scholarly journals Common sage (Salvia officinalis) antiviral role: potentiality of a Unani hand sanitizer in COVID-19 (corona virus) second wave control

2021 ◽  
Vol 6 (4) ◽  
pp. 611-617
Author(s):  
MA Momith Azad ◽  
Abdullah Al Mahmud ◽  
Md Shahidul Islam ◽  
Ahmed Iqbal Gouhar
Keyword(s):  
Salvia Officinalis ◽  
Personal Hygiene ◽  
World Population ◽  
The Novel ◽  
Unani Medicine ◽  
Hand Sanitizer ◽  
The World ◽  
Novel Coronavirus ◽  
Second Wave ◽  
Chemical Mixing

The world has been fighting against a pandemic for more than a year, caused by a highly infectious disease named COVID-19 rooted by the novel coronavirus 2019. It has already been spread out in most of the countries and a few of which are experiencing second wave. The Novel coronavirus-2019 (SARS CoV-2) incurred more than 1.6 million deaths and 76 million cases in the world population (till 20 December 2020). Although some vaccines are being launched, however, their effectivity and availability are still unknown. Maintaining personal hygiene and social distance are the best way of protection. Hand washing is the utmost recommendation for the maintenance of personal hygiene since hands can be contaminated by the droplets easily. Particularly, in pandemic situations, it is crucial to interrupt the transmission chain of the virus by the practice of proper hand sanitization. The hand sanitization solely depends on the use of effective hand disinfecting agents. Natural formula-based disinfectants can be preferable to chemicals because of higher efficacy and lower adverse effects. Unani medicine is the system based on natural formulations. „Raihan‟ (common sage, Salvia officinalis) is frequently used in Unani medicine for its higher disinfectant role. Common sage extract with ethanol may provide superior efficacy against COVID-19. In this article, we presented information on common sage and its potentiality using with ethanol as a natural, skin-friendly hand sanitizer to prevent harmful action of chemical mixing synthetic sanitizer. Asian J. Med. Biol. Res. December 2020, 6(4): 611-617

scholarly journals Exploring the role and mechanism of COVID-19 apps in fighting the current pandemic

2020 ◽  
Vol 0 ◽  
pp. 1-6
Author(s):  
Karthikeyan P. Iyengar ◽  
Rachit Jain ◽  
David Ananth Samy ◽  
Vijay Kumar Jain ◽  
Raju Vaishya ◽  
...  
Keyword(s):  
Data Privacy ◽  
Viral Transmission ◽  
Contact Tracing ◽  
The Novel ◽  
Test Track ◽  
The World ◽  
Novel Coronavirus ◽  
And Control ◽  
Second Wave ◽  
Transmission Test

As COVID-19 pandemic spread worldwide, policies have been developed to contain the disease and prevent viral transmission. One of the key strategies has been the principle of “‘test, track, and trace” to minimize spread of the virus. Numerous COVID-19 contact tracing applications have been rolled around the world to monitor and control the spread of the disease. We explore the characteristics of various COVID-19 applications and especially the Aarogya Setu COVID-19 app from India in its role in fighting the current pandemic. We assessed the current literature available to us using conventional search engines, including but not limited to PubMed, Google Scholar, and Research Gate in May 2020 till the time of submission of this article. The search criteria used MeSH keywords such as “COVID-19,” “pandemics,” “contact tracing,” and “mobile applications.” A variable uptake of different COVID-19 applications has been noted with increasing enrolment around the world. Security concerns about data privacy remain. The various COVID-19 applications will complement manual contact tracing system to assess and prevent viral transmission. Test, track, trace, and support policy will play a key role in avoidance of a “second wave” of the novel coronavirus severe acute respiratory syndrome coronavirus 2 outbreak.

scholarly journals Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 924 ◽  
Author(s):  
Elia Bari ◽  
Ilaria Ferrarotti ◽  
Laura Saracino ◽  
Sara Perteghella ◽  
Maria Luisa Torre ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Antiviral Treatment ◽  
Therapeutic Strategies ◽  
World Population ◽  
The Novel ◽  
Pharmacological Effects ◽  
The World ◽  
The Moment ◽  
Novel Coronavirus

From the end of 2019, the world population has been faced the spread of the novel coronavirus SARS-CoV-2 responsible for COVID-19 infection. In approximately 14% of the patients affected by the novel coronavirus, the infection progresses with the development of pneumonia that requires mechanical ventilation. At the moment, there is no specific antiviral treatment recommended for the COVID-19 pandemic and the therapeutic strategies to deal with the infection are only supportive. In our opinion, mesenchymal stem cell secretome could offer a new therapeutic approach in treating COVID-19 pneumonia, due to the broad pharmacological effects it shows, including anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties.

scholarly journals COVID-19 AND TOURISM

2021 ◽  
Vol 9 (4) ◽  
pp. 788-804
Author(s):  
Mehtab Alam ◽  
◽  
Rizwana Parveen ◽  
Keyword(s):  
World Economy ◽  
First Aid ◽  
International Travel ◽  
World Population ◽  
The Novel ◽  
Wild Fire ◽  
The World ◽  
To Come ◽  
Novel Coronavirus ◽  
Entire Planet

