scholarly journals Osseointegration of Maxillary Dental Implants in Diabetes Mellitus Patients: A Randomized Clinical Trial Human Histomorphometric Study

2020 ◽  
Vol 10 (19) ◽  
pp. 6762
Author(s):  
Lyly Sam ◽  
Siriporn Chattipakorn ◽  
Pathawee Khongkhunthian
Keyword(s):  
Type 2 Diabetes ◽  
Bone Formation ◽  
Dental Implants ◽  
Pearson Correlation ◽  
Titanium Implant ◽  
Control Group ◽  
Healthy Controls ◽  
New Bone Formation ◽  
Implant Surface

Background: Survival of dental implants in well-controlled Type 2 diabetes (T2DM) was found to be comparable to that in healthy patients. However, to our best knowledge, there have been no studies of the bone histomorphometry of osseointegration in patients with Type 2 diabetes. Purpose: To compare bone-implant-contact (BIC) and new bone formation between well-controlled Type 2 diabetes with HbA1c of less than 8% and healthy controls. Methods: 10 diabetic (T2DM) patients and 10 healthy controls were selected. Each patient received a 2.5 mm × 5 mm micro-implant in the maxilla, in either the premolar or first molar area. After 8 weeks of healing, the micro-implant was retrieved using a trephine bur and sent for bone histomorphometric analysis. A commercial titanium implant was immediately placed as the conventional treatment. Results: The mean BIC (30.73%) in T2DM patients was significantly lower than in the healthy patients (41.75%) (p = 0.01). New bone formation around the implant surface was reduced in T2DM patients (36.25%) compared to that in the control group (44.14%) (p = 0.028). The Pearson correlation coefficient revealed a strong correlation between increased HbA1c and decreased BIC (p < 0.05) and decreased new bone formation (p < 0.05). Conclusions: Within the limitation of this study, bone-to-implant contact and bone healing around dental implants in T2DM patients were significantly lower than in healthy patients.

Aldosterone Induces Vasoconstriction in Individuals with Type 2 Diabetes: Effect of Acute Antioxidant Administration

2020 ◽  
Author(s):  
Stine Høyer Finsen ◽  
Mie Rytz Hansen ◽  
Pernille B Lærkegaard Hansen ◽  
Stefan P Mortensen
Keyword(s):  
Type 2 Diabetes ◽  
Blood Flow ◽  
Plasma Aldosterone ◽  
Control Group ◽  
High Dose ◽  
Healthy Controls ◽  
Leg Blood Flow ◽  
Arterial Blood ◽  
Increased Risk

Abstract Context Individuals with type 2 diabetes have an increased risk of endothelial dysfunction and cardiovascular disease. Plasma aldosterone could contribute by reactive oxygen species–dependent mechanisms by inducing a shift in the balance between a vasoconstrictor and vasodilator response to aldosterone. Objective We aimed to investigate the acute vascular effects of aldosterone in individuals with type 2 diabetes compared with healthy controls and if infusion of an antioxidant (n-acetylcysteine [NAC]) would alter the vascular response. Methods In a case–control design, 12 participants with type 2 diabetes and 14 healthy controls, recruited from the general community, were studied. Leg hemodynamics were measured before and during aldosterone infusion (0.2 and 5 ng min–1 [L leg volume]–1) for 10 minutes into the femoral artery with and without coinfusion of NAC (125 mg kg–1 hour–1 followed by 25 mg kg–1 hour–1). Leg blood flow and arterial blood pressure was measured, and femoral arterial and venous blood samples were collected. Results Compared with the control group, leg blood flow and vascular conductance decreased during infusion of aldosterone at the high dose in individuals with type 2 diabetes, whereas coinfusion of NAC attenuated this response. Plasma aldosterone increased in both groups during aldosterone infusion and there was no difference between groups at baseline or during the infusions. Conclusion These results suggests that type 2 diabetes is associated with a vasoconstrictor response to physiological levels of infused aldosterone and that the antioxidant NAC diminishes this response.

Direct Current Electric Stimulation in Implant Osseointegration: An Experimental Animal Study With Sheep

2013 ◽  
Vol 39 (6) ◽  
pp. 671-679 ◽  
Author(s):  
Guhan Dergin ◽  
Mustafa Akta ◽  
Bahar Gürsoy ◽  
Yalçin Devecioglu ◽  
Mehmet Kürkçü ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dental Implants ◽  
Direct Current ◽  
Electric Stimulation ◽  
Bone Fractures ◽  
Late Phase ◽  
Biochemical Properties ◽  
Control Group ◽  
New Bone Formation ◽  
Significant Difference

