scholarly journals Pulmonary Fibroelastotic Remodelling Revisited

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1362
Author(s):  
Peter Braubach ◽  
Christopher Werlein ◽  
Stijn E. Verleden ◽  
Isabell Maerzke ◽  
Jens Gottlieb ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Underlying Disease ◽  
Systematic Evaluation ◽  
Hematopoietic Stem ◽  
Histological Criteria ◽  
Anatomic Distribution ◽  
Definition Of ◽  
In Transit ◽  
First Time ◽  
Radio Chemotherapy

Pulmonary fibroelastotic remodelling occurs within a broad spectrum of diseases with vastly divergent outcomes. So far, no comprehensive terminology has been established to adequately address and distinguish histomorphological and clinical entities. We aimed to describe the range of fibroelastotic changes and define stringent histological criteria. Furthermore, we wanted to clarify the corresponding terminology in order to distinguish clinically relevant variants of pulmonary fibroelastotic remodelling. We revisited pulmonary specimens with fibroelastotic remodelling sampled during the last ten years at a large European lung transplant centre. Consensus-based definitions of specific variants of fibroelastotic changes were developed on the basis of well-defined cases and applied. Systematic evaluation was performed in a steps-wise algorithm, first identifying the fulcrum of the respective lesions, and then assessing the morphological changes, their distribution and the features of the adjacent parenchyma. We defined typical alveolar fibro-elastosis as collagenous effacement of the alveolar spaces with accompanying hyper-elastosis of the remodelled and paucicellular alveolar walls, independent of the underlying disease in 45 cases. Clinically, this pattern could be seen in (idiopathic) pleuroparenchymal fibro-elastosis, interstitial lung disease with concomitant alveolar fibro-elastosis, following hematopoietic stem cell and lung transplantation, autoimmune disease, radio-/chemotherapy, and pulmonary apical caps. Novel in-transit and activity stages of fibroelastotic remodelling were identified. For the first time, we present a comprehensive definition of fibroelastotic remodelling, its anatomic distribution, and clinical associations, thereby providing a basis for stringent patient stratification and prediction of outcome.

scholarly journals Ontogenic changes in diel vertical migration patterns compared with known allometric changes in three mesopelagic squid species suggest an expanded definition of a paralarva

2010 ◽  
Vol 67 (7) ◽  
pp. 1436-1443 ◽  
Author(s):  
Elizabeth K. Shea ◽  
Michael Vecchione
Keyword(s):  
Vertical Migration ◽  
Diel Vertical Migration ◽  
Prey Capture ◽  
Morphological Changes ◽  
Migration Patterns ◽  
Squid Species ◽  
Visual Markers ◽  
Definition Of ◽  
Species Specific ◽  
First Time

Abstract Shea, E. K., and Vecchione, M. 2010. Ontogenic changes in diel vertical migration patterns compared with known allometric changes in three mesopelagic squid species suggest an expanded definition of a paralarva. – ICES Journal of Marine Science, 67: 1436–1443. Planktonic and newly hatched cephalopods are routinely called paralarvae. Currently, the onset of diel vertical migration (DVM) marks the end of the paralarval phase, although changes in ontogenic growth trajectories may also be used. Patterns of DVM are reported for the first time for three poorly understood mesopelagic squid species. Discrete-depth samples taken during the Amsterdam Mid North Atlantic Plankton Expeditions (AMNAPE) of 1980–1983 are used to examine the timing of ecological and morphological changes in Chtenopteryx sicula, Mastigoteuthis magna, and Brachioteuthis sp. 3. DVM patterns are species-specific, and ontogenic changes in DVM coincide with allometric changes in the arm, fin, and funnel characters of C. sicula at 7 mm mantle length. Mastigoteuthis magna is not concentrated in the upper 250 m of the water column during the day, and no clear DVM pattern is found in Brachioteuthis sp. 3, meaning that the endpoint of the paralarval phase cannot be defined ecologically in these species. Other ecological transformations, e.g. changes in prey-capture ability, are therefore explored as alternatives to DVM. The pad-shaped club and long neck are proposed as visual markers of the end of the paralarval phase of C. sicula and Brachioteuthis sp. 3, respectively.

