scholarly journals Early Diagnosis of Canine Hip Laxity: Correlation between Clinical Orthopedic Examinations and the FCI Scoring Method in a Closed Cohort of Rottweilers

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 416
Author(s):  
Britta Vidoni ◽  
Veronika Bauer ◽  
Barbara Bockstahler ◽  
Michaela Gumpenberger ◽  
Alexander Tichy ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Small Sample Size ◽  
Small Animal ◽  
Small Sample ◽  
Scoring Method ◽  
Angle Measurements ◽  
Examination Time ◽  
Breed Differences ◽  
Positive Correlations ◽  
Canine Hip Dysplasia

Canine hip dysplasia is a multifactorial disorder characterized by hip laxity and osteoarthritis. The early diagnosis of hip laxity is an important topic in small animal orthopedics. This study aimed to evaluate the correlation between clinical orthopedic examinations and the Fédération Cynologique Internationale (FCI) scoring method. Thirty purebred Rottweilers were examined at approximately four (20 ± 2 weeks), eight (35 ± 2 weeks), and twelve months of age (54 ± 1 weeks), respectively. The Ortolani, Barlow, and Bardens tests and reduction/subluxation angle measurements were performed at each time. FCI scoring was conducted at the third examination time. Positive correlations were recorded between the reduction angle and Ortolani test, reduction angle and FCI score, and Ortolani test and FCI score for the second and third examination dates. No correlation was observed between the subluxation angle and other methods. Despite previous studies reporting 16–20 weeks as the earliest age for diagnosing hip laxity in dogs, in our study, early diagnosis was possible from the age of 35 ± 2 weeks. This difference might originate from the small sample size, low number of the dogs with severe grades of laxity, and breed differences.

scholarly journals Fainter harder brighter softer: a correlation between αox, X-ray spectral state, and Eddington ratio in tidal disruption events

2020 ◽  
Vol 497 (1) ◽  
pp. L1-L6
Author(s):  
Thomas Wevers
Keyword(s):  
Small Sample Size ◽  
Galactic Nuclei ◽  
Small Sample ◽  
Tidal Disruption ◽  
X Ray ◽  
Relative Contribution ◽  
Positive Correlations ◽  
Optical Surveys ◽  
X Ray Binaries ◽  
Mass Functions

Abstract We explore the accretion states of tidal disruption events (TDEs) using a sample of seven X-ray bright sources. To this end, we estimate the relative contribution of the disc and corona to the observed X-ray emission through spectral modelling, and assess the X-ray brightness (through αox, L$_{2\ \rm keV}$, and fEdd,X) as a function of the Eddington ratio. We report strong positive correlations between αox and fEdd,bol; fEdd,X and fEdd,UV; and an anticorrelation for L$_{2\ \rm keV}$ and fEdd,UV. TDEs at high fEdd,bol have thermal dominated X-ray spectra and high (soft) αox, whereas those at low fEdd,bol show a significant power-law contribution and low (hard) αox. Similar to X-ray binaries and active galactic nuclei, the transition between X-ray spectral states occurs around fEdd,bol ≈ 0.03, although the uncertainty is large due to the small sample size. Our results suggest that X-ray surveys are more likely to discover TDEs at low fEdd,bol, whereas optical surveys are more sensitive to TDEs at high Eddington ratios. The X-ray and optical selected TDEs have different UV and X-ray properties, which should be taken into account when deriving rates, luminosity, and black hole mass functions.

scholarly journals Human milk for neonatal pain relief during ophthalmoscopy

2013 ◽  
Vol 47 (5) ◽  
pp. 1039-1045 ◽  
Author(s):  
Laiane Medeiros Ribeiro ◽  
Thaila Correa Castral ◽  
Liciane Langona Montanholi ◽  
Mariana Firmino Dare ◽  
Aline Carolina de Araujo Silva ◽  
...  
Keyword(s):  
Pain Relief ◽  
Early Diagnosis ◽  
Human Milk ◽  
Premature Infants ◽  
Neonatal Intensive Care ◽  
Small Sample Size ◽  
Small Sample ◽  
University Hospital ◽  
Experimental Investigations ◽  
Significant Difference

