scholarly journals Potential Benefits of a Minimal Dose Eccentric Resistance Training Paradigm to Combat Sarcopenia and Age-Related Muscle and Physical Function Deficits in Older Adults

2021 ◽  
Vol 12 ◽  
Author(s):  
Sara A. Harper ◽  
Brennan J. Thompson
Keyword(s):  
Older Adults ◽  
Resistance Training ◽  
Functional Performance ◽  
Functional Decline ◽  
Therapeutic Interventions ◽  
Training Paradigm ◽  
Exercise Participation ◽  
Minimal Dose ◽  
Age Related ◽  
And Function

The ability of older adults to perform activities of daily living is often limited by the ability to generate high mechanical outputs. Therefore, assessing and developing maximal neuromuscular capacity is essential for determining age-related risk for functional decline as well as the effectiveness of therapeutic interventions. Interventions designed to enhance neuromuscular capacities underpinning maximal mechanical outputs could positively impact functional performance in daily life. Unfortunately, < 10% of older adults meet the current resistance training guidelines. It has recently been proposed that a more “minimal dose” RT model may help engage a greater proportion of older adults, so that they may realize the benefits of RT. Eccentric exercise offers some promising qualities for such an approach due to its efficiency in overloading contractions that can induce substantial neuromuscular adaptations. When used in a minimal dose RT paradigm, eccentric-based RT may be a particularly promising approach for older adults that can efficiently improve muscle mass, strength, and functional performance. One approach that may lead to improved neuromuscular function capacities and overall health is through heightened exercise tolerance which would favor greater exercise participation in older adult populations. Therefore, our perspective article will discuss the implications of using a minimal dose, submaximal (i.e., low intensity) multi-joint eccentric resistance training paradigm as a potentially effective, and yet currently underutilized, means to efficiently improve neuromuscular capacities and function for older adults.

scholarly journals PREDICTING FUNCTIONAL DECLINE IN OLDER ADULTS: MORE ACTIVITY NOW EQUALS LESS DECLINE LATER

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S519-S519
Author(s):  
Brenda Whitehead
Keyword(s):  
Older Adults ◽  
Physical Function ◽  
Functional Decline ◽  
Activity Level ◽  
Physical Conditioning ◽  
Activity Engagement ◽  
Social Clubs ◽  
Age Related ◽  
Aging Attitudes ◽  
And Function

Abstract According to the Function Spiral Model (Whitehead, 2017), aging attitudes influence activity engagement, which impacts functional ability via physical conditioning (or deconditioning). This study tests the activity ♢ conditioning ♢ function segment of the model using 59 older adults aged 61-92 (Mage = 76 at Time 1) who participated in 2 in-person assessments of physical health, gait, and function, spaced 3 years apart. Participants also completed mail-in questionnaires, reporting engagement in activities (walking, gardening, household chores, social clubs, etc.) at each time point. Hypotheses were 1) a lower activity level at Time 1 would predict greater decline in physical function across the 3-year span, and 2) that this effect would be mediated by changes in physical conditioning. Dependent t-tests revealed that both physical function—as indicated by the timed Get Up and Go test—and physical conditioning—as indicated by peak respiratory flow—declined during the period. The regression model testing the effect of activity engagement at Time 1 on decline in physical function (controlling for age, baseline function, and activity change) supported hypothesis 1 (-0.43, p = .003): more activity at Time 1 predicted less decline in physical function over time. Instead of supporting the mediation hypothesis, the model including both activity and conditioning demonstrated the strength of the activity at Time 1 effect, which actually increased in magnitude (-0.48, p = .001). Although the hypothesized mediation was not supported, the findings highlight current activity engagement as an important mechanism for slowing the progression of future age-related functional decline.

scholarly journals PROTEIN SUPPLEMENTATION DOES NOT RESCUE MUSCLE MASS AND FUNCTION–HEAVY RESISTANCE TRAINING IS REQUIRED

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S86-S87
Author(s):  
Lars Holm ◽  
Rasmus Bechshoeft ◽  
Soren Reitelseder ◽  
Kenneth Mertz ◽  
Jacob Bulow ◽  
...  
Keyword(s):  
Older Adults ◽  
Resistance Training ◽  
Muscle Mass ◽  
Protein Intake ◽  
Protein Supplementation ◽  
Light Load ◽  
Age Related ◽  
Heavy Resistance Training ◽  
And Function ◽  
The Impact

Abstract The requirement of an enhanced dietary protein intake to counteract the age-related loss of muscle mass is still debated. Further, the dinner meal generally contains the majority of protein and energy and since, the muscle of older adults responds less to protein intake than that of younger adults it is hypothesized that older adults would benefit from taking more protein in at other meals. The aim of this study was to investigate whether the provision of protein supplements for breakfast and lunch meals over the course of a year would make healthy, older, home-dwelling adults (N=136) take in more protein and whether that then would affect their muscle mass (primary outcome) and a number of metabolic health parameters, muscle strength parameters and functional capabilities. More than 77% ingested more than 75% of the provided supplements, irrespective of supplementation type (isocaloric carbohydrate; collagen hydrolysate low quality protein: whey hydrolysate high quality protein). Providing supplementation for a year among older adults makes them comply very well. However, provision of extra protein has no impact on the muscle mass or strength or on the functional parameters. Further, we studied the impact of adding resistance training on top of WHEY protein supplementation and found that heavy more than light-load resistance training affects fat-free mass and maximal-voluntary contraction. Daily protein intake can be enhanced by supplementation but do not impact muscle mass and function over the course of a year, where heavy resistance training on top benefits, but to a lesser than expected degree.

