scholarly journals Red Cell Distribution Width Has a Negative Prognostic Role in Dogs with Myxomatous Mitral Valve Disease

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 778
Author(s):  
Carlo Guglielmini ◽  
Chiara Martina Valentini ◽  
Barbara Contiero ◽  
Carlotta Valente ◽  
Helen Poser
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Disease ◽  
Complete Blood Count ◽  
Cox Proportional Hazards ◽  
Valve Disease ◽  
Red Cell Distribution Width ◽  
Hematological Parameter ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

Red cell distribution width (RDW) is a quantitative measurement of anisocytosis. This hematological parameter is an important prognostic biomarker for different cardiovascular disorders in humans but its influence on survival has been poorly investigated in dogs with cardiovascular disease. The RDW and various clinical, complete blood count, serum biochemical and echocardiographic variables were retrospectively investigated in 146 client-owned dogs with myxomatous mitral valve disease (MMVD) at various disease stages, with or without concurrent diseases and treatment. Laboratory variables, including RDW, urea, and white blood cell (WBC), in addition to the echocardiographic variable left atrium to aorta ratio were found to be independent predictors of all-cause mortality at six months in a multivariable Cox proportional hazards regression model. In particular, the hazard ratio of RDW was 1.203 (95% confidence interval = 1.045–1.384; p = 0.010). The negative effect of increased RDW on outcome was confirmed using Kaplan–Meier curve analysis. The results of this study indicate that RDW acted as an independent predictor of negative outcome in dogs with MMVD.

scholarly journals Red cell distribution width and mortality in pediatric sepsis

2017 ◽  
Vol 56 (6) ◽  
pp. 320 ◽  
Author(s):  
Trina Devina ◽  
Munar Lubis ◽  
Erna Mutiara ◽  
Gema Nazri Yanni ◽  
Rina Amalia C. Saragih ◽  
...  
Keyword(s):  
Complete Blood Count ◽  
Cross Sectional Study ◽  
Red Cell Distribution Width ◽  
Hematological Parameter ◽  
Red Cell ◽  
Cell Distribution ◽  
Chi Square ◽  
Cross Sectional ◽  
Distribution Width ◽  
Pediatric Sepsis

Background Red cell distribution width (RDW) is a hematological parameter routinely obtained as part of the complete blood count. Recently, RDW has emerged as a potential independent predictor of clinical outcomes in adults with sepsis. However, RDW as a mortality predictor in pediatric populations has not been well established.Objective To determine the relationship between RDW value and mortality outcomes in pediatric sepsis patients.Methods We performed a cross-sectional study of 40 consecutive pediatric patients with sepsis admitted to the PICU from December 2013 to March 2014. All patients’ RDW were collected within 24 hours of sepsis diagnosis. We determined the association between RDW and hemoglobin (Hb) using Spearman’s correlation. The RDW values of 11.5-14.5% were considered to be normal while those > 14.5% were considered to be elevated. We compared mortality and PICU length of stay (LoS) between the normal and elevated RDW groups using Chi-square and Mann-Whitney tests.Results The median age of patients was 34 months (range 2 months to 17 years). There were 28 (70%) male subjects. Subjects’ median RDW was 14.8% (range 11.2-27.8%) and was not correlated with Hb (r=0.056; P=0.73). Mortality rates in the normal and elevated RDW groups were 40% and 45%, respectively. There were no significant associations between RDW group and mortality (P=0.749) or PICU LoS (P=0.350).Conclusion Unlike in adults, RDW values are not correlated with mortality in pediatric sepsis patients. 

scholarly journals Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Shadae R. Foster ◽  
Lowell L. Dilworth ◽  
Jean Sparks ◽  
Ruby L. Alexander-Lindo ◽  
Felix O. Omoruyi
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Amylase Activity ◽  
Diabetic Rats ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Type 2 Diabetic

This study evaluated the effect of combined inositol hexakisphosphate (IP6) and inositol supplement on organ weight, intestinal ATPase activities, complete blood count, and serum analytes in streptozotocin (STZ)-induced type 2 diabetic rats. High-fat diet and a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) were used to induce type 2 diabetes mellitus in Sprague–Dawley rats. The diabetic groups were then treated with either combined IP6 and inositol supplement or glibenclamide for four weeks. Organ weights, intestinal ATPase activities, complete blood count, serum α-amylase, total protein, albumin, and globulin content were determined. Pancreatic weight was significantly reduced while relative kidney and liver weights were elevated in the group treated with combined IP6 and inositol supplement compared to the nondiabetic control. Serum α-amylase activity for the glibenclamide and combination treated groups was significantly improved compared to that of the untreated diabetic group. Red cell distribution width percentage was significantly lower in the combination treated group compared to that in the untreated diabetic group, while intestinal ATPase activities were unaffected by the treatment regime. Combined IP6 and inositol supplement consumption may protect people with diabetes from increased risk of cardiovascular diseases due to the supplement's ability to maintain red cell distribution width percentage towards the normal control group.

