scholarly journals Systematic Review of Exposure to Bisphenol A Alternatives and Its Effects on Reproduction and Thyroid Endocrine System in Zebrafish

2021 ◽  
Vol 11 (4) ◽  
pp. 1837
Author(s):  
Jiyun Lee ◽  
Kyong Whan Moon ◽  
Kyunghee Ji
Keyword(s):  
Bisphenol A ◽  
Endocrine System ◽  
Egg Yolk ◽  
Thyroid Stimulating Hormone ◽  
Limited Information ◽  
Bisphenol S ◽  
Hormone Production ◽  
Chemical Structures ◽  
Similar Chemical ◽  
Offspring Generation

Bisphenol A (BPA), which is widely used for manufacturing polycarbonate plastics and epoxy resins, has been banned from use in plastic baby bottles because of concerns regarding endocrine disruption. Substances with similar chemical structures have been used as BPA alternatives; however, limited information is available on their toxic effects. In the present study, we reviewed the endocrine disrupting potential in the gonad and thyroid endocrine system in zebrafish after exposure to BPA and its alternatives (i.e., bisphenol AF, bisphenol C, bisphenol F, bisphenol S, bisphenol SIP, and bisphenol Z). Most BPA alternatives disturbed the endocrine system by altering the levels of genes and hormones involved in reproduction, development, and growth in zebrafish. Changes in gene expression related to steroidogenesis and sex hormone production were more prevalent in males than in females. Vitellogenin, an egg yolk precursor produced in females, was also detected in males, confirming that it could induce estrogenicity. Exposure to bisphenols in the parental generation induced a decrease in the hatchability associated with offspring generation. In zebrafish exposed to bisphenols, significant decreases in thyroxine concentrations and increases in thyroid-stimulating hormone concentrations were commonly observed. Alternative compounds used to replace a chemical of concern are believed to be less toxic than the original compound; however, several BPA alternatives appear to have similar or greater effects on the endocrine system in zebrafish. Since endocrine systems interact with each other, further studies are needed to assess the primary target of BPA alternatives among the endocrine axes.

scholarly journals White rot fungi can be a promising tool for removal of bisphenol A, bisphenol S, and nonylphenol from wastewater

2020 ◽  
Vol 27 (32) ◽  
pp. 39958-39976 ◽  
Author(s):  
Agnieszka Grelska ◽  
Magdalena Noszczyńska
Keyword(s):  
Bisphenol A ◽  
Hormone Receptors ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
White Rot Fungi ◽  
Ligninolytic Enzymes ◽  
Rapid Expansion ◽  
White Rot ◽  
Bisphenol S ◽  
Promising Tool

Abstract Endocrine-disrupting chemicals (EDC) are a wide group of chemicals that interfere with the endocrine system. Their similarity to natural steroid hormones makes them able to attach to hormone receptors, thereby causing unfavorable health effects. Among EDC, bisphenol A (BPA), bisphenol S (BPS), and nonylphenol (NP) seem to be particularly harmful. As the industry is experiencing rapid expansion, BPA, BPS, and NP are being produced in growing amounts, generating considerable environmental pollution. White rot fungi (WRF) are an economical, ecologically friendly, and socially acceptable way to remove EDC contamination from ecosystems. WRF secrete extracellular ligninolytic enzymes such as laccase, manganese peroxidase, lignin peroxidase, and versatile peroxidase, involved in lignin deterioration. Owing to the broad substrate specificity of these enzymes, they are able to remove numerous xenobiotics, including EDC. Therefore, WRF seem to be a promising tool in the abovementioned EDC elimination during wastewater treatment processes. Here, we review WRF application for this EDC removal from wastewater and indicate several strengths and limitations of such methods.

scholarly journals Qsar Analysis of the Estrogen Activities of Bisphenol a Analogs using Multiple Linear Regression and Artificial Neural Network

2019 ◽  
Vol 35 (2) ◽  
Author(s):  
Vu Van Dat ◽  
Le Kim Long ◽  
Doan Van Phuc ◽  
Nguyen Hoang Trang ◽  
Nguyen Van Trang
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Artificial Neural Network ◽  
Linear Regression ◽  
Bisphenol A ◽  
Multiple Linear Regression ◽  
Bisphenol S ◽  
Qsar Analysis ◽  
Chemical Structures ◽  
Artificial Neural

