scholarly journals Solving the Puzzle: What Is the Role of Progestogens in Neovascularization?

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1686
Author(s):  
Zhi Xia ◽  
Jian Xiao ◽  
Qiong Chen
Keyword(s):  
Progesterone Receptor ◽  
Sex Steroids ◽  
Underlying Mechanism ◽  
Physiological Changes ◽  
Exact Role ◽  
The Past ◽  
Naturally Occurring ◽  
Pathological Conditions ◽  
Insight Into

Ovarian sex steroids can modulate new vessel formation and development, and the clarification of the underlying mechanism will provide insight into neovascularization-related physiological changes and pathological conditions. Unlike estrogen, which mainly promotes neovascularization through activating classic post-receptor signaling pathways, progesterone (P4) regulates a variety of downstream factors with angiogenic or antiangiogenic effects, exerting various influences on neovascularization. Furthermore, diverse progestins, the synthetic progesterone receptor (PR) agonists structurally related to P4, have been used in numerous studies, which could contribute to unequal actions. As a result, there have been many conflicting observations in the past, making it difficult for researchers to define the exact role of progestogens (PR agonists including naturally occurring P4 and synthetic progestins). This review summarizes available evidence for progestogen-mediated neovascularization under physiological and pathological circumstances, and attempts to elaborate their functional characteristics and regulatory patterns from a comprehensive perspective.

National Museums, National Narratives, and Identity Politics

2017 ◽  
Author(s):  
Cristina Lleras
Keyword(s):  
Identity Politics ◽  
Resistance To Change ◽  
National Museum ◽  
Traditional Role ◽  
National Narratives ◽  
The Past ◽  
National Museums ◽  
Insight Into

The purpose of this chapter is to examine the surge of identity politics and the diversification of heritage and the tensions that arise with the traditional role of national museums that are expected to support the model of a unitary national identity through their narratives and collections. Engaging with distinct patrimonies and transformations in museums checkmates stagnant notions of heritage, but in turn, these actions might also instigate resistance to change. A case study at the National Museum of Colombia will provide an insight into competing notions of heritage, which can be understood as the relics of a material past, but may also be seen as the meanings created about the past. This analysis instigates thoughts about the role that history and historians might play in the elaboration of narratives of identity.

University Startup Accelerators: Startup Launchpads or Vehicles for Entrepreneurial Learning?

2020 ◽  
pp. 251512742093175
Author(s):  
Lynn E. Metcalf ◽  
Thomas M. Katona ◽  
Jonathan L. York
Keyword(s):  
Return On Investment ◽  
Future Research ◽  
Uniform Structure ◽  
Primary Role ◽  
Entrepreneurial Ecosystem ◽  
The Past ◽  
Mode Of Operation ◽  
The University ◽  
Insight Into

Over the past decade, universities have invested heavily in startup accelerator programs; however, their role in the university entrepreneurial ecosystem is ambiguous. Are university startup accelerators intended to educate or are they created to facilitate business starts and to contribute to regional economic development? In contrast, most private-sector startup accelerators serve a consistent and differentiated role in the entrepreneurial ecosystem—they provide programming and resources to startups to increase the probability of a return on investment. Understanding the role of university startup accelerators is an important precursor to evaluating their impact and whether or not the return is worth the considerable investment. In this study, we poll university accelerator directors to gain their perspective on the role(s) that university startup accelerators play and to identify how they are structured and operated. Our research reveals a fairly uniform structure and mode of operation. While facilitating business starts is a key role for some, it confirms education as the primary role for university startup accelerators. We outline appropriate means of assessing the learning that takes place in accelerator programs, offer insight into how these findings can help accelerator directors deliver on outcomes and demonstrate impact, and propose avenues for future research.

scholarly journals The Role of Phosphatases in Nuclear Envelope Disassembly and Reassembly and Their Relevance to Pathologies

Cells ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 687 ◽  
Author(s):  
Florentin Huguet ◽  
Shane Flynn ◽  
Paola Vagnarelli
Keyword(s):  
Cell Cycle ◽  
Cell Division ◽  
Nuclear Envelope ◽  
Current Understanding ◽  
The Past ◽  
Pathological Conditions ◽  
Regulation Of Cell Cycle

The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining healthy cells and any deviation from this can result in pathological conditions. This review aims at assessing the current understanding of how phosphatases contribute to the remodelling of the nuclear envelope during its disassembling and reformation after cell division and how errors in this process may lead to the development of diseases.

