scholarly journals MicroRNA as a Novel Biomarker in the Diagnosis of Head and Neck Cancer

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 844
Author(s):  
Jacek Kabzinski ◽  
Monika Maczynska ◽  
Ireneusz Majsterek
Keyword(s):  
Squamous Cell Carcinoma ◽  
Head And Neck ◽  
The Body ◽  
Future Research ◽  
Rna Molecules ◽  
Common Cancer ◽  
Non Coding Rna ◽  
Potential Problems ◽  
Patient Groups ◽  
Potential Use

Head and neck squamous cell carcinoma is the sixth most common cancer worldwide, with 890,000 new cases and 450,000 deaths in 2018, and although the survival statistics for some patient groups are improving, there is still an urgent need to find a fast and reliable biomarker that allows early diagnosis. This niche can be filled by microRNA, small single-stranded non-coding RNA molecules, which are expressed in response to specific events in the body. This article presents the potential use of microRNAs in the diagnosis of HNSCC, compares the advances in this field to other diseases, especially other cancers, and discusses the detailed use of miRNA as a biomarker in profiling and predicting the treatment outcome with radiotherapy and immunotherapy. Potential problems and difficulties related to the development of this promising technology, and areas on which future research should be focused in order to overcome these difficulties, were also indicated.

scholarly journals Differential expression and prognostic value of long non-coding RNA in HPV-negative head and neck squamous cell carcinoma

Head & Neck ◽  
2018 ◽  
Vol 40 (7) ◽  
pp. 1555-1564 ◽  
Author(s):  
Sulsal-Ul Haque ◽  
Liang Niu ◽  
Damaris Kuhnell ◽  
Jacob Hendershot ◽  
Jacek Biesiada ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Differential Expression ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Neck Squamous Cell Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients

Reproduction ◽  
2014 ◽  
Vol 148 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Fulu Dong ◽  
Yuan Zhang ◽  
Fei Xia ◽  
Yi Yang ◽  
Sidong Xiong ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Molecular Mechanisms ◽  
Target Genes ◽  
Expression Profiles ◽  
Normal Pregnancy ◽  
Recurrent Spontaneous Abortion ◽  
Future Research ◽  
Rna Molecules ◽  
Non Coding Rna ◽  
Transcriptional Gene Regulation

MicroRNAs (miRNAs) are non-coding RNA molecules of about 22 nucleotides that involved in post-transcriptional gene regulation. Evidence indicates that miRNAs play essential roles in endometriosis, pre-eclampsia, infertility and other reproductive system diseases. However, whether miRNAs are involved in recurrent spontaneous abortion (RSA) is unclear. In this work, we analysed the miRNA expression profiles in six pairs of villus or decidua from RSA patients and normal pregnancy (NP) women using a human miRNA microarray. Some of the chip results were confirmed by RT-qPCR. In the villi of RSA patients, expression of hsa-miR-184, hsa-miR-187 and hsa-miR-125b-2 was significantly higher, while expression of hsa-miR-520f, hsa-miR-3175 and hsa-miR-4672 was significantly lower, comparing with those of NP control. As well, a total of five miRNAs (hsa-miR-517c, hsa-miR-519a-1, hsa-miR-522, hsa-miR-520h and hsa-miR-184) were upregulated in the decidua of RSA patients. The target genes of these differentially expressed miRNAs were predicted by miRWalk, and we speculate a network of miRNA regulating RSA by target genes function on adhesion, apoptosis and angiogenesis. Our study may help clarify the molecular mechanisms which are involved in the progression of RSA, and provide a reference for future research.

scholarly journals Circulating small non coding RNA signature in head and neck squamous cell carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (22) ◽  
pp. 19246-19263 ◽  
Author(s):  
Berta Victoria Martinez ◽  
Joseph M. Dhahbi ◽  
Yury O. Nunez Lopez ◽  
Katarzyna Lamperska ◽  
Paweł Golusinski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Non Coding Rna ◽  
Rna Signature

scholarly journals Expression of the long non-coding RNA HOTAIR as a prognostic factor in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (42) ◽  
pp. 73029-73036 ◽  
Author(s):  
Giuseppe Troiano ◽  
Vito Carlo Alberto Caponio ◽  
Linda Boldrup ◽  
Xiaolian Gu ◽  
Lorenzo Lo Muzio ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Clinical Potential of miRNAs in Human and Infectious Diseases

2020 ◽  
Author(s):  
Malak Haidar ◽  
Gordon Langlsey
Keyword(s):  
Infectious Diseases ◽  
Human Disease ◽  
Host Response ◽  
Disease Development ◽  
General Outline ◽  
Rna Molecules ◽  
Non Coding Rna ◽  
Therapeutic Tools ◽  
Clinical Potential ◽  
Potential Use

MicroRNAs (miRNAs) are small non-coding RNA molecules that play critical roles in human disease. Several miRnome profiling studies have identified miRNAs deregulated in cancer and infectious diseases and miRNAs are also involved in regulation of the host response to infection. Thereby, the usage of miRNAs as biomarkers and potential treatments for both human and infectious diseases is under development. This review will provide insights into the contribution of miRNAs to pathogenesis and disease development and will present a general outline of the potential use of miRNAs as therapeutic tools.

scholarly journals A „szabad” nukleinsavak jelentősége a noninvazív diagnosztikában

2016 ◽  
Vol 157 (48) ◽  
pp. 1900-1909 ◽  
Author(s):  
Bálint Nagy ◽  
Zoltán Csanádi ◽  
Róbert Póka
Keyword(s):  
Physiological Role ◽  
Clinical Diagnostics ◽  
The Body ◽  
Rna Molecules ◽  
Non Invasive ◽  
Physiological Processes ◽  
Specificity And Sensitivity ◽  
Non Coding Rna ◽  
Diagnosis And Classification ◽  
New Generation

There is a great interest to determine the physiological role of “free” nucleic acids, and to use them in the clinical diagnostics. These could be DNA, mRNA, microRNA and long non-coding RNA molecules, they are in the body fluids, like serum, tear, saliva, etc. Their exact role in the normal and pathological physiological processes is still in the focus of the research, while their use in the diagnostics is becoming more and more important. The use of „free” DNA in the non-invasive prenatal diagnosis is the first clinical application of the new generation sequencers, these methods are able to reach 99.9% specificity and sensitivity for the detection of the most common trisomies. There are promising results in their use in the diagnosis and classification of heart and cardiovascular diseases. In oncology the possibility to use the “liquid biopsy” captured the attention of not only researchers and clinicians, but the whole community. There is not enough data until today for the clinical utility and applicability of these methods. Orv. Hetil., 2016, 157(48), 1900–1909.

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