scholarly journals Changes in Plasma Bioactive Lipids and Inflammatory Markers during a Half-Marathon in Trained Athletes

2021 ◽  
Vol 11 (10) ◽  
pp. 4622
Author(s):  
Melania Gaggini ◽  
Cristina Vassalle ◽  
Fabrizia Carli ◽  
Maristella Maltinti ◽  
Laura Sabatino ◽  
...  
Keyword(s):  
Acute Exercise ◽  
Vascular Endothelial ◽  
Bioactive Lipids ◽  
Inflammatory Parameters ◽  
Markers Of Inflammation ◽  
Research Perspectives ◽  
Exercise Adaptation ◽  
Specific Species ◽  
Endothelial Growth Factor ◽  
Specific Lipid

Background: Exercise may affect lipid profile which in turn is related to inflammation, although changes of ceramides, diacylglycerols-DAG and sphingomyelin-SM and their relationship with inflammatory parameters following a half-marathon have never been examined. Methods: Ceramides, DAG and SM, and markers of inflammation (soluble fractalkine-CX3CL1, vascular endothelial growth factor-VEGF, interleukin6-IL-6 and tumor necrosis factorα-TNFα) were evaluated in trained half-marathoners before, post-race (withdrawal within 20 min after the race end) and 24 h after. Results: IL-6 and CX3CL1 increased immediately after the race, returning to baseline after 24 h. Total ceramides and total DAG significantly decreased post-race. Several ceramide classes decreased after exercise, while only one of the DAG (36:3) changed significantly. Total SM and specific species did not significantly change. Conclusion: Some inflammatory parameters (IL-6 and CX3CL1) transiently increased after the race, and, being reversible, these changes might represent a physiological response to acute exercise rather than a damage-related response. The decrease of specific lipid classes, i.e., DAGs and ceramides, and the lack of their relationship with inflammatory parameters, suggest their involvement in beneficial training effects, opening promising research perspectives to identify additional mechanisms of aerobic exercise adaptation.

Effect of Age and Acute Exercise on Circulating Angioregulatory Factors

2020 ◽  
pp. 1-8
Author(s):  
Meredith J. Luttrell ◽  
Benjamin R. Mardis ◽  
Joshua M. Bock ◽  
Erika Iwamoto ◽  
Satoshi Hanada ◽  
...  
Keyword(s):  
Older Adults ◽  
Vascular Endothelial Growth Factor ◽  
Acute Exercise ◽  
Striated Muscle ◽  
Age Groups ◽  
Vascular Endothelial ◽  
Similar Increase ◽  
Endothelial Growth Factor ◽  
Circulating Levels ◽  
Effect Of Age

The balance of angiogenic factors, including vascular endothelial growth factor (VEGF), and angiostatic factors, like thrombospondin-1 (TSP-1) and endostatin, controls striated muscle angiogenic responses to exercise training. The effect of age on circulating levels of these factors following a bout of exercise is unclear. The authors hypothesized that older adults would have lower circulating VEGF but higher TSP-1 and endostatin after exercise compared with young adults. Ten young and nine older participants cycled for 45 min at 60% estimated HRmax. Serum [VEGF], [TSP-1], and [endostatin] obtained before (PREX), immediately after (POSTX0), and 3 hr after (POSTX3) exercise were analyzed. [VEGF] increased in older adults only from PREX to POSTX0 (p < .05). [TSP-1] increased in both age groups (p < .05). There was no effect of age or exercise on [endostatin]. In conclusion, immediately after exercise, both groups had a similar increase in [TSP-1], but [VEGF] increased in older adults only.

Effect of training on the response of plasma vascular endothelial growth factor to exercise in patients with peripheral arterial disease

2006 ◽  
Vol 111 (6) ◽  
pp. 401-409 ◽  
Author(s):  
Rachel E. Wood ◽  
Brad E. Sanderson ◽  
Christopher D. Askew ◽  
Philip J. Walker ◽  
Simon Green ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Exercise Training ◽  
Acute Exercise ◽  
Oxygen Demand ◽  
Control Group ◽  
Vascular Endothelial ◽  
Walking Test ◽  
Before And After ◽  
Endothelial Growth Factor

