or twice a day (0.2 g/time) for 7–14 days. The dosage or duration was modified for individuals. Clinical outcomes of Celebrex adjuvant therapy were evaluated by vital signs, laboratory tests, and computed tomography upon the discontinuance of Celebrex.ResultsWe found that the concentrations of PGE2 in urine samples of COVID-19 patients were significantly higher than that of healthy individuals (mean value is 170 ng/ml vs 18.8 ng/ml, p<0.01) and positively correlated with the progression of COVID-19. Among the experimental group (ordinary n=29, severe n=7, critical n=1), 25 cases were treated with full dose and 11 cases with half dose of Celebrex, and 1 case with Ibuprofen. The remission rate were 100%, 82% and 57% in full dose, half dose and control group respectively. Celebrex significantly reduced the PGE2 levels and promoted recovery of ordinary or severe COVID-19.ConclusionOur study suggests that Celebrex adjuvant treatment may be helpful for the therapy of COVID-19.

scholarly journals Celebrex Adjuvant Therapy on Coronavirus Disease 2019: An Experimental Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Wenxin Hong ◽  
Yan Chen ◽  
Kai You ◽  
Shenglin Tan ◽  
Feima Wu ◽  
...  
Keyword(s):  
Clinical Study ◽  
Vital Signs ◽  
Mean Value ◽  
Urine Samples ◽  
Adjunctive Treatment ◽  
Control Group ◽  
Prospective Clinical Study ◽  
Prostaglandin E ◽  
Full Dose ◽  
Half Dose

Background: The pandemic of coronavirus disease 2019 (COVID-19) resulted in grave morbidity and mortality worldwide. There is currently no effective drug to cure COVID-19. Based on analyses of available data, we deduced that excessive prostaglandin E2 (PGE2) produced by cyclooxygenase-2 was a key pathological event of COVID-19.Methods: A prospective clinical study was conducted in one hospital for COVID-19 treatment with Celebrex to suppress the excessive PGE2 production. A total of 44 COVID-19 cases were enrolled, 37 cases in the experimental group received Celebrex as adjuvant (full dose: 0.2 g, bid; half dose: 0.2 g, qd) for 7–14 days, and the dosage and duration was adjusted for individuals, while seven cases in the control group received the standard therapy. The clinical outcomes were evaluated by measuring the urine PGE2 levels, lab tests, CT scans, vital signs, and other clinical data. The urine PGE2 levels were measured by mass spectrometry. The study was registered and can be accessed at http://www.chictr.org.cn/showproj.aspx?proj=50474.Results: The concentrations of PGE2 in urine samples of COVID-19 patients were significantly higher than those of PGE2 in urine samples of healthy individuals (mean value: 170 ng/ml vs 18.8 ng/ml, p &lt; 0.01) and positively correlated with the progression of COVID-19. Among those 37 experimental cases, there were 10 cases with age over 60 years (27%, 10/37) and 13 cases (35%, 13/37) with preexisting conditions including cancer, atherosclerosis, and diabetes. Twenty-five cases had full dose, 11 cases with half dose of Celebrex, and one case with ibuprofen. The remission rates in midterm were 100%, 82%, and 57% of the full dose, half dose, and control group, respectively, and the discharged rate was 100% at the endpoint with Celebrex treatment. Celebrex significantly reduced the PGE2 levels and promoted recovery of ordinary and severe COVID-19. Furthermore, more complications, severity, and death rate were widely observed and reported in the COVID-19 group of elders and with comorbidities; however, this phenomenon did not appear in this particular Celebrex adjunctive treatment study.Conclusion: This clinical study indicates that Celebrex adjuvant treatment promotes the recovery of all types of COVID-19 and further reduces the mortality rate of elderly and those with comorbidities.

scholarly journals THE EFFECT OF DEFINITIONS TOWARD STUDENTS’ VOCABULARY

2018 ◽  
Vol 6 (1) ◽  
pp. 34
Author(s):  
Tawali Tawali
Keyword(s):  
Experimental Study ◽  
Alternative Hypothesis ◽  
T Test ◽  
Second Grade ◽  
Control Group ◽  
Second Grade Students ◽  
Post Test ◽  
The Subject ◽  
And Control ◽  
Experimental Group

