scholarly journals Pediatric Septic Arthritis of the Knee Due to a Multi-Sensitive Streptococcus pyogenes Strain Responsive to Clindamycin—A Case Report

Children ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 189
Author(s):  
Giada Maria Di Pietro ◽  
Irene Maria Borzani ◽  
Sebastiano Aleo ◽  
Samantha Bosis ◽  
Paola Marchisio ◽  
...  
Keyword(s):  
Septic Arthritis ◽  
Streptococcus Pyogenes ◽  
Antibiotic Sensitivity ◽  
Antimicrobial Treatment ◽  
Antibiotic Regimen ◽  
Hematogenous Spread ◽  
Clinical Resistance ◽  
Antibiotic Sensitivity Test ◽  
Clinical Conditions

Septic arthritis is an inflammatory process usually generated by a bacterial infection. The knee is one of the most frequently involved joints. The etiology varies depending on age, and hematogenous spread remains the primary cause in children. Herein, we report a case of a previously healthy three-year-old female who was referred to our institution for acute swelling of her right knee. After a clinical and radiological diagnosis of septic arthritis, an empirical treatment with a combination of cefotaxime and clindamycin was initiated. The isolation of a multi-sensitive Streptococcus pyogenes strain from the joint’s effusion prompted the discontinuation of clindamycin and the usage of cefotaxime alone. One week later, an ultrasound was executed due to worsening in the patient’s clinical conditions, and an organized corpuscular intra-articular effusion with diffuse synovial thickening was revealed. Cefotaxime was therefore replaced with clindamycin, which improved the symptoms. Despite the antibiotic sensitivity test having revealed a microorganism with sensitivity to both cephalosporin and clindamycin, clinical resistance to cefotaxime was encountered and a shift in the antimicrobial treatment was necessary to ensure a full recovery. This case study confirms that an antibiotic regimen based solely on a susceptibility test may be ineffective for such cases.

scholarly journals BACTERIOLOGICAL EXAMINATION OF PUS SAMPLE COLLECTED FROM A COW: A CASE STUDY

2016 ◽  
Vol 4 (12) ◽  
pp. 31-33
Author(s):  
Subha Ganguly
Keyword(s):  
Present Article ◽  
Antibiotic Sensitivity ◽  
Neck Region ◽  
Sensitivity Test ◽  
Bacteriological Examination ◽  
Antibiotic Sensitivity Test

The present article reports on the bacteriological examination and antibiotic sensitivity test of pus sample collected from an abscess at the neck region of a cow.

A RETROSPECTIVE STUDY ON ANTIBIOTIC USAGE IN A TERTIARY CARE HOSPITAL

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Anna Joy ◽  
Aparna Anand ◽  
Arathy R Nath ◽  
Meera S Nair ◽  
Dr. K. G. Prasanth
Keyword(s):  
Retrospective Study ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Sensitivity Test ◽  
Actual Process ◽  
Care Hospital ◽  
Rational Use ◽  
Antibiotic Susceptibility Test ◽  
Antibiotic Sensitivity Test ◽  
Rational Use Of Antibiotics

Antibiotics are one of the most commonly prescribed drugs today. Rational use of antibiotics is therefore extremely important as their injudicious use can adversely affect the patient. Drug Utilization Evaluation (DUE) is a system of ongoing systematic criteria based evaluation of drug that will help to ensure that medicines are used appropriately. It is drug/disease specific and can be structured so that it will assess the actual process of prescribing, dispensing, or administration of drug. The retrospective study was conducted At Pk Das Institute of Medical Sciences, Palakkad, Kerala for a duration of 6 months (February 2017 - January 2018). A source of data includes Patient case sheets &medication charts, nursing charts, culture & sensitivity reports. The inclusion criterion includes Patients aged between 18- 80 year, prescribed with oral and parenteral antibiotics. . On analyzing the gender, male gender (n= 111, 55.5%) were higher in numbers as compared to female counterparts (n=89, 44.5%). In our study the majority of the patients prescribed with antibiotics were with the clinical assessment of COPD (n=39, 19.5%), UTI (n=37, 18.5%) and LRTI (n=28, 14%), Bronchial asthma (n=19, 9.5%) respectively. On analyzing the data based on antibiotic sensitivity test, antibiotic test were performed and followed in (n=64,32%)prescriptions and in (n=47,23.5%)prescriptions were test is not followed respectively. In (n=89,44.5%) prescriptions, antibiotic sensitivity test is not performed. On analysis of antibiotics prescribed, the most commonly prescribed antibiotics were cephalosporins, of these ceftriaxone was highly prescribed of all (n=95). The high percentage of antibiotic prescriptions may indicate a high probability of irrational use. This study also point out irrational use of antibiotics are more leading to resistance, misuse and serious problems. So certain strategies should be put forward to strengthen rational use of antibiotics. Keywords: Antibiotics, Antibiotic Susceptibility Test, Irrational use, Resistance