Ophthalmoscopy performed for the early diagnosis of retinopathy of prematurity (ROP) is painful for preterm infants, thus necessitating interventions for minimizing pain. The present study aimed to establish the effectiveness of human milk, compared with sucrose, for pain relief in premature infants subjected to ophthalmoscopy for the early diagnosis of ROP. This investigation was a pilot, quasi-experimental study conducted with 14 premature infants admitted to the neonatal intensive care unit (NICU) of a university hospital. Comparison between the groups did not yield a statistically significant difference relative to the crying time, salivary cortisol, or heart rate (HR). Human milk appears to be as effective as sucrose in relieving acute pain associated with ophthalmoscopy. The study’s limitations included its small sample size and lack of randomization. Experimental investigations with greater sample power should be performed to reinforce the evidence found in the present study.

scholarly journals Towards Usable E-Health

2017 ◽  
Vol 08 (02) ◽  
pp. 470-490 ◽  
Author(s):  
Vanessa Sousa ◽  
Karen Dunn Lopez
Keyword(s):  
Systematic Review ◽  
Small Sample Size ◽  
Data Extraction ◽  
Small Sample ◽  
Ease Of Use ◽  
Future Research ◽  
Quality Appraisal ◽  
Scoring Method ◽  
Cognitive Limitations ◽  
Data Extraction Tool

SummaryBackground: The use of e-health can lead to several positive outcomes. However, the potential for e-health to improve healthcare is partially dependent on its ease of use. In order to determine the usability for any technology, rigorously developed and appropriate measures must be chosen.Objectives: To identify psychometrically tested questionnaires that measure usability of e-health tools, and to appraise their generalizability, attributes coverage, and quality.Methods: We conducted a systematic review of studies that measured usability of e-health tools using four databases (Scopus, PubMed, CINAHL, and HAPI). Non-primary research, studies that did not report measures, studies with children or people with cognitive limitations, and studies about assistive devices or medical equipment were systematically excluded. Two authors independently extracted information including: questionnaire name, number of questions, scoring method, item generation, and psychometrics using a data extraction tool with pre-established categories and a quality appraisal scoring table.Results: Using a broad search strategy, 5,558 potentially relevant papers were identified. After removing duplicates and applying exclusion criteria, 35 articles remained that used 15 unique questionnaires. From the 15 questionnaires, only 5 were general enough to be used across studies. Usability attributes covered by the questionnaires were: learnability (15), efficiency (12), and satisfaction (11). Memorability (1) was the least covered attribute. Quality appraisal showed that face/content (14) and construct (7) validity were the most frequent types of validity assessed. All questionnaires reported reliability measurement. Some questionnaires scored low in the quality appraisal for the following reasons: limited validity testing (7), small sample size (3), no reporting of user centeredness (9) or feasibility estimates of time, effort, and expense (7).Conclusions: Existing questionnaires provide a foundation for research on e-health usability. However, future research is needed to broaden the coverage of the usability attributes and psychometric properties of the available questionnaires.Citation: Sousa VEC, Lopez KD. Towards usable e-health: A systematic review of usability questionnaires. Appl Clin Inform 2017; 8: 470–490 https://doi.org/10.4338/ACI-2016-10-R-0170

Promoting early dementia diagnosis: a video designed by patients, for patients

2016 ◽  
Vol 29 (5) ◽  
pp. 863-867 ◽  
Author(s):  
Nina Baruch ◽  
Charlotte L. Allan ◽  
Maureen Cundell ◽  
Samuel Clark ◽  
Brian Murray
Keyword(s):  
Early Diagnosis ◽  
Small Sample Size ◽  
Small Sample ◽  
Memory Clinic ◽  
Patient Feedback ◽  
Before And After ◽  
Diagnosis Of Dementia ◽  
Memory Clinics ◽  
Advance Decisions ◽  
Level Of Understanding

