scholarly journals Three-Dimensional Printing of Hydroxyapatite Composites for Biomedical Application

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 353
Author(s):  
Yanting Han ◽  
Qianqian Wei ◽  
Pengbo Chang ◽  
Kehui Hu ◽  
Oseweuba Valentine Okoro ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Biomedical Application ◽  
Three Dimensional ◽  
Antibacterial Properties ◽  
Natural Polymers ◽  
Three Dimensional Printing ◽  
3D Printed ◽  
Dental Applications ◽  
Hard Tissue Engineering

Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite. However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields. In recent years, three-dimensional (3D) printing has been shown to provide a fast, precise, controllable, and scalable fabrication approach for the synthesis of HA-based scaffolds. This review therefore explores available 3D printing technologies for the preparation of porous HA-based nanocomposites. In the present review, different 3D printed HA-based scaffolds composited with natural polymers and/or synthetic polymers are discussed. Furthermore, the desired properties of HA-based composites via 3D printing such as porosity, mechanical properties, biodegradability, and antibacterial properties are extensively explored. Lastly, the applications and the next generation of HA-based nanocomposites for tissue engineering are discussed.

scholarly journals Three-dimensional printing for heart diseases: clinical application review

2021 ◽  
Author(s):  
Yanyan Ma ◽  
Peng Ding ◽  
Lanlan Li ◽  
Yang Liu ◽  
Ping Jin ◽  
...  
Keyword(s):  
3D Printing ◽  
Clinical Application ◽  
Heart Diseases ◽  
Three Dimensional ◽  
Convincing Evidence ◽  
Surgical Interventions ◽  
Three Dimensional Printing ◽  
Complex Anatomy ◽  
Precise Understanding ◽  
3D Printed

AbstractHeart diseases remain the top threat to human health, and the treatment of heart diseases changes with each passing day. Convincing evidence shows that three-dimensional (3D) printing allows for a more precise understanding of the complex anatomy associated with various heart diseases. In addition, 3D-printed models of cardiac diseases may serve as effective educational tools and for hands-on simulation of surgical interventions. We introduce examples of the clinical applications of different types of 3D printing based on specific cases and clinical application scenarios of 3D printing in treating heart diseases. We also discuss the limitations and clinically unmet needs of 3D printing in this context.

Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering

2021 ◽  
pp. 002199832098856
Author(s):  
Marcela Piassi Bernardo ◽  
Bruna Cristina Rodrigues da Silva ◽  
Luiz Henrique Capparelli Mattoso
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Poly Lactic Acid ◽  
Scanning Calorimetry ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft.

scholarly journals Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

2020 ◽  
Vol 6 (1) ◽  
pp. 57-69
Author(s):  
Amirhosein Fathi ◽  
Farzad Kermani ◽  
Aliasghar Behnamghader ◽  
Sara Banijamali ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

scholarly journals 3D-Printed Biopolymers for Tissue Engineering Application

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Xiaoming Li ◽  
Rongrong Cui ◽  
Lianwen Sun ◽  
Katerina E. Aifantis ◽  
Yubo Fan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Three Dimensional ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Potential Applications ◽  
3D Printed ◽  
Dimensional Object

3D printing technology has recently gained substantial interest for potential applications in tissue engineering due to the ability of making a three-dimensional object of virtually any shape from a digital model. 3D-printed biopolymers, which combine the 3D printing technology and biopolymers, have shown great potential in tissue engineering applications and are receiving significant attention, which has resulted in the development of numerous research programs regarding the material systems which are available for 3D printing. This review focuses on recent advances in the development of biopolymer materials, including natural biopolymer-based materials and synthetic biopolymer-based materials prepared using 3D printing technology, and some future challenges and applications of this technology are discussed.

scholarly journals Three-Dimensional Printing Strategies for Irregularly Shaped Cartilage Tissue Engineering: Current State and Challenges

2022 ◽  
Vol 9 ◽  
Author(s):  
Hui Wang ◽  
Zhonghan Wang ◽  
He Liu ◽  
Jiaqi Liu ◽  
Ronghang Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Cartilage Tissue ◽  
Future Research ◽  
Engineering Construction ◽  
Three Dimensional Printing ◽  
Current State ◽  
Dimensional Printing

