Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites

Unintended pregnancy is a situation that every woman may encounter, and medical abortion is the first choice for women, but abortion often brings many sequelae. Angelica sinensis Radix (Danggui) and Leonuri Herba (Yimucao) are widely used in the treatment of gynecological diseases, which can regulate menstrual disorders, amenorrhea, dysmenorrhea, and promote blood circulation and remove blood stasis, but the mechanism for the treatment of abortion is not clear. We determined the ability of Danggui and Yimucao herb pair (DY) to regulate the Th1/Th2 paradigm by detecting the level of progesterone in the serum and the expression of T-bet and GATA-3 in the spleen and uterus. Then, we detected the level of metabolites in the serum and enriched multiple metabolic pathways. The arachidonic acid pathway can directly regulate the differentiation of Th1/Th2 cells. This may be one of the potential mechanisms of DY in the treatment of abortion.

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Professor Ruixia Pei’s Clinical Experience in Treating Globus Hystericus with “Harmonizing Method”

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v5i5.2480 ◽

2021 ◽

Vol 5 (5) ◽

pp. 51-53

Author(s):

Di Sun ◽

Ruixia Pei ◽

Xingyu Chen ◽

Fen Zhang

Keyword(s):

Clinical Experience ◽

Basic Principle ◽

Blood Circulation ◽

Blood Stasis ◽

Promote Blood Circulation ◽

The Core ◽

Emotional Dysfunction ◽

Yin And Yang ◽

Remove Blood Stasis

To summarize professor Pei’s experience in treating globus hystericus. Methods: Learn from your teacher. Results: Professor Pei had been suffering from the disease for more than 30 years and had her unique views on the treatment of globus hystericus, which are mostly for emotional dysfunction, liver Qi is not comfortable, functioning of Qi is not adjusted, Yin and Yang imbalance. The basic principle of treatment is to grasp the core pathogenesis, take harmony as the method and balance as the duration, harmonize Qi, regulate Yin and Yang, use drugs to disperse the liver and rectify Qi, as well as auxiliary treatment with products to promote blood circulation, remove blood stasis, dryness and dampness, and clear heat.

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Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation

Plants ◽

10.3390/plants10061192 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1192

Author(s):

Ping-Hsun Lu ◽

Chan-Yen Kuo ◽

Chuan-Chi Chan ◽

Lu-Kai Wang ◽

Mao-Liang Chen ◽

...

Keyword(s):

Platelet Aggregation ◽

Blood Circulation ◽

Human Platelet ◽

Blood Stasis ◽

Active Components ◽

Promote Blood Circulation ◽

Anticancer Properties ◽

Human Platelet Aggregation ◽

Adp Receptors ◽

Remove Blood Stasis

Safflower extract is commonly used as a traditional Chinese medicine to promote blood circulation and remove blood stasis. The antioxidant and anticancer properties of safflower extracts have been extensively studied, but their antiaggregative effects have been less analyzed. We found that safflower extract inhibited human platelet aggregation induced by ADP. In addition, we further analyzed several safflower extract compounds, such as hydroxysafflor yellow A, safflower yellow A, and luteolin, which have the same antiaggregative effect. In addition to analyzing the active components of the safflower extract, we also analyzed their roles in the ADP signaling pathways. Safflower extract can affect the activation of downstream conductors of ADP receptors (such as the production of calcium ions and cAMP), thereby affecting the expression of activated glycoproteins on the platelet membrane and inhibiting platelet aggregation. According to the results of this study, the effect of safflower extract on promoting blood circulation and removing blood stasis may be related to its direct inhibition of platelet activation.

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A systematic review and meta-analysis of clinical research on treating angina pectoris of coronary heart disease with traditional Chinese medicine to promote blood circulation and remove blood stasis

Annals of Palliative Medicine ◽

10.21037/apm-21-2233 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Wen Chen ◽

Bijuan Wang ◽

Yanzhi Ge ◽

Haipeng Xu ◽

Chunyan Jiang ◽

...

Keyword(s):

Systematic Review ◽

Coronary Heart Disease ◽

Heart Disease ◽

Chinese Medicine ◽

Angina Pectoris ◽

Blood Circulation ◽

Meta Analysis ◽

Blood Stasis ◽

Promote Blood Circulation ◽

Remove Blood Stasis

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An Empirical Analysis of Director Mingjun Zhao’s Experience in Treating Chronic Heart Failure

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v5i6.2761 ◽

2021 ◽

Vol 5 (6) ◽

pp. 36-39

Author(s):

Zijuan He ◽

Mingjun Zhao

Keyword(s):

Heart Failure ◽

Chinese Medicine ◽

Chronic Heart Failure ◽

Traditional Chinese Medicine ◽

Blood Stasis ◽

Shaanxi Province ◽

Promote Blood Circulation ◽

Drug Pair ◽

Standardized Treatment ◽

Remove Blood Stasis

With the aggravation of an aging population, the prevalence of chronic heart failure is increasing. As a famous traditional Chinese medicine practitioner in Shaanxi Province, Mingjun Zhao is amicable at using traditional Chinese medicine to treat chronic heart failure. He believes that the pathogenesis of the condition is mainly due to the lack of heart Yang, deficiency of heart Qi, as well as the combination of water and blood stasis. Therefore, in treating this condition, it is essential to warm and nourish heart Yang, replenish Qi to benefit water, and promote blood circulation to remove blood stasis. Based on the standardized treatment used in western medicine, traditional Chinese medicine should be reasonably and accurately combined with it as a drug pair into a prescription, thus highlighting the advantages of the combination of traditional Chinese medicine in the treatment of chronic heart failure to a great extent.