Role of metabolism in K-induced tension changes in guinea pig taenia coli

1965 ◽  
Vol 208 (6) ◽  
pp. 1203-1205 ◽  
Author(s):  
M. Pfaffman ◽  
N. Urakawa ◽  
W. C. Holland
Keyword(s):  
Guinea Pig ◽  
Active Transport ◽  
Underlying Mechanism ◽  
Taenia Coli ◽  
Na Transport ◽  
Phasic Response ◽  
Metabolic Intermediates ◽  
Substrate Removal ◽  
Insight Into

Further insight into the underlying mechanism(s) of the K-induced phasic and tonic contractions of the taenia coli of the guinea pig was obtained by examining the effects of various metabolic intermediates, inhibitors of metabolism and active transport, on these responses. Evidence is presented to support the thesis that the tonic response is dependent on the aerobic breakdown of carbohydrates and is abolished by substrate removal, a decrease of temperature, DNP, lithium, and ouabain. These same factors have little or no effect on the phasic response. From the evidence presented, it is concluded that the phasic response is a passive process, whereas the tonic contracture is an active one depending on metabolism and possibly linked to active Na transport.

scholarly journals Psychological and biological background of the interaction between psoriasis and stress

2014 ◽  
Vol 155 (24) ◽  
pp. 939-948 ◽  
Author(s):  
L. János Kálmán ◽  
Xénia Gonda ◽  
Lajos Kemény ◽  
Zoltán Rihmer ◽  
Zoltán Janka
Keyword(s):  
Neurogenic Inflammation ◽  
Significant Proportion ◽  
Stress Perception ◽  
Exact Role ◽  
New Techniques ◽  
The Past ◽  
Psychotherapeutic Interventions ◽  
Objective Evidence ◽  
Long Time

Stress is considered as a major contributor to the development and exacerbation of psoriasis by a significant proportion of patients and dermatologists. As both stressor and its effects are subject-dependent, thus extremely difficult to measure, our understanding of the exact role of stress in disease development was limited for a long time. In the past decade several new studies were carried out which expanded our knowledge on the pathophysiologic processes linking stress to psoriasis via with their objective measurements and the applied new techniques. The authors review the current literature of both psychological (alexithymia, personality, affect) and biological (cortisol, epinephrine, neurogenic inflammation) factors influencing stress perception and response in psoriasis. Results of recent investigations support previous reports about the interaction between stress and psoriasis with objective evidence. Knowing how effective stress-reducing psychopharmacologic and psychotherapeutic interventions are in the treatment of psoriasis the authors hope that this review contributes to a wider acceptance of the psychosomatic attitude in everyday dermatologic practice. Orv. Hetil., 2014, 155(24), 939–948.

scholarly journals Effects of adiponectin on human trophoblast invasion

2010 ◽  
Vol 207 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Delphine Benaitreau ◽  
Esther Dos Santos ◽  
Marie-Christine Leneveu ◽  
Nadia Alfaidy ◽  
Jean-Jacques Feige ◽  
...  
Keyword(s):  
First Trimester ◽  
Extravillous Trophoblast ◽  
Trophoblast Invasion ◽  
Placental Development ◽  
Independent Manner ◽  
Human Trophoblast ◽  
Pathological Conditions ◽  
First Trimester Of Pregnancy ◽  
Insight Into

Adiponectin is an adipokine with insulin-sensitizing, anti-inflammatory, anti-atherogenic, and anti-proliferative effects. The expression of specific adiponectin receptors in the placenta and in the endometrium suggests a role for this cytokine in placental development, but this role has not yet been elucidated. The invasion of trophoblast cells during the first trimester of pregnancy being crucial to placentation process, we have studied adiponectin effects on human trophoblast invasive capacities. We found that adiponectin stimulated human trophoblast cell migration in HTR-8/SVneo cells in a dose-independent manner. In addition, adiponectin also significantly enhanced invasion of HTR-8/SVneo cells and of human extravillous trophoblast from first trimester placenta. These pro-invasive effects of adiponectin in human trophoblasts seem to be mediated in part via increased matrix metalloproteinases (MMP2 and MMP9) activities and via repression of TIMP2 mRNA expression. Our results suggest that adiponectin could be a positive regulator of the early invasion process by modulating the MMP/TIMP balance. Moreover, these results provide an insight into the role of adiponectin in pathological conditions characterized by insufficient or excessive trophoblast invasion.

A “Radical” Problem: The Poor and the English Reformers in the Mid-Seventeenth Century

1990 ◽  
Vol 29 (2) ◽  
pp. 118-146 ◽  
Author(s):  
Lotte Mulligan ◽  
Judith Richards
Keyword(s):  
Seventeenth Century ◽  
Social Reform ◽  
Economic Organization ◽  
Social Differentiation ◽  
Left Wing ◽  
The Past ◽  
The Poor ◽  
Problems And Solutions ◽  
Insight Into

Debates about poverty in mid-seventeenth-century England have, for some years, been a staple of historical studies. In our own time, where the numbers of the dispossessed continue to challenge the success of current modes of social and economic organization, such an interest is understandable and to be welcomed. But the relevance of studies of past problems and solutions and their applicability to present purposes is more complex than is usually recognized.The immediate benefit of studying discussions for change in mid-seventeenth-century England is that they provide an unusual insight into how members of that society conceived of it. In particular, their observations about the problems of poverty and the role of the poor offer us an understanding of the perceived social structure, the ethical bases for social differentiation, and the degree to which the future could be envisioned as differing from the past or present. Such understandings of proposed social change are invaluable for historians wishing to grasp the underlying assumptions on which past thought and action was predicated.Past proposals for social reform, however, have also been the focus of a significantly different enquiry by historians. In order to render those past programs more comprehensible (and more directly “relevant”) to modern readers, they are often placed on a “conservative” versus “radical” continuum, one end of which has sometimes been marked “extreme left wing.” This article argues that any such classification inevitably leads to misunderstandings of the authors and of their programs and, consequently, misrepresents both to the present.