Although there have been remarkable advances in cartilage tissue engineering, construction of irregularly shaped cartilage, including auricular, nasal, tracheal, and meniscus cartilages, remains challenging because of the difficulty in reproducing its precise structure and specific function. Among the advanced fabrication methods, three-dimensional (3D) printing technology offers great potential for achieving shape imitation and bionic performance in cartilage tissue engineering. This review discusses requirements for 3D printing of various irregularly shaped cartilage tissues, as well as selection of appropriate printing materials and seed cells. Current advances in 3D printing of irregularly shaped cartilage are also highlighted. Finally, developments in various types of cartilage tissue are described. This review is intended to provide guidance for future research in tissue engineering of irregularly shaped cartilage.

scholarly journals Utility of Three-Dimensional Printing for Preoperative Assessment of Children with Extra-Cranial Solid Tumors: A Systematic Review

2022 ◽  
Vol 14 (1) ◽  
pp. 32-39
Author(s):  
Sachit Anand ◽  
Nellai Krishnan ◽  
Prabudh Goel ◽  
Anjan Kumar Dhua ◽  
Vishesh Jain ◽  
...  
Keyword(s):  
Systematic Review ◽  
3D Printing ◽  
Solid Tumors ◽  
Surgical Planning ◽  
Three Dimensional ◽  
Current Evidence ◽  
Printing Technology ◽  
Three Dimensional Printing ◽  
3D Printed ◽  
Dimensional Printing

Background: In cases with solid tumors, preoperative radiological investigations provide valuable information on the anatomy of the tumor and the adjoining structures, thus helping in operative planning. However, due to a two-dimensional view in these investigations, a detailed spatial relationship is difficult to decipher. In contrast, three-dimensional (3D) printing technology provides a precise topographic view to perform safe surgical resections of these tumors. This systematic review aimed to summarize and analyze current evidence on the utility of 3D printing in pediatric extra-cranial solid tumors. Methods: The present study was registered on PROSPERO—international prospective register of systematic reviews (registration number: CRD42020206022). PubMed, Embase, SCOPUS, and Google Scholar databases were explored with appropriate search criteria to select the relevant studies. Data were extracted to study the bibliographic information of each article, the number of patients in each study, age of the patient(s), type of tumor, organ of involvement, application of 3D printing (surgical planning, training, and/or parental education). The details of 3D printing, such as type of imaging used, software details, printing technique, printing material, and cost were also synthesized. Results: Eight studies were finally included in the systematic review. Three-dimensional printing technology was used in thirty children with Wilms tumor (n = 13), neuroblastoma (n = 7), hepatic tumors (n = 8), retroperitoneal tumor (n = 1), and synovial sarcoma (n = 1). Among the included studies, the technology was utilized for preoperative surgical planning (five studies), improved understanding of the surgical anatomy of solid organs (two studies), and improving the parental understanding of the tumor and its management (one study). Computed tomography and magnetic resonance imaging were either performed alone or in combination for radiological evaluation in these children. Different types of printers and printing materials were used in the included studies. The cost of the 3D printed models and time involved (range 10 h to 4–5 days) were reported by two studies each. Conclusions: 3D printed models can be of great assistance to pediatric surgeons in understanding the spatial relationships of tumors with the adjacent anatomic structures. They also facilitate the understanding of families, improving doctor–patient communication.

scholarly journals Tissue Engineering and Three-Dimensional Printing in Periodontal Regeneration: A Literature Review

2020 ◽  
Vol 9 (12) ◽  
pp. 4008
Author(s):  
Simon Raveau ◽  
Fabienne Jordana
Keyword(s):  
Selective Laser Sintering ◽  
Periodontal Regeneration ◽  
Three Dimensional ◽  
Computer Assisted ◽  
Natural Polymers ◽  
Three Dimensional Printing ◽  
Computer Assisted Design ◽  
New Ideas ◽  
3D Printed ◽  
Dimensional Printing

