Skin Care Formulations and Lipid Carriers as Skin Moisturizing Agents

Skin care formulations have evolved as the interaction of health and beauty products for the skin. Their benefits are based on the combination of cosmetic active ingredients and targeted application. Cosmetic actives have been used in novel formulations for decades (sunscreens, anti-aging treatments, etc.), but the problems with their low solubility, low penetration, and physicochemical instability when applied to the skin have yet to be solved. One way to circumvent these shortcomings is to use lipid carriers, which are known to play an important role in the solubility of poorly soluble compounds by facilitating skin permeation and improving stability. This review addresses recent advances in skin care products that use novel nanotechnology-based lipid systems (liposomes, solid lipid nanoparticles, etc.) to deliver moisturizing cosmetic actives and improve product efficacy.

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Development of Solid Lipid Nanoparticles for Enhanced Solubility of Poorly Soluble Drugs

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2010.1169 ◽

2010 ◽

Vol 6 (6) ◽

pp. 634-640 ◽

Cited By ~ 26

Author(s):

Sriharsha Gupta Potta ◽

Sriharsha Minemi ◽

Ravi Kumar Nukala ◽

Chairmane Peinado ◽

Dimitrios A. Lamprou ◽

...

Keyword(s):

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Poorly Soluble Drugs ◽

Solid Lipid ◽

Enhanced Solubility ◽

Poorly Soluble

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Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: A Review of the Effect of Physicochemical Formulation Factors in the Optimization Process, Different Preparation Technique, Characterization, and Toxicity

Current Nanoscience ◽

10.2174/1573413714666180809120435 ◽

2019 ◽

Vol >15 (5) ◽

pp. 436-453

Author(s):

Ganesan Poovi ◽

Thangavel Mahalingam Vijayakumar ◽

Narayanasamy Damodharan

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Nanostructured Lipid Carriers ◽

Pharmacokinetic Studies ◽

Preparation Technique ◽

Solid Lipid ◽

Research Findings ◽

Poorly Soluble ◽

Poorly Soluble Drug

Background:The high molecular weight and increasing lipophilicity drug face many problems starting from the drug development to formulation and conduction of pharmacological, toxicological and pharmacokinetic studies to its biological application. To overcome this problem, a different formulation of nano-sized drugs was developed recently. The use of Solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs) offers new insight into the formulation of the poorly soluble drug.Objective:The study aimed to investigate the literature with regard to the development of SLNs and NLCs for lipid-based nano drug delivery of poorly soluble drugs, with a view to identifying the factors influencing the optimization of the formulation of SLNs and NLCs and strategies to decrease the use of organic solvent during the preparation.Results:This review highlights the simple and easily scaled-up novel lipid nanoparticles (SLNs and NLCs) and their factors to be considered in the formulation for the proper selection of excipients. Also, this review summarizes the research findings reported by the different researchers regarding the principle formulation components, different preparation techniques, characterization, and toxicology of lipid nanoparticles.Conclusion:The SLNs/NLCs make this drug delivery system as one of the promising delivery systems, and safe colloidal lipid carriers for the delivery of poorly soluble drug and will be a solution to the formulation scientist for the solubility and permeability problem associated with the drugs to assure its good bioavailability.

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Skin permeation of buprenorphine and its ester prodrugs from lipid nanoparticles: lipid emulsion, nanostructured lipid carriers and solid lipid nanoparticles

Journal of Microencapsulation ◽

10.3109/02652040902746679 ◽

2009 ◽

Vol 26 (8) ◽

pp. 734-747 ◽

Cited By ~ 20

Author(s):

Jhi-Joung Wang ◽

Kuo-Sheng Liu ◽

K. C. Sung ◽

Chia-Yin Tsai ◽

Jia-You Fang

Keyword(s):

Solid Lipid Nanoparticles ◽

Lipid Emulsion ◽

Skin Permeation ◽

Lipid Nanoparticles ◽

Nanostructured Lipid Carriers ◽

Solid Lipid ◽

Ester Prodrugs

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SLN (Solid Lipid Nanoparticles) as new solid carrier of active ingredients in cosmetics

European Journal of Pharmaceutical Sciences ◽

10.1016/s0928-0987(97)86447-0 ◽

1996 ◽

Vol 4 ◽

pp. S148 ◽

Cited By ~ 6

Author(s):

