Association of Common Variants of TNFSF13 and TNFRSF13B Genes with CLL Risk and Clinical Picture, as Well as Expression of Their Products—APRIL and TACI Molecules

Interactions between APRIL (TNFSF13) and its receptor TACI (TNFRSF13B) are implicated in providing survival benefits for chronic lymphocytic leukaemia (CLL) cells. Here we explored the relationship between TNFSF13 and TNFRSF13B SNPs and expression of APRIL and TACI molecules and performed extended case-control study to evaluate earlier observations. Expression of APRIL and TACI was detected by FACS for 72 and 145 patients, respectively, and soluble APRIL was measured by ELISA in plasma of 122 patients. Genotypes were determined in 439 CLL patients and 477 control subjects with TaqMan Assays or restriction fragment length polymorphism (RFLP). The rs4968210GG genotype of TNFSF13 was associated with a lower percentage of CD19+APRIL+ cells in CLL patients when compared to (AA + GA) genotypes (p-value = 0.027). Homozygosity at rs11078355 TNFRSF13B was associated with higher CD19+ TACI+ cell percentage in CLL patients (p-value = 0.036). The analysis of extended groups of patients and healthy controls confirmed the association of TNFSF13 rs3803800AA genotype with a higher CLL risk (OR = 2.13; CI95% = 1.21; 3.75; p-value = 0.007), while the possession of TNFRSF13B rs4985726G allele (CG + GG) genotype was associated with lower risk of CLL (OR = 0.69; CI95% = 0.51; 0.95; p-value = 0.02). Genetic variants of TNFSF13 and TNFRSF13B may have an impact on APRIL and TACI expression and may be considered as possible CLL risk factors.

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Antioxidant potential of diet: Association between dietary antioxidant index and odds of coronary heart disease: A case-control study

Mediterranean Journal of Nutrition and Metabolism ◽

10.3233/mnm-211503 ◽

2021 ◽

pp. 1-13

Author(s):

Farhad Vahid ◽

Zahra Nasiri ◽

Amir Abbasnezhad ◽

Ezatollah Fazeli Moghadam

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Antioxidant Capacity ◽

Case Control Study ◽

Case Control ◽

P Value ◽

Dietary Antioxidants ◽

Dietary Antioxidant ◽

The Relationship ◽

Control Study

BACKGROUND: Oxidative stress and chronic inflammation are among the leading causes of coronary heart disease (CHD). Studies investigated the relationship between dietary antioxidants and the risk/odds of CHD, and contradictory results have been reported. Dietary antioxidant index (DAI) is a novel and reliable nutritional tool that examines the diet’s overall antioxidant capacity. Its validity was examined using serum total antioxidant capacity and malondialdehyde. OBJECTIVE: This study aimed to investigate the relationship between DAI score and odds of CHD. METHODS: In this incidence case-control study, 320 individuals with a definitive diagnosis of CHD and 320 participants without CHD or related risk factors attending the same hospitals/polyclinics were selected as the case and control groups. We estimated the DAI by summing up six standardized intakes of major dietary antioxidants, including manganese, vitamin E, A, C, selenium, and zinc. RESULTS: Modeling DAI categorized according to the median (–0.38), in multi-adjusted model showed a significant protective association with the odd of CHD (OR = 0.72; 95%CI:0.51–0.99, p-value = 0.05). Also, modeling DAI as a continuous variable in multi-adjusted models (OR = 0.94;95%CI:0.90–0.95; p-value = 0.01) showed significant results. CONCLUSION: Using the DAI to investigate the relationship between dietary antioxidants and CHD can show more realistic results than a single study of antioxidants.

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Birth Month And Prevalence Of Atopic Dermatitis In Children Under 3 Years In Antananarivo, Madagascar

10.21203/rs.2.23109/v1 ◽

2020 ◽

Author(s):

Fandresena Arilala Sendrasoa ◽

Volatantely Ratovonjanahary ◽

Mendrika Fifaliana Rakotoarisaona ◽

Malalaniaina Andrianarison ◽

Onivola Raharolahy ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

University Hospital ◽

P Value ◽

Month Of Birth ◽

Birth Month ◽

History Of ◽

The University ◽

The Relationship ◽

Control Study

Abstract BACKGROUND: Several studies have been done to evaluate the relationship between month of birth and atopic diseases but the results are contradictory. So, we aim to evaluate the correlation between the month of birth and the prevalence of AD in Malagasy children less than 3 years.METHODS: A case-control study was conducted based on patients’ data of the department of Dermatology in the University Hospital Joseph Raseta Befelatanana (UH/JRB) Antananarivo. It included 354 children less than 3 years seen in this department between January 2010 and December 2018. For each AD patient, two age and sex-matched controls without a history of AD were selected from the same period.RESULTS: This study included 118 AD cases and 236 non-AD controls. Our case-control study found that there are no statistically significant correlation between birth month and risk of AD in Malagasy children < 3 years. However, the fewest children with AD were born in February (17.86%, OR: 0.40, CI 95%: 0.11-1.14), and the most were born in August (45.16%, OR: 1,73; CI 95%: 0,75-3,88). Asthma, allergic rhinitis and allergic conjunctivitis were significantly correlated with AD in our patients.CONCLUSION: Our case-control study found that there are no statistically significant correlation between birth month and risk of AD in children < 3 years. However, the high frequency of AD in children born in August (dry season) compared to non-AD controls was not negligible (p-value =0,05 and X 2 3,27).

