scholarly journals Sex Differences in Post-exercise Hypotension, Ambulatory Blood Pressure Variability, and Endothelial Function After a Power Training Session in Older Adults

2021 ◽  
Vol 12 ◽  
Author(s):  
Leandro de Oliveira Carpes ◽  
Lucas Betti Domingues ◽  
Renato Schimitt ◽  
Sandra C. Fuchs ◽  
Taha Alhalimi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Endothelial Function ◽  
Training Session ◽  
Reduce Blood Pressure ◽  
Power Training ◽  
Clinical Trial Registration ◽  
Post Exercise ◽  
Men And Women ◽  
Post Exercise Hypotension

Background: The efficacy of power training (PT) to acutely reduce blood pressure (BP) in participants with hypertension is controversial, and no studies have assessed the influence of sex on post-exercise hypotension and its mechanisms in older adults.Purpose: The aims of this secondary, exploratory analysis were to compare the effects of a single bout of PT on post-exercise hypotension, BP variability, and endothelial function between older men and women with hypertension.Methods: Twenty-four participants with hypertension (12 men and 12 women aged to >60 years old) took part in this crossover study and randomly performed two experimental sessions: power exercise training (PT) and non-exercising control session (Con). The PT protocol was composed of 3 sets of 8–10 repetitions of five exercises performed in the following order: leg press, bench press, knee extension, upright row, and knee flexion, using an intensity corresponding to 50% of one repetition maximal test (1RM) and 2-min intervals between sets and exercises. The concentric phase of exercises during each repetition was performed “as fast as possible,” while the eccentric phase lasted 1 to 2 s. During Con, the participants remained at seated rest on the same exercise machines, but without any exercise. Each protocol lasted 40 min. Office BP, flow-mediated dilatation (FMD), 24-h ambulatory BP, and the average real variability (ARV) of systolic and diastolic BP were assessed before and after experimental sessions.Results: Comparing PT with Con, a reduced office BP after exercise was found in men (systolic BP—average post 1 h: −14 mmHg, p < 0.001; diastolic BP—average post 1 h: −8 mmHg, p < 0.001) and only a reduced systolic BP in women (average post 1 h: −7 mmHg, p = 0.04). Comparing men and women, a reduced systolic BP (post 60': −15 mmHg, p = 0.048; average post 1 h: −7 mmHg, p = 0.046) and diastolic BP (post 60': −9 mmHg, p = 0.049) after the first hour were found in men. In relation to 24-h ambulatory BP, ARV, and FMD, no statistically significant differences were found between men and women.Conclusion: In older adults with hypertension, the office BP response after the experimental sessions was different in men and women, showing that the PT protocol is more effective to acutely reduce BP in men. Additionally, the mechanisms behind this reduction remain unclear. This finding suggests that sex cannot be combined to analyze post-exercise hypotension.Clinical Trial Registration: ClinicalTrials.gov, Identifier: NCT03615625.

scholarly journals Ischemic Preconditioning Promotes Post-Exercise Hypotension in a Session of Resistance Exercise in Normotensive Trained Individuals

2019 ◽  
Vol 17 (1) ◽  
pp. 78 ◽  
Author(s):  
Patricia Panza ◽  
Jefferson Novaes ◽  
Luiz Guilherme Telles ◽  
Yuri Campos ◽  
Gleisson Araújo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Resistance Exercise ◽  
Ischemic Preconditioning ◽  
Training Session ◽  
Vascular Occlusion ◽  
Acute Effect ◽  
Post Exercise ◽  
Resistance Exercises ◽  
Experimental Protocols ◽  
Post Exercise Hypotension