Expansion of the capillary network, or angiogenesis, occurs following endurance training. This process, which is reliant on the presence of VEGF (vascular endothelial growth factor), is an adaptation to a chronic mismatch between oxygen demand and supply. Patients with IC (intermittent claudication) experience pain during exercise associated with an inadequate oxygen delivery to the muscles. Therefore the aims of the present study were to examine the plasma VEGF response to acute exercise, and to establish whether exercise training alters this response in patients with IC. In Part A, blood was collected from patients with IC (n=18) before and after (+20 and +60 min post-exercise) a maximal walking test to determine the plasma VEGF response to acute exercise. VEGF was present in the plasma of patients (45.11±29.96 pg/ml) and was unchanged in response to acute exercise. Part B was a training study to determine whether exercise training altered the VEGF response to acute exercise. Patients were randomly assigned to a treatment group (TMT; n=7) that completed 6 weeks of high-intensity treadmill training, or to a control group (CON; n=6). All patients completed a maximal walking test before and after the intervention, with blood samples drawn as for Part A. Training had no effect on plasma VEGF at rest or in response to acute exercise, despite a significant increase in maximal walking time in the TMT group (915±533 to 1206±500 s; P=0.009) following the intervention. The absence of a change in plasma VEGF may reflect altered VEGF binding at the endothelium, although this cannot be confirmed by the present data.

scholarly journals Persistent Elevation of Vascular Endothelial Growth Factor and Prostacyclin Following Cardiopulmonary Maladaptation to High Altitude: A Pilot study

2007 ◽  
Vol 30 (3) ◽  
pp. 42
Author(s):  
Vy-Van Le ◽  
Michel White ◽  
Rhian Touyz ◽  
Heather Ross ◽  
Yves Tessier ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Pilot Study ◽  
Growth Factor ◽  
High Altitude ◽  
Acute Mountain Sickness ◽  
Model Systems ◽  
Cardiac Transplant ◽  
Vascular Endothelial ◽  
Markers Of Inflammation ◽  
Endothelial Growth Factor

Background: Exposure to hypobaric hypoxemia causes acute mountain sickness (AMS) in 40% of subjects acutely exposed to an altitude of 4,000 m. Vascular endothelial growth factor (VEGF) and cytokines appear to play a role in AMS in model systems. The objective of this pilot study was to explore the change in VEGF, the vasodilatory prostacyclin PGI-2, interleukin-6 and thiobarbituric acid reactive substances (TBARS) levels following prolonged exposure to hypobaric hypoxemia on Bolivian Altiplano. The secondary objective was to investigate the relationship between these markers with good versus poor adaptation to high altitude. Methods: The study population consisted of 7 climbers aged 24-64 yr. One cardiac transplant and one kidney transplant recipients participated in this study. Aerobic capacity was assessed on a treadmill using a RAMP protocol with gas exchange analyses. Blood samples were harvested within 48 hr of departure and within 24 hr returning to sea level. Results: Selected biochemisty parameters are presented in the table: *** Table in Full Text PDF. *** Data are mean ±SD. CP= cardiopulmonary. Both cardiac and Tx recipients did not experience AMS. Maximum altitude achieved: ∗6120-6522; †5680; ‡5300 meters. Conclusions: Pulmonary maladaptation to high altitude results in a 2-fold elevated VEGF and PGI-2 without concomitant increase of markers of inflammation or oxidative stress. VEGF does not appear to increase in cerebral maladaptation to high altitude. Further investigations are needed to better understand the role of VEGF and other biomarkers during the process of adaptation or maladaptation to high altitude.

scholarly journals Diagnostic and prognostic role of markers of inflammation and vascular endothelial growth factor in infectious endocarditis

2017 ◽  
Vol 95 (7) ◽  
pp. 618-622
Author(s):  
Serafima Ya. Tazina ◽  
T. A. Fedorova ◽  
N. A. Semenenko ◽  
A. P. Roitman ◽  
V. I. Burtsev ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Markers Of Inflammation ◽  
Tnf Α ◽  
Analysis Of Dynamics ◽  
Severity Of The Disease ◽  
Factor Α ◽  
Endothelial Growth Factor

The peculiarities of primary and secondary infective endocarditis (IE) were studied in 62 patients with primary and secondary IE, uncomplicated and complicated disease treated in S. P. Botkin city clinical hospital including analysis of dynamics of tumor necrosis factor α (TNF α), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) within 3 weeks after the onset of antibiotic therapy. A rise in TNF α and IL-6 levels was shown to correlate with the severity of the disease and the development of infectious-toxic syndrome. Most patients had an increased level of VEGF, a mediator involved in the regulation of inflammation. It was shown that combination of high TNF-α and IL-6 levels with the initially low or gradually increasing VEGF levelsuggests the unfavourable prognosis characteristic of the most heavily diseased anddeceased patients.

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