A. Dingler ◽

S. Krohs ◽

G. Lukowski ◽

S. Gohla ◽

R.H. Müller

Keyword(s):

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Active Ingredients ◽

Solid Lipid ◽

Solid Carrier

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Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery

Journal of Pharmacy & Pharmaceutical Sciences ◽

10.18433/jpps31788 ◽

2021 ◽

Vol 24 ◽

pp. 509-532

Author(s):

Nestor Mendoza-Muñoz ◽

Zaida Urbán-Morlán ◽

Gerardo Leyva-Gómez ◽

María de la Luz Zambrano-Zaragoza ◽

Elizabeth ¨Piñón-Segundo ◽

...

Keyword(s):

Oral Administration ◽

Solid Lipid Nanoparticles ◽

Oral Drug Delivery ◽

Neurological Diseases ◽

Lipid Nanoparticles ◽

Oral Drug ◽

Beneficial Effects ◽

Solid Lipid ◽

First Choice ◽

Poorly Soluble

Nanoparticles have shown overall beneficial effects in drug administration. Specifically, solid lipid nanoparticles (SLN) have emerged as an alternative to polymer-based systems. However, the oral administration of SLN, the first choice for conventional medications, has not been addressed due to the taboo surrounding the complicated transit that this delivery route entails. This review focuses on the encapsulation of drugs into SLN as a strategy for improving oral administration. Examples of applications of SLN to enhance the absorption and bioavailability of poorly-soluble drugs and protect acid-labile active molecules are discussed. This work also emphasizes the importance of developing SLN-based systems to treat health issues such as neurological diseases and cancer, and combat antibiotic resistance, three significant and increasingly common current public health problems. The review sections clarify how SLN can improve bioavailability, target therapeutic agents, and reduce side effects.

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Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery

Therapeutic Delivery ◽

10.4155/tde-2020-0075 ◽

2020 ◽

Vol 11 (11) ◽

pp. 685-700

Author(s):

Omar Sarheed ◽

Douha Shouqair ◽

KVRNS Ramesh ◽

Muhammad Amin ◽

Joshua Boateng ◽

...

Keyword(s):

Solid Lipid Nanoparticles ◽

Skin Permeation ◽

Tween 80 ◽

Physicochemical Characteristics ◽

Lipid Nanoparticles ◽

Water Addition ◽

Oil Emulsion ◽

Solid Lipid ◽

Ultrasound Assisted

Aim: To prepare loratadine-loaded solid lipid nanoparticles (SLNs) using a modified two-step ultrasound-assisted phase inversion temperature (PIT) process. Results/methodology: Loratadine was dissolved in beeswax and Tween 80 was dissolved in water. The two phases were mixed together to prepare a water-in-oil emulsion preconcentrate (w/o) at a PIT of 85°C, followed by gradual water addition at 25°C to trigger nanoparticles formation (o/w). Kinetic stability was investigated. No change in the size was observed within 6 months. Fourier-transform infrared spectroscopy demonstrated stability of the emulsions via molecular structure of water at the interface of the o/w nanoemulsions. SLNs enhanced the in vitro skin permeation of loratadine. Conclusion: Stable SLNs were successfully prepared by ultrasound-assisted PIT.

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Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles / Povećana fotostabilnost, smanjena permeacija i iritacija izotretinoina iz kruto-tekućih nanočestica

Acta Pharmaceutica ◽

10.2478/v10007-012-0032-z ◽

2012 ◽

Vol 62 (4) ◽

pp. 547-562 ◽

Cited By ~ 19

Author(s):

Golmohammadzadeh Shiva ◽

Mortezania Somaye ◽

Jaafari Mahmoud Reza

Keyword(s):

Solid Lipid Nanoparticles ◽

Skin Permeation ◽

Mouse Skin ◽

Morphological Characteristics ◽

Average Diameter ◽

Lipid Nanoparticles ◽

Homogenization Method ◽

Scanning Calorimetry ◽

Solid Lipid

The aim of this study was to develop new solid lipid nanoparticles of isotretinoin (IT-SLNs) and evaluate the ability of IT-SLNs to improve photostability, reduce skin permeation and irritating effects. IT-SLNs were prepared by the hot high pressure homogenization method. Size, zeta potential and morphological characteristics of the preparations were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC). IT-SLNs had a small average diameter of 74.05 ± 8.91 nm and high encapsulation efficiency (EE) of 80.6 ± 1.2 %. The results showed that the entrapment of IT into SLNs reduced significantly its photodegradation. The in vitro permeation data showed that IT-SLNs can accumulate in the different layers of the skin and prevent systemic uptake of IT in mouse skin. IT-SLNs also significantly increased IT accumulation in the different layers of the stratum corneum of human skin. IT-SLN formulation was significantly less irritating compared to commercial IT-GEL, which shows its potential for improving skin tolerability and being a carrier for topical delivery of IT.