scholarly journals What is the role of depression in the discrepancy between estimated and actual iPhone use? An exploratory analysis using cubic response surface analysis

2021 ◽  
Author(s):  
Craig Sewall ◽  
Douglas Parry
Keyword(s):  
Response Surface ◽  
Digital Media ◽  
Surface Analysis ◽  
Media Use ◽  
Response Surface Analysis ◽  
Self Report ◽  
The Past ◽  
Almost All ◽  
Insight Into

The association between depression and digital media use has received substantial research and popular attention in recent years. While meta-analytic evidence indicates that there is a small, positive relationship between digital media use and depression, almost all studies rely on self-report measures of digital media use. Evidence suggests these measures are poor reflections of usage measures derived from digital trace data. Additionally, a recent study showed that the error in self-reported digital media use is likely biased systematically by factors that are fundamental to the effect being investigated: respondents’ volume of use and level of depression. The current exploratory study harnesses cubic response surface analysis—a novel analytical approach in this domain—to advance our understanding of how inaccuracies in self-report measures of digital media use can be explained by respondent attributes, in this case their level of depression and actual iPhone usage. A sample of 325 iPhone users provided estimates of their total iPhone use over the past week, their actual iPhone use as recorded by the Apple Screen Time application, and a measure of their depression (CESD-R-10). The results of the analysis indicate that depression is i.) more strongly associated with estimated than device-logged DMU; ii.) more associated with over-estimating than under-estimating of DMU; and iii.) more associated with inaccuracy at lower versus higher levels of DMU. The findings raise important questions concerning the validity of conclusions in this area and provide insight into the structure of measurement error in self-report estimates of digital media use.

scholarly journals The Role of Public-Private Partnerships in Higher Education How Tertiary Institutions in emerging Economies benefit from Public-Private Partnerships

2017 ◽  
Vol 2 (1) ◽  
pp. 1-7
Author(s):  
Ronak Warasthe
Keyword(s):  
Higher Education ◽  
Emerging Economies ◽  
Tertiary Education ◽  
Added Value ◽  
Public Private Partnerships ◽  
Tertiary Institutions ◽  
The Past ◽  
Different Types ◽  
Insight Into

Abstract The number of Public-Private Partnerships in the education sector is growing in developing and emerging economies. Traditionally governments are the main financial contributor to education however, the involvement of the private sector is an increasing one. While more established in primary and secondary education, PPPs in tertiary education are a phenomenon rather slowly growing in the past decades (Patrinos, Barrera-Osorio, & Guaqueta, 2009). There are various concepts of PPPs in higher education each targeting different goals. In order to give an insight into different types of PPPs, the typology according to Mabizela has been briefly displayed and the case of a PPP in Namibia is given. The framework of the partnership was compiled to give an outlook on the practicability of partnerships. The paper exemplifies that both partners within a PPP can benefit from the added value they may generate for their target group. Thus, the benefit depends on quality, relevance and execution of the partnership.

scholarly journals Bifidobacterium infantis Metabolizes 2′Fucosyllactose-Derived and Free Fucose Through a Common Catabolic Pathway Resulting in 1,2-Propanediol Secretion

2020 ◽  
Vol 7 ◽  
Author(s):  
Liv R. Dedon ◽  
Ezgi Özcan ◽  
Asha Rani ◽  
David A. Sela
Keyword(s):  
Gut Microbiome ◽  
Bifidobacterium Longum ◽  
Underlying Mechanism ◽  
Catabolic Pathway ◽  
Oligosaccharide Structure ◽  
Infant Gut Microbiome ◽  
Microbe Interactions ◽  
The Impact ◽  
Insight Into

Human milk oligosaccharides (HMOs) enrich beneficial bifidobacteria in the infant gut microbiome which produce molecules that impact development and physiology. 2′fucosyllactose (2′FL) is a highly abundant fucosylated HMO which is utilized by Bifidobacterium longum subsp. infantis, despite limited scientific understanding of the underlying mechanism. Moreover, there is not a current consensus on whether free fucose could be metabolized when not incorporated in a larger oligosaccharide structure. Based on metabolic and genomic analyses, we hypothesize that B. infantis catabolizes both free fucose and fucosyl oligosaccharide residues to produce 1,2-propanediol (1,2-PD). Accordingly, systems-level approaches including transcriptomics and proteomics support this metabolic path. Co-fermentation of fucose and limiting lactose or glucose was found to promote significantly higher biomass and 1,2-PD concentrations than individual substrates, suggesting a synergistic effect. In addition, and during growth on 2′FL, B. infantis achieves significantly higher biomass corresponding to increased 1,2-PD. These findings support a singular fucose catabolic pathway in B. infantis that is active on both free and HMO-derived fucose and intimately linked with central metabolism. The impact of fucose and 2′FL metabolism on B. infantis physiology provides insight into the role of fucosylated HMOs in influencing host- and microbe-microbe interactions within the infant gut microbiome.

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