scholarly journals Update on Febrile Neutropenia in Pediatric Oncological Patients Undergoing Chemotherapy

Children ◽  
2021 ◽  
Vol 8 (12) ◽  
pp. 1086
Author(s):  
Federica Cennamo ◽  
Riccardo Masetti ◽  
Prisca Largo ◽  
Alberto Argentiero ◽  
Andrea Pession ◽  
...  
Keyword(s):  
Risk Factors ◽  
Febrile Neutropenia ◽  
Sufficient Evidence ◽  
Future Research ◽  
Oncological Patients ◽  
Underlying Illness ◽  
Common Etiology ◽  
Specific Factors ◽  
Febrile Episodes ◽  
Evidence Based Guideline

Febrile neutropenia (FN) is a common complication of chemotherapy in oncological children and one of the most important causes of morbidity and mortality in these patients. The early detection of a bacteremia and the rapid therapeutic intervention are crucial to improve the outcome. We analyzed the literature in order to clarify the epidemiology of FN in children undergoing chemotherapy, the specific factors associated with a negative outcome, the most common etiology, and the value of biological markers as a tool to make an early diagnosis or to monitor the evolution of the infection. Several studies have tried to identify specific factors that could help the clinician in the detection of an infection and in its microbiological identification. However, due to the heterogenicity of the available studies, sufficient evidence is lacking to establish the role of these risk factors in clinical practice and future research on this topic appear mandatory. Determinations of risk factors, etiology, and markers of febrile episodes in these patients are complicated by the characteristics of the underlying illness and the effects of treatments received. Although some studies have tried to develop an evidence-based guideline for the empiric management of FN in pediatrics, validated predictive scores and algorithms are still lacking and urgently needed.

Examining Gender-Specific and Gender-Neutral Risk Factors in Women Who Sexually Offend

2018 ◽  
Vol 46 (4) ◽  
pp. 511-527 ◽  
Author(s):  
Ethan A. Marshall ◽  
Holly A. Miller
Keyword(s):  
Risk Factors ◽  
Future Research ◽  
Specific Information ◽  
Gender Neutral ◽  
Specific Factors ◽  
And Gender ◽  
Sexually Offended ◽  
Victimization History ◽  
Gender Specific

Research on justice-involved women has provided evidence for the importance of using gender-specific information in the assessment, treatment, and understanding of criminal pathways and risk of recidivism in women who have committed offenses. Although research on women who have sexually offended suggests there are differences between men and women who sexually offend, no studies have compared gender-specific and gender-neutral factors to predict recidivism with this group. The current study provided an examination of gender-specific and gender-neutral recidivism risk factors in a sample of 225 women who had sexually offended and were subsequently released from custody with an average follow-up time of about 5 years. Results of the study indicate gender-specific factors, such as mental illness symptoms and victimization history, are demonstrative of risk of reoffense in women who sexually offend. These findings provide implications for future research regarding risk assessment and more effective application of treatment for this understudied population.

scholarly journals The Trajectory of Caregiver Burden and Risk Factors in Dementia Progression: A Systematic Review

2020 ◽  
Vol 77 (3) ◽  
pp. 1107-1115
Author(s):  
Robin van den Kieboom ◽  
Liselore Snaphaan ◽  
Ruth Mark ◽  
Inge Bongers
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Caregiver Burden ◽  
Neuropsychiatric Symptoms ◽  
Future Research ◽  
Physical And Mental Health ◽  
Behavioral Impairment ◽  
External Resources ◽  
Specific Factors

Background: Caring for patients with dementia at home is often a long-term process, in which the independence of the patient declines, and more responsibility and supervision time is required from the informal caregiver. Objective: In order to minimize and reduce caregiver burden, it is important to explore its trajectory and the accompanying risk factors as dementia progresses; the objective of this systematic review. Methods: PRISMA guidelines were followed in this systematic review. Three databases, PubMed, PsycINFO, and EMbase, were systematically searched in November 2019 using specific keywords. Results: 1,506 hits emerged during the systematic search but only eleven articles actually met the inclusion criteria for this review. The trajectory of caregiver burden is highly variable and depends on multiple factors. Important risk factors included: patients’ behavioral and neuropsychiatric symptoms, and their decline in functioning in (I)ADL; the caregiver’s age, gender, and physical and mental health; and, within the dyads (patient/caregiver), cohabitation and kinship. Conclusion: There is no one-size-fits-all for predicting how caregiver burden will change over time, but specific factors (like being a spouse and increased behavioral impairment and decline in functional status in the patient) may heighten the risk. Other factors, not yet comprehensively included in the published studies, might also prove to be important risk factors. Future research in the field of reducing caregiver burden is recommended to integrate the patient, caregiver, and context characteristics in the trajectory of caregiver burden, and to assess more clearly the phase of the dementia progression and use of external resources.

