scholarly journals A Multidisciplinary Diagnostic Approach Reveals a Higher Prevalence of Indolent Systemic Mastocytosis: 15-Years’ Experience of the GISM Network

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6380
Author(s):  
Roberta Zanotti ◽  
Massimiliano Bonifacio ◽  
Cecilia Isolan ◽  
Ilaria Tanasi ◽  
Lara Crosera ◽  
...  
Keyword(s):  
Systemic Mastocytosis ◽  
Adult Population ◽  
Young Patients ◽  
Fragility Fractures ◽  
Veneto Region ◽  
Epidemiology Data ◽  
The Mean ◽  
Cutaneous Mastocytosis ◽  
The Impact ◽  
Indolent Systemic Mastocytosis

Systemic mastocytosis (SM) and other adult clonal mast cell disorders (CMD) are often underestimated, and their epidemiology data are scarce. We aimed at evaluating the impact of the activity of the Interdisciplinary Group for Study of Mastocytosis (GISM) of Verona on the prevalence and incidence of CMD. We examined the data of 502 adult patients diagnosed with CMD and residing in the Veneto Region, consecutively referred to GISM between 2006 and 2020. SM was diagnosed in 431 cases, while 71 patients had cutaneous mastocytosis or other CMD. Indolent SM represented the most frequent SM variant (91.0%), mainly with the characteristics of bone marrow mastocytosis (54.8%). The prevalence of SM in the adult population of the Veneto region and of the Verona province was 10.2 and 17.2/100,000 inhabitants, respectively. The mean incidence of new SM cases in Verona was 1.09/100,000 inhabitants/year. Hymenoptera venom allergy was the main reason (50%) leading to the CMD diagnosis. Osteoporosis, often complicated by fragility fractures, was present in 35% of cases, even in young patients, especially males. Our data show a higher prevalence and incidence of SM than previously reported, confirming that reference centers with multidisciplinary approach are essential for the recognition and early diagnosis of CMD.

scholarly journals OR30-01 Real-World Minimed™ 670G System Use and Glycemic Outcomes of Pediatric and Adult Individuals Living with Type 1 Diabetes (T1D) in the United States

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Robert Alan Vigersky ◽  
Michael Stone ◽  
Pratik Agrawal ◽  
Alex Zhong ◽  
Kevin Velado ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Real World ◽  
Adult Population ◽  
Age Groups ◽  
The United States ◽  
System Use ◽  
System Data ◽  
The Mean ◽  
The Impact ◽  
The U.S

Abstract Introduction: The MiniMed™ 670G system was FDA-approved in 2016 for adults and adolescents ≥14yrs, and in 2018 for children ages 7-13yrs with T1D. Since then, use of the system has grown to over 180,000 people in the U.S. The glycemic control benefits of real-world MiniMed™ 670G system Auto Mode use in the U.S. were assessed. Methods: System data (aggregated five-minute instances of sensor glucose [SG]) uploaded from March 2017 to July 2019 by individuals (N=118,737) with T1D and ≥7yrs of age who enabled Auto Mode were analyzed to determine the mean % of overall time spent <54mg/dL/<70mg/dL (TBR); between 70-180mg/dL (TIR); and >180mg/dL/>250mg/dL (TAR). The impact of Auto Mode was further assessed in a sub-group of individuals (N=51,254) with, at least, 7 days of SG data for both Auto Mode turned ON and turned OFF. The % of TIR, TBR and TAR, and the associated glucose management indicator (GMI) were evaluated for the overall OFF (2,524,570 days) and ON (6,308,806 days) periods, and across different age groups. Results: System data TIR was 71.3%; TBR was 0.4% and 1.9%, respectively; and TAR was 26.8% and 6.2%, respectively. User-wise data of Auto Mode OFF versus ON showed a mean of 70.3% of the time spent in Auto Mode, that TIR increased from 60.9% to 69.9%; and that both TBR and TAR decreased. For those 7-13yrs (N=1,417), TIR increased from 48.7% to 61.5%; TBR increased from 0.5% to 0.6% and from 2.0% to 2.2%, respectively; and TAR decreased from 49.3% to 36.3% and from 20.5% to 13.0%, respectively. For those 14-21yrs (N=4,194), TIR increased from 51.0% to 61.5%; TBR decreased from 0.7% to 0.6% and from 2.3% to 2.0%, respectively; and TAR decreased from 46.7% to 36.5% and from 18.5% to 12.5%, respectively. For those ≥22yrs (N=45,643), TIR increased from 62.2% to 70.9%; TBR decreased from 0.7% to 0.5% and from 2.6% to 1.9%, respectively; and TAR decreased from 35.2% to 27.3% and from 9.9% to 6.3%, respectively. The mean GMI decreased by 0.23% (overall), 0.48% (7-13yrs), 0.35% (14-21yrs), and 0.22% (≥22yrs), respectively, with Auto Mode ON versus OFF. Discussion: In over 6 million days of real-world MiniMed™ 670G system Auto Mode use in the U.S., TIR of a large pediatric and adult population with T1D improved by 9% compared to when Auto Mode was OFF, which was comparable to or exceeded the TIR observed in the smaller pivotal trials. These results further support outcomes of the pivotal trials and increased glycemic control with system use.