ABSTRACTEarly diagnosis of dementia allows people to access effective treatment and make advance decisions while they still have capacity. We aimed to encourage people to attend memory clinic, in order to boost rates of diagnosis. We created a patient information video about Oxford Health NHS Foundation Trust Memory Clinics, to inform and empower those awaiting assessment and to promote early diagnosis.Fourteen people (patients, carers, and staff) were approached prior to developing the video to ascertain their views on the themes the video should cover. The video consisted of unscripted interviews with patients, carers, and staff. We surveyed participants and new patients attending memory clinic to get feedback on the video and to assess patients’ level of understanding and confidence about a memory assessment before and after watching the video. The video content was refined based on this feedback and a final version was produced.Patient feedback demonstrated that confidence and understanding increased after watching the video.Although this study is limited by its small sample size and lack of access to those with undiagnosed dementia, feedback suggested that the video empowered and reassured those awaiting assessment and could be used as a tool to reduce barriers to early diagnosis. Patients and carers involved in making the video found it a therapeutic activity in itself.

scholarly journals Transcriptome Analysis Identifies Novel Prognostic Genes in Osteosarcoma

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Junfeng Chen ◽  
Xiaojun Guo ◽  
Guangjun Zeng ◽  
Jianhua Liu ◽  
Bin Zhao
Keyword(s):  
Regression Model ◽  
Risk Model ◽  
Cox Regression ◽  
Small Sample Size ◽  
Small Sample ◽  
Prognostic Biomarkers ◽  
Survival Prediction ◽  
Scoring Method ◽  
Cox Regression Model ◽  
Primary Bone Tumor

Osteosarcoma (OS), a malignant primary bone tumor often seen in young adults, is highly aggressive. The improvements in high-throughput technologies have accelerated the identification of various prognostic biomarkers for cancer survival prediction. However, only few studies focus on the prediction of prognosis in OS patients using gene expression data due to small sample size and the lack of public datasets. In the present study, the RNA-seq data of 82 OS samples, along with their clinical information, were collected from the TARGET database. To identify the prognostic genes for the OS survival prediction, we selected the top 50 genes of contribution as the initial candidate genes of the prognostic risk model, which were ranked by random forest model, and found that the prognostic model with five predictors including CD180, MYC, PROSER2, DNAI1, and FATE1 was the optimal multivariable Cox regression model. Moreover, based on a multivariable Cox regression model, we also developed a scoring method and stratified the OS patients into groups of different risks. The stratification for OS patients in the validation set further demonstrated that our model has a robust performance. In addition, we also investigated the biological function of differentially expressed genes between two risk groups and found that those genes were mainly involved with biological pathways and processes regarding immunity. In summary, the identification of novel prognostic biomarkers in OS would greatly assist the prediction of OS survival and development of molecularly targeted therapies, which in turn benefit patients’ survival.

scholarly journals Demographic, physiological, psychological, and on-ice performance indicators predict plus/minus status of recreational ice hockey players across a season

2020 ◽  
Vol 50 (4) ◽  
pp. 463-469
Author(s):  
Claudio R. Nigg ◽  
Andreas Gessner ◽  
Carina Nigg ◽  
Marco Giurgiu ◽  
Rainer Neumann
Keyword(s):  
Performance Indicators ◽  
Small Sample Size ◽  
Small Sample ◽  
Ice Hockey ◽  
Medium Size ◽  
Recreational Athletes ◽  
Psychological Indicators ◽  
Hockey Players ◽  
Task Cohesion ◽  
Positive Correlations

