scholarly journals Multidrug Resistance and Virulence Factors of Escherichia coli Harboring Plasmid-Mediated Colistin Resistance: mcr-1 and mcr-3 Genes in Contracted Pig Farms in Thailand

2020 ◽  
Vol 7 ◽  
Author(s):  
Nwai Oo Khine ◽  
Kittitat Lugsomya ◽  
Benjarong Kaewgun ◽  
Lertrob Honhanrob ◽  
Panupong Pairojrit ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Multidrug Resistance ◽  
Virulence Factors ◽  
Colistin Resistance ◽  
Pig Farms

scholarly journals Genomic Characterization of New Variant of Hydrogen Sulfide (H2S)-Producing Escherichia coli with Multidrug Resistance Properties Carrying the mcr-1 Gene in China

Antibiotics ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 80 ◽  
Author(s):  
Silpak Biswas ◽  
Mohammed Elbediwi ◽  
Guimin Gu ◽  
Min Yue
Keyword(s):  
Escherichia Coli ◽  
Hydrogen Sulfide ◽  
Multidrug Resistance ◽  
Bacterial Infections ◽  
Multidrug Resistant ◽  
Health Concern ◽  
Colistin Resistance ◽  
New Variant ◽  
Genomic Characterization ◽  
Human Infections

Colistin is considered to be a ‘last-resort’ antimicrobial for the treatment of multidrug-resistant Gram-negative bacterial infections. Identification of Enterobacteriaceae, carrying the transferable colistin resistance gene mcr-1, has recently provoked a global health concern. This report presents the first detection of a hydrogen sulfide (H2S)-producing Escherichia coli variant isolated from a human in China, with multidrug resistance (MDR) properties, including colistin resistance by the mcr-1 gene, which could have great implications for the treatment of human infections.

scholarly journals Escherichia coli with virulence factors and multidrug resistance in the Plankenburg River

2014 ◽  
Vol 110 (9/10) ◽  
pp. 1-6 ◽  
Author(s):  
Corne Lamprecht ◽  
Marco Romanis ◽  
Nicola Huisamen ◽  
Anneri Carinus ◽  
Nika Schoeman ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Multidrug Resistance ◽  
Virulence Factors

scholarly journals Full Genome Sequence of pT3, a Multiresistant Plasmid Carrying the mcr-3.5 Colistin Resistance Gene, Recovered from an Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolate from Crickets Sold as Food

2019 ◽  
Vol 8 (29) ◽  
Author(s):  
Katrin Zurfluh ◽  
Marc J. A. Stevens ◽  
Melissa Bucher ◽  
Laurent Poirel ◽  
Patrice Nordmann ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Genome Sequence ◽  
Resistance Genes ◽  
Full Genome Sequence ◽  
Full Genome ◽  
Colistin Resistance ◽  
Coli Isolate ◽  
Single Plasmid

Here, we sequenced multidrug resistance plasmid pT3, which encodes mcr-3.5 and other resistance genes. The cooccurrence of mcr genes and other resistance genes on a single plasmid is of concern.

scholarly journals Genome Sequence of Avian Escherichia coli Strain IHIT25637, an Extraintestinal Pathogenic E. coli Strain of ST131 Encoding Colistin Resistance Determinant MCR-1

2016 ◽  
Vol 4 (5) ◽  
Author(s):  
Christa Ewers ◽  
Stephan Göttig ◽  
Maria Bülte ◽  
Sophie Fiedler ◽  
Manuela Tietgen ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Genome Sequence ◽  
Coli Strain ◽  
Sequence Type ◽  
Resistance Determinant ◽  
Colistin Resistance ◽  
E Coli ◽  
Expec Strain

Sequence type 131 (ST131) is one of the predominant Escherichia coli lineages among extraintestinal pathogenic E. coli (ExPEC) that causes a variety of diseases in humans and animals and frequently shows multidrug resistance. Here, we report the first genome sequence of an ST131-ExPEC strain from poultry carrying the plasmid-encoded colistin resistance gene mcr-1 .

scholarly journals Antimicrobial resistance among canine enteric Escherichia coli isolates and prevalence of attaching–effacing and extraintestinal pathogenic virulence factors in Spain

2020 ◽  
Vol 68 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Eloisa Sevilla ◽  
Raúl C. Mainar-Jaime ◽  
Bernardino Moreno ◽  
Inmaculada Martín-Burriel ◽  
Mariano Morales ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Multidrug Resistance ◽  
Antimicrobial Resistance ◽  
Virulence Factors ◽  
Shiga Toxin ◽  
E Coli ◽  
Extended Spectrum ◽  
Specific Virulence

