scholarly journals Population-Based Screening for Endometrial Cancer: Human vs. Machine Intelligence

2020 ◽  
Vol 3 ◽  
Author(s):  
Gregory R. Hart ◽  
Vanessa Yan ◽  
Gloria S. Huang ◽  
Ying Liang ◽  
Bradley J. Nartowt ◽  
...  
Keyword(s):  
Machine Learning ◽  
Endometrial Cancer ◽  
False Positive Rate ◽  
Population Based ◽  
Personal Health ◽  
Average Risk ◽  
Endometrial Cancer Risk ◽  
Machine Learning Model ◽  
Fold Reduction ◽  
Positive Rate

Incidence and mortality rates of endometrial cancer are increasing, leading to increased interest in endometrial cancer risk prediction and stratification to help in screening and prevention. Previous risk models have had moderate success with the area under the curve (AUC) ranging from 0.68 to 0.77. Here we demonstrate a population-based machine learning model for endometrial cancer screening that achieves a testing AUC of 0.96.We train seven machine learning algorithms based solely on personal health data, without any genomic, imaging, biomarkers, or invasive procedures. The data come from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). We further compare our machine learning model with 15 gynecologic oncologists and primary care physicians in the stratification of endometrial cancer risk for 100 women.We find a random forest model that achieves a testing AUC of 0.96 and a neural network model that achieves a testing AUC of 0.91. We test both models in risk stratification against 15 practicing physicians. Our random forest model is 2.5 times better at identifying above-average risk women with a 2-fold reduction in the false positive rate. Our neural network model is 2 times better at identifying above-average risk women with a 3-fold reduction in the false positive rate.Our machine learning models provide a non-invasive and cost-effective way to identify high-risk sub-populations who may benefit from early screening of endometrial cancer, prior to disease onset. Through statistical biopsy of personal health data, we have identified a new and effective approach for early cancer detection and prevention for individual patients.

scholarly journals Dear Watch, Should I get a COVID Test? Designing deployable machine learning for wearables

2021 ◽  
Author(s):  
Anna Goldenberg ◽  
Bret Nestor ◽  
Jaryd Hunter ◽  
Raghu Kainkaryam ◽  
Erik Drysdale ◽  
...  
Keyword(s):  
Public Health ◽  
Machine Learning ◽  
Real World ◽  
False Positive Rate ◽  
Wearable Devices ◽  
Classification Performance ◽  
Wearable Device ◽  
Screening Tools ◽  
Machine Learning Model ◽  
Positive Rate

Abstract Commercial wearable devices are surfacing as an appealing mechanism to detect COVID-19 and potentially other public health threats, due to their widespread use. To assess the validity of wearable devices as population health screening tools, it is essential to evaluate predictive methodologies based on wearable devices by mimicking their real-world deployment. Several points must be addressed to transition from statistically significant differences between infected and uninfected cohorts to COVID-19 inferences on individuals. We demonstrate the strengths and shortcomings of existing approaches on a cohort of 32,198 individuals who experience influenza like illness (ILI), 204 of which report testing positive for COVID-19. We show that, despite commonly made design mistakes resulting in overestimation of performance, when properly designed wearables can be effectively used as a part of the detection pipeline. For example, knowing the week of year, combined with naive randomised test set generation leads to substantial overestimation of COVID-19 classification performance at 0.73 AUROC. However, an average AUROC of only 0.55 +/- 0.02 would be attainable in a simulation of real-world deployment, due to the shifting prevalence of COVID-19 and non-COVID-19 ILI to trigger further testing. In this work we show how to train a machine learning model to differentiate ILI days from healthy days, followed by a survey to differentiate COVID-19 from influenza and unspecified ILI based on symptoms. In a forthcoming week, models can expect a sensitivity of 0.50 (0-0.74, 95% CI), while utilising the wearable device to reduce the burden of surveys by 35%. The corresponding false positive rate is 0.22 (0.02-0.47, 95% CI). In the future, serious consideration must be given to the design, evaluation, and reporting of wearable device interventions if they are to be relied upon as part of frequent COVID-19 or other public health threat testing infrastructures.

scholarly journals Dear Watch, Should I Get a COVID-19 Test? Designing deployable machine learning for wearables