Abstract 14819: The Red Cell Distribution Width Predicts Mortality among Patients Free from Systemic Inflammation

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Benjamin D Horne ◽  
Joseph B Muhlestein ◽  
Sterling T Bennett ◽  
Jeffrey L Anderson
Keyword(s):  
Complete Blood Count ◽  
Collaborative Study ◽  
High Sensitivity ◽  
Red Cell Distribution Width ◽  
Causal Mechanism ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Mortality And Morbidity ◽  
Markers Of Inflammation

Background: The causal mechanism is unknown for why the red cell distribution width (RDW) predicts mortality and morbidity outcomes. One explanation is an inflammatory process: statistically significant, weak magnitude correlations (r<0.30) have been found between RDW and markers of inflammation. This study evaluated the association of RDW with mortality in patients with normal levels of inflammation, as indicated by normal high-sensitivity C-reactive protein (hsCRP) and white blood cell count (WBC). Methods: Intermountain Heart Collaborative Study patients undergoing coronary angiography (N=650) from 1994-2000 were evaluated if they never smoked, were free of acute myocardial infarction (MI), and had baseline hsCRP≤3 mg/L, WBC>4 K/μL, and WBC≤10.6 K/μL. RDW and WBC were tested clinically at index hospitalization via the complete blood count; hsCRP testing used stored research samples. Subjects were followed until December, 2013, and all-cause mortality was determined from hospital records, Utah death certificates, and US Social Security data. Results: Age averaged 66.7±11.6 years, 31.1% were female, and 62.9% died during a mean follow-up of 15.2±1.6 years (range:12.6-19.6 years). Continuous RDW predicted mortality after adjustment for demographics, risk factors, comorbidities, and baseline treatments (hazard ratio [HR]=1.15 per +1%, 95% CI=1.06, 1.26; p=0.002). In quartiles, this was significant for Q4 vs. Q1 (survival 23.6% vs. 43.4%, HR=1.56, CI=1.17, 2.08; p=0.003), but not Q2 (HR=1.18, p=0.29) or Q3 (HR=1.08, p=0.60) vs.Q1. In subjects with hsCRP<1 mg/L (n=259), RDW (adj. HR=1.13 per +1%, CI=0.99, 1.29, p=0.08) and RDW quartiles [Q2: adj. HR=1.70 (p=0.036), Q3: HR=1.88 (p=0.020), Q4: HR=1.97 (p=0.013) vs. Q1] predicted mortality. Among subjects free from heart failure (LVEF≥40%), diabetes, prior or current coronary disease, prior MI, stroke, renal failure, COPD, and depression (n=66), RDW had adjusted HR=1.70 per +1% (CI=1.06, 2.75; p=0.029). Conclusions: RDW predicted mortality in patients with normal hsCRP and WBC. This suggests that RDW marks the risk of a breadth of health concerns, likely including but not limited to inflammation. Further investigation is required to explain the causes of RDW elevation.

Association of elevated red cell distribution width and overall survival in multiple myeloma.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 8534-8534
Author(s):  
Sam Rubinstein ◽  
Elizabeth Sigworth ◽  
Qingxia M Chen ◽  
Sandip Chaugai ◽  
Robert F. Cornell ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Overall Survival ◽  
Complete Blood Count ◽  
Staging System ◽  
Cox Proportional Hazards Model ◽  
Red Cell Distribution Width ◽  
Mechanistic Study ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

