scholarly journals Bayesian Inference of Vocal Fold Material Properties from Glottal Area Waveforms Using a 2D Finite Element Model

2019 ◽  
Vol 9 (13) ◽  
pp. 2735 ◽  
Author(s):  
Paul J. Hadwin ◽  
Mohsen Motie-Shirazi ◽  
Byron D. Erath ◽  
Sean D. Peterson

Bayesian estimation has been previously demonstrated as a viable method for developing subject-specific vocal fold models from observations of the glottal area waveform. These prior efforts, however, have been restricted to lumped-element fitting models and synthetic observation data. The indirect relationship between the lumped-element parameters and physical tissue properties renders extracting the latter from the former difficult. Herein we propose a finite element fitting model, which treats the vocal folds as a viscoelastic deformable body comprised of three layers. Using the glottal area waveforms generated by self-oscillating silicone vocal folds we directly estimate the elastic moduli, density, and other material properties of the silicone folds using a Bayesian importance sampling approach. Estimated material properties agree with the “ground truth” experimental values to within 3 % for most parameters. By considering cases with varying subglottal pressure and medial compression we demonstrate that the finite element model coupled with Bayesian estimation is sufficiently sensitive to distinguish between experimental configurations. Additional information not available experimentally, namely, contact pressures, are extracted from the developed finite element models. The contact pressures are found to increase with medial compression and subglottal pressure, in agreement with expectation.

Author(s):  
L. Hai ◽  
A. M. Al-Jumaily ◽  
A. Mirnajafi

The vibration characteristics of the vocal folds are investigated using a finite element model which incorporates the in-homogeneity and anisotropy of the materials and the irregularity of the geometry. The model employs the cover and body theory to build the structure of the vocal folds and implements measured viscoelastic properties of the mucosa and the transverse isotropic elastic properties of the muscles. It has the potential to simulate some vocal-fold disorders and determine the change in characteristics. To determine the oscillation characteristics of the folds, the eigenfrequency and eigenmodes of the finite element model are determined using the ABAQUS software. The model results compare well with some experiments performed on a silicon vocal fold. It is anticipated that the model will help to identify voice disorders such as vocal-fold paralysis and vocal-fold nodules.


2005 ◽  
Vol 114 (11) ◽  
pp. 847-852 ◽  
Author(s):  
David A. Berry ◽  
Haven Reininger ◽  
Fariborz Alipour ◽  
Diane M. Bless ◽  
Charles N. Ford

Objectives: A systematic study of the influence of vocal fold scarring on phonation was conducted. In particular, phonatory variables such as fundamental frequency, oral acoustic intensity, and phonation threshold pressure (PTP) were investigated as a function of the size and position of the laryngeal scar. Methods: By means of a finite element model of vocal fold vibration, the viscoelastic properties of both normal and scarred vocal fold mucosae were simulated on the basis of recent rheological data obtained from rabbit and canine models. Results: The study showed that an increase in the viscoelasticity of the scarred mucosa resulted in an increase in fundamental frequency, an increase in PTP, and a decrease in oral acoustic intensity. With regard to positioning of the scar, the PTP increased most significantly when the scar was within ±2 mm of the superior-medial junction of the vocal folds. Conclusions: The systematic data obtained in this investigation agree with the general clinical experience. In the future, these findings may be further validated on human subjects as newly emerging technologies such as linear skin rheometry and optical coherence tomography allow the histologic and viscoelastic properties of the normal and scarred vocal fold mucosae to be measured in the clinic.


Author(s):  
H. Lan ◽  
A. M. Al-Jumaily ◽  
A. Mirnajafi

During phonation, the vocal folds collision in the glottal closure is considered as a risk factor for pathology development. Based on the finite element model using the software ABAQUS™, the impact stresses between the vocal folds are studied.


Author(s):  
Sean M. Finley ◽  
J. Harley Astin ◽  
Evan Joyce ◽  
Andrew T. Dailey ◽  
Douglas L. Brockmeyer ◽  
...  

