scholarly journals Clinical Characterisation and Management of the Main Treatment-Induced Toxicities in Patients with Hepatocellular Carcinoma and Cirrhosis

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 584
Author(s):  
Fausto Meriggi ◽  
Massimo Graffeo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Impairment ◽  
Hepatic Cirrhosis ◽  
Disease Stage ◽  
The Past ◽  
Systemic Treatments ◽  
Key Points ◽  
Locoregional Therapies ◽  
Almost All ◽  
Selection Of

The incidence of hepatocellular carcinoma (HCC) continues to increase worldwide, particularly in Western countries. In almost all cases, HCC develops in subjects with hepatic cirrhosis, often as the result of hepatitis B or C virus infection, alcohol abuse or metabolic forms secondary to non-alcoholic steatohepatitis. Patients with HCC and hepatic symptoms can therefore present symptoms that are attributable to both conditions. These patients require multidisciplinary management, calling for close interaction between the hepatologist and the oncologist. Indeed, the treatment of HCC requires, depending on the disease stage and the degree of hepatic impairment, locoregional therapies that can in turn be broken down into surgical and nonsurgical treatments and systemic treatments used in the event of progression after the administration of locoregional treatments. The past decade has seen the publication of countless papers of great interest that have radically changed the scenario of treatment for HCC. Novel therapies with biological agents and immunotherapy have come to be standard options in the approach to treatment of this cancer, obtaining very promising results where in the past chemotherapy was almost never able to have an impact on the course of the disease. However, in addition to being costly, these drugs are not devoid of adverse effects and their management cannot forgo the consideration of the underlying hepatic impairment. Patients with HCC and cirrhosis therefore require special attention, starting from the initial characterisation needed for an appropriate selection of those to be referred for treatment, as these patients are almost never fit. In this chapter, we will attempt to investigate and clarify the key points of the management of the main toxicities induced by locoregional and systemic treatments for HCC secondary to cirrhosis.

scholarly journals Why do women become teachers while men don’t?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
David Carroll ◽  
Jaai Parasnis ◽  
Massimiliano Tani
Keyword(s):  
Theoretical Models ◽  
Primary Teachers ◽  
Secondary Schooling ◽  
Female Teachers ◽  
The Past ◽  
Science Technology ◽  
Market Women ◽  
And Mathematics ◽  
Almost All ◽  
Selection Of

Abstract Across countries, almost all primary and pre-primary teachers are women while few men in the occupation tend to specialise in secondary schooling and administration. We investigate the decision to become a teacher versus alternative occupations for graduates in Australia over the past 15 years. We find that this gender distribution reflects relative returns in the labour market: women with bachelor qualifications receive higher returns in teaching, while similarly educated men enjoy substantially higher returns in other occupations. We also find evidence that schools which can, and do, make higher wage offers successfully attract more male teachers as well as more female teachers with a degree in science, technology, engineering, and mathematics. These results are consistent with the predictions of theoretical models of self-selection of intrinsically motivated workers.

scholarly journals Molecular Targets, Pathways, and Therapeutic Implications for Hepatocellular Carcinoma

2020 ◽  
Vol 21 (15) ◽  
pp. 5232
Author(s):  
Jun Gong ◽  
Jeremy Chuang ◽  
May Cho ◽  
Kyra Toomey ◽  
Andrew Hendifar ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Trials ◽  
Targeted Therapies ◽  
Cancer Mortality ◽  
Molecular Targets ◽  
Advanced Hepatocellular Carcinoma ◽  
Advanced Hcc ◽  
Therapeutic Implications ◽  
The Past ◽  
Selection Of

Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer mortality worldwide. While significant advances have been made for the treatment of advanced hepatocellular carcinoma in the past few years, the prognosis remains poor and effective biomarkers to guide selection of therapies remain noticeably absent. However, several targeted therapies have been approved in the past few years that have improved the outlook for this disease. In this review, we will highlight the recent therapies approved for the treatment of advanced HCC and discuss promising therapeutic options, targets, and pathways for drug development and consideration for future clinical trials.