The impact of sensitive KIT D816V detection on recognition of Indolent Systemic Mastocytosis

2015 ◽  
Vol 39 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Giovanna De Matteis ◽  
Roberta Zanotti ◽  
Sabrina Colarossi ◽  
Caterina De Benedittis ◽  
Andrès Garcia-Montero ◽  
...  
Keyword(s):  
Systemic Mastocytosis ◽  
The Impact ◽  
Indolent Systemic Mastocytosis ◽  
Kit D816v

scholarly journals Height of Male Prisoners in Santiago de Chile during the Nitrate Era: The Penalty of being Unskilled, Illiterate, Illegitimate and Mapuche

2020 ◽  
Vol 17 (17) ◽  
pp. 6261
Author(s):  
Manuel Llorca-Jaña ◽  
Javier Rivas ◽  
Damian Clarke ◽  
Diego Barría Traverso
Keyword(s):  
Adult Population ◽  
Physical Growth ◽  
Height Distribution ◽  
Santiago De Chile ◽  
Northern European ◽  
The Mean ◽  
Male Inmates ◽  
University Degree ◽  
The Impact ◽  
Male Prisoners

This article contributes to the study of inequality in the biological welfare of Chile’s adult population during the nitrate era, ca. 1880s–1930s, and in particular focuses on the impact of socioeconomic variables on height, making use of a sample of over 20,000 male inmates of the capital’s main jail. It shows that inmates with a university degree were taller than the rest; that those born legitimate were taller in adulthood; that those (Chilean born) whose surnames were Northern European were also taller than the rest, and in particular than those with Mapuche background; and that those able to read and write were also taller than illiterate inmates. Conditional regression analysis, examining both correlates at the mean and correlates across the height distribution, supports these findings. We show that there was more height inequality in the population according to socioeconomic status and human capital than previously thought, while also confirming the importance of socioeconomic influences during childhood on physical growth.

IMPACT OF BEAUVERIA BASSIANA ON THE COTTONWOOD BORER, PLECTRODERA SCALATOR (COLEOPTERA: CERAMBYCIDAE), IN A COMMERCIAL COTTONWOOD NURSERY.

1989 ◽  
Vol 24 (2) ◽  
pp. 186-190 ◽  
Author(s):  
B. T. Forschler ◽  
G. L. Nordin
Keyword(s):  
Beauveria Bassiana ◽  
Populus Deltoides ◽  
Adult Population ◽  
Control Treatment ◽  
High Dose ◽  
Flight Period ◽  
Treatment Area ◽  
Larval Population ◽  
The Mean ◽  
The Impact

A commercial Beauveria bassiana (Balsamo) Vuillemin conidial formulation, AGB 6178, was applied as a soil drench against the cottonwood borer, Plectrodera scalator (F.), in a commercial eastern cottonwood, Populus deltoides, nursery. Doses of 0, 2 × 109, 2 × 1010 and 1 × 1011 conidia/m2 were applied in June 1986. The adult population was monitored throughout its flight period (June–August) for B. bassiana infection. Greater than 60% of the adults collected in the treatment area post-treatment were infected with B. bassiana. The impact of the fungal application on the larval population was assessed 8 months later by the removal and dissection of the treated rootstocks. Though no differences were detected in the number of second-year larvae recovered, the mean number of first-year larvae found at the high dose (1 × 1011 CFU's/m2) was significantly less (LSD, alpha 0.05) than the mean number of larvae found in the control treatment (0 CFU's/m2), 5.0 and 9.4 larvae/10 rootstocks, respectively.

