scholarly journals The Methylation of Clock Genes in Perinatal Depression: Which Role for Oxytocin?

2021 ◽  
Vol 12 ◽  
Author(s):  
Simona Iodice ◽  
Martina Di Paolo ◽  
Jennifer Lynn Barkin ◽  
Letizia Tarantini ◽  
Silvia Grassi ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Rating Scales ◽  
Edinburgh Postnatal Depression Scale ◽  
Perinatal Depression ◽  
Clock Genes ◽  
Depression Scale ◽  
Protective Role ◽  
Prenatal Attachment ◽  
Gene Methylation ◽  
Neuropeptide Release

Background: Perinatal Depression (PD) is a widespread disabling condition that is hypothesized to be associated with abnormalities in circadian rhythms and neuropeptide release including oxytocin (OXT).Methods: Fourty-four pregnant women (28 with PD, and 16 controls) were evaluated through the Edinburgh Postnatal Depression Scale (EPDS), the State/Trait Anxiety Inventory Form Y (STAI-Y), and the Prenatal Attachment Inventory (PAI). A blood sample was collected from all participants, and OXT plasma levels, DNA methylation of clock genes, as well as of FOXp3 and HERV-W were measured. Linear regression analyses were performed to assess the effect of oxytocin on the methylation of selected genes. Continuous ordinal regression models was further applied to see if the score of rating scales was associated to gene methylation, adjusting for oxytocin-methylation interaction.Results: OXT plasma levels were positively associated with CRY1 methylation. Women with higher OXT plasma levels showed an association between higher degree of CRY2 methylation (thus, reduced expression) and lower EPDS (OR = 0.21; P = 0.043) and STAI-S scores (OR = 6.96; P = 0.019). Finally, with high OXT levels, hypermethylation of CRY1 was associated to higher scores on the PAI (OR = 2.74; P = 0.029) while higher methylation of HERV-W related to lower PAI scores (OR = 0.273; P = 0.019).Conclusion: Our results suggest a possible protective role played by oxytocin in the development of PD by promoting a favorable methylation profile characterized by reduced expression of CRY1 and CRY2. Moreover, oxytocin strengthens the association between maternal prenatal attachment with a favorable pattern of methylation of clock genes and HERV-W, which is essential for pregnancy outcomes.

scholarly journals The Association between Plasma ERVWE1 Concentrations and Affective Symptoms during Pregnancy: Is This a Friendly Alien?

2020 ◽  
Vol 17 (24) ◽  
pp. 9217
Author(s):  
Marta Serati ◽  
Cecilia Maria Esposito ◽  
Silvia Grassi ◽  
Valentina Bollati ◽  
Jennifer Lynn Barkin ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Rating Scales ◽  
Psychiatric Symptoms ◽  
Depression Scale ◽  
Protective Role ◽  
Endogenous Retrovirus ◽  
Endogenous Retroviruses ◽  
Human Endogenous Retrovirus ◽  
Blood Collection ◽  
Duration Of Symptoms

Human endogenous retroviruses (HERVs) comprise 8% of the human genome, and HERV DNA was reported to be essential in human embryonic development. Specifically, HERV-W encodes a protein, syncytin-1, alternatively known as ERVWE1 (Human Endogenous Retrovirus W EnvC7-1 Envelope Protein), participating in human placental morphogenesis and having a role in immune system regulation. Syncytin-1 activity is increased in neuropsychiatric disorders, autoimmune diseases, and cancer. In our study, forty-four women in the third trimester of pregnancy were tested for ERVWE1 plasma levels. In concomitance with blood samples the following rating scales were administered to women: the Edinburgh Postnatal Depression Scale (EPDS), State Anxiety Inventory (STAI-S), Trait Anxiety Inventory (STAI-T), and Prenatal Attachment Inventory (PAI). We found that higher ERVWE1 protein plasma levels were significantly associated with higher PAI scores (p = 0.02), an earlier gestational age at the time of blood collection (p = 0.01), a longer duration of symptoms (p = 0.03), and fewer lifetime attempted suicides (p = 0.02). Our results seem to support the role of ERVWE1 in maintaining clinical psychiatric symptoms as a result of potential prolonged inflammation. At the same time, this protein may have a protective role in pregnant women by a reduction of suicidal behavior and a better mother–fetus relationship.