This research is aimed to find out the effect of definitions toward students’ vocabulary mastery: it was an experimental study at the second grade student of MTs NW Haqqul Yaqin Sayang- sayang. The subject of this research was the second grade of MTs NW Haqqul Yaqin Sayang- sayang.The research was used experimental method with quantitative approach. The population of this research consist of 55 students, and the sample is 29 for experimental group while 26 for control group. The technique of collecting data was used definition for experimental group and matching word with antonym for control group. The data was collected by using post-test only and the data was analyzed by t-test formula. Based on data analysis the mean score of experimental group was 76,4 and control group was 69,23, beside of that standard deviation for experimental group was 114,28 and for control group was 113,09 and the value of t-test was 2,44 and t-table was 2,000. Degree of freedom is 53 with significant level 0,05. It means that the value of t-test was higher than t-table (t-test ˃ t-table). The alternative hypothesis (Ha) was accepted and null hypothesis (Ho) was rejected. Thus, the conclusion of this research was there was an effect of definition toward students’ vocabulary mastery: an experimental study at the second grade students of MTs NW Haqqul Yaqin Sayang-sayang.

scholarly journals A STUDY OF THE EFFECT OF THE PHYTOCHEMICAL CONTENT OF P. AMERICANALEAF ON HEMATOLOGICAL SYSTEM OF ALBINO RATS

2021 ◽  
Vol 9 (04) ◽  
pp. 464-467
Author(s):  
Ngozi a ◽  
◽  
N. Omeke ◽  
Haruna M. Ndahi ◽  
◽  
...  
Keyword(s):  
Adverse Effect ◽  
Experimental Study ◽  
Aqueous Extract ◽  
Leaf Extract ◽  
Control Group ◽  
Albino Rats ◽  
Phytochemical Content ◽  
Other Substances ◽  
And Control ◽  
Experimental Group

Given the medicinal importance of the avocado plant in alternative medicine,the present study aimed to study the effect of the phytochemical content of P. americana leaf extract on the hematological system of albino rats. Albino rats were obtained andclustered into sixgroups,with five rats per groupsimultaneously were assigned experimental and control. The rats in the experimental group were administered with varying doses of the prepared aqueous extract of P. americanawithin the period of the study. The rats in the control group were administered with other substances such as water and feed for the study period.The hematological system of the experimental animal was assessed after the administration of the extract, and it was observed that the aqueous extract of P. americana leaf recorded no significant adverse effect on the hematology system of the experimental study animal.

scholarly journals When Learners Prefer the Wrong Explanation: Misconceptions in Physics Explainer Videos and the Illusion of Understanding

2021 ◽  
Author(s):  
Christoph Kulgemeyer ◽  
Jörg Wittwer
Keyword(s):  
Experimental Study ◽  
Control Group ◽  
Control Groups ◽  
Physics Instruction ◽  
University Courses ◽  
Mistaken Belief ◽  
And Control ◽  
Immense Potential ◽  
Group D ◽  
Experimental Group

Online explanation videos on platforms like YouTube are popular among students and serve as an important resource for both distance learning and regular science education. Despite their immense potential, some of the explainer videos for physics include problematic explanation approaches, possibly fostering misconceptions. However, some of them manage to achieve good ratings on YouTube. A possible reason could be that explainer videos with misconceptions foster an “illusion of understanding”—the mistaken belief that a topic has been understood. In particular, misconceptions close to everyday experiences might elicit greater interest and appear more convincing than scientifically correct explanations. This experimental study was conducted to research this effect. Physics learners (N = 149), with a low prior knowledge enrolled in introductory university courses on primary education, were randomly assigned to experimental and control groups. While the experimental group watched a video introducing the concept of force relying on misconceptions, the control group watched the scientifically correct video. Both videos were comparable in terms of comprehensibility and duration. In the posttest, the experimental group believed that the video was scientifically correct, well-explained, and that they do not require further instruction to understand the concept—indicators of an illusion of understanding. The video including misconceptions was perceived as better understandable than the scientifically correct video (d = 0.62*). The experimental group was significantly more convinced by the misconception after watching the video than the control group (d = 1.86**). They learnt more erroneous knowledge about the misconception than the control group about the scientifically correct concept (Cohen’s q = 0.37*). We argue that this might become problematic (a) in physics instruction because students who have watched a misleading video might regard further teaching in school as irrelevant, and (b) learners might tend to rate videos including misconceptions better on an online platform like YouTube.

scholarly journals The Effectiveness Of English Interactive Media In Teaching Writing (An Experimental Study Conducted For Eleventh Graders In SMA N 1 Sedayu, Bantul Yogyakarta)

2017 ◽  
Vol 3 (1) ◽  
pp. 17
Author(s):  
Atayewa Merjen Gurbangeldiyewna ◽  
Hermayawati Hermayawati
Keyword(s):  
Experimental Study ◽  
Interactive Media ◽  
Total Sample ◽  
T Test ◽  
Teaching Writing ◽  
Control Group ◽  
Writing Skill ◽  
Computer Based ◽  
And Control ◽  
Experimental Group