2021 ◽  
Author(s):  
Bret Nestor ◽  
Jaryd Hunter ◽  
Raghu Kainkaryam ◽  
Erik Drysdale ◽  
Jeffrey B Inglis ◽  
...  
Keyword(s):  
Public Health ◽  
Machine Learning ◽  
Real World ◽  
False Positive Rate ◽  
Wearable Devices ◽  
Classification Performance ◽  
Wearable Device ◽  
Screening Tools ◽  
Machine Learning Model ◽  
Positive Rate

Commercial wearable devices are surfacing as an appealing mechanism to detect COVID-19 and potentially other public health threats, due to their widespread use. To assess the validity of wearable devices as population health screening tools, it is essential to evaluate predictive methodologies based on wearable devices by mimicking their real-world deployment. Several points must be addressed to transition from statistically significant differences between infected and uninfected cohorts to COVID-19 inferences on individuals. We demonstrate the strengths and shortcomings of existing approaches on a cohort of 32,198 individuals who experience influenza like illness (ILI), 204 of which report testing positive for COVID-19. We show that, despite commonly made design mistakes resulting in overestimation of performance, when properly designed wearables can be effectively used as a part of the detection pipeline. For example, knowing the week of year, combined with naive randomised test set generation leads to substantial overestimation of COVID-19 classification performance at 0.73 AUROC. However, an average AUROC of only 0.55 ± 0.02 would be attainable in a simulation of real-world deployment, due to the shifting prevalence of COVID-19 and non-COVID-19 ILI to trigger further testing. In this work we show how to train a machine learning model to differentiate ILI days from healthy days, followed by a survey to differentiate COVID-19 from influenza and unspecified ILI based on symptoms. In a forthcoming week, models can expect a sensitivity of 0.50 (0-0.74, 95% CI), while utilising the wearable device to reduce the burden of surveys by 35%. The corresponding false positive rate is 0.22 (0.02-0.47, 95% CI). In the future, serious consideration must be given to the design, evaluation, and reporting of wearable device interventions if they are to be relied upon as part of frequent COVID-19 or other public health threat testing infrastructures.

Machine Learning Accelerated Genetic Algorithms for Computational Materials Search

2018 ◽  
Author(s):  
Steen Lysgaard ◽  
Paul C. Jennings ◽  
Jens Strabo Hummelshøj ◽  
Thomas Bligaard ◽  
Tejs Vegge
Keyword(s):  
Machine Learning ◽  
Genetic Algorithm ◽  
Genetic Algorithms ◽  
Au Nanoparticles ◽  
Learning Model ◽  
Energy Calculations ◽  
Atomic Distribution ◽  
Machine Learning Model ◽  
Fold Reduction ◽  
Computational Materials

A machine learning model is used as a surrogate fitness evaluator in a genetic algorithm (GA) optimization of the atomic distribution of Pt-Au nanoparticles. The machine learning accelerated genetic algorithm (MLaGA) yields a 50-fold reduction of required energy calculations compared to a traditional GA.

scholarly journals You Only Look Once, But Compute Twice: Service Function Chaining for Low-Latency Object Detection in Softwarized Networks

2021 ◽  
Vol 11 (5) ◽  
pp. 2177
Author(s):  
Zuo Xiang ◽  
Patrick Seeling ◽  
Frank H. P. Fitzek
Keyword(s):  
Machine Learning ◽  
Object Detection ◽  
Low Latency ◽  
Connected Vehicles ◽  
Network Nodes ◽  
Machine Learning Model ◽  
Fold Reduction ◽  
Broad Variety ◽  
Computational Resources ◽  
Service Latency

With increasing numbers of computer vision and object detection application scenarios, those requiring ultra-low service latency times have become increasingly prominent; e.g., those for autonomous and connected vehicles or smart city applications. The incorporation of machine learning through the applications of trained models in these scenarios can pose a computational challenge. The softwarization of networks provides opportunities to incorporate computing into the network, increasing flexibility by distributing workloads through offloading from client and edge nodes over in-network nodes to servers. In this article, we present an example for splitting the inference component of the YOLOv2 trained machine learning model between client, network, and service side processing to reduce the overall service latency. Assuming a client has 20% of the server computational resources, we observe a more than 12-fold reduction of service latency when incorporating our service split compared to on-client processing and and an increase in speed of more than 25% compared to performing everything on the server. Our approach is not only applicable to object detection, but can also be applied in a broad variety of machine learning-based applications and services.