OBJECTIVE The underlying biomechanical differences between the pediatric and adult cervical spine are incompletely understood. Computational spine modeling can address that knowledge gap. Using a computational method known as finite element modeling, the authors describe the creation and evaluation of a complete pediatric cervical spine model. METHODS Using a thin-slice CT scan of the cervical spine from a 5-year-old boy, a 3D model was created for finite element analysis. The material properties and boundary and loading conditions were created and model analysis performed using open-source software. Because the precise material properties of the pediatric cervical spine are not known, a published parametric approach of scaling adult properties by 50%, 25%, and 10% was used. Each scaled finite element model (FEM) underwent two types of simulations for pediatric cadaver testing (axial tension and cardinal ranges of motion [ROMs]) to assess axial stiffness, ROM, and facet joint force (FJF). The authors evaluated the axial stiffness and flexion-extension ROM predicted by the model using previously published experimental measurements obtained from pediatric cadaveric tissues. RESULTS In the axial tension simulation, the model with 50% adult ligamentous and annulus material properties predicted an axial stiffness of 49 N/mm, which corresponded with previously published data from similarly aged cadavers (46.1 ± 9.6 N/mm). In the flexion-extension simulation, the same 50% model predicted an ROM that was within the range of the similarly aged cohort of cadavers. The subaxial FJFs predicted by the model in extension, lateral bending, and axial rotation were in the range of 1–4 N and, as expected, tended to increase as the ligament and disc material properties decreased. CONCLUSIONS A pediatric cervical spine FEM was created that accurately predicts axial tension and flexion-extension ROM when ligamentous and annulus material properties are reduced to 50% of published adult properties. This model shows promise for use in surgical simulation procedures and as a normal comparison for disease-specific FEMs.


Author(s):  
X. G. Tan ◽  
R. Kannan ◽  
Andrzej J. Przekwas

Until today the modeling of human body biomechanics poses many great challenges because of the complex geometry and the substantial heterogeneity of human body. We developed a detailed human body finite element model in which the human body is represented realistically in both the geometry and the material properties. The model includes the detailed head (face, skull, brain, and spinal cord), the skeleton, and air cavities (including the lung). Hence it can be used to accurately acquire the stress wave propagation in the human body under various loading conditions. The blast loading on the human surface was generated from the simulated C4 blast explosions, via a novel combination of 1-D and 3-D numerical formulations. We used the explicit finite element solver in the multi-physics code CoBi for the human body biomechanics. This is capable of solving the resulting large system containing millions of unknowns in an extremely scalable fashion. The meshes generated for these simulations are of good quality. This enables us to employ relatively large time step sizes, without resorting to the artificial time scaling treatment. In order to study the human body dynamic response under the blast loading, we also developed an interface to apply the blast pressure loading on the external human body surface. These newly developed models were used to conduct parametric simulations to find out the brain biomechanical response when the blasts impact the human body. Under the same blast loading we also show the differences of brain response when having different material properties for the skeleton, the existence of other body parts such as torso.


2017 ◽  
Vol 89 (2) ◽  
pp. 274-279
Author(s):  
Thomas Wright ◽  
Imran Hyder ◽  
Mitchell Daniels ◽  
David Kim ◽  
John P. Parmigiani

Purpose The purpose of this paper is to determine which of the ten material properties of the Hashin progressive damage model significantly affect the maximum load-carrying ability of center-notched carbon fiber panels under in-plane tension and out-of-plane bending. Design/methodology/approach The approach used is to calculate the maximum load using a finite element model for a range of material property values as specified by a fraction factorial design. The finite element model used has been experimentally validated in prior work. Findings Results showed that for the laminates considered, at most three and as few as one of the ten Hashin material properties significantly affected the magnitude of the maximum load. Practical implications While the results of this paper only specifically apply to the laminates included in the study, the results suggest that, in general, only a small number of the Hashin material properties affect laminate load-carrying ability. Originality/value Knowing which properties are significant is of value in selecting materials to optimize performance and also in determining which properties need to be known to a high accuracy.


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