The objectives of the study are to find out the ability of the students in writing descriptive text both before and after the treatment either at control group or experiment group; to find out the effectiveness of Interactive Media for teaching writing descriptive text; to find out what writing elements that received significant improvement after being taught by Interactive Media. This research was conducted using experimental study to overcome students’ problem in learning English especially writing skill. The researcher used two classes as the subject: XI MIPA-1 as the experiment group and XI MIPA-4 as control group. Those MIPA classes belong to Argo Mulyo High School /SMA N 1 Sedayu, Argomulyo, Bantul.The experimental class was taught the descriptive text by using Interactive Media in the form of Macromedia Flash while control groupwas taught by using non-computer based lessons. Total sample of both classes were 60 students. The research was conducted within quasi-experiment study which used pre-post tests design of experiment and control groups. The researcher used this method in order to find out whether computer-based instruction/Interactive Media could make significant improvement on the students’ descriptive writing skill. Such effectiveness was seen from difference of means between pre-post of both control and experiment groups and its t-test score at the degree of significancy. The t-test was higher than the t-table, Interactive Media then was proved significancy in improving the students’ writing descriptive text skill. The students’ writing was analyzed and scored based on rubrics postulated by Brown and Bailey including paragraph organization, its content, language structure, vocabulary and mechanics. The experiment shows that the t-test was (3.16) which is higher than t-table (2.000). The aspects of wtiting that has significant improvement were content, organization, structure, vocabulary - means pre-test of experimental group = 76.5 and control group = 70.8 increased into, experimental group = 87.22 and control group = 78.8 during post test with standard deviation of experimental group = 7.7 and control group = 9.97. Since there was a significant improvement of students’ writing skill by using Interactive Media, this research then confirms that Interactive Media is effective for teaching writing at SMA level.

scholarly journals The influence of the silage with high acidity on the rumen fermentation of cows

2004 ◽  
Vol 52 (1) ◽  
pp. 91-96
Author(s):  
Petr Doležal
Keyword(s):  
Acid Content ◽  
Rumen Fluid ◽  
Live Weight ◽  
Rumen Fermentation ◽  
Mean Value ◽  
Control Group ◽  
Maize Silage ◽  
Group A ◽  
And Control ◽  
Experimental Group

Twenty dairy cows were used in an experiment at which the influence of silages with different content of acids on the rumen fermentation was studied. Animals were divided into experimental and control group, each of them about 10 individuals. Feeding ratio consisted of maize silage (26 kg), alfalfa silage (13 kg), meadow hay (1 kg) and corn mixture (8.5 kg). The experimental group was fed an inoculated maize silage, with higher contents of fermentation acids. Intake of total acids per 1 kg live weigh was higher in the experimental group than control group (1.98 g/kg; 1.48 g/kg live weight, respectively). The rumen fluid was taken per orally 2-3 hours after feeding. Mean value of pH of rumen fluid was significantly (P<0.05) lower in the experimental group (5.8 ± 0.08) in comparison with control group (6.2 ± 0.06).The most significant increase (P<0.01) of VFA content (125 ± 5.2 mmol/l) and lactic acid content (4.8 ± 0.2 mmol/l) was observed in rumen fluid of experimental group. Significant differences (P<0.05) of propionic acid and butyric acid content were also found out between the groups. Nevertheless, acetic acid content was insignificant (P>0.05) lower in experimental group. A protozoa (infusoria) content was significantly (P<0.01) lower in the experimental group (175.76 ± 12.54 thousand/ml) as compared with the control group (288.1 ± 13.73 thousand/ml).

scholarly journals The Effect of De Bono Model on Students’ Achievement in Writing Descriptive Text of 2018/2019 Eleventh Year Students of SMA Yayasan Pendidikan Harapan Bangsa Kuala Kabupaten Langkat

2018 ◽  
Vol 10 (2) ◽  
pp. 28-37
Author(s):  
Conny Conny ◽  
Aginta Endingna Sembiring
Keyword(s):  
Experimental Study ◽  
Data Analysis ◽  
Alternative Hypothesis ◽  
T Test ◽  
Control Group ◽  
Writing Achievement ◽  
Writing Test ◽  
And Control ◽  
Experimental Group