Etiology, clinical presentation, laboratory diagnostics, pathogenesis of impetigo and treatment methods

2020 ◽  
pp. 64-70
Author(s):  
Anastasiya Laknitskaya
Keyword(s):  
Streptococcus Pyogenes ◽  
Skin Diseases ◽  
Group A Streptococcus ◽  
Antibiotic Sensitivity ◽  
Antioxidant Defense System ◽  
Laboratory Diagnostics ◽  
Treatment Methods ◽  
Group A ◽  
The Individual

Currently, one of the priority medical and social problems is the optimization of treatment methods for pyoderma associated with Streptococcus pyogenes — group A streptococcus (GAS). To date, the proportion of pyoderma, the etiological factor of which is Streptococcus pyogenes, is about 6 % of all skin diseases and is in the range from 17.9 to 43.9 % of all dermatoses. Role of the bacterial factor in the development of streptococcal pyoderma is obvious. Traditional treatment complex includes antibacterial drugs selected individually, taking into account the antibiotic sensitivity of pathognomonic bacteria, and it is not always effective. Currently implemented immunocorrection methods often do not take into account specific immunological features of the disease, the individual, and the fact that the skin performs the function of not only a mechanical barrier, but it is also an immunocompetent organ. Such an approach makes it necessary to conduct additional studies clarifying the role of factors of innate and adaptive immunity, intercellular mediators and antioxidant defense system, that allow to optimize the treatment of this pathology.

Antibiotic susceptibility testing of bacteria in drinking water sources in Akungba‐Akoko, Ondo State, Nigeria

2011 ◽  
Vol 1 (4) ◽  
pp. 233-237
Author(s):  
A. O. Ajayi ◽  
N. F. Agangan
Keyword(s):  
Drinking Water ◽  
Water Samples ◽  
Multiple Drug Resistance ◽  
Antibiotic Sensitivity ◽  
Water Sources ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Antibiotic Resistant ◽  
Antibiotic Sensitivity Test ◽  
The University

In present investigation, the bacteriological analysis and antibiotic sensitivitypattern of drinking water samples collected from different sources ofAkungba Ã¢â‚¬ÂAkoko, Nigeria was done. The antibiotics mainly considered in ourstudy for determining the sensitivity were amongst the commonly used inthis area for treatment of infectious diseases. As a result, the bacteriologicalindex, especially coliform count was observed notably high with 72 x10 1 cfu/ml for stream sample and 26.4 x 10 1 cfu/ml for borehole sample. The majorbacterial isolates identified in the water samples were Staphylococcus sp,E.coli  Ã¢â‚¬Ânegative bacteria wereobserved showing 75% and 65% resistant to Septrin and Amoxicillin respectively.Also, multiple drug resistance was observed for many antibiotics.Therefore, the presence of high amount antibiotic resistant bacteria of clinicalimportance is reported in these water sources which are usually consumedby students and members of the University community. Hence, thisstudy necessitates the need for water treatment so that epidemics of waterbornebacterial disease can be averted in this region., Klebsiella sp, Pseudomonas sp., Enterococcus sp., Bacillus cereus andothers. With regards to the antibiotic sensitivity test, all isolates showed100% resistance to Ampicillin and Cloxacillin and 85.7% resistance to Zinnacef[a cephalosporin product]. However, the gram 

Bacterial Aetiology of Pharyngotonsillitis in Paediatric Age Group in a Tertiary Care Hospital in Kerala

2021 ◽  
Vol 8 (39) ◽  
pp. 3441-3447
Author(s):  
Thushara Ushakumari Bhuvanendran ◽  
Beena V.G.
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever ◽  
Bacterial Pathogens ◽  
Antibiotic Sensitivity ◽  
Acute Glomerulonephritis ◽  
Age Group ◽  
Common Organism