Ischemic preconditioning (IPC) is a method that has been used prior to resistance exercise to improve performance. However, little is known about its effect before a resistance exercise training session on hemodynamic responses. Thus, the aim of the study was to verify the acute effect of IPC before a session of resistance exercises on the systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) of trained normotensive trained individuals. Sixteen men (25.3 ± 1.7 years; 78.4 ± 6.2 kg; 176.9 ± 5.4 cm, 25.1 ± 1.5 m2.kg−1) trained in resistance exercise (RE) (5.0 ± 1.7 years) were evaluated in five sessions on non-consecutive days. The first two sessions’ subjects performed one repetition maximum (RM) test and retest, and for the next three sessions, they performed the experimental protocols: (a) IPC + RE; (b) SHAM + RE; (c) RE. The RE protocol consisted of six multi-joint exercises, three sets at 80% of 1RM until concentric failure. Blood pressure was monitored pre-session, immediately after and every 10 min for 60 min after RE. IPC consisted of 4 × 5 min of vascular occlusion/reperfusion at 220 mmHg. SHAM (fake protocol) consisted of 20 mmHg of vascular occlusion/reperfusion. The IPC + RE protocol showed significant reductions on SBP, DBP, and MBP compared with SHAM + RE (p < 0.05) and with RE (p < 0.05). The IPC + RE protocol presented a greater magnitude and duration of post-exercise hypotension (PEH) from 20 to 60 min after exercise in SBP (−11 to 14 mmHg), DBP (−5 to 14 mmHg), and MBP (−7 to 13 mmHg). Therefore, we can conclude that the application of IPC before an RE session potentiated the PEH in normotensive individuals trained in resistance exercise.

scholarly journals Post-exercise hypotension in concurrent training: a systematic review

2020 ◽  
Vol 22 ◽  
Author(s):  
Diego De Mello ◽  
Thatiane Lopes Valentim Di Paschoale Ostolin
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Arterial Hypertension ◽  
Acute Effect ◽  
Reduce Blood Pressure ◽  
Concurrent Training ◽  
Effective Strategy ◽  
Eligibility Criteria ◽  
Post Exercise ◽  
Post Exercise Hypotension

Abstract Physical exercise is capable to reduce blood pressure (BP) acutely in a phenomenon described as post-exercise hypotension (PEH). However, the acute effect of concurrent training on PEH needs clarification. The present review aimed to verify and summarize the acute effect of concurrent training on PEH in normotensive and hypertensive subjects. The search was carried out in the databases PubMed, Scielo, and Lilacs, and resulted in 3806 articles. Only 14 studies met the eligibility criteria and were selected. According to included studies, concurrent training can promote PEH regardless of the order, volume, and intensity prescribed, being an effective strategy in the control of arterial hypertension. There is no consensus in the literature regarding the best prescription strategy, as well as the order of execution of the types of exercise.

scholarly journals Post-exercise hypotension of normotensive young men through track running sessions

2015 ◽  
Vol 21 (3) ◽  
pp. 192-195 ◽  
Author(s):  
Emerson Pardono ◽  
Manuella de Oliveira Fernandes ◽  
Luan Morais Azevêdo ◽  
Jeeser Alves de Almeida ◽  
Marcio Rabelo Mota ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Men ◽  
Daily Basis ◽  
Physically Active ◽  
Post Exercise ◽  
Laboratory Exercise ◽  
Practical Applications ◽  
Pharmacological Mechanism ◽  
Minute Post ◽  
Post Exercise Hypotension

INTRODUCTION: After a single session of physical exercise the blood pressure is reduced (post-exercise hypotension, PHE) and it has been considered as a non-pharmacological mechanism to control the blood pressure. When the exercise is performed since youth it can prevent or avoid hypertension. However, it is important to consider studies with clear practical applications to optimize its reproducibility on a daily basis. OBJECTIVE: Analyze the PEH of normotensive and physically active young men after two track running sessions (maximum and submaximal). METHODS: Participated in this study 62 physically active young men (23.3 ± 4.2 years old; 75.5 ± 9.8 kg; 177.7 ± 5.5 cm; 12.0 ± 4.6% body fatF; 52.4 ± 4.0 mL.kg-1.min-1oxygen uptake), which performed a maximum laboratory exercise test for determination of maximal oxygen uptake (VO2max - aerobic power) and subsequently three randomly running sessions (maximum - T1600; submaximal - T20; control - CON), with 48h interval between themselves. Blood pressure (BP) was measured each 15min during a 60 min period after sessions. RESULTS: Both the maximum and the submaximal exercise lead to PEH. The post-exercise values of systolic blood pressure and diastolic blood pressure differed from resting value in session T20 (p<0.05). The same pattern occurred after T1600 (p<0.05), evidenced from 30th minute post-exercise. The CON did not result in PEH. The magnitude of decay for the mean BP at the 45th after maximum exercise was higher than the other sessions (p<0.05). CONCLUSION: We concluded that both maximum and submaximal exercises, performed on a track running condition, caused PEH in young normotensive and physically active men.