Validation of the Edinburgh Postnatal Depression Scale for Use With Young Childbearing Women

2017 ◽  
Vol 25 (1) ◽  
pp. 1E-16E
Author(s):  
Kira Friesen ◽  
Wendy E. Peterson ◽  
Janet Squires ◽  
Cathryn Fortier
Keyword(s):  
Principal Component Analysis ◽  
Young Adults ◽  
Young Women ◽  
Test Scores ◽  
Postnatal Depression ◽  
Edinburgh Postnatal Depression Scale ◽  
Perinatal Depression ◽  
Depression Scale ◽  
Principal Component ◽  
Childbearing Women

Background and Purpose: The Edinburgh Postnatal Depression Scale (EPDS) was created specifically to screen for perinatal depression. The purpose of this study was to assess the psychometric properties of the EPDS for use in a population of pregnant and postpartum 14- to 24-year-olds in Canada. Methods: The Standards for Educational and Psychological Testing was used as the psychometric framework to assess the validity, reliability, and acceptability of responses obtained using the EPDS with pregnant and postpartum adolescents and young adults. Results: There were 102 young women who were surveyed. Principal component analysis supported the EPDS as a 2-dimensional instrument. Test scores also showed the EPDS to be reliable and acceptable. Conclusions: The EPDS was found to be a psychometrically sound tool for use in this population of young childbearing women.

A Stepped-Collaborative Perinatal Depression Model

2018 ◽  
Vol 25 (5) ◽  
pp. 376-384 ◽  
Author(s):  
Mary M. Rock
Keyword(s):  
Edinburgh Postnatal Depression Scale ◽  
Perinatal Depression ◽  
Treatment Time ◽  
Depression Scale ◽  
Psychiatric Evaluation ◽  
Care Providers ◽  
Doctor Of Nursing Practice ◽  
Institutional Review ◽  
Practice Method ◽  
Clinically Significant

BACKGROUND: Perinatal depression (PD) screening has been defined for decades, but treatment remains ill-defined, with few mental health (MH) providers helping depressed women during this delicate time. The nurse practitioner (NP) is in a position to help women through PD with the use of a collaborative treatment model. AIMS: This DNP (doctor of nursing practice) inquiry investigated a stepped collaborative care model (CCM) to see whether the PD model improved time from referral to evaluation and decreased depression scores over a 6-month treatment period for women who came to an NP MH practice. METHOD: After obtaining approval from the institutional review board and the clients, the Edinburgh Postnatal Depression Scale was administered to 37 women at psychiatric evaluation and subsequent MH visits over a 6-month period. Time from referral to evaluation and depression scores were analyzed. RESULTS: The CCM met the goal of 30 days from referral to evaluation. Prenatal clients had a statistically significant decrease in depression scores, and postpartum client scores were clinically significant. CONCLUSION: A CCM among care providers facilitates prompt intake to treatment time within 1 month of identification of depression, and a decrease in depression scores in women measured by sequential depression screen scores. The study may provide ideas for evidence-based NP practice by use of the model to treat depression in this group of women.

scholarly journals Thirty years with the Edinburgh Postnatal Depression Scale: voices from the past and recommendations for the future

2019 ◽  
Vol 214 (3) ◽  
pp. 127-129 ◽  
Author(s):  
John Cox
Keyword(s):  
Postnatal Depression ◽  
Edinburgh Postnatal Depression Scale ◽  
Perinatal Depression ◽  
Depression Scale ◽  
Self Report ◽  
Future Studies ◽  
The Past ◽  
Financial Interest ◽  
Practical Usefulness ◽  
The World

SummaryThe Edinburgh Postnatal Depression Scale (EPDS) was published over 30 years ago as a ten-item self-report questionnaire to facilitate the detection of perinatal depression – and for use in research. It is widely used at the present time in many regions of the world and has been translated into over 60 languages. It is occasionally misused. In this editorial, updated recommendations for optimal use in primary and secondary care as well as research are provided. Future studies to evaluate its use and validity in naturalistic community populations are now required, and to determine the psychometric properties and practical usefulness of the EPDS when completed online.Declaration of interestJ.C. has no financial interest in the use of, or reproduction of, the EPDS.

Factors Associated With Maternal Depression in the Maldives: A Prospective Cohort Study

2018 ◽  
Vol 30 (3) ◽  
pp. 244-251 ◽  
Author(s):  
R. Abdul Raheem ◽  
Hui J. Chih ◽  
Colin W. Binns
Keyword(s):  
Depressive Symptoms ◽  
Maternal Depression ◽  
Edinburgh Postnatal Depression Scale ◽  
Stressful Life Events ◽  
Perinatal Depression ◽  
Depression Scale ◽  
Sociodemographic Factors ◽  
Future Studies ◽  
Established Risk Factor ◽  
Antenatal Depressive Symptoms

The aim of the study was to document perinatal depression in mothers in the Maldives and associated factors. A cohort of 458 mothers was recruited at the 2 major hospitals in Malé, the Maldives, and followed from 36 weeks of pregnancy to 3 months after birth. The Edinburgh Postnatal Depression Scale (EPDS) was used to measure maternal depression. Maternal sociodemographic factors and infant’s health were also recorded. The prevalence of depressive symptoms (EPDS score ≥13) at 36 weeks of pregnancy and at 1 and 3 months postpartum were 24%, 27%, and 12%, respectively. Having experienced stressful life events is an established risk factor for maternal depression across these time points. Having depressive symptoms during the postpartum period is significantly associated with presence of antenatal depressive symptoms. Future studies may look into effectiveness of strategies that cope with stressors in the management of maternal depression.