RADIOTHERAPY FOR LYMPHOMAS: A 40-YEAR EXPERIENCE OF ONE CENTER

2018 ◽  
Vol 64 (4) ◽  
pp. 539-543
Author(s):  
Yuliya Vinogradova ◽  
Anastasiya Chumachenko ◽  
Nikolay Ilin
Keyword(s):  
Radiation Treatment ◽  
Allogeneic Transplantation ◽  
Original Method ◽  
Hematopoietic Stem ◽  
Sequential Development ◽  
Radio Therapy ◽  
Local Lesions ◽  
Total Body ◽  
First Time ◽  
Medium Dose

The 40-year experience of the department of radiotherapy for lymphoma of the «RRCRST named after. ac. A.M. Granov» of the Ministry of Health of Russia from the standpoint of today is discussed in the article. Modern methods of radiation treatment of Hodgkin's lymphoma at the stages of their sequential development, unique methods of local and total skin radio-therapy with electrons in skin lymphomas, the experience of radiotherapy in patients with lymphomas of various structures of the organ of vision, and the features of fractionation in radiotherapy for patients with plasma-cell tumors are considered. The department developed an original method of medium-dose total body radiotherapy in terms of the conditioning regime before allogeneic transplantation of hematopoietic stem cells for patients with leukemia and lymphomas, for the first time the experience of radiation therapy of patients with acute leukemia with local lesions of various organs and tissues was accumulated.

A Strategy for Design of Marine Pollution Monitoring Studies

1986 ◽  
Vol 18 (4-5) ◽  
pp. 15-26 ◽  
Author(s):  
D. A. Segar ◽  
E. Stamman
Keyword(s):  
Information Needs ◽  
Marine Pollution ◽  
Monitoring Program ◽  
Pollution Monitoring ◽  
Systematic Evaluation ◽  
Management Information ◽  
Different Types ◽  
Management Context ◽  
Definition Of ◽  
Scientific Testing

Most historical marine pollution monitoring has proven useless in a management context. A strategy for development of effective marine pollution monitoring programs is outlined. This strategy is based on the following steps: 1) systematic evaluation of the management information needs, 2) identification of the hypothetical impacts associated with those management concerns, and 3) investigation of the feasibility of monitoring those effects such that the existence, or absence, of a specified level of effects can be established in a statistically-valid manner. There are two fundamentally different types of monitoring program: site-specific and regional. These two types of program differ markedly in scope and approach when designed through application of this strategy. The strategy requires development of null hypotheses which address management concerns and which are amenable to scientific testing. In order for the program to be successful, the null hypotheses selected for inclusion in a marine pollution monitoring program must address levels of effect which are predefined to be environmentally significant. The definition of environmentally significant effect levels is a difficult process which must be primarily the responsibility of the managerial community.

scholarly journals New Challenges for Biobanks: Accreditation to the New ISO 20387:2018 Standard Specific for Biobanks

BioTech ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 13
Author(s):  
Pasquale De Blasio ◽  
Ida Biunno
Keyword(s):  
Performance Monitoring ◽  
Quality Management System ◽  
Internal Audit ◽  
Accreditation Body ◽  
Accreditation Process ◽  
Testing Facility ◽  
Collection Data ◽  
Definition Of ◽  
First Time ◽  
Operational Aspects

