scholarly journals Association Between Abundance of Haemophilus in the Gut Microbiota and Negative Symptoms of Schizophrenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Cuizhen Zhu ◽  
Mingming Zheng ◽  
Usman Ali ◽  
Qingrong Xia ◽  
Zhongxian Wang ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Gut Microbiota ◽  
Psychiatric Symptoms ◽  
Psychotic Symptoms ◽  
Control Group ◽  
Pearson’S Correlation ◽  
Acute Group ◽  
Pearson's Correlation ◽  
Pearson’S Correlation Analysis ◽  
And Control

Increasing evidence indicates an interaction between dysbiosis of the microbiota and the pathogenesis of schizophrenia. However, limited information is available on the specific microbial communities associated with symptoms of schizophrenia. Therefore, this study aimed to investigate gut microbiota dysbiosis and its relationship with psychopathologies in schizophrenia. We recruited 126 participants and divided them into three groups according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria—acute group (patients with acute schizophrenia), remission group (patients with schizophrenia in remission), and control group (healthy controls). Psychotic symptoms were evaluated using the Positive and Negative Syndrome Scale. Microbiota compositions, diversity and community structure were evaluated using 16S rRNA sequencing. Pearson's correlation analysis was used to evaluate the association between bacterial taxa and psychotic symptoms. The beta-diversity of microbiota composition in the acute group was distinct from that in the remission and control groups (PC1 = 21.11% vs. PC2 = 12.86%, P = 0.021). Furthermore, Pearson's correlation analysis revealed that abundance of Haemophilus was positively correlated with negative psychiatric symptoms (r = 0.303, P = 0.021), while abundance of Coprococcus was negatively correlated with negative psychiatric symptoms (r = −0.285, P = 0.025). Moreover, abundance of Haemophilus was positively correlated with cognition (r = 0.428, P = 0.009), excitement (r = 0.266, P = 0.037), and depression (r = 0.295, P = 0.020). The study findings suggest that alterations in certain gut microbiota may interfere with psychological symptoms in schizophrenia. Our results provide evidence that may help in the development of therapeutic strategies using microbial-based targets. The data that support the findings of this study have been deposited in the NCBI (https://submit.ncbi.nlm.nih.gov/) with accession number SUB9453991.

scholarly journals Remote administration of the symbol digit modalities test to individuals with multiple sclerosis is reliable: A short report

2021 ◽  
Vol 7 (1) ◽  
pp. 205521732199485
Author(s):  
Tehila Eilam-Stock ◽  
Michael T Shaw ◽  
Kathleen Sherman ◽  
Lauren B Krupp ◽  
Leigh E Charvet
Keyword(s):  
Multiple Sclerosis ◽  
Correlation Analysis ◽  
Gold Standard ◽  
Short Report ◽  
Strongly Correlated ◽  
Cognitive Screening ◽  
Pearson’S Correlation ◽  
Screening Approach ◽  
Pearson's Correlation ◽  
Pearson’S Correlation Analysis

Background The Symbol Digit Modalities Test (SDMT) is the gold standard for cognitive screening in multiple sclerosis (MS). Objective Due to the recent COVID-19 pandemic and the increased need for virtual clinical visits, we examined the reliability of remote administration of the SDMT vs. standard in-person administration to individuals with MS. Methods Pearson’s correlation analysis was performed between SDMT scores on the in-person and remote administrations. Results For n = 132 participants, remote and in-person SDMT scores were strongly correlated (r = .80, p = .000). Conclusion Remote administration of the SDMT is a reliable cognitive screening approach in MS.

scholarly journals Do height and weight play an important role in block and attack efficiency in high-level men's volleyball?