The study is concerning with experimental study which discussed the effect of de Bono model students writing descriptive text. It took place at SMA yayasan pendidikan harapan bangsa kuala kabupaten langkat. The subjects were the eleventh year students with the population of 72 students. 72 students were chosen as the sample and group into experimental and control group. Each group consisted of 36 students. The experimental group was taught with de bono model while the control one was taught without De bono model. A writing test was used to collect the data on the students’ writing achievement. The data collected were analyzed by using t-test. The result of the data analysis showed that the t-observed was 7,24. It was higher that the value of t-table (tt) is 1,66 for 5% and 2,38 for 1%. This meant that the alternative hypothesis (Ha) was accepted. It can be concluded that there is effect of De Bono model on students writing descriptive text of 2018/2019 eleventh year students of SMA yayasan pendidikan harapan bangsa kuala kabupaten langkat.Keyword: Writing, Descriptive text, De Bono model, Six thinking hats

scholarly journals Development of Students' Pedagogical Abilities through Socio-Psychological Training

2021 ◽  
Vol 16 (16) ◽  
pp. 79
Author(s):  
Araily Shakirova ◽  
Galina Romanova ◽  
Svetlana Vlasova
Keyword(s):  
Mean Value ◽  
Control Group ◽  
Full Time ◽  
Psychological Training ◽  
Post Test ◽  
Standard Devia ◽  
Student’S T ◽  
And Control ◽  
Experimental Group ◽  
Student’S T Test

The research is devoted to the study of the effect of socio-psychological training on the development of pedagogical abilities in rising teachers. The study involved 88 full-time five-year students of the Xxxx Academy (Moscow) and four-year students of Xxxx University (Taldykorgan). The goal was achieved based on a system of special tasks with the involvement of socio-psychological trainings. The experiment and research were carried out for 6 months. The standard devia-tion in the sample and the Student's t-test were studied for the experimental and control groups. The result of the post-test is the opposite; thus, the mean value of the experimental group is higher than that of the control group. The study re-vealed that there is a weak positive relationship between age and pedagogical abil-ities (r <0.2). The results of the study also indicate a positive correlation between gender and pedagogical abilities (r> 0.3). Thus, in accordance with the goal set, it was determined that socio-psychological training improves students' pedagogical abilities. The results of this study can be recommended to teachers of universities and training centers, as well as pedagogical students.

scholarly journals THE EFFECTS OF DRAMA TRAINING ON INTERPERSONAL MANAGEMENT SKILL OF MANAGERS

2017 ◽  
Vol 5 (2) ◽  
pp. 293-313
Author(s):  
Recep İbrahim PINAR ◽  
Özgür KÖKALAN
Keyword(s):  
Experimental Study ◽  
Research Methods ◽  
Quantitative Research ◽  
Control Group ◽  
Management Skill ◽  
Quantitative Research Methods ◽  
Research Results ◽  
Software Program ◽  
And Control ◽  
Experimental Group

The main purpose of this study is to examine the effects of drama training on interpersonal management skill of managers. The experimental study was conducted in this research. The participants of the study were 20 managers divided into 10 as an experimental group and 10 as a control group. The drama training was given to participants of the experimental group by a specialist trainer and then the effects of this training were analyzed by quantitative research methods. In the quantitave researh, a questionnaire that were used to determine the interpersonal management skill of managers were conducted before the training for both the participants of the experimental group and control group. In order to determine the effects of drama training, the same quantionnaire were again conducted to all participants after the training and the effects of training on the participants of experimental group were analyzed by a quantitative software program called as SPSS 20.0. According to research results, it was proved that the interpersonal management skill was developed because of drama training. 

scholarly journals THE EFFECT OF APPLYING PLANTED QUESTION ON STUDENTS’ ACHIEVEMENT IN WRITING NARRATIVE TEXT OF NINETH GRADE OF SMP PABAKU STABAT

2020 ◽  
Vol 12 (2) ◽  
pp. 80-89
Author(s):  
Freddy Wilamenggi ◽  
Conny M.Hum
Keyword(s):  
Experimental Study ◽  
Data Analysis ◽  
Alternative Hypothesis ◽  
T Test ◽  
Narrative Text ◽  
Control Group ◽  
Writing Ability ◽  
Writing Test ◽  
And Control ◽  
Experimental Group

The study is concerning with experimental study which discussed the effect of planted question technique on students’ achievement in writing narrative text. It took place at SMP Pabaku Stabat. The subjects were the nineth grade students with the population of 132 students. 60 students were chosen as the sample and group into experimental and control group. Each group consisted of 30 students. The experimental group was taught with planted question technique while the control one was taught without planted question technique. A writing test was used to collect the data on the students’ writing ability. The data collected were analyzed by using t-test. The result of the data analysis showed that the t-observed was 6,53. It was higher that the value of t-table (tt) is 1,67 for 5% and 2,39 for 1%. This meant that the alternative hypothesis (Ha) was accepted. It can be concluded that there is effect of planted question technique on students’ achievement in writing narrative text of nineth grade of SMP Pabaku Stabat.

Sign in / Sign up

Export Citation Format

Share Document