scholarly journals Using a Human Interviewer or an Automatic Interviewer in the Evaluation of Patients with AD from Speech

2021 ◽  
Vol 11 (7) ◽  
pp. 3228
Author(s):  
Jesús B. Alonso-Hernández ◽  
María Luisa Barragán-Pulido ◽  
José Manuel Gil-Bordón ◽  
Miguel Ángel Ferrer-Ballester ◽  
Carlos M. Travieso-González
Keyword(s):  
Alzheimer’S Disease ◽  
Feature Extraction ◽  
Automatic System ◽  
Visual Stimuli ◽  
Spontaneous Speech ◽  
Automatic Analysis ◽  
Cross Sectional ◽  
Control Subjects ◽  
Discriminatory Capacity ◽  
Evolutionary Control

Currently, there are more and more frequent studies focused on the evaluation of Alzheimer’s disease (AD) from the automatic analysis of the speech of patients, in order to detect the presence of the disease in an individual or for the evolutionary control of the disease. However, studies focused on analyzing the effect of the methodology used to generate the spontaneous speech of the speaker who undergoes this type of analysis are rare. The objective of this work is to study two different strategies to facilitate the generation of the spontaneous speech of a speaker for further analysis: the use of a human interviewer that promotes the generation of speech through an interview and the use of an automatic system (an automatic interviewer) that invites the speaker to describe certain visual stimuli. In this study, a database called Cross-Sectional Alzheimer Prognosis R2019 has been created, consisting of speech samples from speakers recorded using both methodologies. The speech recordings have been studied through a feature extraction based on five basic temporal measurements. This study demonstrates the discriminatory capacity between the speakers with AD and the control subjects independent of the strategy used in the generation of spontaneous speech. These results are promising and can serve as a basis for knowing the effectiveness and extension of automated interview processes, especially in telemedicine and telecare scenarios.

scholarly journals Influence of visual stimuli on spatial navigation and memory of MCI, Alzheimer's disease patients and healthy control subjects

2017 ◽  
Vol 60 ◽  
pp. e88-e89
Author(s):  
Mélanie Cogné ◽  
Sophie Auriacombe ◽  
Louise Vasa ◽  
François Tison ◽  
Evelyne Klinger ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Spatial Navigation ◽  
Visual Stimuli ◽  
Control Subjects ◽  
Healthy Control

Profiling spontaneous speech decline in Alzheimer's disease: a longitudinal study

2013 ◽  
Vol 25 (6) ◽  
pp. 320-327 ◽  
Author(s):  
Katrina Forbes-McKay ◽  
Michael F Shanks ◽  
Annalena Venneri
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Phonological Processing ◽  
Longitudinal Design ◽  
Spontaneous Speech ◽  
Speech Impairment ◽  
Cross Sectional ◽  
Description Task ◽  
Prospective Longitudinal

ObjectiveThis study aims to document the nature and progression of spontaneous speech impairment suffered by patients with Alzheimer's disease (AD) over a 12-month period, using both cross-sectional and prospective longitudinal design.MethodsThirty one mild–moderate AD patients and 30 controls matched for age and socio-cultural background completed a simple and complex oral description task at baseline. The AD patients then underwent follow-up assessments at 6 and 12 months.ResultsCross-sectional comparisons indicated that mild–moderate AD patients produced more word-finding delays (WFDs) and empty and indefinite phrases, while producing fewer pictorial themes, repairing fewer errors, responding to fewer WFDs, produce shorter and less complex phrases and produce speech with less intonational contour than controls. However, the two groups could not be distinguished on the basis of phonological paraphasias. Longitudinal follow-up, however, suggested that phonological processing deteriorates over time, where the prevalence of phonological errors increased over 12 months.DiscussionConsistent with findings from neuropsychological, neuropathological and neuroimaging studies, the language deterioration shown by the AD patients shows a pattern of impairment dominated by semantic errors, which is later joined by a disruption in the phonological aspects of speech.