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Cosmeceuticals: Nanotechnology-Based Strategies for the Delivery of Phytocompounds

Current Pharmaceutical Design ◽

10.2174/1381612825666190709211101 ◽

2019 ◽

Vol 25 (21) ◽

pp. 2314-2322 ◽

Cited By ~ 1

Author(s):

Carmelo Puglia ◽

Debora Santonocito

Keyword(s):

Solid Lipid Nanoparticles ◽

Skin Permeation ◽

Lipid Nanoparticles ◽

Water Soluble ◽

Toxicity Profile ◽

Physico Chemical ◽

Cosmetic Ingredients ◽

Cosmetic Formulations ◽

Poorly Water Soluble ◽

Low Solubility

Cosmeceuticals are innovative emerging health and beauty aid products that combine the benefits of cosmetic active ingredients and often innovative technological solutions of formulation and delivery. For decades, phytocompounds have been used in cosmetics as sunscreen, moisturizing, antiaging, and skin-based therapy. When compared to synthetic cosmetic ingredients, phytocompounds are generally milder, have a more favourable toxicity profile, and are biodegradable. The major concerns in the usage of phytocompounds are their low solubility, low penetration and physico-chemical instability when applied on the skin. To overcome these issues, different nanotechnology-based systems have been proposed and some of them are already on the market. Nanotechnologies can improve the solubility of poorly water-soluble compounds, facilitate skin permeation and increase their stability against light and temperature. Liposomes, solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, and cyclodextrins are examples of nanotechnology-based systems currently in use to improve the performances of phytocompounds in skin care. This review focuses on cosmeceuticals that explore nanotechnology-based systems for the delivery of phytocompounds and emphasizes how these approaches can improve product performances with respect to conventional cosmetic formulations.

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DEVELOPMENT AND EVALUATION OF CLOBETASOL–LOADED SOLID LIPID NANOPARTICLES FOR TOPICAL TREATMENT OF PSORIASIS

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019v11i5.33592 ◽

2019 ◽

pp. 143-150 ◽

Cited By ~ 1

Author(s):

K. RAMESH REDDY ◽

S. V. SATYANARAYANA ◽

V. JAYASANKAR REDDY

Keyword(s):

Particle Size ◽

Drug Release ◽

Solid Lipid Nanoparticles ◽

Skin Permeation ◽

Entrapment Efficiency ◽

Lipid Nanoparticles ◽

Drug Deposition ◽

Solid Lipid ◽

Prolonged Drug Release

Objective: The current research was structured to achieve a maximum topical delivery for the drug clobetasol-17-propionate (CP) and to predict the effects of various independent variables like lipid: drug ratio, surfactant, and homogenization time on particulate characters and performance solid lipid nanoparticles (SLNs). Methods: CP loaded SLNs were formulated by Emulsification–Homogenization method and optimized using 33 full factorial designs (Design-Expert software 11.0). Drug loaded SLNs were evaluated for various parameters like particle size, surface charge, polydispersity index, entrapment efficiency, surface morphology, thermal analysis, in vitro drug release through skin (Franz diffusion cell), drug deposition study and stability. Results: The optimized formulation (SLNs) attains a minimal Particle size of 133.3±3.66 nm, Poly dispersibility index of 0.179±0.081, % entrapment efficiency of 78.1±1.11 and Zeta potential of-36.2±0.11mV. Skin permeation study of CP loaded SLNs suspension showed prolonged drug release up to 24h. Maximum drug deposition was obtained after developing the drug into SLNs (48.22µg/ml) when compared to the pure drug (19.12µg/ml). Conclusion: SLNs were promising colloidal particulate carriers by which prolonged drug release and improved skin permeation was achieved for the drug Clobetasol 17- propionate.

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