The three-dimensional printing of scaffolds is an interesting alternative to the traditional techniques of periodontal regeneration. This technique uses computer assisted design and manufacturing after CT scan. After 3D modelling, individualized scaffolds are printed by extrusion, selective laser sintering, stereolithography, or powder bed inkjet printing. These scaffolds can be made of one or several materials such as natural polymers, synthetic polymers, or bioceramics. They can be monophasic or multiphasic and tend to recreate the architectural structure of the periodontal tissue. In order to enhance the bioactivity and have a higher regeneration, the scaffolds can be embedded with stem cells and/or growth factors. This new technique could enhance a complete periodontal regeneration. This review summarizes the application of 3D printed scaffolds in periodontal regeneration. The process, the materials and designs, the key advantages and prospects of 3D bioprinting are highlighted, providing new ideas for tissue regeneration.

scholarly journals Development of Smartphone-Controlled Hand and Arm Exoskeleton for Persons with Disability

2020 ◽  
Vol 11 (1) ◽  
pp. 161-170
Author(s):  
J-R. R. Diego ◽  
Dan William C. Martinez ◽  
Gerald S. Robles ◽  
John Ryan C. Dizon
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Three Dimensional ◽  
Prosthetic Device ◽  
Three Dimensional Printing ◽  
Plastic Materials ◽  
3D Printed ◽  
Available Technology ◽  
Electronic Parts ◽  
Dimensional Printing

AbstractThis study addresses the need for assistive technology of people who lost control of their upper limbs as well as people who are undergoing rehabilitation. Loss of upper limb control causes lack of functionality and social acceptability especially for many people in developing countries with fewer available technology. The study develops a modern but low-cost prosthetic device that can be controlled by users using a smartphone and can be rapidly manufactured using three-dimensional printing (3D printing) of plastic materials. The development of the prosthetic device includes designing the mechanical and electronic parts, programming the Arduino board and Android application for control, simulation and analysis of 3D printed parts most subjected to stress, and 3D printing the parts under different settings. The device was tested in terms of time spent and capacity of lifting varying loads when not worn and when worn by users. The device can effectively lift 500 grams of load in one second for a person weighing between 50 to 60 kilograms.

scholarly journals Surface Roughness Effect on the 3d Printed Butt Joints Strength

2015 ◽  
Author(s):  
V. Kovan ◽  
G. Altan ◽  
E.S. Topal ◽  
H.E. Camurlu
Keyword(s):  
Surface Roughness ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Three Dimensional ◽  
Thickness Effect ◽  
Fused Deposition Modelling ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
3D Printed ◽  
Dimensional Object

Three-dimensional printing or 3D printing (also called additive manufacturing) is any of various processes used to make a three-dimensional object. Fused deposition modelling (FDM) is an additive manufacturing technology commonly used for modelling, prototyping, and production applications. It is one of the techniques used for 3D printing. FDM is somewhat restricted in the size and the variation of shapes that may be fabricated. For parts too large to fit on a single build, for faster job builds with less support material, or for parts with finer features, sectioning and bonding FDM parts is a great solution. The strength of adhesive bonded FDM parts is affected by the surface roughness. In this study, the layer thickness effect on bonding strength is experimentally studied and the results are discussed.

3D Reconstruction Role in Surgical Treatment of Sinonasal Tumours

2018 ◽  
Vol 69 (6) ◽  
pp. 1455-1457
Author(s):  
Dragos Octavian Palade ◽  
Bogdan Mihail Cobzeanu ◽  
Petronela Zaharia ◽  
Marius Dabija
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Patient Specific ◽  
Three Dimensional Printing ◽  
Great Progress ◽  
3D Printed ◽  
Medical Modeling ◽  
Dimensional Printing ◽  
Tissue Defects

Three-dimensional printing has numerous applications and has gained much interest in the medical world. The constantly improving quality of 3D-printing applications has contributed to their increased use on patients. Nowadays, 3D printing is very well integrated in the surgical practice and research. Also, the field of head and neck reconstructive surgery is constantly evolving because of the three-dimensional printing, a technology which can be widely used in a variety of situations such as reconstruction of tissue defects, surgical planning, medical modeling and prosthesis. By using 3D printing into tissue engineering and materials, it may be possible for otolaryngologists to implant 3D printed functional grafts into patients and will also provide a rapid production of personalized patient-specific devices. Advances in 3D printed implants and future tissue-engineered constructs will bring great progress to the field of otorhinolaryngology.

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