scholarly journals Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 924 ◽  
Author(s):  
Elia Bari ◽  
Ilaria Ferrarotti ◽  
Laura Saracino ◽  
Sara Perteghella ◽  
Maria Luisa Torre ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Antiviral Treatment ◽  
Therapeutic Strategies ◽  
World Population ◽  
The Novel ◽  
Pharmacological Effects ◽  
The World ◽  
The Moment ◽  
Novel Coronavirus

From the end of 2019, the world population has been faced the spread of the novel coronavirus SARS-CoV-2 responsible for COVID-19 infection. In approximately 14% of the patients affected by the novel coronavirus, the infection progresses with the development of pneumonia that requires mechanical ventilation. At the moment, there is no specific antiviral treatment recommended for the COVID-19 pandemic and the therapeutic strategies to deal with the infection are only supportive. In our opinion, mesenchymal stem cell secretome could offer a new therapeutic approach in treating COVID-19 pneumonia, due to the broad pharmacological effects it shows, including anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

Mesenchymal Stromal Cell Therapy For Critically Ill Patients With COVID-19 (Preprint)

2020 ◽  
Author(s):  
Koray Yalcin ◽  
Cansu Hemsinlioglu ◽  
Rehile Zengin ◽  
Meral Sonmezoglu ◽  
Riza Hakan Erbay ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Specific Treatment ◽  
Intravenous Route ◽  
The Novel ◽  
Inflammatory Biomarker ◽  
Reactive Protein ◽  
Advanced Stages ◽  
Novel Coronavirus

UNSTRUCTURED The novel coronavirus disease 2019 (COVID-19) continues to spread over the world and there is still no specific treatment. Beside many drug studies, there is not enough data about the place of cellular therapies. In this study, we used second passage cGMP grade umbilical cord-derived Mesenchymal Stromal Cell (MSC) via a combined intratracheal/intravenous route as a novel administration protocol. After the treatment, the values of inflammatory biomarker C-reactive protein of all patients decreased significantly [(before MSC therapy, mean: 84,8 mg/L (2,4-272 mg/L); after MSC administration, mean: 6,5 mg/L (0,3-25,3 mg/L)], procalcitonin decreased for 6 of 7 patients, increasing lymphocyte count was detected in 5 of 7 patients and pulmonary functions PaO2/FiO2 and Positive End-Expiratory Pressure (PEEP) improved in 5 of 7 patients within 7 days after MSC therapy. At the time of MSC administration, all 7 patients were receiving mechanical ventilation. After MSC therapy, 4 of 7 patients were weaned from mechanical ventilation. Although this study has limitations, the outcomes are promising for the advanced stages of COVID-19 pneumonia.

scholarly journals Common sage (Salvia officinalis) antiviral role: potentiality of a Unani hand sanitizer in COVID-19 (corona virus) second wave control

2021 ◽  
Vol 6 (4) ◽  
pp. 611-617
Author(s):  
MA Momith Azad ◽  
Abdullah Al Mahmud ◽  
Md Shahidul Islam ◽  
Ahmed Iqbal Gouhar
Keyword(s):  
Salvia Officinalis ◽  
Personal Hygiene ◽  
World Population ◽  
The Novel ◽  
Unani Medicine ◽  
Hand Sanitizer ◽  
The World ◽  
Novel Coronavirus ◽  
Second Wave ◽  
Chemical Mixing

The world has been fighting against a pandemic for more than a year, caused by a highly infectious disease named COVID-19 rooted by the novel coronavirus 2019. It has already been spread out in most of the countries and a few of which are experiencing second wave. The Novel coronavirus-2019 (SARS CoV-2) incurred more than 1.6 million deaths and 76 million cases in the world population (till 20 December 2020). Although some vaccines are being launched, however, their effectivity and availability are still unknown. Maintaining personal hygiene and social distance are the best way of protection. Hand washing is the utmost recommendation for the maintenance of personal hygiene since hands can be contaminated by the droplets easily. Particularly, in pandemic situations, it is crucial to interrupt the transmission chain of the virus by the practice of proper hand sanitization. The hand sanitization solely depends on the use of effective hand disinfecting agents. Natural formula-based disinfectants can be preferable to chemicals because of higher efficacy and lower adverse effects. Unani medicine is the system based on natural formulations. „Raihan‟ (common sage, Salvia officinalis) is frequently used in Unani medicine for its higher disinfectant role. Common sage extract with ethanol may provide superior efficacy against COVID-19. In this article, we presented information on common sage and its potentiality using with ethanol as a natural, skin-friendly hand sanitizer to prevent harmful action of chemical mixing synthetic sanitizer. Asian J. Med. Biol. Res. December 2020, 6(4): 611-617

scholarly journals Current strategies in diagnostics and therapeutics against novel coronavirus disease (COVID-19)