With the outbreak of the novel coronavirus (COVID-19), the whole world has been in a total shutdown. It came out as a challenge to just not some specific countries of continents, but to the entire planet. With no preparation for such type of pandemic and the time and effort required to come up with a fully functional and tested vaccine, the planet went down on its knees. Non pharmaceutical methods were the first aid for the outbreak. Unprecedented country wide lockdowns, stay at home decisions, closure of global as well as local travel, closure of public gatherings greatly disrupted the world economy. International travel bans were the first to be practiced which roughly affected 100% of the world population. With restrictions on public gatherings and movement of people, tourism came to a stand-still in March-April 2020. By this time, COVID-19 had reached most of the countries and the virus was spreading like wild fire.

scholarly journals Myths: Barriers to Fighting the COVID-19 Pandemic

2021 ◽  
Author(s):  
Olabode Omotoso ◽  
Teibo John ◽  
Gbenga Ojo
Keyword(s):  
The Elderly ◽  
Disease Outbreak ◽  
Human Interaction ◽  
World Population ◽  
The Novel ◽  
Conspiracy Theories ◽  
What Works ◽  
The World ◽  
The Common ◽  
Novel Coronavirus

Myths are widely dispersed but false ideologies or misconceptions. With the thousands of deaths recorded daily and the negative toll of the novel coronavirus disease (COVID-19) on public health, national economy, and human interaction, it remains surprising how people are still being swayed by conspiracy theories. Due to the novelty of the disease, the quest for an answer, what works, and what does not work gave room for the propagation of misinformation, especially on social media. Identifying and debunking myths is very important in managing disease outbreak, since myths can negatively influence the response of people to preventive and containment strategies. Major proponents of COVID-19 myths have promoted their falsehood on the guise that it is a biological weapon engineered to control the world population. Others have also falsely claimed the use of antibiotics or other antiviral drugs in the treatment of COVID-19 and that COVID-19 is no worse than the common flu or it is just the disease of the elderly. This has promoted refusal to take up the COVID-19 vaccine and increased non-adherence to the preventive guidelines. Myths have been a major stumbling block to curtailing the menace of COVID-19. All hands must be on deck to fight this.

scholarly journals Modeling Behavioural Evolution as Social Predictor for the Coronavirus Contagion and Immunization in Nigeria

2020 ◽  
Vol 3 (2) ◽  
pp. 135-144
Author(s):  
Arnold Adimabua Ojugo ◽  
Andrew Okonji Eboka
Keyword(s):  
United States Of America ◽  
The United States ◽  
Health Conditions ◽  
World Population ◽  
The Novel ◽  
Death Toll ◽  
The Social ◽  
The World ◽  
The Rich ◽  
Novel Coronavirus

Since the outbreak of the novel coronavirus (covid-19) pandemic from China in 2019, it has left the world leaders in great confusing due to its fast-paced propagation and spread that has left infected a world population of over Eleven Million persons with over five hundred and thirty four thousand deaths and counting with the United States of America, Brazil, Russia, India and Peru in the lead on these death toll. The pandemic whose increased mortality rate is targeted at ‘aged’ citizens, patients with low immunology as well as patients with chronic diseases and underlying health conditions. Study models covid-19 pandemic via a susceptible-infect-remove actor-based graph, with covid-19 virus as the innovation diffused within the social graph. We measure the rich connective patterns of the actor-based graph, and explore personal feats as they influence other nodes to adopt or reject an innovation. Results shows current triggers (lifting of inter-intra state migration bans) and shocks (exposure to covid-19 by migrants) will lead to late widespread majority adoption of 23.8-percent. At this, the death toll will climb from between 4.43-to-5.61-percent to over 12%.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

scholarly journals An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Padmalochan Hembram
Keyword(s):  
Immune System ◽  
Dark Side ◽  
Main Body ◽  
The Novel ◽  
Transmission Chain ◽  
The World ◽  
Therapeutic Molecules ◽  
Rapid Transmission ◽  
Novel Coronavirus ◽  
Near Future

Abstract Background Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak. Main body of the abstract The origin of this virus is yet unknown; however, rapid transmission from human-to-human “Anthroponosis” has widely confirmed. The world is witnessing a continuous hike in SARS-CoV-2 infection. In light of the outbreak of coronavirus disease 19, we have aimed to highlight the basic and vital information about the novel coronavirus. We provide an overview of SARS-CoV-2 transmission, timeline and its pathophysiological properties which would be an aid for the development of therapeutic molecules and antiviral drugs. Immune system plays a crucial role in virus infection in order to control but may have dark side when becomes uncontrollable. The host and SARS-CoV-2 interaction describe how the virus exploits host machinery and how overactive host immune response can cause disease severity also addressed in this review. Short conclusion Safe and effective vaccines may be the game-changing tools, but in the near future wearing mask, washing hands at regular intervals, avoiding crowed, maintaining physical distancing and hygienic surrounding, must be good practices to reduce and break the transmission chain. Still, research is ongoing not only on how vaccines protect against disease, but also against infection and transmission.

scholarly journals COVID-19 Vaccination: From Interesting Agent to the Patient

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 120
Author(s):  
Anis Daou
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Circulatory System ◽  
The Novel ◽  
Lead Compound ◽  
Fda Approval ◽  
The World ◽  
The Central Nervous System ◽  
Novel Coronavirus

The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.

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