scholarly journals Study on the Molecular Basis of Huanglian Jiedu Decoction Against Atopic Dermatitis Integrating Chemistry, Biochemistry, and Metabolomics Strategies

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing Chen ◽  
Saizhen Chen ◽  
Jinguang Chen ◽  
Bixin Shen ◽  
Zhengli Jiang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Molecular Mechanisms ◽  
Skin Inflammation ◽  
Treated Group ◽  
Chemical Components ◽  
Biochemical Indices ◽  
Significant Chemical ◽  
Physiological And Biochemical ◽  
Metabolomics Analysis

Atopic dermatitis (AD) is a common chronic relapsing skin inflammation, which severely affect the quality of life of patients. Inhibiting itching and enhancing immunity to mitigate scratching are key elements in the fight against AD. Huanglian Jiedu decoction (HLJDD) has multiple pharmacological effects in the treatment of AD. However, the effective ingredients and underlying molecular mechanisms have not yet been fully explored. Thus, this study integrates chemistry, biochemistry, and metabolomics strategies to evaluate the active substance basis of HLJDD against AD. First, HLJDD was split to five fractions (CPF, 40AEF, 90AEF, PEF and WEF) and 72 chemical components were identified. NSD (Non-similarity degree) among the different fractions showed significant chemical differences (>81%). Interleukin IL-13, IL-17A, IL-3, IL-31, IL-33, IL4, IL-5, TSLP, IgE, and histamine in the serum, and IL-4Rα, JAK1, and HRH4 levels in skin, participating in inhibiting itching and regulating immunity signaling, were found to be restored to varying degrees in AD treating with HLJDD and its fractions, especially 40AEF and CPF. Untargeted metabolomics analysis demonstrated that forty metabolites were differential metabolites in plasma between the HLJDD-treated group and the AD group, involving in histidine metabolism, arginine biosynthesis, pyrimidine metabolism, and so on. Further, targeted metabolomics analysis revealed that eleven differential metabolites, associating with physiological and biochemical indices, were significant improved in the HLJDD and its fractions groups. In conclusion, HLJDD exhibited anti-AD effects by inhibiting itching and enhancing immunity, which in turn regulating the levels of relative metabolites, and CPF and 40AEF were considered the most important components of HLJDD.

scholarly journals Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section IV: Treatment Options for the Management of Atopic Dermatitis

2018 ◽  
Vol 22 (1_suppl) ◽  
pp. 21S-29S ◽  
Author(s):  
Gurbir Dhadwal ◽  
Lorne Albrecht ◽  
Robert Gniadecki ◽  
Yves Poulin ◽  
Jensen Yeung ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Topical Therapy ◽  
Treatment Options ◽  
Skin Barrier ◽  
Skin Inflammation ◽  
Skin Barrier Function ◽  
Improve Quality ◽  
Consensus Document ◽  
Basic Care

The objectives of therapy for atopic dermatitis (AD) are to reduce skin inflammation and pruritus, restore skin barrier function, and improve quality of life (QoL). Treatments can be classified as moisturizing and basic care, topical therapy, phototherapy, and systemic therapy. In this review, we summarize the treatments for AD and recommendations for their use.

scholarly journals Molecular Mechanisms of Atopic Dermatitis Pathogenesis

2021 ◽  
Vol 22 (8) ◽  
pp. 4130
Author(s):  
Jowita Sroka-Tomaszewska ◽  
Magdalena Trzeciak
Keyword(s):  
Atopic Dermatitis ◽  
Molecular Mechanisms ◽  
Genetic Disorders ◽  
Indirect Costs ◽  
Innate And Adaptive Immunity ◽  
Inflammatory Dermatosis ◽  
Emerging Therapies ◽  
Starting Point ◽  
Altered Immune Response

Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic feature is persistent itching of the skin. The chronic, relapsing course of the disease, economic burden, and the whole family’s involvement in the treatment process immensely reduce the quality of life of patients and their families. The disease emerges as a social problem by increasing indirect costs, such as visiting a doctor, absenteeism from work and school, and avoiding social interactions. Thepathophysiology of atopic dermatitis is complex and multifactorial. It includes genetic disorders, a defect in the epidermal barrier, an altered immune response, anddisruption of the skin’s microbial balance. The numerous complex changes at thegenetic level and innate and adaptive immunity provide the basis for characterizing the various phenotypes and endotypes of atopic dermatitis. Emerging therapies rely on the action of specific molecules involved in the disease’s pathogenesis. It may be the starting point for the individualization of atopic dermatitis treatment. This paper will try to present some molecular mechanisms of atopic dermatitis and their clinical implications.

scholarly journals Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis—A New Look on an Old Story: A Review

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1179
Author(s):  
Andrzej Kazimierz Jaworek ◽  
Jacek Cezary Szepietowski ◽  
Przemysław Hałubiec ◽  
Anna Wojas-Pelc ◽  
Jolanta Jaworek
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Sleep Disturbances ◽  
Skin Inflammation ◽  
Inflammatory Dermatosis ◽  
Sleep Abnormalities ◽  
Chronic Skin ◽  
Endogenous Substances

Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and recurrent course, which significantly reduces the quality of life. Sleep disturbances are considered to be remarkably burdensome ailments in patients with AD, and are routinely included during assessment of disease severity. Therefore, endogenous substances engaged in the control of circadian rhythms might be important in pathogenesis of AD and, possibly, be used as biomarkers of disease severity or even in development of novel therapies. Melatonin (MT), the indoleamine produced by pineal gland (but also by multiple other tissues, including skin), plays a pivotal role in maintaining the sleep/wake homeostasis. Additionally, it possesses strong antioxidant and anti-inflammatory properties, which might directly link chronic skin inflammation and sleep abnormalities characteristic of AD. The objective of this work is to systematically present and summarize the results of studies (both experimental and clinical) that investigated the role of MT in the AD, with a focus on the antioxidant and immunomodulatory effects of MT.

scholarly journals New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab Administration

2021 ◽  
Vol 20 (5) ◽  
pp. 390-395
Author(s):  
Nikolay N. Murashkin ◽  
Leonid A. Opryatin ◽  
Roman V. Epishev ◽  
Alexander I. Materikin ◽  
Eduard T. Ambarchyan ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Inflammation ◽  
Efficacy And Safety ◽  
Barrier Dysfunction ◽  
Treatment Results ◽  
New Era ◽  
Short And Long Term ◽  
Chronic Skin

Atopic dermatitis (AD) is a disease characterized by chronic skin inflammation and epidermal barrier dysfunction leading to decrease in patients' quality of life. AD is widespread in general population including children. This article covers the disease pathophysiological mechanisms including those that depend on the endotype, as well as core principles of systemic therapy for children with moderate and severe AD. Features of targeted therapy of such patients with dupilumab (IL-4 and IL-13 inhibitor) are presented. The studies' results on dupilumab efficacy and safety in the short- and long-term are shown.

scholarly journals Protective effect of Ellipticine in ovalbumin (OVA)-induced murine model of allergic rhinitis via dual inhibition of COX-2 and NF-κB

2021 ◽  
pp. 1-11
Author(s):  
Jian Wang ◽  
Xiao Liu ◽  
Zhi Liu ◽  
Yanxia Ge ◽  
Shuangwen He
Keyword(s):  
Allergic Rhinitis ◽  
Disease Control ◽  
Murine Model ◽  
Molecular Mechanisms ◽  
Treated Group ◽  
Health Concern ◽  
Dependent Manner ◽  
Tnf Α ◽  
Cox 2

Abstract Allergic rhinitis (AR) is a serious health concern across the globe. Despite its non-fatal character, it accounts for affecting millions of people across the world and is deemed responsible to affect their quality of life and put a significant economic burden. In the current study, we aimed to assess the anti-allergic and anti-inflammatory effects and the underlying molecular mechanisms of ellipticine (ETC) against AR using ovalbumin (OVA)-induced murine model of allergic rhinitis. The ETC was administered to mice via intra-peritoneal route after suspending in 5% CMC after sensitization by OVA. Results of the study suggested that ETC causes a significant reduction the nose rubs as compared to disease control. A significant reduction in the serum level of histamine, IgG1, TNF-α, IL-1β, MIP-2, and IL-6 was found in ETC treated group in a dose-dependent manner as compared to OVA challenged mice. It also reduces eosinophils in BALF of AR mice. In western blot analysis, the expression of aberrantly activated COX-2 and NF-ĸB found significantly reduced in ETC treated group due to inhibition of TLR-4 and caspase-1 as compared to disease-control mice. ETC showed significant interaction with residues of the active site of COX-2 and NF-ĸB. Collectively, our results indicated that ETC can be used to improve present therapeutic strategies against AR.