Background: The emergence of “multi-omics” and “multi-parametric” types of analysis based on a high number of biospecimens enforces the use of a great number of high-quality “Biological Materials and Associated Data” (BMaD). To meet the demands of biomedical research, several Biological Resource Centers (BRCs) or Biobanks world-wide have implemented a specific Quality Management System (QMS) certified ISO 9001:2015 or accredited by CAP9 ISO 20387:2018. For the first time, ISO, with the support of several Biobanking experts, issued the ISO 20387:2018 which is the first ISO norm specific for Biobanks. The fundamental difference with present certification/accreditation standards is that the ISO 20387:2018 focuses not only on the operational aspects of the Biobank, but also on the “competence of the Biobank to carry our specific Biobanking tasks”. Methods: The accreditation process for ISO 20387:2018 required the definition of: (1) objectives, goals and organizational structure of the Biobank, including procedures for governance, confidentiality and impartiality policies; (2) standard operating procedures (SOPs) of all activities performed, including acquisition, analysis, collection, data management, distribution, preparation, preservation, testing facility and equipment maintenance, calibration, and monitoring; (3) procedures for control of documents and records, the identification of risks and opportunities, improvements, corrective actions, nonconforming records and evaluation of external providers (4) an internal audit and management reviews, verification of QMS performance, monitoring of quality objectives and personnel qualification and competency in carrying out specific Biobanking tasks. Results: The accreditation process is performed by an independent authorized organization which certifies that all processes are performed according to the QMS, and that the infrastructure is engineered and managed according to the GDP and/or GMP guidelines. Conclusion: Accreditation is given by an accreditation body, which recognizes formally that the Biobank is “competent to carry out specific Biobanking tasks”.

Improving the Volumetric Efficiency of the Axial Piston Pump

2012 ◽  
Vol 134 (11) ◽  
Author(s):  
Shu Wang
Keyword(s):  
Operating Conditions ◽  
Volumetric Efficiency ◽  
Valve Plate ◽  
Piston Pump ◽  
Efficient Design ◽  
Axial Piston Pumps ◽  
Definition Of ◽  
Engineering Practices ◽  
First Time ◽  
Axial Piston

The volumetric efficiency is one of the most important aspects of system performance in the design of axial piston pumps. From the standpoint of engineering practices, the geometric complexities of the valve plate (VP) and its multiple interactions with pump dynamics pose difficult obstacles for optimization of the design. This research uses the significant concept of pressure carryover to develop the mathematical relationship between the geometry of the valve plate and the volumetric efficiency of the piston pump. For the first time, the resulting expression presents the theoretical considerations of the fluid operating conditions, the efficiency of axial piston pumps, and the valve plate designs. New terminology, such as discrepancy of pressure carryover (DPC) and carryover cross-porting (CoCp), is introduced to explain the fundamental principles. The important results derived from this study can provide clear recommendations for the definition of the geometries required to achieve an efficient design, especially for the valve plate timings. The theoretical results are validated by simulations and experiments conducted by testing multiple valve plates under various operating conditions.

Updating the knowledge of the flower flies (Diptera: Syrphidae) from Chile: Illustrated catalog, extinction risk and biological notes

Zootaxa ◽  
2021 ◽  
Vol 4959 (1) ◽  
pp. 1-178
Author(s):  
RODRIGO M. BARAHONA-SEGOVIA ◽  
PAMELA RIERA ◽  
LAURA PAÑINAO-MONSÁLVEZ ◽  
VICENTE VALDÉS GUZMÁN ◽  
PATRICIA HENRÍQUEZ-PISKULICH
Keyword(s):  
Extinction Risk ◽  
Critical Role ◽  
Floral Biology ◽  
Iucn Red List ◽  
Decomposition Of Organic Matter ◽  
Management Plans ◽  
Flower Flies ◽  
Iucn Red List Criteria ◽  
Definition Of ◽  
First Time