Integrated FAHP-VIKOR model for green supplier selection in a Nickle coating SME

2020 ◽  
pp. 133-139
Author(s):  
Sanatan Ratna ◽  
B Kumar
Keyword(s):  
Staff Training ◽  
Supplier Selection ◽  
Fuzzy Ahp ◽  
Research Work ◽  
Supplier Evaluation ◽  
Green Supplier Selection ◽  
The Past ◽  
Coating Industry ◽  
Sustainability Issue ◽  
Selection Of

In the past few decades, there has been lot of focus on the issue of sustainability. This has occurred due to the growing concerns related to climate change and the growing awareness about environmental concerns. Also, the competition at global level has led to the search for the most sustainable route in the industries. The current research work deals with the selection of green supplier in a Nickle coating industry based on certain weighted green attributes. For this purpose, a hybrid tool comprising of Fuzzy AHP (Fuzzy Analytical Hierarchy) and VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje) is used. The Fuzzy AHP is used for assigning proper weights to the selected criteria for supplier evaluation, while VIKOR is used for final supplier selection based on the weighted criteria. The three criterions for green supplier selection are, Ecological packaging, Corporate socio-environmental responsibility and Staff Training. The outcome of the integrated model may serve as a steppingstone to other SMEs in different sectors for selecting the most suitable supplier for addressing the sustainability issue.

BP Global Energy Outlook 2030

2013 ◽  
pp. 109-128 ◽  
Author(s):  
C. Rühl
Keyword(s):  
Emerging Economies ◽  
Energy Demand ◽  
Fossil Fuels ◽  
Net Energy ◽  
Global Energy ◽  
The Past ◽  
Market Shares ◽  
The Us ◽  
Almost All ◽  
Oil Gas

This paper presents the highlights of the third annual edition of the BP Energy Outlook, which sets out BP’s view of the most likely developments in global energy markets to 2030, based on up-to-date analysis and taking into account developments of the past year. The Outlook’s overall expectation for growth in global energy demand is to be 36% higher in 2030 than in 2011 and almost all the growth coming from emerging economies. It also reflects shifting expectations of the pattern of supply, with unconventional sources — shale gas and tight oil together with heavy oil and biofuels — playing an increasingly important role and, in particular, transforming the energy balance of the US. While the fuel mix is evolving, fossil fuels will continue to be dominant. Oil, gas and coal are expected to converge on market shares of around 26—28% each by 2030, and non-fossil fuels — nuclear, hydro and renewables — on a share of around 6—7% each. By 2030, increasing production and moderating demand will result in the US being 99% self-sufficient in net energy. Meanwhile, with continuing steep economic growth, major emerging economies such as China and India will become increasingly reliant on energy imports. These shifts will have major impacts on trade balances.

Excessive Belching: a Separate Syndrome or Another Symptom of Functional Dyspepsia?

2020 ◽  
Vol 30 (3) ◽  
pp. 55-60 ◽  
Author(s):  
A. A. Sheptulin ◽  
O. A. Storonova
Keyword(s):  
Functional Dyspepsia ◽  
Functional Gastrointestinal Disorders ◽  
High Resolution Manometry ◽  
Published Evidence ◽  
Key Points ◽  
Dyspeptic Symptoms ◽  
The Relationship ◽  
Rome Iv ◽  
Selection Of ◽  
Optimal Treatment Strategy

Aim of review. Interpretation of published evidence on the relationship between the excessive belching syndrome and functional dyspepsia (FD) and their management in patient care.Key points. According to the Rome IV criteria of functional gastrointestinal disorders (FGID), excessive belching in the absence of other dyspeptic symptoms is to be considered a manifestation of the excessive belching syndrome, which can be of gastric or supragastric nature. Combination of high-resolution manometry and impedancemetry allows an accurate diagnosis of belching and selection of optimal treatment strategy. Belching complicated by other symptoms of dyspepsia is to be considered yet another FD symptom according to the Rome IV criteria of FGID. Prokinetics are recommended to relieve belching in such cases.Conclusion. Understanding the relationship between the excessive belching syndrome and FD requires further research.