Power training for older adults

2006 ◽  
Vol 31 (2) ◽  
pp. 87-94 ◽  
Author(s):  
Michelle M Porter
Keyword(s):  
Older Adults ◽  
Resistance Training ◽  
Strength Training ◽  
Strength Loss ◽  
Power Training ◽  
Performance Tasks ◽  
Positive Effects ◽  
Age Related ◽  
And Function ◽  
Prevention Of Disability

Resistance training is widely advocated for older adults to alleviate the muscle and strength loss that occurs with aging. While primary and secondary prevention of disability are often mentioned as benefits of strength training, the evidence for this is limited and inconclusive. Researchers have started to examine another form of resistance training that may prove to be more beneficial than strength training in terms of the reduction of age-related disability. Power training is being investigated because several studies have shown a stronger relationship between power and function than between strength and function. Early studies on power training suggest that neuromuscular power can be increased to a greater extent with high velocity or explosive training than strength training alone. In addition, there may be more positive effects on performance tasks measured in the laboratory, although evidence on disability reduction was very limited. Adverse events were reported in several studies, although the risk for injuries appears to be higher for testing than for training itself. Future well-designed studies on the risks and benefits of power training should provide more evidence on this promising form of resistance training for older adults of varying health and functional status.Key words: aging, resistance training, physical activity, physical function.

scholarly journals Spontaneous Eye Blinks Predict Executive Functioning in Seniors

2021 ◽  
Author(s):  
Jessika I. V. Buitenweg ◽  
Jaap M. J. Murre ◽  
K. Richard Ridderinkhof
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Executive Functioning ◽  
Cognitive Training ◽  
Functional Decline ◽  
Future Research ◽  
Blink Rate ◽  
Memory Updating ◽  
Age Related ◽  
Working Memory Updating

AbstractAs the world’s population is aging rapidly, cognitive training is an extensively used approach to attempt improvement of age-related cognitive functioning. With increasing numbers of older adults required to remain in the workforce, it is important to be able to reliably predict future functional decline, as well as the individual advantages of cognitive training. Given the correlation between age-related decline and striatal dopaminergic function, we investigated whether eye blink rate (EBR), a non-invasive, indirect indicator of dopaminergic activity, could predict executive functioning (response inhibition, switching and working memory updating) as well as trainability of executive functioning in older adults. EBR was collected before and after a cognitive flexibility training, cognitive training without flexibility, or a mock training. EBR predicted working memory updating performance on two measures of updating, as well as trainability of working memory updating, whereas performance and trainability in inhibition and switching tasks could not be predicted by EBR. Our findings tentatively indicate that EBR permits prediction of working memory performance in older adults. To fully interpret the relationship with executive functioning, we suggest future research should assess both EBR and dopamine receptor availability among seniors.

The Association Between Sarcopenia and Postoperative Outcomes Among Older Adults With Hip Fracture: A Systematic Review

2021 ◽  
pp. 073346482110065
Author(s):  
Ming-Hsiu Chiang ◽  
Yi-Jie Kuo ◽  
Yu-Pin Chen
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Hip Fracture ◽  
Postoperative Mortality ◽  
Clinical Event ◽  
High Morbidity ◽  
Adverse Health Outcomes ◽  
Age Related ◽  
Study Selection ◽  
And Function

Hip fracture is a serious clinical event with high morbidity and mortality. Sarcopenia is characterized by age-related loss of muscle mass and function, leading to several adverse health outcomes. In this systematic review, no limitation criteria were used for study selection and 327 studies were identified in the initial search. Of these, 11 studies comprising a total of 2,314 patients were selected. The overall proportion of older adults with hip fracture having sarcopenia was 44%, with a disparity of approximately 10% between men and women. Most studies have indicated that older adults with sarcopenia had poorer postoperative functional recovery than those without sarcopenia; the association between sarcopenia and high postoperative mortality or long hospital stay was heterogeneous. Well-organized studies with longer follow-up periods are warranted.

scholarly journals AGE-BASED STEREOTYPE THREAT: A SYSTEMATIC REVIEW OF PRIMING TECHNIQUES AND THEIR EFFECTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S455-S456
Author(s):  
Francesco Vailati Riboni ◽  
Francesco Pagnini
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Stereotype Threat ◽  
Functional Performance ◽  
Later Life ◽  
Experimental Methods ◽  
Experimental Manipulation ◽  
Older Individuals ◽  
Negative Stereotypes ◽  
Age Related