Abstract. This study gives a quantitative structure-activity relationship (QSAR) analysis of the estrogen activities of bisphenol A and analogs. The chemical structures of 23 Bisphenol A analogs have been characterized by quantum-electronic descriptors. The present study was performed using multiple regression analysis (MLR) and artificial neural network (ANN). The quantitative model was accordingly proposed and the toxicity of the compounds was interpreted based on the multivariate statistical analysis. This study shows that the results obtained by MLR were suitable and have served to predict estrogen activities, but compared to the results of the ANN model, we conclude that the prediction achieved by the latter is more effective and better than MLR model. Following to the obtained results, our proposed model may be useful to predict of Estrogen activities and risk assessment of chemicals. Keywords QSAR, Bisphenol A, multiple linear regression, artificial neural network References [1] Rezg R, El-Fazaa S, Gharbi N, Mornagui B (March 2014). "Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives".Environment International 2014, 64, 83–90. [2] Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS (2010). Zhang, Baohong, ed."Association of Urinary Bisphenol a Concentration with Heart Disease: Evidence from NHANES 2003/06". PLoS ONE 5 (1). [3] Manikkam, M.; Tracey, R.; Guerrero-Bosagna, C.; Skinner, M. K. (January 24, 2013). "Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations".PLoS ONE 8 (1). 1–16. [4] D.R. Doerge, N.C. Twaddle, M. Vanlandingham, R.P. Brown, J.W. Fisher, Toxicol. Appl. Pharmacol. 2011, 255, 261.[5] Ho SM, Tang WY, Belmonte de Frausto J, Prins GS (2006). "Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4". Cancer Res. 66 (11): 5624–32. [6] Johanna R. Rochester and Ashley L. Bolden (2015 Jul) “Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes”. Environ Health Perspect123(7):643-50.[7] Kelly, P. C., William, A. T., Thomas, E. W., QSAR models of thein vitro estrogen activity of bisphenol A analogs, QSAR Comb.Sci., 2003, 22: 78―88.[8]. Frisch, M. J. T., G. W. et al , Gaussian 09, Revision D.01. Gaussian, Inc., Wallingford CT, 2009.[9]. Zhao, Y.; Truhlar, D., The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: two new functionals and systematic testing of four M06-class functionals and 12 other functionals. Theor Chem[10] J. Devillers (1996), Strengths and Weaknesses of the Backpropagation Neural Network in QSAR and QSPR Studies, in: J. Devillers (Ed.) Neural Networks in QSAR and Drug Design, Academic Press, London, pp.1-46.[11] K. Hornik (1991), AppSroximation capabilities of multilayer feedforward networks, Neural Networks, 4 251-257.[12] A. Adad, M. Larif, R. Hmamouchi, M. Bouachrine, T. Lakhlifi, J. Comp. Meth. Mol. Des. 4(3) (2014) 72-83.[13] A. Golbraikh, A. Tropsha, Beware of q2. J. Mol. Graphics Model. 20 (2002) 269–276.  

scholarly journals Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Mu Yuan ◽  
Ming-Zhu Bai ◽  
Xu-Feng Huang ◽  
Yue Zhang ◽  
Jing Liu ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Endocrine Disrupting Chemicals ◽  
Positive Association ◽  
Implantation Failure ◽  
Chemical Structures ◽  
Similar Chemical ◽  
Endocrine Disrupting ◽  
Estrogenic Properties ◽  
The Relationship ◽  
Human Fluids

Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.

scholarly journals Studies on the Modification of Commercial Bisphenol-A-Based Epoxy Resin Using Different Multifunctional Epoxy Systems

2021 ◽  
Vol 2 (2) ◽  
pp. 419-430
Author(s):  
Ankur Bajpai ◽  
James R. Davidson ◽  
Colin Robert
Keyword(s):  
Mechanical Properties ◽  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Bisphenol A ◽  
Epoxy Resin ◽  
Tensile Fracture ◽  
Chemical Structures ◽  
Amino Phenol ◽  
Epoxy Systems

The tensile fracture mechanics and thermo-mechanical properties of mixtures composed of two kinds of epoxy resins of different chemical structures and functional groups were studied. The base resin was a bi-functional epoxy resin based on diglycidyl ether of bisphenol-A (DGEBA) and the other resins were (a) distilled triglycidylether of meta-amino phenol (b) 1, 6–naphthalene di epoxy and (c) fluorene di epoxy. This research shows that a small number of multifunctional epoxy systems, both di- and tri-functional, can significantly increase tensile strength (14%) over neat DGEBA while having no negative impact on other mechanical properties including glass transition temperature and elastic modulus. In fact, when compared to unmodified DGEBA, the tri-functional epoxy shows a slight increase (5%) in glass transition temperature at 10 wt.% concentration. The enhanced crosslinking of DGEBA (90 wt.%)/distilled triglycidylether of meta-amino phenol (10 wt.%) blends may be the possible reason for the improved glass transition. Finally, the influence of strain rate, temperature and moisture were investigated for both the neat DGEBA and the best performing modified system. The neat DGEBA was steadily outperformed by its modified counterpart in every condition.

scholarly journals Synthesis and Biological Activity of New Brassinosteroid Analogs of Type 24-Nor-5β-Cholane and 23-Benzoate Function in the Side Chain