2017 ◽  
Vol 26 (1) ◽  
pp. 64 ◽  
Author(s):  
Raini Stamm ◽  
Meelis Stamm ◽  
Aleksander Jairus ◽  
Reino Toop ◽  
Reeda Tuula ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Pearson’S Correlation ◽  
Anthropometric Characteristics ◽  
Pearson's Correlation ◽  
Pearson’S Correlation Analysis ◽  
Standard Deviations ◽  
High Level

The research objective was to study the relationships of players’ efficiency in attack and block with their anthropometric characteristics. Data on men’s weight and height and their proficiency in the game were used. The subjects were the members of the Estonian, Italian, French and Croatian national volleyball teams who participated in Pool B of the European Championship. Data are given on men’s height, weight, age, total number of spikes, attack errors, attacks won, efficiency of attack, total number of blocks, block errors, blocks won, and efficiency of block. In addition, the number of points won by men and their positions in the game are given. Minimums, maximums, standard deviations and means were calculated. To find correlations, Pearson’s correlation analysis (p<0.05) was used. In our study, taller and heavier players proved to be more efficient at attack. Comparison of positions showed that middle blockers were taller and performed more blocks, setters were shorter and performed the least of attacks, and outside attackers and opposite attackers were of medium height and carried the greatest load of attack. As a conclusion, it was found that, in professional volleyball, height correlated with the efficiency of attack (r= 0.534; p<0.05), and weight also correlated with the efficiency of attack (r= 0.518; p<0.05). There was no correlation between the anthropometric characteristics and block in volleyball at the professional level in our study. In volleyball, the greatest load at attack is carried by outside attackers and opposite attackers, while middle blockers have the greatest load at block. Setters perform the smallest number of attacks.

scholarly journals The influence of Organizational Climate and Organizational Socialization on Knowledge Management: An empirical study in banking sector of Pakistan

2019 ◽  
Vol 12 (2) ◽  
pp. 1797-1804
Author(s):  
Raza Hussain Lashari ◽  
Abdul Khaliq Alvi
Keyword(s):  
Knowledge Management ◽  
Correlation Analysis ◽  
Empirical Study ◽  
Organizational Climate ◽  
Organizational Support ◽  
Banking Sector ◽  
Organizational Socialization ◽  
Pearson’S Correlation ◽  
Pearson's Correlation ◽  
Pearson’S Correlation Analysis

The basic objective of the empirical study is to identify the influence of organizational socialization (OS) and organizational climate (OC) on knowledge management (KM) among the banking sector of Pakistan. The above said sector is selected as population of the current research. By using the simple random sampling technique, different branches of public banks and private banks are selected as a sample. 270 questionnaires were circulated to top level managers and middle level managers. 240 questionnaires were filled by employees and used for analysis. The overall response rate was 89%. Different statistical techniques i.e. Pearson’s correlation analysis, multiple regression analysis and reliability analysis are applied on collected data. The results of Pearson’s correlation analysis shows that there is positive relationship between organizational climate (OC), organizational socialization (OS), knowledge management (KM), its dimensions i.e. knowledge sharing (KS) and knowledge application (KA). Moreover, regression analysis’s results explain that organizational socialization is strong predictor of knowledge management as compare to organizational climate. From the management point of view, the results give clear clue to Pakistan’s banking sector must understand the importance of organizational socialization, organizational climate for the purpose of knowledge management. In future researches, data may be collected to other sectors like telecom industry, textile industry and education sector etc. for more generalizing the results. Moreover, researches some other variables like social interaction, perceived organizational support, and perceived supervisor support may also be conducted.     

scholarly journals CAREER MANAGEMENT ANALYSIS IN TERMS OF AGE

2019 ◽  
Vol 4 (7) ◽  
pp. 168-175
Author(s):  
NUGZAR PAICHADZE ◽  
NATALIA KHARADZE ◽  
NINO PARESASHVILI ◽  
DEA PIRTSKHALAISHVILI
Keyword(s):  
Correlation Analysis ◽  
Correlation Coefficient ◽  
Positive Attitude ◽  
Statistical Significance ◽  
Chi Square ◽  
Pearson’S Correlation ◽  
Significance Level ◽  
Chi Square Test ◽  
Pearson's Correlation ◽  
Pearson’S Correlation Analysis