Endometrial cancer risk after fertility treatment: a population-based cohort study

2021 ◽  
Author(s):  
Sonia Guleria ◽  
Allan Jensen ◽  
Vanna Albieri ◽  
Bugge Nøhr ◽  
Kirsten Frederiksen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Fertility Treatment ◽  
Endometrial Cancer Risk

scholarly journals Identification of newborns at risk for autism using electronic medical records and machine learning

2019 ◽  
Author(s):  
Rayees Rahman ◽  
Arad Kodesh ◽  
Stephen Z Levine ◽  
Sven Sandin ◽  
Abraham Reichenberg ◽  
...  
Keyword(s):  
Machine Learning ◽  
Autism Spectrum Disorder ◽  
Positive Predictive Value ◽  
Electronic Medical Records ◽  
Predictive Value ◽  
False Positive ◽  
Medical Records ◽  
False Positive Rate ◽  
Autism Spectrum ◽  
Positive Rate

AbstractImportanceCurrent approaches for early identification of individuals at high risk for autism spectrum disorder (ASD) in the general population are limited, where most ASD patients are not identified until after the age of 4. This is despite substantial evidence suggesting that early diagnosis and intervention improves developmental course and outcome.ObjectiveDevelop a machine learning (ML) method predicting the diagnosis of ASD in offspring in a general population sample, using parental electronic medical records (EMR) available before childbirthDesignPrognostic study of EMR data within a single Israeli health maintenance organization, for the parents of 1,397 ASD children (ICD-9/10), and 94,741 non-ASD children born between January 1st, 1997 through December 31st, 2008. The complete EMR record of the parents was used to develop various ML models to predict the risk of having a child with ASD.Main outcomes and measuresRoutinely available parental sociodemographic information, medical histories and prescribed medications data until offspring’s birth were used to generate features to train various machine learning algorithms, including multivariate logistic regression, artificial neural networks, and random forest. Prediction performance was evaluated with 10-fold cross validation, by computing C statistics, sensitivity, specificity, accuracy, false positive rate, and precision (positive predictive value, PPV).ResultsAll ML models tested had similar performance, achieving an average C statistics of 0.70, sensitivity of 28.63%, specificity of 98.62%, accuracy of 96.05%, false positive rate of 1.37%, and positive predictive value of 45.85% for predicting ASD in this dataset.Conclusion and relevanceML algorithms combined with EMR capture early life ASD risk. Such approaches may be able to enhance the ability for accurate and efficient early detection of ASD in large populations of children.Key pointsQuestionCan autism risk in children be predicted using the pre-birth electronic medical record (EMR) of the parents?FindingsIn this population-based study that included 1,397 children with autism spectrum disorder (ASD) and 94,741 non-ASD children, we developed a machine learning classifier for predicting the likelihood of childhood diagnosis of ASD with an average C statistic of 0.70, sensitivity of 28.63%, specificity of 98.62%, accuracy of 96.05%, false positive rate of 1.37%, and positive predictive value of 45.85%.MeaningThe results presented serve as a proof-of-principle of the potential utility of EMR for the identification of a large proportion of future children at a high-risk of ASD.

scholarly journals IoT Dataset Validation Using Machine Learning Techniques for Traffic Anomaly Detection

Electronics ◽  
2021 ◽  
Vol 10 (22) ◽  
pp. 2857
Author(s):  
Laura Vigoya ◽  
Diego Fernandez ◽  
Victor Carneiro ◽  
Francisco Nóvoa
Keyword(s):  
Machine Learning ◽  
Anomaly Detection ◽  
False Positive Rate ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
High Detection Rate ◽  
Security Vulnerabilities ◽  
Smart Systems ◽  
Learning Techniques ◽  
Positive Rate

