Adherence to lifestyle recommendations of the World Cancer Research Fund/american Institute for Cancer Research of breast cancer survivors on adjuvant hormone therapy and associated factors

Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (n = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study.

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Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations and the Risk of Breast Cancer

Nutrients ◽

10.3390/nu12030607 ◽

2020 ◽

Vol 12 (3) ◽

pp. 607 ◽

Cited By ~ 2

Author(s):

Federica Turati ◽

Michela Dalmartello ◽

Francesca Bravi ◽

Diego Serraino ◽

Livia Augustin ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Research ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Processed Meat ◽

Research Fund ◽

American Institute ◽

The World ◽

Control Study

The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) introduced in 2007, and updated in 2018, nutrition-related recommendations for cancer prevention. Previous studies generally reported inverse associations of breast cancer with the 2007 recommendations, while no study has yet evaluated the association with the 2018 guidelines. We investigated the association between adherence to the 2018 WCRF/AICR recommendations and breast cancer risk in a case–control study from Italy and Switzerland (1991–2008) including 3034 incident histologically-confirmed breast cancer cases and 3392 hospital controls. Adherence to the 2018 guidelines was summarized through a score incorporating eight recommendations (body fatness, physical activity, consumption of wholegrains/vegetables/fruit/beans, “fast foods” and other processed foods high in fat, starches, or sugars, red/processed meat, sugar-sweetened drinks, alcohol, breastfeeding), with higher scores indicating higher adherence. Odds ratios (OR) were estimated using multiple logistic regression models. We also conducted a meta-analysis including 15 additional studies using random-effects models. In our case–control study, adherence to the 2018 WCRF/AICR guidelines was inversely associated with breast cancer, with ORs of 0.60 (95% confidence interval (CI), 0.51–0.70) for a score ≥5.5 vs. ≤4.25, and of 0.83 (95% CI, 0.79–0.88) for a 1-point increment. In our study, 25% of breast cancers were attributable to low-to-moderate guideline adherence. In the meta-analysis, the pooled relative risks (RRs) were 0.73 (95% CI, 0.65–0.82, p heterogeneity among studies < 0.001) for the highest vs. the lowest WCRF/AICR score category, and 0.91 (95% CI, 0.88–0.94, p heterogeneity < 0.001) for a 1-point increment. This work provides quantitative evidence that higher adherence to the WCRF/AICR recommendations reduces the risk of breast cancer, thus opening perspectives for prevention.

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Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and breast cancer risk in the Cancer de Màma (CAMA) study

Public Health Nutrition ◽

10.1017/s1368980015000634 ◽

2015 ◽

Vol 18 (18) ◽

pp. 3337-3348 ◽

Cited By ~ 16

Author(s):

Anouar Fanidi ◽

Pietro Ferrari ◽

Carine Biessy ◽

Carolina Ortega ◽

Angélica Angeles-Llerenas ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Cancer Research ◽

Postmenopausal Women ◽

Activity Level ◽

Mexican Population ◽

Cáncer De Mama ◽

Research Fund ◽

American Institute ◽

The World

AbstractObjectiveWe investigated the association between adherence to the recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and breast cancer (BC) risk in the Cancer de Màma (CAMA) study in a Mexican population.DesignPopulation-based case–control study.SubjectsIncident BC cases (n 1000) and controls (n 1074) matched on age, region and health-care system were recruited.SettingIn-person interviews were conducted to assess BC risk factors and habitual diet was assessed with an FFQ. Conformity to the WCRF/AICR recommendations was evaluated through a score incorporating seven WCRF/AICR components (body fatness, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks and breast-feeding), with high scores indicating adherence to the WCRF/AICR recommendations.ResultsNo statistically significant associations between WCRF/AICR score and risk of BC were observed. After excluding BMI from the WCRF/AICR score, the top quartile was associated with a decreased BC risk overall, with ORQ4–Q1=0·68 (95 % CI 0·49, 0·92, Ptrend=0·03), and among postmenopausal women, with ORQ4–Q1=0·60 (95 % CI 0·39, 0·94, Ptrend=0·03). Inverse associations were observed between BMI and risk of BC overall and among premenopausal women, with OR=0·57 (95 % CI 0·42, 0·76, Ptrend<0·01) and 0·48 (95 % CI 0·31, 0·73, Ptrend<0·01), respectively. Physical activity level was inversely associated with BC risk.ConclusionsThe WCRF/AICR index was not related with BC risk in the CAMA study. A combination of six components excluding BMI showed strong protective associations, particularly in postmenopausal women. Further prospective studies are required to clarify the role of adherence to WCRF/AICR recommendations, particularly with respect to BMI, in the Mexican population.

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Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and breast cancer risk

International Journal of Cancer ◽

10.1002/ijc.30015 ◽

2016 ◽

Vol 138 (11) ◽

pp. 2657-2664 ◽

Cited By ~ 35

Author(s):

Holly R. Harris ◽

Leif Bergkvist ◽

Alicja Wolk

Keyword(s):

Breast Cancer ◽

Cancer Research ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Research Fund ◽

American Institute ◽

The World ◽

Research Recommendations

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Current and past adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations in survivors of breast cancer

Roczniki Państwowego Zakładu Higieny ◽

10.32394/rpzh.2019.0081 ◽

2019 ◽

pp. 295-305

Author(s):

Emilia Kałędkiewicz ◽

Dorota Szostak-Węgierek

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Cancer Research ◽

Dietary Habits ◽

Control Group ◽

Study Group ◽

Research Fund ◽

American Institute ◽

The World ◽

History Of

Background. Breast cancer is the first in the structure of the incidence of neoplastic diseases in women, with the number of affected individuals becoming higher every year. The risk of breast cancer is influenced not only by genetic factors, but also by the lifestyle. Proper dietary habits, a high level of physical activity and normal body weight not only reduce the risk of developing a primary neoplastic lesion, but also a recurrence. In 2007 the World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) published their recommendations concerning lifestyle in the prophylaxis of neoplasms. Objective. The aim of the study was to assess whether the adherence to WCRF/AICR recommendations influenced the risk of developing breast cancer in women. Materials and methods. A case control study included 108 women aged over 50 with a history of breast cancer. The study group was divided into two subgroups: women who completed oncological treatment and experienced no recurrences for at least 5 years (group I, n=82) and women who had a recurrence (group II, n=26). The control group included women with no history of breast cancer (n=74). The adherence of lifestyle was assessed by assigning points for 8 WCRF/AICR recommendations. The results were compared in the study and control groups, both in all participants and separately in those who declared no changes in dietary habits after being diagnosed with breast cancer. Results. The adherence of lifestyle to WCRF/AICR recommendations was significantly lower in the group of women with a history of cancer compared to the control group. It was reported both in the study group as a whole (5.5 ± 1.34 vs 6.4 ± 1.48 points) and in those who declared no changes in dietary habits after being diagnosed with breast cancer (5.3 ± 1.24 vs 6.6 ± 1.38 points). The differences in the lifestyles of the participants with breast cancer and those in the control group were associated predominantly with the adherence to recommendations concerning appropriate physical activity, avoiding the consumption of sweetened drinks and limiting the consumption of processed and red meat. Conclusions. The results of the study confirmed the benefits of complying with WCRF/AICR recommendations in the prevention of breast cancer.

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