scholarly journals Development of a New Analytical Method for Determination of Veterinary Drug Oxyclozanide by Electrochemical Sensor and Its Application to Pharmaceutical Formulation

Chemosensors ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 25 ◽  
Author(s):  
Ersin Demir ◽  
Hulya Silah
Keyword(s):  
Tap Water ◽  
Anodic Stripping Voltammetry ◽  
Pulse Amplitude ◽  
Pharmaceutical Formulation ◽  
Anodic Peak ◽  
Veterinary Drug ◽  
Carbon Paste ◽  
Experimental Conditions ◽  
Analytical Technique ◽  
Time Frequency

A novel highly selective, sensitive and simple analytical technique was recommended for the investigation of anthelmintic veterinary drug oxyclozanide based on square wave anodic stripping voltammetry (SWASV) by using a carbon paste electrode (CPE). According to the cyclic voltammetric data, the oxidation and electron transfer processes of oxyclozanide were found as irreversible and adsorption-controlled, respectively. The voltammetric anodic peak response was characterized with respect to pH, accumulation potential, accumulation time, frequency and pulse amplitude, etc. Under these optimized experimental conditions, the anodic peak density of oxyclozanide was linear to oxyclozanide concentrations in the range from 0.058 to 4.00 mg/L. The described electrochemical method was successfully carried out for the oxyclozanide in pharmaceutical formulation and tap water with mean percentage recovery of 101.5 % and 102.2 %, respectively. The results of pharmaceutical formulation studies were statistically compared to the high-performance liquid chromatographic method.

scholarly journals Detection of mercury by a new sensor based CPE modified with extract of takaout plant

2016 ◽  
Vol 5 (4) ◽  
pp. 514-520
Author(s):  
Abdelaziz Ait sidi mou ◽  
Aicha Ouarzane ◽  
Mama El Rhazi
Keyword(s):  
Carbon Paste Electrode ◽  
Tap Water ◽  
Pulse Amplitude ◽  
Carbon Paste ◽  
Accumulation Time ◽  
Wave Voltammetry ◽  
Anodic Peak Current ◽  
Optimized Conditions ◽  
Paste Electrode

A new carbon paste electrode (CPE) modified with extract takaout was developed for the determination of mercury using square wave voltammetry (SWV).  Compared with carbon paste electrode, the anodic peak current had a significant increase at the modified electrode. Under the optimized conditions (amount of modifier 3%, 0.1 M acetate buffer pH 2, accumulation potential -0.6 V, accumulation time 300 s, resting time 10 s, frequency 25 Hz, pulse amplitude 0.050 V, step height 2 mV), a linear response was obtained in the concentration range from 3.1 to 11 µM Hg(II) and the detection limit was 0.42 µM. The results indicate that this electrode is sensitive and effective for determination of Hg2+ in the tap water sample.

scholarly journals Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode

2020 ◽  
Vol 67 (4) ◽  
pp. 1053-1060
Author(s):  
Sayed I. M. Zayed ◽  
Yousry M. Issa
Keyword(s):  
Carbon Paste Electrode ◽  
Supporting Electrolyte ◽  
Pulse Amplitude ◽  
Differential Pulse ◽  
Pharmaceutical Formulation ◽  
Carbon Paste ◽  
Voltammetric Method ◽  
Voltammetric Techniques ◽  
Paste Electrode

The electrochemical behavior of chlorzoxazone at the carbon paste electrode was investigated in 0.04 mol/L Britton-Robinson buffer pH 6.50 using cyclic and differential pulse voltammetric techniques. Cyclic voltammetric studies indicated that the oxidation of the drug was irreversible and controlled mainly by diffusion. Experimental and instrumental parameters were optimized (50 mV/s scan rate, 50 mV pulse amplitude, and 0.04 mol/L Britton-Robinson (BR) buffer pH 6.50 as a supporting electrolyte) and a sensitive differential pulse anodic voltammetric method has been developed for the determination of the drug over the concentration range 0.17–1.68 μg/mL chlorzoxazone, with detection and quantitation limits of 0.05 and 0.16 μg/mL, respectively. The proposed voltammetric method was successfully applied to the determinationof the drug in its pharmaceutical formulation (Myoflex tablets), and in spiked human urine samples.