Between Jerusalem and Athens

2018 ◽  
Author(s):  
Nurit Yaari
Keyword(s):  
Real Time ◽  
Social Conditions ◽  
Cultural Events ◽  
Greek Drama ◽  
The Past ◽  
Key Points ◽  
Mise En Scene ◽  
Dramatic Writing ◽  
Artistic Performance

How does a theatrical tradition emerge in the fields of dramatic writing and artistic performance? Can a culture, in which theatre played no part in the past, create a theatrical tradition in real time—and how? What was the contribution of classical Greek drama to the evolution of Israeli theatre? How do political and social conditions affect the encounter between cultures—and what role do they play in creating a theatre with a distinctive identity? This book, the first of its kind, attempts to answer these and other questions, by examining the reception of classical Greek drama in the Israeli theatre over the last seventy years. It deals with dramatic and aesthetic issues while analysing translations, adaptations, new writing, mise-en-scène, and ‘post dramatic’ performances of classical Greek drama that were created and staged at key points of the development of Israeli culture amidst fateful political, social, and cultural events in the country’s history.

Building Research Teams

2017 ◽  
Author(s):  
Ken Peach
Keyword(s):  
Common Goal ◽  
Research Teams ◽  
Building Research ◽  
The Past ◽  
Collective Activity ◽  
Research Administrators ◽  
Working Together ◽  
Common Goals ◽  
Almost All ◽  
Century Science

This chapter discusses the process of building research teams. Increasingly over the past three-quarters of a century, science has become a collective activity, with teams of tens, hundreds or even thousands of scientists, engineers and technicians working together on a common goal. Consequently, almost all research involves building, motivating and maintaining a research team. Even a theoretical group is likely to have one or two postdocs, graduate students and visitors, but research teams will, in addition, have engineers and technicians, as well as, possibly, research administrators. The chapter also addresses the importance of creating and maintaining a good team and team spirit, as large projects are assembled from a large number of small teams working on common goals, usually in a loose federated structure with some overall coordination and leadership.

Evidence-based Assessment

2010 ◽  
pp. 76-98
Author(s):  
John Hunsley ◽  
Eric J. Mash
Keyword(s):  
Decision Making ◽  
Clinical Assessment ◽  
Assessment Process ◽  
Evidence Based ◽  
The Past ◽  
Specific Assessment ◽  
The Many ◽  
Selection Of ◽  
Made In

Evidence-based assessment relies on research and theory to inform the selection of constructs to be assessed for a specific assessment purpose, the methods and measures to be used in the assessment, and the manner in which the assessment process unfolds. An evidence-based approach to clinical assessment necessitates the recognition that, even when evidence-based instruments are used, the assessment process is a decision-making task in which hypotheses must be iteratively formulated and tested. In this chapter, we review (a) the progress that has been made in developing an evidence-based approach to clinical assessment in the past decade and (b) the many challenges that lie ahead if clinical assessment is to be truly evidence-based.

scholarly journals Standardizing human brain parcellations

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Ross M. Lawrence ◽  
Eric W. Bridgeford ◽  
Patrick E. Myers ◽  
Ganesh C. Arvapalli ◽  
Sandhya C. Ramachandran ◽  
...  
Keyword(s):  
Human Brain ◽  
Coordinate Space ◽  
The Past ◽  
File Storage ◽  
Statistical Inferences ◽  
Standardized Protocol ◽  
Storage Format ◽  
Labeling Scheme ◽  
Selection Of ◽  
Brain Atlases

AbstractUsing brain atlases to localize regions of interest is a requirement for making neuroscientifically valid statistical inferences. These atlases, represented in volumetric or surface coordinate spaces, can describe brain topology from a variety of perspectives. Although many human brain atlases have circulated the field over the past fifty years, limited effort has been devoted to their standardization. Standardization can facilitate consistency and transparency with respect to orientation, resolution, labeling scheme, file storage format, and coordinate space designation. Our group has worked to consolidate an extensive selection of popular human brain atlases into a single, curated, open-source library, where they are stored following a standardized protocol with accompanying metadata, which can serve as the basis for future atlases. The repository containing the atlases, the specification, as well as relevant transformation functions is available in the neuroparc OSF registered repository or https://github.com/neurodata/neuroparc.

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