Generation of Concentration Gradients by a Outer-Circumference-Driven On-Chip Mixer

The concentration control of reagents is an important factor in microfluidic devices for cell cultivation and chemical mixing, but it is difficult to realize owing to the characteristics of microfluidic devices. We developed a microfluidic device that can generate concentration gradients among multiple main chambers. Multiple main chambers are connected in parallel to the body channel via the neck channel. The main chamber is subjected to a volume change through a driving chamber that surrounds the main chamber, and agitation is performed on the basis of the inequality of flow caused by expansion or contraction. The neck channel is connected tangentially to the main chamber. When the main chamber expands or contracts, the flow in the main chamber is unequal, and a net vortex is generated. The liquid moving back and forth in the neck channel gradually absorbs the liquid in the body channel into the main chamber. As the concentration in the main chamber changes depending on the pressure applied to the driving chamber, we generated a concentration gradient by arranging chambers along the pressure gradient. This allowed for us to create an environment with different concentrations on a single microchip, which is expected to improve observation efficiency and save space.

Two electrical engineers, one problem, and evolution produced the same solution: A historical note

This note adds historical context into solving the problem of improving the speed of the step response of a low-order plant in two different types of control systems, a chemical mixing system and the human saccadic system. Two electrical engineers studied the above problem: one to understand and model how nature and evolution solved it and the other to design a control system to solve it in a man-made commercial system. David A. Robinson discovered that fast and accurate saccades were produced by a pulse-step of neural innervation applied to the extraocular plant. Leonidas M. Mantgiaris invented a method to achieve rapid and accurate chemical mixing by applying a large stimulus for a short period of time and then replacing it with the desired steady-state value (i.e., a “pulse-step” input). Thus, two humans used their brains to: 1) determine how the human brain produced human saccades; and 2) invent a control-system method to produce fast and accurate chemical mixing. That the second person came up with the same method by which his own brain was making saccades may shed light on the question of whether the human brain can fully understand itself.

Common sage (Salvia officinalis) antiviral role: potentiality of a Unani hand sanitizer in COVID-19 (corona virus) second wave control

The world has been fighting against a pandemic for more than a year, caused by a highly infectious disease named COVID-19 rooted by the novel coronavirus 2019. It has already been spread out in most of the countries and a few of which are experiencing second wave. The Novel coronavirus-2019 (SARS CoV-2) incurred more than 1.6 million deaths and 76 million cases in the world population (till 20 December 2020). Although some vaccines are being launched, however, their effectivity and availability are still unknown. Maintaining personal hygiene and social distance are the best way of protection. Hand washing is the utmost recommendation for the maintenance of personal hygiene since hands can be contaminated by the droplets easily. Particularly, in pandemic situations, it is crucial to interrupt the transmission chain of the virus by the practice of proper hand sanitization. The hand sanitization solely depends on the use of effective hand disinfecting agents. Natural formula-based disinfectants can be preferable to chemicals because of higher efficacy and lower adverse effects. Unani medicine is the system based on natural formulations. „Raihan‟ (common sage, Salvia officinalis) is frequently used in Unani medicine for its higher disinfectant role. Common sage extract with ethanol may provide superior efficacy against COVID-19. In this article, we presented information on common sage and its potentiality using with ethanol as a natural, skin-friendly hand sanitizer to prevent harmful action of chemical mixing synthetic sanitizer. Asian J. Med. Biol. Res. December 2020, 6(4): 611-617

Importance of the Induced Recharge Term in Riverbank Filtration: Hydrodynamics, Hydrochemical, and Numerical Modelling Investigations

While ensuring adequate drinking water supply is increasingly being a worldwide challenging need, managed aquifer recharge (MAR) schemes may provide reliable solutions in order to guarantee safe and continuous supply of water. This is particularly true in riverbank filtration (RBF) schemes. Several studies aimed at addressing the treatment capabilities of such schemes, but induced aquifer recharge hydrodynamics from surface water bodies caused by pumping wells is seldom analysed and quantified. In this study, after presenting a detailed description of the Serchio River RBF site, we used a multidisciplinary approach entailing hydrodynamics, hydrochemical, and numerical modelling methods in order to evaluate the change in recharge from the Serchio river to the aquifer due to the building of the RBF infrastructures along the Serchio river (Lucca, Italy). In this way, we estimated the increase in aquifer recharge and the ratio of bank filtrate to ambient groundwater abstracted at such RBF scheme. Results highlight that in present conditions the main source of the RBF pumping wells is the Serchio River water and that the groundwater at the Sant’Alessio plain is mainly characterized by mixing between precipitation occurring in the higher part of the plain and the River water. Based on chemical mixing, a precautionary amount of abstracted Serchio River water is estimated to be on average 13.6 Mm3/year, which is 85% of the total amount of water abstracted in a year (~16 Mm3). RBF is a worldwide recognized MAR technique for supplying good quality and reliable amount of water. As in several cases and countries the induced recharge component is not duly acknowledged, the authors suggest including the term “induced” in the definition of this type of MAR technique (to become then IRBF). Thus, clear reference may be made to the fact that the bank filtration is not completely due to natural recharge, as in many cases of surface water/groundwater interactions, but it may be partly/almost all human-made.

Radiative-transfer modeling of nebular-phase type II supernovae

Nebular phase spectra of core-collapse supernovae (SNe) provide critical and unique information on the progenitor massive star and its explosion. We present a set of one-dimensional steady-state non-local thermodynamic equilibrium radiative transfer calculations of type II SNe at 300 d after explosion. Guided by the results obtained from a large set of stellar evolution simulations, we craft ejecta models for type II SNe from the explosion of a 12, 15, 20, and 25 M⊙ star. The ejecta density structure and kinetic energy, the 56Ni mass, and the level of chemical mixing are parametrized. Our model spectra are sensitive to the adopted line Doppler width, a phenomenon we associate with the overlap of Fe II and O I lines with Ly α and Ly β. Our spectra show a strong sensitivity to 56Ni mixing since it determines where decay power is absorbed. Even at 300 d after explosion, the H-rich layers reprocess the radiation from the inner metal rich layers. In a given progenitor model, variations in 56Ni mass and distribution impact the ejecta ionization, which can modulate the strength of all lines. Such ionization shifts can quench Ca II line emission. In our set of models, the [O I] λλ 6300, 6364 doublet strength is the most robust signature of progenitor mass. However, we emphasize that convective shell merging in the progenitor massive star interior can pollute the O-rich shell with Ca, which would weaken the O I doublet flux in the resulting nebular SN II spectrum. This process may occur in nature, with a greater occurrence in higher mass progenitors, and this may explain in part the preponderance of progenitor masses below 17 M⊙ that are inferred from nebular spectra.