Validation of the Hungarian version of Alzheimer’s Disease Assessment Scale – Cognitive Subscale

2012 ◽  
Vol 153 (12) ◽  
pp. 461-466 ◽  
Author(s):  
Magdolna Pákáski ◽  
Gergely Drótos ◽  
Zoltán Janka ◽  
János Kálmán
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Assessment Scale ◽  
Disease Assessment ◽  
Control Subjects ◽  
Cognitive Subscale ◽  
State Examination ◽  
Hungarian Version

The cognitive subscale of the Alzheimer’s Disease Assessment Scale is the most widely used test in the diagnostic and research work of Alzheimer’s disease. Aims: The aim of this study was to validate and investigate reliability of the Hungarian version of the Alzheimer’s Disease Assessment Scale in patients with Alzheimer’s disease and healthy control subjects. Methods: syxty-six patients with mild and moderate Alzheimer’s disease and 47 non-demented control subjects were recruited for the study. The cognitive status was established by the Hungarian version of the Alzheimer’s Disease Assessment Scale and Mini Mental State Examination. Discriminative validity, the relation between age and education and Alzheimer’s Disease Assessment Scale, and the sensitivity and specificity of the test were determined. Results: Both the Mini Mental State Examination and the Alzheimer’s Disease Assessment Scale had significant potential in differentiating between patients with mild and moderate stages of Alzheimer’s disease and control subjects. A very strong negative correlation was established between the scores of the Mini Mental State Examination and the Alzheimer’s Disease Assessment Scale in the Alzheimer’s disease group. The Alzheimer’s Disease Assessment Scale showed slightly negative relationship between education and cognitive performance, whereas a positive correlation between age and Alzheimer’s Disease Assessment Scale scores was detected only in the control group. According to the analysis of the ROC curve, the values of sensitivity and specificity of the Alzheimer’s Disease Assessment Scale were high. Conclusions: The Hungarian version of the Alzheimer’s Disease Assessment Scale was found to be highly reliable and valid and, therefore, the application of this scale can be recommended for the establishment of the clinical stage and follow-up of patients with Alzheimer’s disease. However, the current Hungarian version of the Alzheimer’s Disease Assessment Scale is not sufficient; the list of words and linguistic elements should be selected according to the Hungarian standard in the future. Orv. Hetil., 2012, 153, 461–466.

scholarly journals A Survey on Classification algorithms of Brain Images in Alzheimer’s disease based on Feature Extraction techniques

IEEE Access ◽  
2021 ◽  
pp. 1-1
Author(s):  
Ruhul Amin Hazarika ◽  
Arnab Kumar Maji ◽  
Samarendra Nath Sur ◽  
Babu Sena Paul ◽  
Debdatta Kandar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Feature Extraction ◽  
Classification Algorithms ◽  
Extraction Techniques ◽  
Brain Images

scholarly journals Perceived stress and depressive symptoms not neuropsychiatric symptoms predict caregiver burden in Alzheimer’s disease: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Manee Pinyopornpanish ◽  
Kanokporn Pinyopornpanish ◽  
Atiwat Soontornpun ◽  
Surat Tanprawate ◽  
Angkana Nadsasarn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Depressive Symptoms ◽  
Caregiver Burden ◽  
Perceived Stress ◽  
Neuropsychiatric Symptoms ◽  
Cross Sectional Study ◽  
Assessment Tools ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background Caregiver burden affects the caregiver’s health and is related to the quality of care received by patients. This study aimed to determine the extent to which caregivers feel burdened when caring for patients with Alzheimer’s Disease (AD) and to investigate the predictors for caregiving burden. Methods A cross-sectional study was conducted. One hundred two caregivers of patients with AD at Maharaj Nakorn Chiang Mai Hospital, a tertiary care hospital, were recruited. Assessment tools included the perceived stress scale (stress), PHQ-9 (depressive symptoms), Zarit Burden Interview-12 (burden), Clinical Dementia Rating (disease severity), Neuropsychiatric Inventory Questionnaires (neuropsychiatric symptoms), and Barthel Activities Daily Living Index (dependency). The mediation analysis model was used to determine any associations. Results A higher level of severity of neuropsychiatric symptoms (r = 0.37, p < 0.01), higher level of perceived stress (r = 0.57, p < 0.01), and higher level of depressive symptoms (r = 0.54, p < 0.01) were related to a higher level of caregiver burden. The direct effect of neuropsychiatric symptoms on caregiver burden was fully mediated by perceived stress and depressive symptoms (r = 0.13, p = 0.177), rendering an increase of 46% of variance in caregiver burden by this parallel mediation model. The significant indirect effect of neuropsychiatric symptoms by these two mediators was (r = 0.21, p = 0.001). Conclusion Caregiver burden is associated with patients’ neuropsychiatric symptoms indirectly through the caregiver’s depressive symptoms and perception of stress. Early detection and provision of appropriate interventions and skills to manage stress and depression could be useful in reducing and preventing caregiver burden.

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