In an effort to obtain a high-quality bone-implant interface, several methods involving alteration of surface morphological, physicochemical, and biochemical properties are being investigated. The aim of our study was to increase the osseointegration rate and quality and decrease the waiting period of dental implants before loading by using a microelectric implant stimulator device. It imitates microelectrical signals, which occur in bone fractures described in terms of piezoelectric theory. A single dental implant (Zimmer Dental), 3.7 mm in diameter, was inserted into the tibia of sheep bilaterally. Twenty-four dental implants were inserted into 12 sheep. Implant on the tibia of each sheep was stimulated with 7.5 μA direct current (DC), while the other side did not receive any stimulation and served as a control. Animals were sacrificed 1, 2, and 3 months after implantation. Bone segments with implants were processed with unclassified method. The determination of new bone formation and osseointegration around the dental implants was investigated by means of undecalcified method, histomorphologically. No statistically significant difference in bone-to-implant contact (BIC) ratio, osteoblastic activity, and new bone formation was found between the stimulation group and the control group at the late phase of healing (4, 8, and 12 weeks). No evidence was found that electric stimulation with implanted 7.5 μA DC is effective at late phase implant osseointegration on a sheep experimental model.

scholarly journals Histological and Histomorphometrical Evaluation of a New Implant Macrogeometry. A Sheep Study

2020 ◽  
Vol 17 (10) ◽  
pp. 3477 ◽  
Author(s):  
Sergio Alexandre Gehrke ◽  
Margherita Tumedei ◽  
Jaime Aramburú Júnior ◽  
Tiago Luis Eirles Treichel ◽  
Roni Kolerman ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dental Implants ◽  
Test Group ◽  
Titanium Implants ◽  
Control Group ◽  
New Bone Formation ◽  
Conventional Design ◽  
Random Fashion ◽  
Apical Direction

Decompression or healing chambers between the threads have been proposed to improve and accelerate the osseointegration process of dental implants. The aim of the present work was to test, in an in vivo sheep study, if healing chambers between the threads could produce a better osseointegration process. Thirty titanium implants (15 conventional design (control) and 15 implants with healing chambers (test)) were inserted in a random fashion in the tibia of 3 sheep. The animals were euthanized after 30 days of healing, and the retrieved specimens treated to obtain thin ground sections. Histological observations showed that the quantity of newly formed bone growing in an apical direction was lower in the control group (1095 µm) when compared to the Test group (1658 µm). This difference was statistically significant. Moreover, a layer of osteogenic matrix was present around the portion of implants immersed in the marrow spaces. This osteogenic tissue was thicker in the test group. In conclusion, the present study confirmed the very good results in implants with healing chambers that presented a higher percentage of new bone formation.

scholarly journals Relationship Between Serum Ferritin Level and Hba1c in Bangladeshi Type 2 Diabetic Patients

2018 ◽  
Vol 9 (1) ◽  
pp. 29-33
Author(s):  
Farhana Khondker ◽  
Manindra Nath Roy ◽  
Purnima Rani Saha ◽  
Rubena Huq ◽  
Rumana Ahmed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Pearson Correlation ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Endocrine Disorders ◽  
Medical College

Background: Diabetes mellitus (DM) type 2 is one of the most common endocrine disorders affecting more than 135 million people in the world. The etiology of the disease is not fully understood, but recently subclinical hemochromatosis has been considered as one of the probable causes of DM. This study was carried out to examine the relationship between serum ferritin as a marker of iron overload with DM and HbA1c.Materials & Method: This study was conducted in the Biochemistry department of Sir Salimullah Medical College, Dhaka; over a period of 18 months from July 2013 to December 2014. In this case control study, 46 patients with type 2 diabetes were taken as case, who were referred to theoutpatient department of "Ibrahim General Hospital & Diabetic care & Educational Center"(DCEC). 46 normal individuals were included as the control group, who were matched with the case group regarding age, sex, BMI and Hb%. Ferritin, hemoglobin, HbA1c and fasting plasma sugar were measured in blood samples. Exclusion criteria included anaemia, or any other disease or drug that could affect ferritin levels.Result: Results were analyzed statistically by Chi-square test, Student's t-test, Pearson correlation coefficient test and Odds ratio.Mean serum ferritin was significantly higher in diabetics than in the control group (197.97±75.99 µgm/L vs. 64.24±27.83 µgm/L, p<0.001). There was significant positive correlation between serum ferritin and HbA1cin diabetic patients (p<0.001). In this study, OR of 11.64 was also found.Conclusion: Serum ferritin is positively correlated with type 2 Diabetes Mellitus. And this may be an important and independent predictor for development of diabetes mellitus.Anwer Khan Modern Medical College Journal Vol. 9, No. 1: Jan 2018, P 29-33

Estimations of muscle interstitial insulin, glucose, and lactate in type 2 diabetic subjects

2000 ◽  
Vol 279 (5) ◽  
pp. E1097-E1103 ◽  
Author(s):  
Mikaela Sjöstrand ◽  
Agneta Holmäng ◽  
Lena Strindberg ◽  
Peter Lönnroth
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Blood Flow ◽  
Glucose Uptake ◽  
Normal Subjects ◽  
Control Group ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Leg Blood Flow