scholarly journals Fragility fractures as the initial manifestation of indolent systemic mastocytosis

2015 ◽  
Author(s):  
Evangeline Vassilatou ◽  
Nickolas Gavoyiannakis ◽  
Alexia Chatzipetrou ◽  
Christoforos Koulias ◽  
Michael Makris ◽  
...  
Keyword(s):  
Systemic Mastocytosis ◽  
Fragility Fractures ◽  
Initial Manifestation ◽  
Indolent Systemic Mastocytosis

scholarly journals Long-term efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis

Blood ◽  
2015 ◽  
Vol 126 (8) ◽  
pp. 1009-1016 ◽  
Author(s):  
Stéphane Barete ◽  
Olivier Lortholary ◽  
Gandhi Damaj ◽  
Isabelle Hirsch ◽  
Marie Olivia Chandesris ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Safety Profile ◽  
Systemic Mastocytosis ◽  
Adult Patients ◽  
Efficacy And Safety ◽  
Acceptable Safety Profile ◽  
Key Points ◽  
Cutaneous Mastocytosis ◽  
Indolent Systemic Mastocytosis

Key Points 2-CdA is an effective treatment with a long-term acceptable safety profile in patients with mastocytosis. 2-CdA is effective and safe in indolent systemic mastocytosis and cutaneous mastocytosis refractory to multiple symptomatic therapies.

scholarly journals Assessing and Improving the Knowledge of Sexually Transmitted Infections among High School Adolescents

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Itisha S. Jefferson ◽  
S. Kayo Robinson ◽  
Eleanor Tung-Hahn ◽  
Roan Schumann ◽  
Synthia Marrero-Conti ◽  
...  
Keyword(s):  
High School ◽  
High School Students ◽  
Sexually Transmitted Infections ◽  
Young Patients ◽  
Posttest Score ◽  
Pretest Score ◽  
School Students ◽  
Sexually Transmitted ◽  
The Mean ◽  
The Impact

Background. According to the Center for Disease Control and Prevention (CDC), half of the 20 million new sexually transmitted infections (STIs) occur annually in youth aged 15 to 24. It is critical for dermatologists to be able to provide young patients with accessible education about how to identify, prevent, and treat these conditions. Our pilot study sought to assess the impact of a live presentation about STIs in high school students and to evaluate students’ baseline and acquired knowledge about common STIs using a before and after survey. Methods. This survey study was conducted as part of the health education curriculum at a suburban high school. An interactive scenario-based presentation about STIs was given to participants. Identical, deidentified preintervention and postintervention surveys were completed by subjects to assess their baseline and acquired knowledge of STIs. Each question was worth 1 point, for a total of 8 points. Results. 74 high school students were surveyed. Overall, there was a mean improvement of 1.85 points in the posttest score in comparison to pretest score with a standard deviation of 1.58 ( p < 0.0001 ). Among all participants, the mean pretest score was 1.07 (SD = 0.75) and the mean posttest score was 2.92 (SD = 1.59). Conclusions. This study demonstrated that many young adults are unaware of the common types of STIs, symptoms, and potential complications. While our scenario-based presentation was effective at providing understandable content to help improve students’ knowledge regarding STIs, additional educational resources in varied formats could likely further these gains.

scholarly journals The impact of COVID-19 on trauma and orthopaedic patients requiring surgery during the peak of the pandemic

2020 ◽  
Vol 1 (9) ◽  
pp. 520-529 ◽  
Author(s):  
Nicola D Mackay ◽  
Christopher P Wilding ◽  
Clare R Langley ◽  
Jonathan Young
Keyword(s):  
Spinal Anaesthesia ◽  
Local Anaesthesia ◽  
Young Patients ◽  
Femoral Fractures ◽  
Fragility Fractures ◽  
Minimal Risk ◽  
Proximal Femoral Fractures ◽  
Regional Block ◽  
Orthopaedic Patients ◽  
The Impact