The use of Rating Scales to Identify Post-natal Depression

1989 ◽  
Vol 154 (6) ◽  
pp. 813-817 ◽  
Author(s):  
Brian Harris ◽  
Philip Huckle ◽  
Roger Thomas ◽  
Sandra Johns ◽  
Hedi Fung
Keyword(s):  
Major Depression ◽  
Postnatal Depression ◽  
Rating Scales ◽  
Edinburgh Postnatal Depression Scale ◽  
Depression Scale ◽  
Post Natal Depression

One hundred and forty-seven mothers were screened for major depression at six to eight weeks postpartum. Using predetermined cut-off points, the Edinburgh Postnatal Depression Scale and the Beck scale were compared in their abilities to identify the 15% of subjects who had major depression according to DSM-III criteria. The sensitivity of Edinburgh scale was 95% and its specificity 93%. The performance of the Beck scale was markedly inferior, with a sensitivity of 68% and specificity of 88%.

scholarly journals A hangulati állapot alakulásának kockázati tényezői a perinatalis időszakban

2017 ◽  
Vol 158 (4) ◽  
pp. 139-146 ◽  
Author(s):  
Emőke Adrienn Hompoth ◽  
Annamária Töreki ◽  
Veronika Baloghné Fűrész ◽  
Gábor Németh
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Postnatal Depression ◽  
Edinburgh Postnatal Depression Scale ◽  
Perinatal Depression ◽  
Depression Scale ◽  
First Trimester ◽  
The Other ◽  
Mood Changes ◽  
Unplanned Pregnancies

Abstract: Introduction: The screening of perinatal depression was introduced in Szeged in April 2011. Aim: Our aim was to assess the extent of perinatal mood changing and to explore the risk factors of it. Method: Perinatal nurses gave the Edinburgh Postnatal Depression Scale to the 3849 participants four times. Results: In the first trimester were the highest average scores (3.74) and pathological rate (10.8%) compared to the other measurement occasions. There was a positive correlation between the scores of the measurement occasions. The higher average scores related to the epidural anesthesia almost significantly, but significantly to the low birth weight, unplanned pregnancies, younger and older age, single marital status and multiparity of the participant. Conclusions: Even the first trimester is sensitive to pathological mood changes, which besides with other factors could be risk factors to postpartum depression. To avoid this it is important to continue the screening and provide adequate help. Orv. Hetil., 2017, 158(4), 139–146.

scholarly journals DETERMINANTS OF PERINATAL DEPRESSION IN LICIN BANYUWANGI 2019

2020 ◽  
Vol 1 (1) ◽  
pp. 14
Author(s):  
Achmad Januar Er Putra ◽  
R. M. Yusuf Aji Samudera Nurrobi ◽  
Danang Mukarrom Prasetyo ◽  
Muhammad Vildan Akbar ◽  
Novita Oktaviana ◽  
...  
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Edinburgh Postnatal Depression Scale ◽  
Perinatal Depression ◽  
Depression Scale ◽  
Primary Data ◽  
Cross Sectional ◽  
Observational Descriptive Study ◽  
Very High ◽  
Cluster Random Sampling

Perinatal depression is a mood disorder that occurs in pregnant and postpartum women. To determine the magnitude of the risk of perinatal depression, this study uses the Edinburgh Postnatal Depression Scale (EPDS) screening tool. This study uses primary data in the form of a questionnaire to collect data on screening for depression in pregnant women and postpartum during the last 12 months. This research is an observational descriptive study with cross sectional research design. Sampling was done by cluster random sampling in Segobang Village, Jelun Village, and Banjar Village in Licin District, Banyuwangi Regency. The number of samples obtained was 31 samples. In the EPDS screening results of the pregnant women group, the results showed a very high risk of 18,75%. Whereas in the postpartum maternal group, the results showed a high risk of 6,67%, and a very high risk of 6,67%. Based on the results of the correlation test with Spearman's rho correlation, it can be concluded that there was a significant corellation between maternal age of postpartum with the risk of perinatal depression (α = 0,03).

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