8534 Background: The most widely used multiple myeloma (MM) staging system, the Revised International Staging System (R-ISS), is based on lactate dehydrogenase, albumin, cytogenetics, and beta-2 microglobulin (B2M). B2M has limited clinical utility, is often only obtained to compute R-ISS, and is often a send-out test. Prior studies have shown that elevated red cell distribution width (RDW), a common test that is part of the routine complete blood count, is associated with reduced overall survival (OS) in MM. We hypothesized that a MM staging system could be constructed replacing B2M with RDW. Methods: Patients treated at Vanderbilt University Medical Center from 2000 to 2018 with cancer registry-confirmed MM diagnoses were included. OS was computed by registry-curated death and diagnosis dates; living patients were censored at date last known alive or of last follow up. A Cox proportional hazards model determining the independent effects of R-ISS, age, and RDW on OS was built. An alternate staging system (RDW-SS) was developed, replacing the B2M cutoffs in R-ISS with RDW (stage 1: RDW < 14.0% stage 2: RDW 14.0-15.5%; stage 3: RDW > 15.5%). Cox models comparing RDW-SS and R-ISS after adjustment for age and category of induction therapy (proteasome inhibitor [PI] and immunomodulatory drug [IMiD]), PI only, IMiD only, other) were built. Results: In 604 MM patients with available data, RDW was independently associated with OS after adjustment (HR = 1.069 per 1% RDW increase, p < 0.001). RDW-SS stages were associated with reduced OS (RDW-SS 2 HR 1.52, 95% CI 1.09 – 2.11, p = 0.01; RDW-SS 3 HR 2.13, 95% CI 1.37 – 3.28, p < 0.001) after adjustment; R-ISS stages were not (Table). Conclusions: RDW at MM diagnosis was independently associated with reduced OS, after adjustment for the clinical factors of age and treatment exposure; notably, R-ISS was not. The RDW-SS is simpler to obtain than R-ISS and may have improved prognostic value pending independent validation. If confirmed, mechanistic study of the etiology of this relationship is warranted. [Table: see text]

scholarly journals Comparison of Red Cell Distribution Width (RDW) Value in Congestive Heart Failure (CHF) Patients with Normal Persons

2021 ◽  
Vol 8 (8) ◽  
pp. 27-30
Author(s):  
Marhani Yunita ◽  
Herman Hariman
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Cardiac Dysfunction ◽  
Red Cell Distribution Width ◽  
Hematological Parameter ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Normal People ◽  
Significant Difference

Congestive Heart Failure (CHF) is a complex clinical symptom that is often characterized by structural abnormalities or cardiac dysfunction that impairs the ability of the left ventricle (LV) to fill or pump blood, especially during physical activity. Red Cell Distribution Width (RDW) is a simple, fast, inexpensive and direct hematological parameter, which reflects the level of anisocytosis in vivo. The association between impaired hematopoiesis and cardiac dysfunction is based on the fact that many different conditions are associated with increased heterogeneity of erythrocyte volume, which can be concurrently present in patients with heart failure, while anisocytosis can also directly contribute to the development and worsening of heart failure. This study aims to provide a comparison of RDW values between CHF patients and normal people. This study uses a case control study design where as many as 20 people with CHF will be compared their RDW values with 20 normal people. From a total of 40 patients, the average RDW value in CHF patients was 17.7±2.4 higher than the average RDW value for normal people was 12.6±0.4 and from the results of statistical analysis using the Independent Student t test obtained p value <0.001. There is a significant difference between the RDW values of CHF patients compared to normal people. Keywords: Congestive Heart Failure, CHF, Red Cell Distribution Width, RDW.

Red cell Distribution Width as a Prognostic Predictor in Ventilator Associated Pneumonia

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hazem Mohamed Abd El Rahman Fawzi ◽  
Sherif George Anis Said ◽  
Ashraf Nabil Saleh ◽  
Heba Osama Abd Elnabi
Keyword(s):  
Prognostic Value ◽  
Complete Blood Count ◽  
Red Cell Distribution Width ◽  
Ventilator Associated Pneumonia ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Mechanically Ventilated ◽  
Life Threatening ◽  
Group 2

Abstract Background Ventilator-associated pneumonia (VAP) is the most frequent life-threatening nosocomial infection in intensive care units. It develops in patients mechanically ventilated for at least 48 hours. Objective To evaluate if red cell distribution width has a prognostic value in ventilator associated pneumonia. Patients and Methods This retrospective study included adult patients (&gt; 18 years) who were admitted to ICU and mechanically ventilated a total of 50 patients who were divided into 2 groups: Group 1 (includes 25 patients): patients who were mechanically ventilated then developed ventilator associated pneumonia. Group 2 (includes 25 controls): patients who were mechanically ventilated didn't develop pneumonia during course of ventilation. Results In the current study RDW (red cell distribution width) is significantly higher in patients with pneumonia at the end of the study, also RDW is significantly higher in poor outcome in all study patients regardless developed pneumonia or not during MV. Conclusion RDW is used as an inexpensive index that is routinely reported as a part of the complete blood count, RDW is an important marker for both diagnostic and prognostic purposes in all cause mortality in ICU patients not specifically in mechanically ventilated patients. Larger studies and clinical trials are recommended to determine the clinical outcome of RDW prognostic value in VAP.