Syrphidae, more commonly known as flower flies, are considered one of the most important Diptera families worldwide because of their critical role in pollination, biological control and decomposition of organic matter. The study of these flies in Chile has stagnated due to a lack of local experts as well as the absence of an updated catalog of species. This study is an attempt to remedy the latter of these issues by providing an illustrated and updated catalog to the Syrphidae of Chile. Species are presented under currently accepted names, with synonyms and previous combinations listed and original references. Type localities, world and Chilean distribution by geopolitical Chilean regions, taxonomic and biological notes, a complete record of bibliographic references and extinction risk under IUCN Red List criteria are provided. This catalog recognizes 132 species of Syrphidae, belonging to four subfamilies (Eristalinae, Microdontinae, Pipizinae and Syrphinae), 13 tribes and 47 genera. A total of 46 species (34.84 %) is restricted to the geopolitical territory of Chile. Eight species are considered exotic, one is considered incertae sedis and three are based on doubtful records. Seventeen species of 10 different genera (Copestylum Macquart, 1846; Dolichogyna Macquart, 1842; Eosalpingogaster Hull, 1949b; Eupeodes Osten Sacken, 1877; Meromacrus Rondani, 1848; Palpada Macquart, 1834; Paragus Latreille, 1804; Sphiximorpha Rondani, 1850; Sterphus Philippi, 1865 and Toxomerus Macquart, 1855) are reported from Chile for the first time. A total of 44 species (33.33 %) reported from Chile are directly threatened by human activities such as agriculture, forestry, mining and/or urbanization and indirectly by climate change. The gaps found in the geographic distribution of Chilean flower fly species and what it means for its use by disciplines such as ecology, floral biology and agronomy, are discussed. In addition, the use of this illustrated catalog for biological conservation, the potential definition of priority areas and ecosystem management plans based on this group of Diptera are also discussed. 

Perforation mechanics of UHMWPE soft ballistic sub-laminate and soft ballistic armor pack: A finite element study

2021 ◽  
pp. 089270572110420
Author(s):  
Bazle Z (Gama) Haque ◽  
John W Gillespie
Keyword(s):  
Finite Element ◽  
Single Layer ◽  
Areal Density ◽  
Element Model ◽  
Transverse Impact ◽  
Free Standing ◽  
Uhmwpe Fibers ◽  
Ballistic Limit Velocity ◽  
Definition Of ◽  
First Time

Soft-ballistic sub-laminate (SBSL) made from ultra-high molecular weight polyethylene (UHMWPE) fibers in [0/90] stacking sequence are the building block of a multi-layer soft-ballistic armor pack (SBAP, aka Soft Armor). A systematic study of the perforation dynamics of a single layer SBSL and several multi-layer SBAPs (2, 3, 4, 8, 16, 24, 32 layers) is presented for the first time in the literature. A previously validated finite element model of transverse impact on a single layer is used to study the perforation mechanics of multi-layer SBAPs with friction between individual layers. Following the classical definition of ballistic limit velocity, a minimum perforation velocity has been determined for free-standing single layer SBSL and multi-layer SBAPs. For the multi-layer SBAPs, complete perforations have been identified as progressive perforation of individual layers through the thickness. The minimum perforation velocities of multi-layer SBAPS is linear with the areal density for the eight (8) layer target and thicker. Large deformation behavior and perforation mechanics of the SBAPs is discussed in detail.

Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo

1987 ◽  
Vol 7 (10) ◽  
pp. 3459-3465
Author(s):  
B Lim ◽  
D A Williams ◽  
S H Orkin
Keyword(s):  
Adenosine Deaminase ◽  
Leukemia Virus ◽  
Hematopoietic Cells ◽  
Phosphoglycerate Kinase ◽  
Moloney Murine Leukemia Virus ◽  
Systematic Evaluation ◽  
Hematopoietic Stem ◽  
Specific Sequences

Simplified Moloney murine leukemia virus-based recombinant retrovirus vectors have been constructed which transduce human adenosine deaminase (ADA) cDNA. ADA transcription is under the control of the constitutive promoter for the human X chromosome phosphoglycerate kinase (pgk) gene. In these simplified vectors, dominant selectable markers are not included and selection is dependent on overproduction of functional ADA enzyme. Primary murine hematopoietic cells were infected with helper-free recombinant ADA virus generated from Psi-2 packaging cells. Protein analysis revealed that human ADA enzyme was expressed in progenitor-derived hematopoietic colonies in vitro and CFU-S-derived spleen colonies in vivo. Enzyme expression was dependent on transcription from the pgk promoter. ADA expression in primary murine hematopoietic cells directed by the internal promoter was not adversely affected by the presence of the Moloney virus long terminal repeat enhancer sequence. Use of these vectors allows systematic evaluation of the effects of specific sequences in recombinant retrovirus vectors on expression in primary murine hematopoietic cells in vivo.

scholarly journals CULTURE-BASED STUDIES’ TOPOGRAPHY IN THE MODERN FRENCH SOCIAL SCIENCE