Business career enables human resources to increase qualification opportunities and become recognizable at the same time. In the course of the research, we got interested what kind of attitude towards career issues was in different age groups. What the manner was by which the career of different generation respondents was managed, what the respondents’ attitude is to the career, how they perceive the career management policies implemented by the executives of the organization. The research was conducted in the «Human Potential Management» laboratory at Ivane Javakhishvili Tbilisi State University. 560 respondents participated in the survey. The questionnaire included 32 questions and 125 options for an answer. SPSS statistical software package was used for statistical processing and data analysis. As a result of the research we have developed the hypotheses: Hypothesis 1: Age Q3 affects how people are accepted at work Q5. We used Pearson’s Correlation Analysis to determine the strength of the connection between the variables of this hypothesis. We got the correlation coefficient 0.415. By means of the correlation, it was shown that between these variables there is a moderate positive attitude. To test the reliability of hypothesis we used Chi-square test that indicates that the statistical significance level P (Sig.) does not exceed 0.001. Accordingly, the first hypothesis is reliable. According to both indicators, hypothesis 1: Age Q3 affects how people are accepted at work Q5 has been confirmed. Hypothesis 2: Age Q3 affects working experience Q4. We used Pearson’s Correlation Analysis to determine the strength of the connection between the variables of this hypothesis. We got the correlation coefficient 0.122. By means of the correlation, it was shown that between these variables there is a weak positive attitude. To test the reliability of hypothesis we used Chi-square test that indicates that the statistical significance level P (Sig.) does not exceed 0.001. Accordingly, the first hypothesis is reliable. Consequently, the hypothesis 4 Age Q3 affects whether you were promoted in a career over the last 5 years has been confirmed Hypothesis 5: Age Q3 affects whether a person is searching for a job in a parallel mode Q34. We used Pearson’s Correlation Analysis to determine the strength of the connection between the variables of this hypothesis. We got the correlation coefficient 0.131. By means of the correlation, it was shown that between these variables there is a weak positive attitude. To test the reliability of hypothesis we used Chi-square test that indicates that the statistical significance level P (Sig.) equal to 0.082. Which means that hypothesis 5 is not reliable. Consequently, the hypothesis 5 Q3 Age affects whether a person is searching for a job in a parallel mode Q34 has not been confirmed. Some recommendations were worked out based on the research

scholarly journals Differentiation between Phyllodes Tumors and Fibroadenomas Based on Mammographic Sonographic and MRI Features

Breast Care ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Lale Duman ◽  
Naciye S. Gezer ◽  
Pınar Balcı ◽  
Canan Altay ◽  
Işıl Başara ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Statistical Significance ◽  
Phyllodes Tumor ◽  
Mri Findings ◽  
Pearson’S Correlation ◽  
Phyllodes Tumors ◽  
Mri Features ◽  
Pearson's Correlation ◽  
Pearson’S Correlation Analysis ◽  
Radiological Methods

Background: This study was performed to compare the mammographic, sonographic, and magnetic resonance imaging (MRI) characteristics of phyllodes tumors and fibroadenomas, which may resemble each other. Methods: Preoperative mammograms, B-mode and Doppler sonograms, and dynamic breast MRIs of 72 patients with pathologically proven fibroadenomas and 70 patients with pathologically proven phyllodes tumor were evaluated in this retrospective study. Statistical significance was evaluated using chi-square and Fisher's exact tests. Correlations in lesion size among radiological methods were examined by Pearson's correlation analysis. Results: The features that differed on mammogram were size, shape, and margin of the mass. Sonograms showed significant differences in size, shape, margin, echo pattern, and vascularization of the mass. Pearson's correlation analysis showed strong agreement among radiological methods in terms of assessment of size. Tumor size ≥ 3 cm, irregular shape, microlobulated margins, complex internal echo pattern, and hypervascularity were significant findings of phyllodes tumors. Internal cystic areas on MRI were frequently associated with phyllodes tumors. Conclusion: Mammographic, sonographic, and MRI findings of fibroadenomas and phyllodes tumors could help radiologists to ascertain imaging-histological concordance and guide clinicians in their decision making regarding adequate follow-up or the necessity of biopsy.

