scholarly journals Glycated Hemoglobin and Methods for Its Point of Care Testing

Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 70
Author(s):  
Miroslav Pohanka
Keyword(s):  
Diabetes Mellitus ◽  
Hba1c Level ◽  
Glycated Hemoglobin ◽  
Point Of Care ◽  
Standard Methods ◽  
Glucose Levels ◽  
Point Of Care Test ◽  
Diabetes Mellitus Diagnosis ◽  
Elevated Glucose ◽  
Diagnosis Of Diabetes Mellitus

Glycated hemoglobin (HbA1c) is a product of the spontaneous reaction between hemoglobin and elevated glucose levels in the blood. It is included among the so-called advanced glycation end products, of which is the most important for the clinical diagnosis of diabetes mellitus, and it can serve as an alternative to glycemia measurement. Compared to the diagnosis of diabetes mellitus by glycemia, the HbA1c level is less influenced by a short-term problem with diabetes compensation. Mass spectroscopy and chromatographic techniques are among the standard methods of HbA1c level measurement. Compared to glycemia measurement, there is lack of simple methods for diabetes mellitus diagnosis by means of the HbA1c assay using a point-of-care test. This review article is focused on the surveying of facts about HbA1c and its importance in diabetes mellitus diagnosis, and surveying standard methods and new methods suitable for the HbA1c assay under point-of-care conditions. Various bioassays and biosensors are mentioned and their specifications are discussed.

scholarly journals Utility of Glycated Hemoglobin in Diagnosing Type 2 Diabetes Mellitus: A Community-Based Study

2010 ◽  
Vol 95 (6) ◽  
pp. 2832-2835 ◽  
Author(s):  
Padala Ravi Kumar ◽  
Anil Bhansali ◽  
Muthuswamy Ravikiran ◽  
Shobhit Bhansali ◽  
Pinaki Dutta ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diagnostic Test ◽  
Sensitivity And Specificity ◽  
Predictive Value ◽  
Hba1c Level ◽  
Glycated Hemoglobin ◽  
World Health ◽  
Oral Glucose ◽  
Community Based ◽  
Cut Point

Abstract Context: Although glycated hemoglobin (HbA1c) has recently been incorporated as a diagnostic test by the American Diabetes Association, its validity needs to be established in Asian Indians in a community setting. Objective: The objective of the study was to assess the validity of HbA1c as a screening and diagnostic test in individuals with newly detected diabetes mellitus. Design and Setting: Community based randomized cross sectional study in urban Chandigarh, a city in north India, from April 2008 to August 2009. Subjects: Subjects included 1972 subjects aged 20 yr or older. Intervention: Intervention included an oral glucose tolerance test and glycated hemoglobin in all the subjects. Main Outcome Measures: Utility of HbA1c as a diagnostic method in newly detected diabetes mellitus subjects was evaluated. Results: Using World Health Organization criteria for diagnosis of diabetes mellitus, 134 (6.7%) had newly detected diabetes mellitus, 192 (9.7%) known diabetes mellitus, 329 (16.6%) prediabetes, and 1317 (69.4%) were normal of 1972 people screened. Using only the ADA criteria, 38% people were underdiagnosed. An HbA1c level of 6.1% had an optimal sensitivity and specificity of 81% for diagnosing diabetes. A HbA1c level of 6.5% (±2 sd) and 7% (±2.7 sd) had sensitivity and specificity of 65 and 88% and 42 and 92%, respectively, with corresponding positive predictive value and negative predictive value of 75.2 and 96.5% and 90.4and 94.4%, respectively, for diagnosis of newly detected diabetes mellitus. Conclusion: A HbA1c cut point of 6.1% has an optimal sensitivity and specificity of 81% and can be used as a screening test, and a cut point of 6.5% has optimal specificity of 88% for diagnosis of diabetes.

scholarly journals Modestly Elevated Glucose Levels During Pregnancy Are Associated With a Higher Risk of Future Diabetes Among Women Without Gestational Diabetes Mellitus

Diabetes Care ◽  
2008 ◽  
Vol 31 (5) ◽  
pp. 1037-1039 ◽  
Author(s):  
D. B. Carr ◽  
K. M. Newton ◽  
K. M. Utzschneider ◽  
J. Tong ◽  
F. Gerchman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Glucose Levels ◽  
Elevated Glucose ◽  
Future Diabetes

scholarly journals Influence of the Indicators of Carbohydrate Metabolism on the Elemental Status

2021 ◽  
Author(s):  
Olga Marshinskaia ◽  
Tatiana Kazakova ◽  
Svetlana Notova ◽  
Maksim Molchanov
Keyword(s):  
Diabetes Mellitus ◽  
Trace Elements ◽  
Toxic Elements ◽  
Normal Values ◽  
Chemical Elements ◽  
Serum Parameters ◽  
Glucose Levels ◽  
Icp Ms ◽  
Elemental Status ◽  
Elevated Glucose