Attachment Organization in Suicide Prevention Research

Crisis ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Amanda Venta ◽  
Carla Sharp
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Interpersonal Relationships ◽  
Suicide Ideation ◽  
Suicide Attempts ◽  
Critical Role ◽  
Self Report ◽  
Future Research ◽  
Self Harm

Background: Identifying risk factors for suicide-related thoughts and behaviors (SRTB) is essential among adolescents in whom SRTB remain a leading cause of death. Although many risk factors have already been identified, influential theories now suggest that the domain of interpersonal relationships may play a critical role in the emergence of SRTB. Because attachment has long been seen as the foundation of interpersonal functioning, we suggest that attachment insecurity warrants attention as a risk factor for SRTB. Aims: This study sought to explore relations between attachment organization and suicidal ideation, suicide attempts, and self-harm in an inpatient adolescent sample, controlling for demographic and psychopathological covariates. Method: We recruited 194 adolescents from an inpatient unit and assigned them to one of four attachment groups (secure, preoccupied, dismissing, or disorganized attachment). Interview and self-report measures were used to create four variables reflecting the presence or absence of suicidal ideation in the last year, single lifetime suicide attempt, multiple lifetime suicide attempts, and lifetime self-harm. Results: Chi-square and regression analyses did not reveal significant relations between attachment organization and SRTB, although findings did confirm previously established relations between psychopathology and SRTB, such that internalizing disorder was associated with increased self-harm, suicide ideation, and suicide attempt and externalizing disorder was associated with increased self-harm. Conclusion: The severity of this sample and methodological differences from previous studies may explain the nonsignificant findings. Nonsignificant findings may indicate that the relation between attachment organization and SRTB is moderated by other factors that should be explored in future research.

Political psychology in the digital (mis)information age: A model of news belief and sharing

2020 ◽  
Author(s):  
Jay Joseph Van Bavel ◽  
Elizabeth Ann Harris ◽  
Philip Pärnamets ◽  
Steve Rathje ◽  
Kimberly Doell ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Psychology ◽  
Information Age ◽  
Policy Research ◽  
Integrative Model ◽  
Future Research ◽  
Fake News ◽  
Policy Makers ◽  
Conspiracy Theories ◽  
The Social

The spread of misinformation, including “fake news,” propaganda, and conspiracy theories, represents a serious threat to society, as it has the potential to alter beliefs, behavior, and policy. Research is beginning to disentangle how and why misinformation is spread and identify processes that contribute to this social problem. We propose an integrative model to understand the social, political, and cognitive psychology risk factors that underlie the spread of misinformation and highlight strategies that might be effective in mitigating this problem. However, the spread of misinformation is a rapidly growing and evolving problem; thus scholars need to identify and test novel solutions, and work with policy makers to evaluate and deploy these solutions. Hence, we provide a roadmap for future research to identify where scholars should invest their energy in order to have the greatest overall impact.

Dysfunctional Behavior in Organizations: Insights from the Management Control Literature

2017 ◽  
Vol 37 (4) ◽  
pp. 117-141 ◽  
Author(s):  
Krista Fiolleau ◽  
Theresa Libby ◽  
Linda Thorne
Keyword(s):  
Risk Factors ◽  
Internal Control ◽  
Management Control ◽  
Future Research ◽  
Fraud Triangle ◽  
Audit Risk ◽  
Research Opportunities ◽  
Dysfunctional Behavior ◽  
Research Questions ◽  
Published Research

SUMMARY As the scope of the audit continues to broaden (Cohen, Krishnamoorthy, and Wright 2017), research questions in management control and internal control are beginning to overlap. Even so, there is little overlap between these fields in terms of published research to date. The purpose of this paper is to take a step in bridging the gap between the management control and the internal control literatures. We survey relevant findings from the extant management control literature published between 2003 and 2016 on dysfunctional behavior and the ways in which it might be mitigated. We then use the fraud triangle as an organizing framework to consider how the management control literature might help to address audit risk factors identified in SAS 99/AU SEC 316 (AICPA 2002). The outcome of our analysis is meant to identify and classify the extant management control literature of relevance to research on internal control in a manner that researchers new to the management control literature will find accessible. We conclude with a set of future research opportunities that can help to broaden the scope of current research in internal control.