Abstract Age-based stereotype threat (ABST) occurs when older adults are influenced by negative stereotypes about age-related decline and functional losses and ironically behave in disengaging and self-defeating ways that confirm the stereotype (Steele & Aronson, 1995). Aging stereotypes are found to be strong predictors of health and illness outcomes in later life, and are associated with performance in specific areas, mainly in cognitive and physical domains. The current study reviewed the experimental methods and their reported effects previously published in the literature to determine if there were different ABST methods were associated with different types of age-related outcomes. We conducted a systematic review, screening the scientific literature for papers that included experimental manipulation of age-related stereotypes as an independent variable, focusing on samples of older adults (1113 articles, most published after 2003). Through a classification of the common and distinctive characteristics of the different stereotype manipulation techniques, we were able to identify three specific types of experimental methods: by instruction, tests, and interpersonal exposure. Although the mechanism by which stereotypes are associated with functional outcomes in older adults remains unclear, our review suggests it is possible to experimentally control the activation of the stereotype by manipulating its specific characteristics and the way older participants are exposed to it. Findings also highlight the possibility that specific experimental methods used to induce ABST in older individuals may lead to unique and different consequences on functional performance variation.

scholarly journals Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation?

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 642 ◽  
Author(s):  
Dolan ◽  
Artioli ◽  
Pereira ◽  
Gualano
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Energy Demand ◽  
Muscular Atrophy ◽  
Training Stimulus ◽  
Creatine Supplementation ◽  
The Elderly ◽  
High Energy ◽  
Age Related ◽  
And Function

Sarcopenia is characterized by a loss of muscle mass, quality, and function, and negatively impacts health, functionality, and quality of life for numerous populations, particularly older adults. Creatine is an endogenously produced metabolite, which has the theoretical potential to counteract many of the morphological and metabolic parameters underpinning sarcopenia. This can occur through a range of direct and indirect mechanisms, including temporal and spatial functions that accelerate ATP regeneration during times of high energy demand, direct anabolic and anti-catabolic functions, and enhanced muscle regenerating capacity through positively impacting muscle stem cell availability. Studies conducted in older adults show little benefit of creatine supplementation alone on muscle function or mass. In contrast, creatine supplementation as an adjunct to exercise training seems to augment the muscle adaptive response to the training stimulus, potentially through increasing capacity for higher intensity exercise, and/or by enhancing post-exercise recovery and adaptation. As such, creatine may be an effective dietary strategy to combat age-related muscle atrophy and sarcopenia when used to complement the benefits of exercise training.

scholarly journals Aging, Resistance Training, and Diabetes Prevention

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Kyle D. Flack ◽  
Kevin P. Davy ◽  
Matthew W. Hulver ◽  
Richard A. Winett ◽  
Madlyn I. Frisard ◽  
...  
Keyword(s):  
Older Adults ◽  
Resistance Training ◽  
Glucose Tolerance ◽  
Diabetes Prevention ◽  
Baby Boom ◽  
Related Factors ◽  
Age Related ◽  
Increased Risk ◽  
Factor Α ◽  
Necrosis Factor

With the aging of the baby-boom generation and increases in life expectancy, the American population is growing older. Aging is associated with adverse changes in glucose tolerance and increased risk of diabetes; the increasing prevalence of diabetes among older adults suggests a clear need for effective diabetes prevention approaches for this population. The purpose of paper is to review what is known about changes in glucose tolerance with advancing age and the potential utility of resistance training (RT) as an intervention to prevent diabetes among middle-aged and older adults. Age-related factors contributing to glucose intolerance, which may be improved with RT, include improvements in insulin signaling defects, reductions in tumor necrosis factor-α, increases in adiponectin and insulin-like growth factor-1 concentrations, and reductions in total and abdominal visceral fat. Current RT recommendations and future areas for investigation are presented.

scholarly journals Analysis of Cell and Molecular Phenotypes of a Highly Replicated Longevity-Associated FOXO3 Variant in Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 368-368
Author(s):  
Randi Chen ◽  
Richard Allsopp ◽  
Bradley Willcox ◽  
Philip Davy
Keyword(s):  
Older Adults ◽  
Cross Sectional Study ◽  
Therapeutic Interventions ◽  
Human Longevity ◽  
Clinical Samples ◽  
Cellular Mechanisms ◽  
Cell Dynamics ◽  
Cross Sectional ◽  
Age Related ◽  
Molecular Phenotypes

Abstract Aging demographics in the US, and other industrialized nations, are resulting in rapidly increasing health care costs from age-related diseases. New therapeutic interventions to extend healthspan in older adults requires understanding connections between basic aging biology and human longevity factors. Using clinical samples from the Kuakini Honolulu Heart Program (HHP) and their Offspring, we are examining potential links between molecular and cellular mechanisms of aging and the longevity associated FOXO3 genotype (carriage of SNP rs2802292 “G” allele). Telomere dynamics in leucocytes (LTL) have shown strong correlation with multiple lifestyle and health factors. We previously demonstrated a significant protective relation between FOXO3 longevity genotype and LTL in a cross-sectional study. Now we are assessing a longitudinal relation, at three time points over 20+ years, in older men. We are also exploring stem cell frequency and differentiation capacity in neurological and peripheral blood samples to assess FOXO3 genotype and human cell dynamics.

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