2019 ◽  
pp. 14-17
Author(s):  
B. E. Nosenok
Keyword(s):  
Social Sciences ◽  
Cultural Studies ◽  
Cultural History ◽  
Interdisciplinary Approach ◽  
The Body ◽  
Social Knowledge ◽  
History Of Culture ◽  
Critical Turn ◽  
Definition Of ◽  
First Time

Cultural studies as a humanities researcher takes the place of an expert. The relevance of this topic is due to the lack of development of the issues of “culture-based studies” in Ukrainian culturology. There is a lack of translated into French or Ukrainian languages of French sources published since 1975. French culturological science, which developed after 1975, is almost not represented in Ukrainian culturology. The present stage of the development of French historiography, which lies at the heart of cultural history, and cultural studies, is associated with increased attention to social knowledge. This stage is characterized by the deployment of a “critical turn”, which proceeds from the following principles: the interdisciplinary approach, the significance of cultural expertise, the severity of publications and the multiplicity of their forms, multidisciplinarity. The “critical turn” affects the following spheres of knowledge: la Culturologie, les Études culturelles, les Sciences de la Culture. The article substantiates the relevance of the use of the concept of “culture-based studies” to the definition of processes that are unfolding within the framework of French humanities and are associated exclusively with the theoretical formations in the context of the social sciences. The purpose of the article is to outline a map of culture-based studies in the field of French humanitaristics. The methodology of the article is based on the application of interdisciplinary and multidisciplinary approaches to research in the field of culturology. Also, methodological developments in the field of “critical turn” and the achievements of the sociological circle and the interdisciplinary discussion club “Eranos” were applied. The scientific novelty of the article is to substantiate the appropriateness of the use of the concept of “culture-based studies” on the definition of processes that are unfolding within the framework of French humanitaristics and relate exclusively to theoretical formations in the context of social sciences. This concept to the field of Ukrainian culturology is introduced for the first time. Also, for the first time, the place and forms of culturology in French humanities were clarified. Conclusions. Working with a source base and methodology is one of the points that are compulsory on the way to the solution of the tasks, the main of which is the formation of the body of fundamental works for French history (including the history of culture) and historiography of the period since 1975 year to the present day. On the basis of this building, there is the prospect of building an alternative national cultural history project addressed to the vector of the French historiographical, historical-anthropological and cultural-related issues in the field of social knowledge. The article presents the arguments why it is appropriate to use the concept of “culture-based studies” in the context of conducting research in relation to French humanitaristics, in particular, the modern period of its development.

scholarly journals CRIMINAL DELINQUENCY – CYBERSTALKING: CHARACTERISTICS OF OBJECT AND OBJECTIVE SIDE

2018 ◽  
Vol 2 (83) ◽  
pp. 45
Author(s):  
Uldis Ķinis
Keyword(s):  
Criminal Law ◽  
Criminal Responsibility ◽  
Written Text ◽  
Legitimate Interest ◽  
International Regulations ◽  
Actus Reus ◽  
The Law ◽  
Definition Of ◽  
Objective Side ◽  
First Time

On January 2018 significant amendments to the Criminal Law and the Law On the Procedure for Application of the Criminal Law came into force in Latvia. These changes not only in the first time introduce the criminal responsibility for the emotional violence, but also determine the procedure for assessing emotional disparity, equating the effects to telepathic injuries.In the article, the author reviews a modality of crime “persecution” - cyber-persecution. Although the legislator in the annotation of the law provides that the article also shall be applicable to acts committed in cyberspace, at the same time, the author indicates some problems that may arise due to the narrow interpretation of the law by the law enforcement. The purpose of the article is to study the object (protected legitimate interest) and the objective side (actus reus) of the offense - cyber-stalking. For purposes of research, several methods have been used. The method of comparative analysis, for examination and comparison of external and international regulations. Methods of legal interpretation used to disclose the differences between the understanding of the written text of the definition of the crime and what ought to be understood in the meaning of the norm. Finally, the author presents the conclusions and proposals on the application of the norm.

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