scholarly journals Computational Modeling of Ultrasound C-Scan Imaging Using Transmitted Signal Peak Density

2021 ◽  
Vol 11 (11) ◽  
pp. 4924
Author(s):  
Koushik Paul ◽  
Jeremy Stromer ◽  
Samuel Razmi ◽  
Barbara A. Pockaj ◽  
Leila Ladani ◽  
...  

Ultrasound measurement is a relatively inexpensive and commonly used imaging tool in the health sector. The through-transmission process of ultrasound measurement has been extensively evaluated for detecting abnormalities in tissue pathology. Compared to standard imaging parameters such as amplitude and time of flight, quantitative ultrasound parameters in the frequency domain can provide additional details regarding tissue microstructures. In this study, pressure magnitude or amplitude variation in the frequency spectrum of the received signal was evaluated as a potential imaging technique using the spectral peak density parameter. Computational C-scan imaging analysis was developed through a finite element model. The magnitude variation in the received signal showed different patterns while interacting with and without inclusions. Images were reconstructed based on peak density values that varied with the presence of solid structure. The computational results were verified with the experimental C-scan imaging results from the literature. It was found that magnitude variation can be an effective parameter for C-scan imaging of thin structures. The feasibility of the study was further extended to identify the structure’s relative position along with the sample depth during C-scan imaging. While moving the structure in the direction of the sample depth, the pressure magnitude variation strongly followed a second-degree polynomial trend.

Author(s):  
Jeremy Stromer ◽  
Leila Ladani

Peak density is an ultrasound measurement, which has been found to vary according to microstructure, and is defined as the number of local extrema within the resulting power spectrum of an ultrasound measurement. However, the physical factors which influence peak density are not fully understood. This work studies the microstructural characteristics which affect peak density through experimental, computationa,l and analytical means for high-frequency ultrasound of 22–41 MHz. Experiments are conducted using gelatin-based phantoms with glass microsphere scatterers with diameters of 5, 9, 34, and 69 μm and number densities of 1, 25, 50, 75, and 100 mm−3. The experiments show the peak density to vary according to the configuration. For example, for phantoms with a number density of 50 mm−3, the peak density has values of 3, 5, 9, and 12 for each sphere diameter. Finite element simulations are developed and analytical methods are discussed to investigate the underlying physics. Simulated results showed similar trends in the response to microstructure as the experiment. When comparing scattering cross section, peak density was found to vary similarly, implying a correlation between the total scattering and the peak density. Peak density and total scattering increased predominately with increased particle size but increased with scatterer number as well. Simulations comparing glass and polystyrene scatterers showed dependence on the material properties. Twenty-four of the 56 test cases showed peak density to be statistically different between the materials. These values behaved analogously to the scattering cross section.


Geophysics ◽  
2020 ◽  
Vol 85 (6) ◽  
pp. Q27-Q37
Author(s):  
Yang Shen ◽  
Jie Zhang

Refraction methods are often applied to model and image near-surface velocity structures. However, near-surface imaging is very challenging, and no single method can resolve all of the land seismic problems across the world. In addition, deep interfaces are difficult to image from land reflection data due to the associated low signal-to-noise ratio. Following previous research, we have developed a refraction wavefield migration method for imaging shallow and deep interfaces via interferometry. Our method includes two steps: converting refractions into virtual reflection gathers and then applying a prestack depth migration method to produce interface images from the virtual reflection gathers. With a regular recording offset of approximately 3 km, this approach produces an image of a shallow interface within the top 1 km. If the recording offset is very long, the refractions may follow a deep path, and the result may reveal a deep interface. We determine several factors that affect the imaging results using synthetics. We also apply the novel method to one data set with regular recording offsets and another with far offsets; both cases produce sharp images, which are further verified by conventional reflection imaging. This method can be applied as a promising imaging tool when handling practical cases involving data with excessively weak or missing reflections but available refractions.


Geophysics ◽  
2020 ◽  
Vol 85 (6) ◽  
pp. S405-S416
Author(s):  
Xiaofeng Jia ◽  
Wenyang Chen ◽  
Bin Chen

Reverse time migration (RTM) is a powerful seismic imaging tool that suffers from high computational complexity when dealing with massive data. The simultaneous-shot method can effectively reduce the amount of migration by assembling several sources, although it adds crosstalk noise, which seriously affects the quality of the RTM results. To avoid this problem, we have adopted a time-domain scheme that combines time-delay encoding and amplitude encoding to reduce crosstalk artifacts in simultaneous-source imaging results. This scheme modulates the wavefields of multiple sources to fit the wavefield of a suspended super-virtual shot (SVS), which can eliminate crosstalk artifacts because they are absent in single SVS migration. Numerical examples on a steeply dipping model and the 2D SEG/EAGE salt model show the feasibility of the proposed method. SVS encoding can generate a qualified imaging result and takes less time than plane-wave encoding in the migration process.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaojun Yu ◽  
Chi Hu ◽  
Wenfei Zhang ◽  
Jie Zhou ◽  
Qianshan Ding ◽  
...  

Abstract Background Precise identification, discrimination and assessment of central nervous system (CNS) tumors is of critical importance to brain neoplasm treatment. Due to the complexity and limited resolutions of the existing diagnostic tools, however, it is difficult to identify the tumors and their boundaries precisely in clinical practice, and thus, the conventional way of brain neoplasm treatment relies mainly on the experiences of neurosurgeons to make resection decisions in the surgery process. The purpose of this study is to explore the potential of Micro-optical coherence tomography (μOCT) as an intraoperative diagnostic imaging tool for identifying and discriminating glioma and meningioma with their microstructure imaging ex vivo, which thus may help neurosurgeons to perform precise surgery with low costs and reduced burdens. Methods Fresh glioma and meningioma samples were resected from patients, and then slices of such samples were excised and imaged instantly ex vivo with a lab-built μOCT, which achieves a spatial resolution of ~ 2.0 μm (μm). The acquired optical coherence tomography (OCT) images were pathologically evaluated and compared to their corresponding histology for both tumor type and tumor grade discriminations in different cases. Results By using the lab-built μOCT, both the cross-sectional and en face images of glioma and meningioma were acquired ex vivo. Based upon the morphology results, both the glioma and meningioma types as well as the glioma grades were assessed and discriminated. Comparisons between OCT imaging results and histology showed that typical tissue microstructures of glioma and meningioma could be clearly identified and confirmed the type and grade discriminations with satisfactory accuracy. Conclusions μOCT could provide high-resolution three-dimensional (3D) imaging of the glioma and meningioma tissue microstructures rapidly ex vivo. μOCT imaging results could help discriminate both tumor types and grades, which illustrates the potential of μOCT as an intraoperative diagnostic imaging tool to help neurosurgeons perform their surgery precisely in tumor treatment process.


Author(s):  
K. N. Colonna ◽  
G. Oliphant

Harmonious use of Z-contrast imaging and digital image processing as an analytical imaging tool was developed and demonstrated in studying the elemental constitution of human and maturing rabbit spermatozoa. Due to its analog origin (Fig. 1), the Z-contrast image offers information unique to the science of biological imaging. Despite the information and distinct advantages it offers, the potential of Z-contrast imaging is extremely limited without the application of techniques of digital image processing. For the first time in biological imaging, this study demonstrates the tremendous potential involved in the complementary use of Z-contrast imaging and digital image processing.Imaging in the Z-contrast mode is powerful for three distinct reasons, the first of which involves tissue preparation. It affords biologists the opportunity to visualize biological tissue without the use of heavy metal fixatives and stains. For years biologists have used heavy metal components to compensate for the limited electron scattering properties of biological tissue.


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