scholarly journals Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure

2021 ◽  
Author(s):  
Daniel H. Craighead ◽  
Thomas C. Heinbockel ◽  
Kaitlin A. Freeberg ◽  
Matthew J. Rossman ◽  
Rachel A. Jackman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Muscle Strength ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Systolic Blood Pressure ◽  
High Resistance ◽  
Maximal Inspiratory Pressure ◽  
No Bioavailability ◽  
Inspiratory Muscle Strength

Background High‐resistance inspiratory muscle strength training (IMST) is a novel, time‐efficient physical training modality. Methods and Results We performed a double‐blind, randomized, sham‐controlled trial to investigate whether 6 weeks of IMST (30 breaths/day, 6 days/week) improves blood pressure, endothelial function, and arterial stiffness in midlife/older adults (aged 50–79 years) with systolic blood pressure ≥120 mm Hg, while also investigating potential mechanisms and long‐lasting effects. Thirty‐six participants completed high‐resistance IMST (75% maximal inspiratory pressure, n=18) or low‐resistance sham training (15% maximal inspiratory pressure, n=18). IMST was safe, well tolerated, and had excellent adherence (≈95% of training sessions completed). Casual systolic blood pressure decreased from 135±2 mm Hg to 126±3 mm Hg ( P <0.01) with IMST, which was ≈75% sustained 6 weeks after IMST ( P <0.01), whereas IMST modestly decreased casual diastolic blood pressure (79±2 mm Hg to 77±2 mm Hg, P =0.03); blood pressure was unaffected by sham training (all P >0.05). Twenty‐four hour systolic blood pressure was lower after IMST versus sham training ( P =0.01). Brachial artery flow‐mediated dilation improved ≈45% with IMST ( P <0.01) but was unchanged with sham training ( P =0.73). Human umbilical vein endothelial cells cultured with subject serum sampled after versus before IMST exhibited increased NO bioavailability, greater endothelial NO synthase activation, and lower reactive oxygen species bioactivity ( P <0.05). IMST decreased C‐reactive protein ( P =0.05) and altered select circulating metabolites (targeted plasma metabolomics) associated with cardiovascular function. Neither IMST nor sham training influenced arterial stiffness ( P >0.05). Conclusions High‐resistance IMST is a safe, highly adherable lifestyle intervention for improving blood pressure and endothelial function in midlife/older adults with above‐normal initial systolic blood pressure. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03266510.

Exercise and Weight Loss Reduce Blood Pressure in Men and Women with Mild Hypertension

2001 ◽  
Vol 21 (1) ◽  
pp. 52
Author(s):  
J A Blumenthal ◽  
A Sherwood ◽  
E CD Gullette ◽  
M Babyak ◽  
R Waugh ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Mild Hypertension ◽  
Reduce Blood Pressure ◽  
Men And Women

scholarly journals Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

2015 ◽  
Vol 114 (8) ◽  
pp. 1246-1255 ◽  
Author(s):  
Roberto Sansone ◽  
Ana Rodriguez-Mateos ◽  
Jan Heuel ◽  
David Falk ◽  
Dominik Schuler ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Pulse Wave Velocity ◽  
Endothelial Function ◽  
Cardiovascular Health ◽  
Framingham Risk Score ◽  
Pulse Wave ◽  
Men And Women ◽  
Framingham Risk ◽  
Randomised Controlled