Abstract Little is known about physical, physiological, and psychological performance indicators predicting recreational athletes’ performance. This information may motivate players to become more active and inform coaches where to focus to build confidence, cohesion, and cooperation. This study investigated which performance indicators were related to the plus-minus statistic in German recreational ice hockey players (n = 20 players; 1 female; mean age = 36.25 ± 12.91 years; height = 178.85 ± 8.64 cm; weight = 81.36 ± 12.89 kg; mean years of ice hockey experience = 5.68 ± 8.93) over a season. Anthropometrics, psychological and on-ice performance data were collected mid-season and plus-minus were recorded after each game. Due to the small sample size, significance interpretations are not meaningful; therefore, Cohen’s guidelines were used for r = 0.2 (small), r = 0.5 (medium) and r = 0.8 (large). Medium size positive correlations of plus/minus were found for push-ups (r = 0.52) and squats (r = 0.37). Small positive correlations were found for shot speed (r = 0.33), competitiveness orientation (r = 0.28), and years on team (r = 0.23). Small negative correlations were found for win orientation (r = −0.30), body mass index (r = −0.28), task cohesion (r = −0.24), and percent body fat (r = −0.20). Some performance and psychological indicators are related to recreational ice hockey players’ plus-minus statistic over a season. Coaches and players of recreational teams should focus on muscular strength and endurance, shooting speed, body composition, and enjoying the challenge of competition while lowering their win orientation.

Probing the ultrastructure of the mitotic and meiotic spindle in eggs: An expeditious approach based on semi-thin (0.25 μm) serial sections

1983 ◽  
Vol 41 ◽  
pp. 552-555
Author(s):  
Conly L. Rieder ◽  
S. Bowser ◽  
R. Nowogrodzki ◽  
K. Ross ◽  
G. Sluder
Keyword(s):  
Small Sample Size ◽  
Small Sample ◽  
Meiotic Spindle ◽  
Serial Sections ◽  
Mitotic Apparatus ◽  
Thin Sections ◽  
Cell Cycles ◽  
Ultrastructural Studies

Eggs have long been a favorite material for studying the mechanism of karyokinesis in-vivo and in-vitro. They can be obtained in great numbers and, when fertilized, divide synchronously over many cell cycles. However, they are not considered to be a practical system for ultrastructural studies on the mitotic apparatus (MA) for several reasons, the most obvious of which is that sectioning them is a formidable task: over 1000 ultra-thin sections need to be cut from a single 80-100 μm diameter egg and of these sections only a small percentage will contain the area or structure of interest. Thus it is difficult and time consuming to obtain reliable ultrastructural data concerning the MA of eggs; and when it is obtained it is necessarily based on a small sample size.We have recently developed a procedure which will facilitate many studies concerned with the ultrastructure of the MA in eggs. It is based on the availability of biological HVEM's and on the observation that 0.25 μm thick serial sections can be screened at high resolution for content (after mounting on slot grids and staining with uranyl and lead) by phase contrast light microscopy (LM; Figs 1-2).

Validating the Factor Structure of the Stigma of Suicide Scale–Short Form Spanish Version Among Healthcare Students

Crisis ◽  
2020 ◽  
pp. 1-5
Author(s):  
Ruthmarie Hernández-Torres ◽  
Paola Carminelli-Corretjer ◽  
Nelmit Tollinchi-Natali ◽  
Ernesto Rosario-Hernández ◽  
Yovanska Duarté-Vélez ◽  
...  
Keyword(s):  
Factor Structure ◽  
Structural Equation ◽  
Short Form ◽  
Small Sample Size ◽  
Small Sample ◽  
Spanish Version ◽  
Equation Modeling ◽  
Cross Sectional ◽  
Healthcare Students ◽  
Spanish Speaking

Abstract. Background: Suicide is a leading cause of death among Spanish-speaking individuals. Suicide stigma can be a risk factor for suicide. A widely used measure is the Stigma of Suicide Scale-Short Form (SOSS-SF; Batterham, Calear, & Christensen, 2013 ). Although the SOSS-SF has established psychometric properties and factor structure in other languages and cultural contexts, no evidence is available from Spanish-speaking populations. Aim: This study aims to validate a Spanish translation of the SOSS-SF among a sample of Spanish-speaking healthcare students ( N = 277). Method: We implemented a cross-sectional design with quantitative techniques. Results: Following a structural equation modeling approach, a confirmatory factor analysis (CFA) supported the three-factor model proposed by Batterham and colleagues (2013) . Limitations: The study was limited by the small sample size and recruitment by availability. Conclusion: Findings suggest that the Spanish version of the SOSS-SF is a valid and reliable tool with which to examine suicide stigma among Spanish-speaking populations.