With advancements in engineering and science, the application of smart systems is increasing, generating a faster growth of the IoT network traffic. The limitations due to IoT restricted power and computing devices also raise concerns about security vulnerabilities. Machine learning-based techniques have recently gained credibility in a successful application for the detection of network anomalies, including IoT networks. However, machine learning techniques cannot work without representative data. Given the scarcity of IoT datasets, the DAD emerged as an instrument for knowing the behavior of dedicated IoT-MQTT networks. This paper aims to validate the DAD dataset by applying Logistic Regression, Naive Bayes, Random Forest, AdaBoost, and Support Vector Machine to detect traffic anomalies in IoT. To obtain the best results, techniques for handling unbalanced data, feature selection, and grid search for hyperparameter optimization have been used. The experimental results show that the proposed dataset can achieve a high detection rate in all the experiments, providing the best mean accuracy of 0.99 for the tree-based models, with a low false-positive rate, ensuring effective anomaly detection.

Machine Learning for Automated Polyp Detection in Computed Tomography Colonography

2012 ◽  
pp. 830-850
Author(s):  
Abhilash Alexander Miranda ◽  
Olivier Caelen ◽  
Gianluca Bontempi
Keyword(s):  
Machine Learning ◽  
Computed Tomography ◽  
False Positive ◽  
False Positive Rate ◽  
Learning Algorithms ◽  
Colorectal Polyps ◽  
Machine Learning Algorithms ◽  
Computed Tomography Colonography ◽  
Positive Rate ◽  
Independent Features

This chapter presents a comprehensive scheme for automated detection of colorectal polyps in computed tomography colonography (CTC) with particular emphasis on robust learning algorithms that differentiate polyps from non-polyp shapes. The authors’ automated CTC scheme introduces two orientation independent features which encode the shape characteristics that aid in classification of polyps and non-polyps with high accuracy, low false positive rate, and low computations making the scheme suitable for colorectal cancer screening initiatives. Experiments using state-of-the-art machine learning algorithms viz., lazy learning, support vector machines, and naïve Bayes classifiers reveal the robustness of the two features in detecting polyps at 100% sensitivity for polyps with diameter greater than 10 mm while attaining total low false positive rates, respectively, of 3.05, 3.47 and 0.71 per CTC dataset at specificities above 99% when tested on 58 CTC datasets. The results were validated using colonoscopy reports provided by expert radiologists.

scholarly journals Identification of newborns at risk for autism using electronic medical records and machine learning

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Rayees Rahman ◽  
Arad Kodesh ◽  
Stephen Z. Levine ◽  
Sven Sandin ◽  
Abraham Reichenberg ◽  
...  
Keyword(s):  
Machine Learning ◽  
General Population ◽  
Electronic Medical Records ◽  
False Positive ◽  
Medical Records ◽  
False Positive Rate ◽  
Autism Spectrum ◽  
Health Maintenance ◽  
C Statistic ◽  
Positive Rate

Abstract Background. Current approaches for early identification of individuals at high risk for autism spectrum disorder (ASD) in the general population are limited, and most ASD patients are not identified until after the age of 4. This is despite substantial evidence suggesting that early diagnosis and intervention improves developmental course and outcome. The aim of the current study was to test the ability of machine learning (ML) models applied to electronic medical records (EMRs) to predict ASD early in life, in a general population sample. Methods. We used EMR data from a single Israeli Health Maintenance Organization, including EMR information for parents of 1,397 ASD children (ICD-9/10) and 94,741 non-ASD children born between January 1st, 1997 and December 31st, 2008. Routinely available parental sociodemographic information, parental medical histories, and prescribed medications data were used to generate features to train various ML algorithms, including multivariate logistic regression, artificial neural networks, and random forest. Prediction performance was evaluated with 10-fold cross-validation by computing the area under the receiver operating characteristic curve (AUC; C-statistic), sensitivity, specificity, accuracy, false positive rate, and precision (positive predictive value [PPV]). Results. All ML models tested had similar performance. The average performance across all models had C-statistic of 0.709, sensitivity of 29.93%, specificity of 98.18%, accuracy of 95.62%, false positive rate of 1.81%, and PPV of 43.35% for predicting ASD in this dataset. Conclusions. We conclude that ML algorithms combined with EMR capture early life ASD risk as well as reveal previously unknown features to be associated with ASD-risk. Such approaches may be able to enhance the ability for accurate and efficient early detection of ASD in large populations of children.

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