AbstractCocoa flavanol (CF) intake improves endothelial function in patients with cardiovascular risk factors and disease. We investigated the effects of CF on surrogate markers of cardiovascular health in low risk, healthy, middle-aged individuals without history, signs or symptoms of CVD. In a 1-month, open-label, one-armed pilot study, bi-daily ingestion of 450 mg of CF led to a time-dependent increase in endothelial function (measured as flow-mediated vasodilation (FMD)) that plateaued after 2 weeks. Subsequently, in a randomised, controlled, double-masked, parallel-group dietary intervention trial (Clinicaltrials.gov: NCT01799005), 100 healthy, middle-aged (35–60 years) men and women consumed either the CF-containing drink (450 mg) or a nutrient-matched CF-free control bi-daily for 1 month. The primary end point was FMD. Secondary end points included plasma lipids and blood pressure, thus enabling the calculation of Framingham Risk Scores and pulse wave velocity. At 1 month, CF increased FMD over control by 1·2 % (95 % CI 1·0, 1·4 %). CF decreased systolic and diastolic blood pressure by 4·4 mmHg (95 % CI 7·9, 0·9 mmHg) and 3·9 mmHg (95 % CI 6·7, 0·9 mmHg), pulse wave velocity by 0·4 m/s (95 % CI 0·8, 0·04 m/s), total cholesterol by 0·20 mmol/l (95 % CI 0·39, 0·01 mmol/l) and LDL-cholesterol by 0·17 mmol/l (95 % CI 0·32, 0·02 mmol/l), whereas HDL-cholesterol increased by 0·10 mmol/l (95 % CI 0·04, 0·17 mmol/l). By applying the Framingham Risk Score, CF predicted a significant lowering of 10-year risk for CHD, myocardial infarction, CVD, death from CHD and CVD. In healthy individuals, regular CF intake improved accredited cardiovascular surrogates of cardiovascular risk, demonstrating that dietary flavanols have the potential to maintain cardiovascular health even in low-risk subjects.

The additive blood pressure lowering effects of exercise intensity on post-exercise hypotension

2010 ◽  
Vol 160 (3) ◽  
pp. 513-520 ◽  
Author(s):  
John D. Eicher ◽  
Carl M. Maresh ◽  
Gregory J. Tsongalis ◽  
Paul D. Thompson ◽  
Linda S. Pescatello
Keyword(s):  
Blood Pressure ◽  
Exercise Intensity ◽  
Blood Pressure Lowering ◽  
Post Exercise ◽  
Pressure Lowering ◽  
Post Exercise Hypotension

scholarly journals 200.000 IU of vitamin D does not reduce resting Blood Pressure and Inhibit Post-Exercise Hypotension in elderly women: a pilot study

2020 ◽  
Vol 92 (1) ◽  
Author(s):  
MARIA DA CONCEIÇÃO R. GONÇALVES ◽  
MANOEL MIRANDA NETO ◽  
ISA G.M. CAVALCANTE ◽  
VITTÓRIA R.R.J. SEBADELHE ◽  
MICHELE F. De SOUZA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Pilot Study ◽  
Elderly Women ◽  
Post Exercise ◽  
Resting Blood Pressure ◽  
Post Exercise Hypotension

Postexercise Hypotension After Muscle Power Training Session in Older Adults With Hypertension

2020 ◽  
Vol 28 (4) ◽  
pp. 652-657
Author(s):  
José Machado Filho ◽  
Carlos Leonardo Figueiredo Machado ◽  
Hirofumi Tanaka ◽  
Rodrigo Ferrari
Keyword(s):  
Older Adults ◽  
Essential Hypertension ◽  
Muscle Power ◽  
Training Session ◽  
Control Session ◽  
Power Training ◽  
Arterial Blood ◽  
Postexercise Hypotension ◽  
The One ◽  
And Control