AbstractThe aim of this study was to estimate the prevalence of antimicrobial resistance (AMR) in Escherichia coli from a dog population in Spain and assess specific virulence factors. Susceptibility to 22 antimicrobials was tested along with the production of extended-spectrum β-lactamases (ESBLs) and AmpC in faecal isolates from 100 dogs. Virulence-related genes associated with attaching and effacing E. coli (eae, Stx1, Stx2) and extraintestinal pathogenic E. coli – ExPEC – (papC, hlyA and cnf1) were detected by PCR. At least one kind of AMR was observed in 73% of the isolates. The highest prevalences corresponded to penicillin (45%), aminoglycoside (40%) and non-extended spectrum cephalosporin (39%) classes. Multidrug resistance (MDR) was observed in 53.4% of the resistant isolates. No resistance to colistin was found. Production of ESBL/AmpC enzymes was detected in 5% of E. coli. Shiga toxin-producing E. coli were not observed, enteropathogenic E. coli were identified in only 12% of them, and ExPEC were found in 25%. Dog faeces can be a source of E. coli strains potentially presenting a threat to humans through their virulence factors or AMR. The non-hygienic keeping of animals may increase the risk of colonisation of such pathogens in humans.

scholarly journals IncX2 and IncX1-X2 Hybrid Plasmids Coexisting in a FosA6-Producing Escherichia coli Strain

2017 ◽  
Vol 61 (7) ◽  
Author(s):  
Qinglan Guo ◽  
Jiachun Su ◽  
Christi Lee McElheny ◽  
Nicole Stoesser ◽  
Yohei Doi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Multidrug Resistance ◽  
Resistance Genes ◽  
Coli Strain ◽  
Colistin Resistance ◽  
Content Type ◽  
Accessory Genes

ABSTRACT IncX plasmids are receiving much attention as vehicles of carbapenem and colistin resistance genes, such as bla NDM, bla KPC, and mcr-1. Among them, IncX2 subgroup plasmids remain rare. Here, we characterized IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain that were possibly generated as a consequence of recombination events between an R6K-like IncX2 plasmid and a pLN126_33-like IncX1 plasmid. Variable multidrug resistance mosaic regions were observed in these plasmids, indicating their potential to serve as flexible carriers of resistance genes. The diversity of IncX group plasmid backbones and accessory genes and the evolution of hybrid IncX plasmids pose a challenge in detecting and classifying them.

scholarly journals A Retrospective Study of the Prevalence of Virulence Factors of Escherichia Coli Causing Postweaning Diarrhoea in Spain.

2021 ◽  
Author(s):  
Lorena Pérez Esteruelas ◽  
Miguel Claver Mateos ◽  
Pedro José Sánchez Uribe
Keyword(s):  
Escherichia Coli ◽  
Virulence Factors ◽  
Clinical Signs ◽  
Medicinal Products ◽  
High Prevalence ◽  
Pig Farms ◽  
Prevalent Disease ◽  
High Degree ◽  
Adhesion Factor ◽  
Veterinary Medicinal Products

Abstract Background: Postweaning diarrhoea is one of the most prevalent disease which occurs after weaning. The aim of the study reports the prevalence of virulence factors of Escherichia coli from clinical cases of postweaning diarrhoea on Spanish pig farms based on PCR directly from pooling of faeces samples. A total of 328 pig farms with acute cases of postweaning diarrhoea were sampled, between January 2018 and December 2020. These farms were all located in Spain. Animals were selected based on clinical signs (diarrhoea, dehydration, and increased mortality). A total of 984 four- to eight-week-old pigs within the first 24 hours of the acute phase of the disease were sampled and three rectal swabs were collected from three different pigs on each farm.Results: A total of 328 farms with PWD cases were analyzed between 2018 and 2020. The classification was based on the presence or absence of the different Escherichia coli’s virulence factors. Only 1.2% (4 out of 328) of farms were negative for all the Escherichia coli’s virulence genes. Adhesin involved in diffuse adherence was the most prevalent adhesion factor (68.6%) followed by F18 (67.7%) and F4 (53.4%). Conclusions: the present study shows the high prevalence Escherichia coli in postweaning diarrhoea cases. There is a high degree of variability in the Escherichia coli’s virulence factors within country as well as differences between countries. Further Investigation is needed to fight against postweaning diarrhoea since the use of zinc oxide will be withdrawn from veterinary medicinal products on 26 June 2022 [26,27]and the responsible use of antibiotics is being regulated very closely to be used only when is necessary.

Sign in / Sign up

Export Citation Format

Share Document