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Correlation between Incidence of Diarrhea in Toddlers and Housewife’s Clean and Healthy Lifestyle

J-Kesmas: Jurnal Fakultas Kesehatan Masyarakat (The Indonesian Journal of Public Health) ◽

10.35308/j-kesmas.v7i1.1938 ◽

2020 ◽

Vol 7 (1) ◽

pp. 57

Author(s):

Teuku Alamsyah ◽

Dewi Marianthi

Keyword(s):

Case Control Study ◽

Healthy Lifestyle ◽

Case Control ◽

Hand Washing ◽

P Value ◽

The Public ◽

One Year ◽

The One ◽

The Relationship ◽

Control Study

Diarrhea is one of the public health problems, particularly in infants. Based on the outcomes of the Aceh Besar fitness service survey, Baitussalam sub-district is one of the districts with a excessive wide variety of diarrhea cases, with a total of 520 instances in the one year. This is due to the lack of exact hygiene conduct related to hand washing cleaning soap in the prevention of diarrhea in toddlers. This research ambitions to find out the relationship between the clean and healthy lifestyle housewives on behavior of smooth water use and waste management with diarrhea in children of Baitussalam Subdistrict in Aceh Besar District, Indonesia. This is a descriptive analytic study using a case control study, consist of 28 moms who have children who suffer from diarrhea, and 28 moms who have youngsters do not go through from diarrhea. This lookup resulted in three findings namely there is a relationship between handwashing with cleaning soap with the incidence of diarrhea in infants (p-value 0.003 < α = OR 3.50), there is no relationship between the use of smooth water with the incidence of diarrhea in babies (p-value 1.00 > α = 0.05, OR 1.22) and there is a management relationship with the incidence of diarrhea in teens under five (p-value 0.01 < α = 0.05, OR 4.50).

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SERUM PROLACTINE LEVEL IN PATIENTS OF PSORIASIS VULGARIS AND ITS CORRELATION WITH DISEASE SEVERITY: A CASE-CONTROL STUDY

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i6.303 ◽

2019 ◽

Vol 3 (6) ◽

Author(s):

Pawan Kumar Saini ◽

Devendra Yadav ◽

Rozy Badyal ◽

Suresh Jain ◽

Arti Singh ◽

...

Keyword(s):

Disease Severity ◽

Prolactin Level ◽

Case Control Study ◽

Statistical Significance ◽

Case Control ◽

Serum Prolactin ◽

P Value ◽

Serum Prolactin Level ◽

R Value ◽

Control Study

Background: Psoriasis is an autoimmune chronic inflammatory disorder affecting the skin mediated by T-lymphocytes resulting in production of cytokines which cause hyperproliferation of keratinocytes. Several factors and hormones like Prolactin have an action similar to these cytokines in promoting the multiplication of keratinocytes and other cells like lymphocytes and epithelial cells may have a role on the etiopathogenesis of psoriasis. Aim:-The aim of study is to compare the serum Prolactin levels in patients of psoriasis with a control group. Setting and study design: This is a case-control study conducted in the department of Dermatology, Venereology and Leprosy GMC, Kota over a period of 1year from July 2017 to June 2018 Material and method: The study included 100 cases of psoriasis (60 males and 40 females) and 100 controls similar for age and sex. Serum Prolactin levels were measured by ECLIA and results were obtained. Statistical analysis: Mean and standard deviation were calculated for each variable. Statistical significance of the results was analyzed using correlation analysis (Pearson correlation coefficient) and independent samples t-test. Statistical significance was assumed at p value<0.05. Result: Serum Prolactin level was significantly higher in cases of psoriasis compared to controls (p-value <0.001). PASI score and serum Prolactin levels were found to have a positive correlation (r value = 0.337; p-value: 0.001). No significant correlation was found between serum levels of Prolactin and duration of disease r value= -0.034, P value =0.733). Serum Prolactin level was higher in male patients compared to females patients. Conclusion:- High serum Prolactin may be a biological marker of disease severity in psoriasis and may have a role in the pathogenesis of psoriasis. Further studies with large sample size are required to confirm this hypothesis.

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