The Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a dismal prognosis and a high rate of recurrence and mortality. Therapeutic options are limited. In some cases, the distinction of ACCs from benign adrenal neoplasms with the existing widely available pathological and histopathological tools is difficult. Thus, new biomarkers have been tested. We conducted a review of the recent literature on the advances of the diagnostic, prognostic and therapeutic role of miRNAs on ACC patients. More than 10 miRNAs validated by multiple studies were found to present a diagnostic and prognostic role for ACC patients, from which miR-483-5p and miR-195 were the most frequently met biomarkers. In particular, upregulation of miR-483-5p and downregulation of miR-195 were the most commonly validated molecular alterations. Unfortunately, data on the therapeutic role of miRNA are still scarce and limited mainly at the experimental level. Thus, the role of miRNA regulation in ACC remains an area of active research.

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The Genomics of Myelodysplastic Syndromes: Origins of Disease Evolution, Biological Pathways, and Prognostic Implications

Cells ◽

10.3390/cells9112512 ◽

2020 ◽

Vol 9 (11) ◽

pp. 2512

Author(s):

Hassan Awada ◽

Bicky Thapa ◽

Valeria Visconte

Keyword(s):

Experimental Studies ◽

Gene Mutations ◽

High Rate ◽

Murine Models ◽

Disease Evolution ◽

Molecular Alterations ◽

Disease Phenotypes ◽

Prognostic Implications ◽

Made In

The molecular pathogenesis of myelodysplastic syndrome (MDS) is complex due to the high rate of genomic heterogeneity. Significant advances have been made in the last decade which elucidated the landscape of molecular alterations (cytogenetic abnormalities, gene mutations) in MDS. Seminal experimental studies have clarified the role of diverse gene mutations in the context of disease phenotypes, but the lack of faithful murine models and/or cell lines spontaneously carrying certain gene mutations have hampered the knowledge on how and why specific pathways are associated with MDS pathogenesis. Here, we summarize the genomics of MDS and provide an overview on the deregulation of pathways and the latest molecular targeted therapeutics.

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Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology

International Journal of Molecular Sciences ◽

10.3390/ijms22126272 ◽

2021 ◽

Vol 22 (12) ◽

pp. 6272

Author(s):

Marta Martín-Fernández ◽

Álvaro Tamayo-Velasco ◽

Rocío Aller ◽

Hugo Gonzalo-Benito ◽

Pedro Martínez-Paz ◽

...

Keyword(s):

Endothelial Dysfunction ◽

Emergency Services ◽

Progressive Increase ◽

High Rate ◽

Diagnostic Tools ◽

Major Health Problem ◽

Major Health ◽

Neutrophil Degranulation ◽

New Biomarkers

Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates. The progressive increase of both the incidence and prevalence of sepsis has translated into a significant socioeconomic burden for health systems. Currently, it is the leading cause of noncoronary mortality worldwide and represents one of the most prevalent pathologies both in hospital emergency services and in intensive care units. In this article, we review the role of both endothelial dysfunction and neutrophil dysregulation in the physiopathology of this disease. The lack of a key symptom in sepsis makes it difficult to obtain a quick and accurate diagnosis of this condition. Thus, it is essential to have fast and reliable diagnostic tools. In this sense, the use of biomarkers can be a very important alternative when it comes to achieving these goals. Both new biomarkers and treatments related to endothelial dysfunction and neutrophil dysregulation deserve to be further investigated in order to open new venues for the diagnosis, treatment and prognosis of sepsis.

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Role of Active Research in Recruiting and Retaining Psychologists

PsycEXTRA Dataset ◽

10.1037/e523732007-001 ◽

2006 ◽

Author(s):

Ann Louise Barrick

Keyword(s):

Active Research

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The therapeutic role of yoga in anxiety reduction

PsycEXTRA Dataset ◽

10.1037/e682942012-057 ◽

2011 ◽

Author(s):

Jacksan Judan Fernandes

Keyword(s):

Anxiety Reduction ◽

Therapeutic Role

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Therapeutic role of cell kinetics in acute leukaemia

Clinics in Haematology ◽

10.1016/s0308-2261(78)80009-5 ◽

1978 ◽

Vol 7 (2) ◽

pp. 339-362 ◽

Cited By ~ 32

Author(s):

Zalmen A. Arlin ◽

Jerrold Fried ◽

Bayard D. Clarkson

Keyword(s):

Acute Leukaemia ◽

Cell Kinetics ◽

Therapeutic Role

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In vitro studies reveal a potential therapeutic role of the combination of biguanides and statins for the treatment of prostate cancer

Endocrine Abstracts ◽

10.1530/endoabs.56.gp48 ◽

2018 ◽

Author(s):

Vicente Herrero-Aguayo ◽

Juan M Jimenez-Vacas ◽

Enrique Gomez-Gomez ◽

Antonio J Leon-Gonzalez ◽

Prudencio Saez-Martinez ◽

...

Keyword(s):

Prostate Cancer ◽

In Vitro Studies ◽

Therapeutic Role ◽

Potential Therapeutic Role

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Therapeutic Role of Spirituality in Psychotherapy

Health and Social Care Chaplaincy ◽

10.1558/hscc.v8i1.2 ◽

2013 ◽

Vol 8 (1) ◽

pp. 2-6

Author(s):

James L. Griffith

Keyword(s):

Therapeutic Role

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Crucial role of physiotherapy in treating COVID-19 patients

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.3300 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 967-971

Author(s):

Poonam Thakre ◽

Waqar M. Naqvi ◽

Trupti Deshmukh ◽

Nikhil Ingole ◽

Sourabh Deshmukh

Keyword(s):

Public Health ◽

Distress Syndrome ◽

Public Health Problem ◽

Public Health Emergency ◽

High Rate ◽

Major Public Health Problem ◽

Front Line ◽

The Many ◽

Sixth International

The emergence in China of 2019 of severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) previously provisionally names 2019-nCoV disease (COVID19) caused major global outbreak and is a major public health problem. On 30 January 2020, the WHO declared COVID19 to be the sixth international public health emergency. This present pandemic has engrossed the globe with a high rate of mortality. As a front line practitioner, physiotherapists are expected to be getting in direct contact with patients infected with the virus. That’s why it is necessary for understanding the many aspects of their role in the identification, contains, reduces and treats the symptoms of this disease. The main presentation is the involvement of respiratory system with symptoms like fever, cough, sore throat, sneezing and characteristics of pneumonia leads to ARDS(Acute respiratory distress syndrome) also land up in multiorgan dysfunction syndrome. This text describes and suggests physiotherapy management of acute COVID-19 patients. It also includes recommendations and guidelines for physiotherapy planning and management. It also covers the guidelines regarding personal care and equipment used for treatment which can be used in the treatment of acute adult patients with suspected or confirmed COVID-19.

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