Optimization of tactics of auxiliary genesial technologies at married couples with the burdened genetic anamnesis

2018 ◽  
pp. 103-106
Author(s):  
O.S. Darii ◽  
Keyword(s):  
Risk Factors ◽  
Correlation Analysis ◽  
Clinical Laboratory ◽  
Genetic Research ◽  
Married Couples ◽  
Control Group ◽  
Scientific Justification ◽  
Sterility Treatment ◽  
Laboratory Tool ◽  
And Control

The objective: rising of efficiency of treatment of sterility at married couples with the burdened genetic anamnesis on the basis of scientific justification and introduction of advanced algorithm of prognostic and treatment-and-prophylactic actions. Materials and methods. For the purpose of detection of risk factors of development of sterility and carrying out the correlation analysis were allocated the main group – 100 married couples with sterility in the anamnesis and control group of patients who had labors (n=100) in the anamnesis. The complex of the conducted researches included clinical, laboratory, tool and statistical methods of research. Results. Rising of efficiency of treatment of sterility at married couples with the burdened genetic anamnesis requires carrying out medicogenetic consultation with simultaneous planned preimplantation genetic research in programs of auxiliary genesial technologies. At a choice of this or that method of auxiliary genesial technologies at women with the burdened genetic anamnesis it is necessary to use a technique at which one spermatozoon is entered into an oocyte cytoplasma by means of equipment of a micromanipulation. In the program of training of doctors the obstetrician-gynecologists and urologists of an out-patient link it is necessary to loop thematic improvement concerning sterility treatment at married couples with use of auxiliary genesial technologies. Conclusion. Results of the conducted researches testify to need of rising of efficiency of auxiliary genesial technologies at married couples with the burdened genetic anamnesis. Use by our algorithm of prognostic and treatment-and-prophylactic actions allows to increase efficiency of auxiliary genesial technologies at married couples with the burdened genetic anamnesis for 26.7%. Key words: sterility at married couples, the auxiliary genesial technologies, the burdened genetic anamnesis.

scholarly journals Pre-teens, Audio Analgesia and Dental Care: A Cross-Sectional Study

2020 ◽  
Vol 4 (4) ◽  
pp. 98-101
Author(s):  
Akshaye Kumar ◽  
Priyanka Sharma ◽  
Arjun Malhotra
Keyword(s):  
Cross Sectional Study ◽  
Pain Tolerance ◽  
Control Group ◽  
Cross Sectional ◽  
Pearson’S Correlation ◽  
Promising Alternative ◽  
Pearson's Correlation ◽  
Group 2 ◽  
Fear And Anxiety ◽  
Group 1

INTRODUCTION: Research has proven that music plays an important role in alleviating fear and anxiety among patients.AIM: To assess the effect of audio analgesia in pre-teen children aged 8-12 years undergoing dental restorations. MATERIALS AND METHOD: Data was collected using a pre-tested and pre-validated proforma filled by the child prior to start of the treatment by circling the number corresponding to the expected pain during the procedure [Ranged 0 (No pain) -10 (Maximum pain)]. Children who reported their expected pain above 5, were enrolled in group 1 (The ones receiving audio analgesia) while the remaining were assigned group 2 (controls). Children in group 1 were asked to put on their favourite song using noise cancellation headphones and the procedure was commenced. After completion of the treatment, the VAS scale was re-introduced and the children were asked to re-circle the actual pain experienced during the procedure. Data was analyzed using SPSS version 20.0 using the chi-squared test and Pearson’s correlation coefficient. A significant value was obtained when p was≤ 0.05. RESULTS: Of the total 80 children enrolled in the present study, there were an equal number of males and females (40 each). It was observed that 70.3% of children in group 1 had an increased pain tolerance as compared to only 37.2% of children in the control group(p=0.01). Pearson’s Correlation revealed a positive and linear association (r: +0.721) and a significant relationship (p = 0.03) between both groups. CONCLUSION: Audio analgesia has been proven to a promising alternative to distract the patient from the anxiety faced in the dental setting and is recommended for nervous and anxious patients.

scholarly journals Real-time fMRI neurofeedback as a new treatment for psychiatric disorders: a systematic review