An Initial Investigation of Suicide Attempt Disclosures Among US Veterans

Crisis ◽  
2020 ◽  
pp. 1-7
Author(s):  
Brooke A. Ammerman ◽  
Sarah P. Carter ◽  
Heather M. Gebhardt ◽  
Jonathan Buchholz ◽  
Mark A. Reger
Keyword(s):  
Suicide Attempt ◽  
Mental Health Professionals ◽  
Help Seeking ◽  
Psychiatric Treatment ◽  
Small Sample Size ◽  
Romantic Partners ◽  
Small Sample ◽  
Professional Care ◽  
Patient Disclosure ◽  
Previous Suicide Attempt

Abstract. Background: Patient disclosure of prior suicidal behaviors is critical for effectively managing suicide risk; however, many attempts go undisclosed. Aims: The current study explored how responses following a suicide attempt disclosure may relate to help-seeking outcomes. Method: Participants included 37 veterans with a previous suicide attempt receiving inpatient psychiatric treatment. Veterans reported on their most and least helpful experiences disclosing their suicide attempt to others. Results: Veterans disclosed their suicide attempt to approximately eight individuals. Mental health professionals were the most cited recipient of their most helpful disclosure; romantic partners were the most common recipient of their least helpful disclosures. Positive reactions within the context of the least helpful disclosure experience were positively associated with a sense of connection with the disclosure recipient. Positive reactions within the most helpful disclosure experience were positively associated with the likelihood of future disclosure. No reactions were associated with having sought professional care or likelihood of seeking professional care. Limitations: The results are considered preliminary due to the small sample size. Conclusion: Findings suggest that while positive reactions may influence suicide attempt disclosure experiences broadly, additional research is needed to clarify factors that drive the decision to disclose a suicide attempt to a professional.

Investigating the Dynamics of Suicidal Ideation

Crisis ◽  
2018 ◽  
Vol 39 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Nina Hallensleben ◽  
Lena Spangenberg ◽  
Thomas Forkmann ◽  
Dajana Rath ◽  
Ulrich Hegerl ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Small Sample Size ◽  
Unipolar Depression ◽  
Small Sample ◽  
History Of ◽  
Severity Of Depression ◽  
Ecological Momentary ◽  
Depressive Episodes ◽  
Ema Method ◽  
Shed Light

Abstract. Background: Although the fluctuating nature of suicidal ideation (SI) has been described previously, longitudinal studies investigating the dynamics of SI are scarce. Aim: To demonstrate the fluctuation of SI across 6 days and up to 60 measurement points using smartphone-based ecological momentary assessments (EMA). Method: Twenty inpatients with unipolar depression and current and/or lifetime suicidal ideation rated their momentary SI 10 times per day over a 6-day period. Mean squared successive difference (MSSD) was calculated as a measure of variability. Correlations of MSSD with severity of depression, number of previous depressive episodes, and history of suicidal behavior were examined. Results: Individual trajectories of SI are shown to illustrate fluctuation. MSSD values ranged from 0.2 to 21.7. No significant correlations of MSSD with several clinical parameters were found, but there are hints of associations between fluctuation of SI and severity of depression and suicidality. Limitations: Main limitation of this study is the small sample size leading to low power and probably missing potential effects. Further research with larger samples is necessary to shed light on the dynamics of SI. Conclusion: The results illustrate the dynamic nature and the diversity of trajectories of SI across 6 days in psychiatric inpatients with unipolar depression. Prediction of the fluctuation of SI might be of high clinical relevance. Further research using EMA and sophisticated analyses with larger samples is necessary to shed light on the dynamics of SI.

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