2021 ◽  
Vol 72 (2) ◽  
pp. 171-197
Author(s):  
FAISAL ALOTAIBI
Keyword(s):  
Therapeutic Strategies ◽  
Clinical Findings ◽  
The Novel ◽  
Vaccination Programs ◽  
Diagnostic Strategies ◽  
Antiviral Therapies ◽  
The World ◽  
Supportive Interventions ◽  
Novel Coronavirus ◽  
Made In

Abstract The epidemic of COVID-19 spread quickly through China and engulfed all of the countries across the globe. Several advances have been made in understanding the novel coronavirus’s pathophysiology and in the development of newer diagnostics with pinpoint accuracy. Several newer therapeutic methods have either been accepted or are awaiting acceptance. In many countries, vaccination programs have been rolled out. Despite all these efforts, coronavirus still exists, though with lesser propensity. Multiple new forms of the novel coronavirus unexpectedly appeared in various areas of the world, undermining previously existing diagnosis and care protocols. This article highlights our understanding of the novel coronavirus’s symptoms in brief, pathogenesis, diagnostics, and therapeutic strategies to contain COVID-19. The clinical findings, including serological, radiological, and other advanced diagnostic strategies, contributed much to control the disease. To date, supportive interventions have been used in tandem with potent antiviral therapies such as remdesivir, lopinavir/ritonavir, or corticosteroids with a level of trust in the care of COVID-19 patients. However, in several areas of the world, vaccination initiatives took place; the vaccines’ safety and efficacy to control the outbreak is yet to be identified. This review concludes that improvement in therapies and diagnostics for COVID-19 must continually be explored as new variants constantly emerge.

scholarly journals COVID-19 AND TOURISM

2021 ◽  
Vol 9 (4) ◽  
pp. 788-804
Author(s):  
Mehtab Alam ◽  
◽  
Rizwana Parveen ◽  
Keyword(s):  
World Economy ◽  
First Aid ◽  
International Travel ◽  
World Population ◽  
The Novel ◽  
Wild Fire ◽  
The World ◽  
To Come ◽  
Novel Coronavirus ◽  
Entire Planet

With the outbreak of the novel coronavirus (COVID-19), the whole world has been in a total shutdown. It came out as a challenge to just not some specific countries of continents, but to the entire planet. With no preparation for such type of pandemic and the time and effort required to come up with a fully functional and tested vaccine, the planet went down on its knees. Non pharmaceutical methods were the first aid for the outbreak. Unprecedented country wide lockdowns, stay at home decisions, closure of global as well as local travel, closure of public gatherings greatly disrupted the world economy. International travel bans were the first to be practiced which roughly affected 100% of the world population. With restrictions on public gatherings and movement of people, tourism came to a stand-still in March-April 2020. By this time, COVID-19 had reached most of the countries and the virus was spreading like wild fire.

scholarly journals Myths: Barriers to Fighting the COVID-19 Pandemic

2021 ◽  
Author(s):  
Olabode Omotoso ◽  
Teibo John ◽  
Gbenga Ojo
Keyword(s):  
The Elderly ◽  
Disease Outbreak ◽  
Human Interaction ◽  
World Population ◽  
The Novel ◽  
Conspiracy Theories ◽  
What Works ◽  
The World ◽  
The Common ◽  
Novel Coronavirus

Myths are widely dispersed but false ideologies or misconceptions. With the thousands of deaths recorded daily and the negative toll of the novel coronavirus disease (COVID-19) on public health, national economy, and human interaction, it remains surprising how people are still being swayed by conspiracy theories. Due to the novelty of the disease, the quest for an answer, what works, and what does not work gave room for the propagation of misinformation, especially on social media. Identifying and debunking myths is very important in managing disease outbreak, since myths can negatively influence the response of people to preventive and containment strategies. Major proponents of COVID-19 myths have promoted their falsehood on the guise that it is a biological weapon engineered to control the world population. Others have also falsely claimed the use of antibiotics or other antiviral drugs in the treatment of COVID-19 and that COVID-19 is no worse than the common flu or it is just the disease of the elderly. This has promoted refusal to take up the COVID-19 vaccine and increased non-adherence to the preventive guidelines. Myths have been a major stumbling block to curtailing the menace of COVID-19. All hands must be on deck to fight this.