This study examined the elemental status of the hair and blood biochemistry of young men in the Orenburg region (n=38) with different glucose levels. Estimation of the element status was carried out through the study of the chemical composition of the hair by ICP-AES and ICP-MS. It was found that the studied serum parameters (Ca, Mg, Fe, P cholesterol, thyroxine, TSH and testosterone) were within normal values, and no statistically significant differences were obtained when comparing the groups. The concentration of chemical elements in the hair of the men in each group was in the range of physiologically acceptable values for this region. In the group with elevated glucose levels, there was a tendency for the men to have lower values of Ca and Mg, and higher levels of K, Na, P and a number of toxic elements (Al, Cd, Sn, Hg, Pb). Keywords: elemental status, trace elements, diabetes mellitus, metabolism

Biomarker Glycated Hemoglobin (HbA1c) in Diabetes Mellitus Type II

2021 ◽  
Vol 11 (6) ◽  
pp. 13-14
Author(s):  
Jayanthi Bai ◽  
Jayakrishnan .
Keyword(s):  
Diabetes Mellitus ◽  
Central Government ◽  
Glycated Hemoglobin ◽  
Financial Burden ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Health Complications ◽  
Early Diagnosis Of Diabetes ◽  
Diabetes Mellitus 2 ◽  
Diagnosis Of Diabetes Mellitus

Early diagnosis of diabetes is clinically important in reducing health complications worldwide. In this respect HbA1c has become an accurate biomarker for the diagnosis of Diabetes Mellitus (DM) and its complication [1]. In the present study HbA1c measured in subject of age <20,21-30,31-40 yrs and the level found to show high risk for DM in youngsters. Hence counselling at least once a month is warranted. To be most effective to reduce or prevent the prevalence in youngsters the importance of controlling HbA1c and keeping it at low level can be achieved by including in the curriculum right from school ageing. It will reduce the financial burden on state and central government authorities. Key words: HbA1c, Diabetes Mellitus 2.

Abstract 15820: Differential Myocardial Gene Expression of Glucose Transporters in Heart Transplant Recipients With and Without Diabetes Mellitus

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Marc Vanderheyden ◽  
Leen Delrue ◽  
Sofie Verstreken ◽  
Riet Dierckx ◽  
Ward Heggermont ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Experimental Data ◽  
Heart Transplant ◽  
Glucose Transporters ◽  
Myocardial Glucose Uptake ◽  
Glucose Levels ◽  
Elevated Glucose ◽  
The Impact ◽  
Hba1c Levels

Introduction: The Sodium Glucose cotransporter (SGLT) and glucose transporters(GLUTs) play a crucial role in cellular glucose transport. Although experimental data have shown differential regulation of GLUT4 and SGLT in diabetic cardiomyopathy, the impact of diabetes mellitus (DM) upon myocardial glucose transporters in humans remains undetermined. Aim: To better understand the impact of elevated glucose levels upon myocardial expression of glucose transporters, the endomyocardial gene expression of GLUT1, GLUT4 and SGLT1 was investigated in heart transplant(HTx) recipients, with and without DM, who received a heart from a DM- donor. Methods: At baseline(BL), immediately after HTx and 12 ± 2 months(FU) later, serial endomyocardial biopsies were procured in 26 Htx pts, free of clinical or histological rejection, at time of routine surveillance biopsy. Patients were categorized in DM+ (n = 13pts) and DM- (n = 13 pts), according to the presence of diabetes mellitus (DM) at FU. Results: Despite similar hemodynamics and HbA1c levels at BL, DM+ pts had higher HbA1c levels (46,00 ± 13,79 vs 38,33 ± 4,88; p < 0,05) at FU. No differences were noted in BL GLUT1, GLUT4 and SGLT gene expression between both groups. In DM- pts SGLT1(0,081 ± 0,080 vs 0,188 ± 0,108; p = 0,0036) , GLUT4(0,076 ± 0,068 vs 0,137 ± 0,065; p = 0,0011 )and GLUT1(0,020 ± 0,021 vs 0,022 ± 0,009; p = 0,043) increased significantly at FU whereas no change was observed in DM+ pts. Conclusion: Similar to experimental data, differential endomyocardial regulation in SGLT1 and GLUT4 was noted between DM+ and DM-pts with a blunted upregulation of glucose transporters at 1 year in DM+ HTx pts. These observations are in line with experimental data and suggest that myocardial glucose uptake is differentially regulated in DM+ HTx pts.

scholarly journals Multicenter assessment of a hemoglobin A1c point-of-care device for diagnosis of diabetes mellitus

2018 ◽  
Vol 61 ◽  
pp. 18-22 ◽  
Author(s):  
Philip M. Sobolesky ◽  
Breland E. Smith ◽  
Amy K. Saenger ◽  
Karen Schulz ◽  
Fred S. Apple ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hemoglobin A1c ◽  
Point Of Care ◽  
Diagnosis Of Diabetes Mellitus
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