BACKGROUND Pharyngotonsillitis is defined as a spectrum of conditions ranging from inflammation primarily confined to the tonsils to pharyngitis implying generalized inflammation of the whole of pharynx. Children are more prone to get several episodes of pharyngotonsillitis per year during their school years. Pharyngitis caused by Streptococcus pyogenes can cause two non-suppurative complications, acute rheumatic fever and acute glomerulonephritis which is responsible for significant morbidity and mortality. The present study was conducted to identify the prevalence of bacterial pathogens causing pharyngotonsillitis and to study their antibiotic sensitivity pattern that would indicate the optimum line of treatment. METHOD A total of 200 children at the age group of 2 - 12 years who had clinical features of pharyngotonsillitis according to the inclusion criteria were recruited for this study over a period of one year. With the help of a disposable wooden spatula, pus from the pharyngo tonsillar region was collected and processed. Predominant isolates obtained were identified and antibiotic sensitivity was done. RESULTS Bacteria was isolated from 70 samples. Pharyngotonsillitis was found most prevalent at the age group of 8 – 10 years. Intake of cold food stuffs and passive smoking at home was found to have statistically significant association as risk factor for pharyngotonsillitis. Staphylococcus aureus was the most common organism isolated followed by Streptococcus pyogenes. The other organisms isolated were group G and C streptococci, Streptococcus pneumoniae, Pseudomonas aeruginosa and Klebsiella pneumonia sub species (spp) aerogenes. CONCLUSIONS Staphylococcus aureus was the most common organism isolated, followed by Streptococcus pyogenes. All the isolates of beta haemolytic streptococci were found to be sensitive to penicillin. There was increased incidence of resistance to macrolides among the gram-positive isolates except Streptococcus pneumoniae and it may be due to the wide spread use of macrolides injudiciously. All the bacterial pharyngotonsillitis cases were cured with the antibiotic given according to the sensitivity except one case. KEYWORDS Pharyngotonsillitis, Acute Rheumatic Fever, Acute Glomerulonephritis, Bacterial Pathogens, Antibiogram

scholarly journals Analysis of Streptococcus pyogenes reinfection in pediatric patients in Japan

2021 ◽  
Vol 6 (3) ◽  
pp. 076-082
Author(s):  
Masaaki Minami ◽  
Ryoko Sakakibara ◽  
Mika Watanabe ◽  
Hideo Morita
Keyword(s):  
Treatment Failure ◽  
Streptococcus Pyogenes ◽  
Pediatric Patients ◽  
Rapd Analysis ◽  
Random Amplified Polymorphic Dna ◽  
Drug Susceptibility ◽  
Antimicrobial Treatment ◽  
Test Results ◽  
Patient Age ◽  
Patient Âgé

Acute pharyngitis and tonsillitis caused by Streptococcus pyogenes are common pediatric infectious diseases. Although the presence of penicillin-resistant S. pyogenes has not been confirmed in Japan, the re-isolation rate of S. pyogenes after antimicrobial treatment has been increasing. Thus, we attempted to determine whether the presence of S. pyogenes in pediatric patients treated with antimicrobial treatment was because of treatment failure or reinfection. We examined 19 patients who visited Daido Hospital between 2013 and 2017. The patient age, drug susceptibility patterns of the isolated bacteria, and random amplified polymorphic DNA (RAPD) analysis results were evaluated. The patient age ranged from 3 months to 9 years, seven patients were 5 years old. Seven patients showed consistent drug susceptible test results, and 12 patients showed inconsistent drug susceptible test results. Among these 12 patients, nine patients showed a greater decrease in drug susceptibility than the other three patients. Genetic mismatch was confirmed by RAPD analysis in all seven patients with consistent drug susceptible results. The paired S. pyogenes isolates from the same patient showed the presence of different bacteria. Our results indicate that, in many cases, re-isolation of S. pyogenes is not due to treatment failure, but due to reinfection with other clinical isolates.

scholarly journals Case Report of Rare cause of Acute Hemolytic Anemia in Saudi Patient (Babesiosis)

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Khadiga Ahmed Ismail
Keyword(s):  
Case Report ◽  
Blood Transfusion ◽  
Infected Patient ◽  
Immune Status ◽  
Antimicrobial Treatment ◽  
Zoonotic Diseases ◽  
Severe Anemia ◽  
Clinical Presentations ◽  
Discharge From Hospital ◽  
Clinical Conditions

Babesiosis is one of the protozoan zoonotic diseases its presentation rang from asymptomatic to severe clinical conditions, with severe hemolysis. Immune status of the host and the species of the parasite has impact on the clinical presentations of the infected patient our patient is presented here; the patient was admitted from a countryside with severe anemia and a deterioration in his general condition, he was admitted to intense care unit and received blood transfusion, in addition to antimicrobial treatment in form of azithromycin and Ceftriaxon, his condition improve and released from ICU on the second day and discharge from hospital after improvement on the seventh day.

scholarly journals Acute Monoarthritis in an Immunocompetent Young Adult - Septic Arthritis - A Case Study

2021 ◽  
Vol 39 ◽  
pp. S48
Author(s):  
J. Vignesh Chandran ◽  
R. Kesavan ◽  
C. Nithya ◽  
C.P. Ramani
Keyword(s):  
Young Adult ◽  
Septic Arthritis
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