Previous measurement of insulin in human muscle has shown that interstitial muscle insulin and glucose concentrations are ∼30–50% lower than in plasma during hyperinsulinemia in normal subjects. The aims of this study were to measure interstitial muscle insulin and glucose in patients with type 2 diabetes to evaluate whether transcapillary transport is part of the peripheral insulin resistance. Ten patients with type 2 diabetes and ten healthy controls matched for sex, age, and body mass index were investigated. Plasma and interstitial insulin, glucose, and lactate (measured by intramuscular in situ-calibrated microdialysis) in the medial quadriceps femoris muscle were analyzed during a hyperinsulinemic euglycemic clamp. Blood flow in the contralateral calf was measured by vein plethysmography. At steady-state clamping, at 60–120 min, the interstitial insulin concentration was significantly lower than arterial insulin in both groups (409 ± 86 vs. 1,071 ± 99 pmol/l, P < 0.05, in controls and 584 ± 165 vs. 1,253 ± 82 pmol/l, P < 0.05, in diabetic subjects, respectively). Interstitial insulin concentrations did not differ significantly between diabetic subjects and controls. Leg blood flow was significantly higher in controls (8.1 ± 1.2 vs. 4.4 ± 0.7 ml · 100 g−1· min−1in diabetics, P < 0.05). Calculated glucose uptake was less in diabetic patients compared with controls (7.0 ± 1.2 vs. 10.8 ± 1.2 μmol · 100 g−1· min−1, P < 0.05, respectively). Arterial and interstitial lactate concentrations were both higher in the control group (1.7 ± 0.1 vs. 1.2 ± 0.1, P < 0.01, and 1.8 ± 0.1 vs. 1.2 ± 0.2 mmol/l, P < 0.05, in controls and diabetics, respectively). We conclude that, during hyperinsulinemia, muscle interstitial insulin and glucose concentrations did not differ between patients with type 2 diabetes and healthy controls despite a significantly lower leg blood flow in diabetic subjects. It is suggested that decreased glucose uptake in type 2 diabetes is caused by insulin resistance at the cellular level rather than by a deficient access of insulin and glucose surrounding the muscle cell.

scholarly journals Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

2012 ◽  
Vol 27 (8) ◽  
pp. 1773-1783 ◽  
Author(s):  
Rene Olivares-Navarrete ◽  
Andrew L Raines ◽  
Sharon L Hyzy ◽  
Jung Hwa Park ◽  
Daphne L Hutton ◽  
...  
Keyword(s):  
Bone Formation ◽  
Titanium Implant ◽  
New Bone Formation ◽  
Implant Surface ◽  
Surface Features ◽  
Osteoblast Maturation ◽  
Titanium Implant Surface

Effects of Autogenous Tooth Bone Graft and Platelet-Rich Fibrin in Peri-Implant Defects: An Experimental Study in an Animal Model

2020 ◽  
Vol 46 (3) ◽  
pp. 221-226
Author(s):  
Alper Kızıldağ ◽  
Ufuk Tasdemir ◽  
Taner Arabacı ◽  
Canan Aksu Kızıldağ ◽  
Mevlüt Albayrak ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Dental Implants ◽  
Bone Healing ◽  
Bone Defects ◽  
Control Group ◽  
Graft Material ◽  
New Bone Formation ◽  
Platelet Rich Fibrin ◽  
Bone To Implant Contact

The aim of this study was to evaluate the effect of autogenous tooth bone graft (ATBG) combined with platelet-rich fibrin (PRF) on bone healing in rabbit peri-implant osseous defects. Eighteen New Zealand rabbits were divided into 3 groups. Bone defects were prepared in each rabbit, and then an implant cavity was created in the defects. Dental implants were placed, and the peri-implant bone defects were treated with the following 3 methods: no graft material was applied in the control group, bone defects were treated with ATBG in the ATBG group, and bone defects were treated with ATBG combined with PRF in the ATBG+PRF group. After 28 days, the rabbits were sacrificed, and the dental implants with surrounding bone were removed. New bone formation and the percentage of bone-to-implant contact (BIC) were determined with histomorphometric evaluations. New bone formation was significantly higher in the ATBG+PRF group than the control and ATBG groups (P &lt; .05). In addition, BIC was significantly higher in the ATBG+PRF group than in the control and ATBG groups (P &lt; .05). The combination of ATBG with PRF contributed to bone healing in rabbits with peri-implant bone defects.

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Shah Namrata Vinubhai ◽  
Pardeep Agarwal ◽  
Bushra Fiza ◽  
Ramkishan Jat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Ferritin ◽  
Inflammatory Marker ◽  
Control Group ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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