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Chlorobutanol, a Preservative of Desmopressin, Inhibits Human Platelet Aggregation and Release In Vitro

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647339 ◽

1990 ◽

Vol 64 (03) ◽

pp. 473-477 ◽

Cited By ~ 4

Author(s):

Shih-Luen Chen ◽

Wu-Chang Yang ◽

Tung-Po Huang ◽

Shiang Wann ◽

Che-ming Teng

Keyword(s):

Arachidonic Acid ◽

Platelet Aggregation ◽

Atp Release ◽

Free Calcium ◽

Dependent Manner ◽

Antiplatelet Effect ◽

Human Platelet Aggregation ◽

Acid Pathway ◽

Arachidonic Acid Pathway

SummaryTherapeutic preparations of desmopressin for parenteral use contain the preservative chlorobutanol (5 mg/ml). We show here that chlorobutanol is a potent inhibitor of platelet aggregation and release. It exhibited a significant inhibitory activity toward several aggregation inducers in a concentration- and time-dependent manner. Thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin respectively were markedly inhibited by chlorobutanol. Chlorobutanol had no effect on elastase- treated platelets and its antiplatelet effect could be reversed. It is concluded that the antiplatelet effect of chlorobutanol is mainly due to its inhibition on the arachidonic acid pathway but it is unlikely to have a nonspecitic toxic effect. This antiplatelet effect of chlorobutanol suggests that desmopressin, when administered for improving hemostasis, should not contain chlorobutanol as a preservative.

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Acceptability of no-test medical abortion provided via telemedicine: analysis of patient-reported outcomes

BMJ Sexual & Reproductive Health ◽

10.1136/bmjsrh-2020-200954 ◽

2021 ◽

pp. bmjsrh-2020-200954

Author(s):

Chelsey Porter Erlank ◽

Jonathan Lord ◽

Kathryn Church

Keyword(s):

Patient Reported Outcomes ◽

Medical Abortion ◽

Patient Reported Outcome Measures ◽

Patient Reported Outcome ◽

Post Procedure ◽

High Satisfaction ◽

First Choice ◽

Patient Reported ◽

At Home

IntroductionThe English government approved both stages of early medical abortion (EMA), using mifepristone and misoprostol under 10 weeks’ gestation, for at-home use on 30 March 2020. MSI Reproductive Choices UK (MSUK), one of the largest providers of abortion services in England, launched a no-test telemedicine EMA pathway on 6 April 2020. The objectives of this study were to report key patient-reported outcome measures and to assess whether our sample was representative of the whole population receiving no-test telemedicine EMA.MethodsA sample of all MSUK’s telemedicine EMA patients between April and August 2020 were invited to opt in to a follow-up call to answer clinical and satisfaction questions. A total of 1243 (13.7% of all telemedicine EMAs) were successfully followed-up, on average within 5 days post-procedure.ResultsPatients reported high confidence in telemedicine EMA and high satisfaction with the convenience, privacy and ease of managing their abortion at home. The sample responding were broadly equivalent to the whole population receiving telemedicine. No patient reported that they were unable to consult privately. The majority (1035, 83%) of patients reported preferring the telemedicine pathway, with 824 (66%) indicating that they would choose telemedicine again if COVID-19 were no longer an issue.ConclusionsTelemedicine EMA is a valued, private, convenient and more accessible option that is highly acceptable for patients seeking an abortion, especially those for whom in-clinic visits are logistically or emotionally challenging. Evidence that this pathway would be a first choice again in future for most patients supports the case to make telemedicine EMA permanent.

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Sex-Associated Differences On The Effect Of Asa Or Flurbiprofen On Platelet Function Ex Vivo

10.1055/s-0038-1652096 ◽

1981 ◽

Author(s):

E E Nishizawa ◽

B A Molony ◽

M M Meinzinger ◽

D J Williams

Keyword(s):

Arachidonic Acid ◽

Platelet Function ◽

Bleeding Time ◽

Ex Vivo ◽

Normal Male ◽

Normal Response ◽

Beneficial Effects ◽

Acid Pathway ◽

Induced Aggregation ◽

Arachidonic Acid Pathway

It has been reported that although ASA may have some beneficial effects in males, no differences from placebo was detected in females in clinical trials on venous thrombosis, TIA and stroke. Since ASA inhibits platelet function and because the end-points measured in the above clinical studies may be related to platelet function, we measured bleeding time and platelet aggregation induced by collagen or arachidonic acid following oral administration of ASA (650 mg) or flurbiprofen (100 mg) in normal male and female volunteers (10 per group, total of 40 subjects) between the age of 50 and 70.No sex-associated differences in response with either drug were observed in bleeding time or platelet function. Thus, we were unable to confirm that the observation of beneficial effect of ASA in males was due to its effect on platelets. However, more interestingly there was a statistically shorter bleeding time in males (p = 0.026) before administration of drug. It was also found that despite the normal response to collagen, PRP prepared from pre-drug blood samples from 6 individuals (15%) did not aggregate when stimulated with arachidonic acid at concentrations as high as 1 mM. These results suggest that, at least in some individuals, collagen-induced aggregation may proceed by a pathway independent of the arachidonic acid pathway.

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