scholarly journals A comprehensive review on COVID-19: What we know and how to treat against the novel coronavirus

2021 ◽  
Vol 292 ◽  
pp. 03091
Author(s):  
Jiacheng Wang ◽  
Xianhao Xu ◽  
Zihan Xu
Keyword(s):  
Vaccine Development ◽  
Therapeutic Strategies ◽  
Antiviral Drugs ◽  
Extensive Study ◽  
Passive Immunity ◽  
The Novel ◽  
Comprehensive Review ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

COVID-19 emerged in Wuhan, China, at the end of 2019 and then soon evolved into a global pandemic. The novel coronavirus inducing this pandemic is under extensive study held by researchers all over the world. We give out a comprehensive review of what we have known about this novel coronavirus, including the pathogenesis. Passive immunity, different strategies, and targets for vaccine development and antiviral drugs are introduced as therapeutic strategies. At last, many other properties of SARS-Cov-2 are discussed.

scholarly journals New corona virus: is just a tip of iceberg?

2020 ◽  
Vol 9 (7) ◽  
pp. 1147
Author(s):  
Arvind Narwat ◽  
Seema Rani ◽  
Garima Bhutani ◽  
Rahul Saini ◽  
Kamaldeep Singh
Keyword(s):  
Genome Sequence ◽  
Vaccine Development ◽  
Antiviral Treatment ◽  
Whole Genome Sequence ◽  
Whole Genome ◽  
The Novel ◽  
The Past ◽  
Cruise Ships ◽  
The World ◽  
Novel Coronavirus

The world is again experiencing a global viral epidemic of zoonotic origin. As of March 30, 785807 confirmed cases of coronavirus disease 2019 (COVID-19) and 37820 deaths had been reported in more than 120 countries. Strenuous efforts are being made by various countries of the world to halt transmission through shutting down transport, quarantining entire cities and enforcing the use of face masks. International flights have been cancelled and affected cruise ships quarantined. As in all outbreaks, there is an urgent need to develop effective diagnostics, therapeutics and vaccines. Several experimental diagnostic platforms are already in use in China and elsewhere. The whole-genome sequence of SARS-CoV-2 has been obtained and shared widely. Several potential treatments have been proposed, however, no antiviral treatment has been approved for the novel coronavirus, and despite two outbreaks of novel coronaviruses in the past two decades, vaccine development is still in its infancy.

scholarly journals Modeling Behavioural Evolution as Social Predictor for the Coronavirus Contagion and Immunization in Nigeria

2020 ◽  
Vol 3 (2) ◽  
pp. 135-144
Author(s):  
Arnold Adimabua Ojugo ◽  
Andrew Okonji Eboka
Keyword(s):  
United States Of America ◽  
The United States ◽  
Health Conditions ◽  
World Population ◽  
The Novel ◽  
Death Toll ◽  
The Social ◽  
The World ◽  
The Rich ◽  
Novel Coronavirus

Since the outbreak of the novel coronavirus (covid-19) pandemic from China in 2019, it has left the world leaders in great confusing due to its fast-paced propagation and spread that has left infected a world population of over Eleven Million persons with over five hundred and thirty four thousand deaths and counting with the United States of America, Brazil, Russia, India and Peru in the lead on these death toll. The pandemic whose increased mortality rate is targeted at ‘aged’ citizens, patients with low immunology as well as patients with chronic diseases and underlying health conditions. Study models covid-19 pandemic via a susceptible-infect-remove actor-based graph, with covid-19 virus as the innovation diffused within the social graph. We measure the rich connective patterns of the actor-based graph, and explore personal feats as they influence other nodes to adopt or reject an innovation. Results shows current triggers (lifting of inter-intra state migration bans) and shocks (exposure to covid-19 by migrants) will lead to late widespread majority adoption of 23.8-percent. At this, the death toll will climb from between 4.43-to-5.61-percent to over 12%.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

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