Aims COVID-19 represents one of the greatest global healthcare challenges in a generation. Orthopaedic departments within the UK have shifted care to manage trauma in ways that minimize exposure to COVID-19. As the incidence of COVID-19 decreases, we explore the impact and risk factors of COVID-19 on patient outcomes within our department. Methods We retrospectively included all patients who underwent a trauma or urgent orthopaedic procedure from 23 March to 23 April 2020. Electronic records were reviewed for COVID-19 swab results and mortality, and patients were screened by telephone a minimum 14 days postoperatively for symptoms of COVID-19. Results A total of 214 patients had orthopaedic surgical procedures, with 166 included for analysis. Patients undergoing procedures under general or spinal anaesthesia had a higher risk of contracting perioperative COVID-19 compared to regional/local anaesthesia (p = 0.0058 and p = 0.0007, respectively). In all, 15 patients (9%) had a perioperative diagnosis of COVID-19, 14 of whom had fragility fractures; six died within 30 days of their procedure (40%, 30-day mortality). For proximal femoral fractures, our 30-day mortality was 18.2%, compared to 7% in 2019. Conclusion Based on our findings, patients undergoing procedures under regional or local anaesthesia have minimal risk of developing COVID-19 perioperatively. Those with multiple comorbidities and fragility fractures have a higher morbidity and mortality if they contract COVID-19 perioperatively; therefore, protective care pathways could go some way to mitigate the risk. Our 30-day mortality of proximal femoral fractures was 18.2% during the COVID-19 pandemic in comparison to the annual national average of 6.1% in 2018 and the University Hospital Coventry average of 7% for the same period in 2019, as reported in the National Hip Fracture Database. Patients undergoing procedures under general or spinal anaesthesia at the peak of the pandemic had a higher risk of contracting perioperative COVID-19 compared to regional block or local anaesthesia. We question whether young patients undergoing day-case procedures under regional block or local anaesthesia with minimal comorbidities require fourteen days self-isolation; instead, we advocate that compliance with personal protective equipment, a negative COVID-19 swab three days prior to surgery, and screening questionnaire may be sufficient. Cite this article: Bone Joint Open 2020;1-9:520–529.

The impact of young age on outcome in colon cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 4075-4075
Author(s):  
C. Truong ◽  
S. Kempton ◽  
S. Lum ◽  
J. W. Morgan ◽  
J. H. Wong ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Young Patients ◽  
Stage Iv ◽  
Young Age ◽  
Rank Test ◽  
Primary Tumors ◽  
Old Patients ◽  
Significant Difference ◽  
The Mean ◽  
The Impact

4075 Background: The early age of diagnosis (<40 years) of colon cancer (CC) is generally considered to be associated with a particularly grave prognosis. Our objective was to determine the prognostic relevance of young age on outcome in CC. Methods: Retrospective cohort study from Region 5 of the California Cancer Registry (R5 CCR). Survival by Kaplan- Meier with significance assessed by log-rank test, T-test and Chi Square where appropriate. Results: Between January 1,1994 and December 31, 2003 10,730 patients with CC were diagnosed in R5 CCR. The patients ranged in age from 18–103 years (mean 71.1 years). Two hundred fourteen patients (2%) were 40 years of age or younger. The mean age of young patients was 34.6 years (range 18–40) and for old patients 71.3 years (range 41–103). The mean number of nodes examined were 18.5 in the young CC patient and 18.4 in the remainder of CC patients. There was no significant difference in the anatomic sub-site of the primary between younger and older CC patients (p=0.43). Young patients presented with more advanced primary tumors (T4 18.7% vs. 11.6%, p=0.03), more frequently with more extensive nodal involvement (N+ (54.4% vs. 40.2%, p<0.0001), and more frequently with distant metastatic disease (M1 25.7% vs. 18.3%, p=0.005). Despite these adverse characteristics, young patients had a significantly better disease specific survival (DSS) compared to their older counterparts (5 year survival 70.1% vs. 62.3%, p=0.02). Young patients had a suggestion of improved DSS compared to older patients in Stage I disease (5 yr DSS 96.0% vs. 90.5%, p=0.34) with more certain evidence of improved DSS in Stage II (5 yr DSS 94.8% vs. 79.9%, p=0.02), Stage III (5 yr DSS 73.4% vs. 57.2%, p=0.01) and most profoundly in Stage IV (5 yr DSS 20.1% vs. 0.08%, p=0.002). Conclusions: Despite adverse characteristics at diagnosis, young CC patients have a better DSS than their older counterparts. This is in contrast to the generally held opinion that young CC patients fare worse. This may reflect the ability of young CC patients to accept and tolerate more intense and aggressive therapies. No significant financial relationships to disclose.

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