Risk Factors for CKD Progression

2020 ◽  
pp. CJN.07830520
Author(s):  
Mary Hannan ◽  
Sajid Ansari ◽  
Natalie Meza ◽  
Amanda H. Anderson ◽  
Anand Srivastava ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genome Wide Association Study ◽  
Healthy Lifestyle ◽  
Interdisciplinary Collaboration ◽  
Fibroblast Growth Factor 23 ◽  
Kidney Injury ◽  
The United States ◽  
Future Research ◽  
Ckd Progression ◽  
Factors Associated

The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.

scholarly journals Does the model of additive effect in placebo research still hold true? A narrative review

JRSM Open ◽  
2017 ◽  
Vol 8 (3) ◽  
pp. 205427041668143 ◽  
Author(s):  
Katja Boehm ◽  
Bettina Berger ◽  
Ulrich Weger ◽  
Peter Heusser
Keyword(s):  
Context Effects ◽  
Experimental Studies ◽  
Additive Model ◽  
Drug Effects ◽  
Future Research ◽  
Inclusion Criteria ◽  
Integrative Study ◽  
Additive Relation ◽  
Specific Factors ◽  
Study Designs

Personalised and contextualised care has been turned into a major demand by people involved in healthcare suggesting to move toward person-centred medicine. The assessment of person-centred medicine can be most effectively achieved if treatments are investigated using ‘with versus without’ person-centredness or integrative study designs. However, this assumes that the components of an integrative or person-centred intervention have an additive relationship to produce the total effect. Beecher’s model of additivity assumes an additive relation between placebo and drug effects and is thus presenting an arithmetic summation. So far, no review has been carried out assessing the validity of the additive model, which is to be questioned and more closely investigated in this review. Initial searches for primary studies were undertaken in July 2016 using Pubmed and Google Scholar. In order to find matching publications of similar magnitude for the comparison part of this review, corresponding matches for all included reviews were sought. A total of 22 reviews and 3 clinical and experimental studies fulfilled the inclusion criteria. The results pointed to the following factors actively questioning the additive model: interactions of various effects, trial design, conditioning, context effects and factors, neurobiological factors, mechanism of action, statistical factors, intervention-specific factors (alcohol, caffeine), side-effects and type of intervention. All but one of the closely assessed publications was questioning the additive model. A closer examination of study design is necessary. An attempt in a more systematic approach geared towards solutions could be a suggestion for future research in this field.

Cervical insufficiency: a noteworthy disease with controversies

2020 ◽  
Vol 48 (7) ◽  
pp. 648-655
Author(s):  
Yu Han ◽  
Mengnan Li ◽  
Huijing Ma ◽  
Hailan Yang
Keyword(s):  
Risk Factors ◽  
Diagnosis And Treatment ◽  
Practical Significance ◽  
Future Research ◽  
Cervical Insufficiency ◽  
Factors Associated ◽  
The World ◽  
Potential Risk Factors ◽  
Recurrent Pregnancy Losses ◽  
Recurrent Abortions

AbstractCervical insufficiency (CI) is a mainly disease leading to recurrent abortions and preterm birth which may present in about 1% of obstetric populations. Recurrent pregnancy losses caused by CI incur serious economic burdens on society as well as huge psychological burdens to family members. However, many patients even clinicians in some areas of the world still remain confused about this disease. At the same time, the etiology of CI is still uncertain and it is still a controversial disease in diagnosis and treatment. This article summarizes the potential risk factors associated with CI, which could be worthy of attention and helpful for future research. It also reviews the methods for diagnosis and treatment of CI to better understand this noteworthy disease, as well as presents the related consensus and controversies according to the newly updated guidelines, which has practical significance for conducting more in-depth investigations in the future.

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