2021 ◽  
Vol 22 (9) ◽  
pp. 4808
Author(s):  
Nitza Soto ◽  
Karoll Ferrer ◽  
Katy Díaz ◽  
César González ◽  
Lautaro Taborga ◽  
...  
Keyword(s):  
Good Alternative ◽  
Positive Control ◽  
Starting Material ◽  
Chemical Structures ◽  
High Reaction ◽  
Similar Chemical ◽  
Synthetic Procedure ◽  
Hyodeoxycholic Acid ◽  
External Stresses

Brassinosteroids are polyhydroxysteroids that are involved in different plants’ biological functions, such as growth, development and resistance to biotic and external stresses. Because of its low abundance in plants, much effort has been dedicated to the synthesis and characterization of brassinosteroids analogs. Herein, we report the synthesis of brassinosteroid 24-nor-5β-cholane type analogs with 23-benzoate function and 22,23-benzoate groups. The synthesis was accomplished with high reaction yields in a four-step synthesis route and using hyodeoxycholic acid as starting material. All synthesized analogs were tested using the rice lamina inclination test to assess their growth-promoting activity and compare it with those obtained for brassinolide, which was used as a positive control. The results indicate that the diasteroisomeric mixture of monobenzoylated derivatives exhibit the highest activity at the lowest tested concentrations (1 × 10−8 and 1 × 10−7 M), being even more active than brassinolide. Therefore, a simple synthetic procedure with high reaction yields that use a very accessible starting material provides brassinosteroid synthetic analogs with promising effects on plant growth. This exploratory study suggests that brassinosteroid analogs with similar chemical structures could be a good alternative to natural brassinosteroids.

Gd3+ doped BiVO4 and visible light-emitting diodes (LED) for photocatalytic decomposition of bisphenol A, bisphenol S and bisphenol AF in water

2021 ◽  
pp. 105842
Author(s):  
Carolina Orona-Návar ◽  
Yuri Park ◽  
Varsha Srivastava ◽  
Netzahualpille Hernández ◽  
Jürgen Mahlknecht ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Visible Light ◽  
Light Emitting Diodes ◽  
Photocatalytic Decomposition ◽  
Bisphenol S ◽  
Light Emitting ◽  
Bisphenol Af

scholarly journals Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites

2017 ◽  
Vol 44 ◽  
pp. 287-302 ◽  
Author(s):  
Lalith Perera ◽  
Yin Li ◽  
Laurel A. Coons ◽  
Rene Houtman ◽  
Rinie van Beuningen ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Bisphenol A ◽  
Potential Interaction ◽  
Bisphenol S ◽  
Interaction Sites ◽  
Bisphenol Af ◽  
Stimulation Of

Molecular Motion Analysis of 5CB in PDLCs Using Solid-State 13C NMR Relaxation Spectroscopy

1993 ◽  
Vol 47 (7) ◽  
pp. 933-941 ◽  
Author(s):  
Karen L. Buchert ◽  
Jack L. Koenig ◽  
Shi-Qing Wang ◽  
John L. West
Keyword(s):  
Liquid Crystal ◽  
Solid State ◽  
Polymer Matrix ◽  
Nmr Relaxation ◽  
Domain Size ◽  
Chemical Structures ◽  
Similar Chemical ◽  
Polymer Dispersed ◽  
Submicron Droplets ◽  
Significant Change

In samples of polymer-dispersed liquid crystals (PDLCs), submicron droplets of liquid crystal reside within a polymer matrix. By the use of the cross polarization technique for solid-state 13C NMR spectroscopy, the NMR spectrum of the liquid crystal can be obtained without interference from the polymer spectrum, even though the two materials have some similar chemical structures. Both 13C T1 and 13C T1 ρ relaxation experiments were performed on a PDLC system of 5CB in epoxy as a function of 5CB domain size. The 13C T1 relaxation constants and the localized motions they measure showed no significant change over the liquid crystal domain size studied. However, the 13C T1 ρ relaxation constants and the segmental motions of molecules they measure revealed a significant change over the liquid crystal domain size studied. Therefore, the 13C T1 ρ values can be used to determine the change in mobility of the molecular segments of the SCB molecules resulting from increased interaction between the liquid crystal and the polymer matrix and to further understand the importance of the molecular motions of the liquid crystal in the switching phenomenon for PDLC materials.

Bisphenol A, Bisphenol AF, and Bisphenol S - A comparison of pre- and postnatal endpoints

2018 ◽  
Vol 80 ◽  
pp. 32
Author(s):  
Vicki L. Sutherland ◽  
Barry McIntyre ◽  
Helen Cunny ◽  
Suramya Waidyanatha ◽  
Jui-Hua Hsieh ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Bisphenol S ◽  
Bisphenol Af
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