scholarly journals Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis–A New Look on an Old Story–A Review

2021 ◽  
Author(s):  
Andrzej Kazimierz Jaworek ◽  
Jacek C Szepietowski ◽  
Przemysław Hałubiec ◽  
Anna Wojas-Pelc ◽  
Jolanta Jaworek
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Sleep Disturbances ◽  
Skin Inflammation ◽  
Inflammatory Dermatosis ◽  
Sleep Abnormalities ◽  
Chronic Skin ◽  
Endogenous Substances

Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and recurrent course, which significantly reduces the quality of life. Sleep disturbances are considered to be remarkably burdensome ailments in the patients with AD, and are routinely included during assessment of disease severity. Therefore, endogenous substances engaged in the control of circadian rhythms might be important in pathogenesis of AD and, possibly, be used as biomarkers of disease severity or even in development of novel therapies. Melatonin (MT), the indoleamine produced by pineal gland (but also by multiple other tissues, including skin), plays a pivotal role in maintaining the sleep/wake homeostasis. Additionally, it possess strong antioxidant and anti-inflammatory properties, which might directly link chronic skin inflammation and sleep abnormalities characteristic of AD. The objective of this work is to systematically present and summarize the results of studies (both experimental and clinical) that investigated the role of MT in the AD, with focus on the antioxidant and immunomodulatory effects of MT.

Influence of Appropriate Skin Care on Facial Skin Physiology and Quality of Life in Atopic Dermatitis Patients

2013 ◽  
Vol 75 (1) ◽  
pp. 65-71
Author(s):  
Katsuko KIKUCHI ◽  
Maki OZAWA ◽  
Setsuya AIBA ◽  
Eishin MORITA
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Skin Care ◽  
Facial Skin ◽  
Skin Physiology

Direct and Indirect Effects of Crisaborole Ointment on Quality of Life in Patients with Atopic Dermatitis: A Mediation Analysis

2017 ◽  
Vol 1 ◽  
pp. s36
Author(s):  
Eric Simpson ◽  
Andrew Bushmakin ◽  
Joseph C Cappelleri ◽  
Thomas Luger ◽  
Sonja Stander ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Mediation Analysis ◽  
Indirect Effects ◽  
Direct And Indirect Effects

Abstract Not Available

Physicochemical and bacteriological characterization of hospital effluents and their impact on the environment

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Human Health ◽  
Fecal Coliforms ◽  
Chemical Pollution ◽  
Hospital Effluents ◽  
Biological Contaminants ◽  
Almost All ◽  
Direct Discharge ◽  
Significant Chemical

Liquid effluents discharged by hospitals may contain chemical and biological contaminants whose main source is the different substances used for the treatment of patients. This type of rejection can present a sanitary potentially dangerous risk for human health and can provoke a strong degradation of diverse environmental compartments mainly water and soils. The present study focuses on the quality of the liquid effluents of Hassani Abdelkader’s hospital of Sidi Bel-Abbes (West of Algeria). The results reveal a significant chemical pollution (COD: 879 mgO2/L, BOD5: 850 mgO2/L, NH4+ : 47.9 mg/l, NO2- : 4.2 mg/l, NO3- : 56.8 mg/l with respect to WHO standard of 90 mgO2/L, 30 mgO2/L, 0.5 mg/l, 1 mg/l and 1 mg/l respectively). However, these effluents are biodegradable since the ratio COD/BOD5 do not exceeded the value of 2 in almost all samples. The presence of pathogen germs is put into evidence such as pseudomonas, the clostridium, the staphylococcus, the fecal coliforms and fecal streptococcus. These results show that the direct discharge of these effluents constitutes a major threat to human health and the environment.

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