Fabrication of an electrochemical sensor based on metal–organic framework ZIF-8 for quantitation of silver ions: optimizing experimental conditions using central composite design (CCD)

2020 ◽  
Vol 12 (23) ◽  
pp. 3045-3055
Author(s):  
Farzaneh Hashemi ◽  
Ali Reza Zanganeh ◽  
Farid Naeimi ◽  
Maryam Tayebani
Keyword(s):  
Metal Organic Framework ◽  
Anodic Stripping Voltammetry ◽  
Silver Ions ◽  
Stripping Voltammetry ◽  
Differential Pulse ◽  
Carbon Paste ◽  
Experimental Conditions ◽  
Metal Organic ◽  
Central Composite ◽  
Organic Framework

ZIF-8 was synthesized and carbon paste electrodes (CPEs) modified with this metal–organic framework were utilized for quantitation of silver(i) by the differential pulse anodic stripping voltammetry (DPASV) technique.

scholarly journals An efficient electrochemical sensing of hazardous catechol and hydroquinone at direct green 6 decorated carbon paste electrode

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
K. Chetankumar ◽  
B. E. Kumara Swamy ◽  
S. C. Sharma ◽  
S. A. Hariprasad
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Tap Water ◽  
Differential Pulse ◽  
Electrochemical Sensing ◽  
Carbon Paste ◽  
Pulse Voltammetry ◽  
Two Peaks ◽  
Paste Electrode ◽  
Scanning Electron

AbstractIn this proposed work, direct green 6 (DG6) decorated carbon paste electrode (CPE) was fabricated for the efficient simultaneous and individual sensing of catechol (CA) and hydroquinone (HY). Electrochemical deeds of the CA and HY were carried out by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at poly-DG6-modfied carbon paste electrode (Po-DG6-MCPE). Using scanning electron microscopy (SEM) studied the surface property of unmodified CPE (UCPE) and Po-DG6-MCPE. The decorated sensor displayed admirable electrocatalytic performance with fine stability, reproducibility, selectivity, low limit of detection (LLOD) for HY (0.11 μM) and CC (0.09 μM) and sensor process was originated to be adsorption-controlled phenomena. The Po-DG6-MCPE sensor exhibits well separated two peaks for HY and CA in CV and DPV analysis with potential difference of 0.098 V. Subsequently, the sensor was practically applied for the analysis in tap water and it consistent in-between for CA 93.25–100.16% and for HY 97.25–99.87% respectively.

scholarly journals A Novel Reduced Graphene Oxide Modified Carbon Paste Electrode for Potentiometric Determination of Trihexyphenidyl Hydrochloride in Pharmaceutical and Biological Matrices

Sensors ◽  
2021 ◽  
Vol 21 (9) ◽  
pp. 2955
Author(s):  
Josip Radić ◽  
Maša Buljac ◽  
Boštjan Genorio ◽  
Ema Gričar ◽  
Mitja Kolar
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Carbon Paste Electrode ◽  
Anticholinergic Drug ◽  
Modified Carbon Paste Electrode ◽  
Carbon Paste ◽  
Experimental Conditions ◽  
Electroactive Material ◽  
Reduced Graphene ◽  
Paste Electrode

A novel promising carbon paste electrode with excellent potentiometric properties was prepared for the analysis of trihexyphenidyl hydrochloride (THP), the acetylcholine receptor and an anticholinergic drug in real samples. It contains 10.2% trihexyphenidy-tetraphenylborate ionic pair as the electroactive material, with the addition of 3.9% reduced graphene oxide and 0.3% of anionic additive into the paste, which consists of 45.0% dibutylphthalate as the solvent mediator and 40.6% graphite. Under the optimized experimental conditions, the electrode showed a Nernstian slope of 58.9 ± 0.2 mV/decade with a regression coefficient of 0.9992. It exhibited high selectivity and reproducibility as well as a fast and linear dynamic response range from 4.0 × 10−7 to 1.0 × 10−2 M. The electrode remained usable for up to 19 days. Analytical applications showed excellent recoveries ranging from 96.8 to 101.7%, LOD was 2.5 × 10−7 M. The electrode was successfully used for THP analysis of pharmaceutical and biological samples.

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