The aim of the present study was to determine the acute effects of a muscle power training (PT) session on arterial blood pressure (BP) in older adults with hypertension. Thirteen participants (64 ± 4 years) with essential hypertension were randomly assigned to a PT session and control session without exercise. During PT, the participants performed three sets of eight repetitions at 50% of the one-repetition maximum tests. The concentric phase during each repetition was performed as fast as possible. The systolic BP (post-15 min: −1.7 ± 1.8 mmHg [p = .048; d = 0.22]; post-30 min: −3.6 ± 1.7 mmHg [p = .010; d = 0.48]; post-45 min: −3.3 ± 1.3 mmHg [p = .002; d = 0.42]; post-60 min: −3.9 ± 1.7 mmHg [p = .003; d = 0.49]) and diastolic BP (post-15 min: −1.5 ± 1.5 mmHg [p = .053; d = 0.20]; post-30 min: −2.2 ± 1.7 mmHg [p = .001; d = 0.29]; post-45 min: −2.0 ± 2.0 mmHg [p = .001; d = 0.27]; post-60 min: −2.0 ± 1.3 mmHg [p < .001; d = 0.26]) reductions were observed at all times after the PT session, compared with the preexercise and control session. PT is an effective strategy to acutely reduce BP in older patients with essential hypertension.

scholarly journals Sympathetic neural responsiveness to sleep deprivation in older adults: sex differences

2019 ◽  
Vol 317 (2) ◽  
pp. H315-H322 ◽  
Author(s):  
Jason R. Carter ◽  
Ida T. Fonkoue ◽  
Ian M. Greenlund ◽  
Christopher E. Schwartz ◽  
Babak Mokhlesi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Sleep Deprivation ◽  
Postmenopausal Women ◽  
Older Men ◽  
Secondary Outcome ◽  
Plasma Testosterone ◽  
Men And Women ◽  
Total Sleep Deprivation ◽  
Older Men And Women

Our laboratory has previously reported that total sleep deprivation (TSD) modifies muscle sympathetic neural activity (MSNA) differently in young men and women. Because postmenopausal women are among the highest risk for hypertension, this study compares MSNA responses with TSD in older men and women. We hypothesized that TSD would alter MSNA in older adults, with greater sympathoexcitation in postmenopausal women. Twenty-seven participants (14 men and 13 women) between the ages of 55 and 75 yr were tested twice, once after 24-h TSD and once after normal sleep (randomized, crossover design). Our primary outcome measure of MSNA (microneurography) was successful across both conditions in 20 participants (10 men and 10 women). Secondary outcome measures included seated blood pressure, heart rate, and fasting plasma testosterone, estradiol, and progesterone. Age (60 ± 1 vs. 61 ± 2 yr) and BMI (27 ± 1 vs. 26 ± 1 kg/m2) were not different between groups. TSD increased systolic blood pressure in both men (124 ± 5 to 130 ± 4 mmHg) and women (107 ± 5 to 116 ± 4 mmHg), but the increases were not different between groups (condition, P = 0.014; condition × sex, P > 0.05). In contrast, TSD elicited divergent MSNA responses in older men and women. Specifically, MSNA burst frequency increased in postmenopausal women (28 ± 3 to 34 ± 3 burst/min), but not older men (38 ± 3 to 35 ± 3 bursts/min; condition × sex, P = 0.032). In conclusion, TSD elicited sympathoexcitation in postmenopausal women but not age-matched men. These findings provide new mechanistic insight into reported links between sleep deprivation and hypertension. NEW & NOTEWORTHY Epidemiological studies report that sleep deprivation is more strongly associated with hypertension in women than in men. In the present study, 24-h total sleep deprivation (TSD) increased blood pressure in postmenopausal women and age-matched men. In contrast, only women demonstrated increases in muscle sympathetic nerve activity after TSD. The sympathoexcitation observed in postmenopausal women suggests a potential contributing mechanism for epidemiological observations and advances our understanding of the complex relations between sleep, sex, and hypertension. Listen to this article’s corresponding podcast at https://ajpheart.podbean.com/e/total-sleep-deprivation-and-msna-in-older-adults/ .

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