2021 ◽  
Author(s):  
Pamela Pindi ◽  
Josselin Houenou ◽  
Camille Piguet ◽  
Pauline Favre
Keyword(s):  
Psychiatric Disorders ◽  
Real Time ◽  
Functional Mri ◽  
Psychiatric Symptoms ◽  
Psychotic Symptoms ◽  
Control Group ◽  
Controlled Trials ◽  
Brain Response ◽  
Double Blind

Background: Neurofeedback using real-time functional MRI (RT-fMRI-NF) is an innovative technique that allows to voluntarily modulating a targeted brain response and its associated behavior. Despite promising results in the current literature, its effectiveness on symptoms’ management in psychiatric disorders is not yet clearly demonstrated. This review aims to evaluate the effectiveness of RT-fMRI-NF in the treatment of psychiatric disorders and to provide methodological suggestions for future studies. Methods: Web of Science and PubMed databases were searched using the keywords: neurofeedback AND (fMRI OR “functional magnetic resonance imag*” OR “functional MRI”) AND (“real-time” OR “real time”). Twenty-six clinical trials focusing on psychiatric disorders were included and categorized according to the diagnostic categories. The RT-fMRI-NF efficacy was assessed by reporting changes in clinical endpoints before vs. after NF training and before or after NF training vs. follow-up. Results: Among the 26 studies, 18 were controlled trials, of which five showed significant clinical improvement in the experimental vs. control group after the training. Eight studies found an effect at follow-up on ADHD symptoms, emotion dysregulation, depressive symptoms, hallucinations, psychotic symptoms and specific fear. Limitations: Here, we only focused our review on fMRI-based NF training. Conclusion: The use of RT-fMRI-NF as a treatment for psychiatric symptoms is promising. However, further double blind, randomized-controlled trials are warranted.

scholarly journals Comparison of Effects and Brain-Gut Regulatory Mechanisms of Acupuncture and Flunarizine for Migraine: Study Protocol for a Randomized Controlled Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Ya-Nan Wang ◽  
Ming-Sheng Sun ◽  
Xi-Xiu Ni ◽  
Tian Tian ◽  
Lu Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Acupuncture Treatment ◽  
Psychiatric Symptoms ◽  
Controlled Trial ◽  
Gastrointestinal Symptoms ◽  
Central Nervous System Disease ◽  
Regulatory Mechanisms ◽  
Control Group ◽  
Sequencing Analysis ◽  
System Disease

Background. As a central nervous system disease, migraine often coexists with gastrointestinal disorders, which suggests a disruption of brain-gut regulation. Clinical studies have confirmed that acupuncture and flunarizine not only alleviate migraine attacks but also substantially inhibit accompanying gastrointestinal symptoms. However, it is still not clear how acupuncture and flunarizine regulate the interactions of brain, gut, and microbiome. Therefore, this study will combine neuroimaging technology and gut microbiota detection technology to explore and compare the effects and brain-gut modulating mechanisms of acupuncture and flunarizine for migraine. Methods. This randomized clinical trial will recruit 66 patients with migraine without aura. Participants will be randomly assigned in a 1 : 1 ratio to an acupuncture group or a control group. The acupuncture treatment strategy is based on experience from our previous study and consensus meetings with clinical experts. Patients will receive 12 sessions of manual acupuncture treatment (once every other day to a total of three times per week, followed by a 2-day break). Flunarizine will be administered at a dose of 5 mg daily in the control group. Participants in both groups will receive treatment for a period of 4 weeks. The primary outcome is the change in frequency of migraine attacks, and the secondary outcomes include the changes in migraine days (days on which migraine attacks occurred), average migraine severity, gastrointestinal symptoms, psychiatric symptoms, and quality of life. Fresh stool samples will be collected, and 16S ribosomal RNA gene sequencing analysis will be used for gut microbiota. Magnetic resonance imaging will be applied to detect between-group changes in brain function. The abovementioned indicators will be collected at baseline, after a 4-week intervention, and at the 12-week follow-up. Discussions. From the perspective of brain-gut regulatory mechanisms, we will combine brain neuroimaging and gut microbiological data to partially reveal the similarities and differences of acupuncture and flunarizine on the treatment of migraine. The trial is registered with ChiCTR2000034417.

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