scholarly journals Correlation Between Red Cell Distribution Width and Peripheral Vascular Disease Severity and Complexity

2019 ◽  
Vol 7 (7) ◽  
pp. 77
Author(s):  
Satılmış ◽  
Karabulut
Keyword(s):  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Clinical Laboratory ◽  
Complete Blood Count ◽  
Clinical Importance ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Peripheral Vascular ◽  
Distribution Width

A traditional hematological marker, red cell distribution width (RDW), is accepted as a novel marker of atherosclerotic vascular diseases. Clinical importance of the RDW as a prognostic biomarker in peripheral vascular disease (PVD) has been reported in a few studies. Herein, we aimed to show the correlation between RDW and PVD severity and its complexity in terms of angiographic evaluation. A total of 118 patients who underwent peripheral lower extremity angiography were subsequently evaluated retrospectively. Upon admission, RDW level was measured with automated complete blood count. Severity and complexity of the PVD was evaluated according to Trans-Atlantic Inter-Society Consensus (TASC II) classification. A TASC II A-B lesion was defined as simple PVD, and a TASC II C-D lesion was defined as prevalent and complex PVD. Then, both groups were compared statistically according to clinical, laboratory, and demographic features, including RDW levels. In 49.6% of the patients, TASC II C-D lesions were observed. Advanced age, male gender, and body mass index (BMI) were associated with TASC II groups. Red cell distribution width levels were correlated with presence of PVD, as well as TASC II grades (p:0.02). The fourth quartile (75th percentile) of the RDW levels was 14.1, and patients with RDW levels ≥14.1 had a more significant correlation with the presence and severity of PVD (p:0.001). In the multivariate regression analysis, elevated RDW was found to be an independent predictor of the presence of PVD and also TASC II C-D lesions (OR:2.26, with a 95% confidence interval (CI) 0.051–0.774; p:0.02). Elevated RDW levels was associated with TASC II C-D lesions, which indicated more prevalent and complex PVD.

scholarly journals Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children

2020 ◽  
Vol 6 (4) ◽  
pp. 00278-2019
Author(s):  
Daniel Morell-Garcia ◽  
Núria Toledo-Pons ◽  
Pilar Sanchis ◽  
Josep Miquel Bauça ◽  
José María Sánchez ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Sleep Apnoea ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
C Reactive Protein ◽  
Distribution Width ◽  
Reactive Protein ◽  
Severity Prediction

IntroductionRed cell distribution width (RDW) is a parameter included in the complete blood count which informs about the size of the circulating red blood cell population and its distribution. In adults, an increase in RDW was shown to be associated both with obstructive sleep apnoea (OSA) and with an increase in cardiovascular mortality. The aim of this study was to determine whether RDW is a potential biomarker for screening children with moderate–severe OSA.MethodsAn observational study in snoring patients was performed. All patients underwent a sleep study and were classified either as simple snorers (apnoea–hypopnoea index (AHI) <1 event·h−1) or as patients with OSA (mild AHI ≥1 to <5 events·h−1; moderate–severe AHI ≥5 events·h−1). Blood analyses (complete blood count and C-reactive protein) were performed for every individual.ResultsA total of 175 individuals were recruited. The mean age was 8.3±3.6 years. Correlation studies between RDW and several sleep-related parameters showed negative significant associations with minimum oxygen saturation, and positive significant associations with oxygen desaturation index (≥3% and ≥4%), AHI and the arousal index. A predictive model for paediatric severe OSA (AHI ≥5 events·h−1) was found based on mean corpuscular haemoglobin concentration (MCHC) <34.9 g·dL−1 and RDW >13.1% values, adjusting for body mass index z-score and age (area under the curve 0.657; p=0.004). In addition, differences were found in eosinophil count and C-reactive protein concentrations among the three subgroups.ConclusionsIn children, RDW stands out as a biomarker associated with the severity of OSA. The use of RDW and MCHC could be a simple but useful tool for the severity prediction of paediatric OSA in snoring patients.

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