scholarly journals Multidisciplinary Approach to Interstitial Lung Diseases: Nothing Is Better than All of Us Together

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 488
Author(s):  
Carlo Vancheri ◽  
Antonio Basile
Keyword(s):  
Gas Exchange ◽  
Lung Diseases ◽  
Multidisciplinary Approach ◽  
Large Family ◽  
Interstitial Lung Diseases ◽  
Diagnostic Assessment ◽  
Special Issue ◽  
Radiological Features ◽  
Diagnostic Approaches ◽  
Better Than

Interstitial Lung Diseases (ILDs) are a large family of disorders characterized by inflammation and/or fibrosis of areas of the lung dedicated to gas exchange. In this Special Issue entitled “Clinical and Radiological Features of Interstitial Lung Diseases”, we collected a series of contributions in which a multidisciplinary approach was crucial for the correct diagnostic assessment of ILD. Sharing knowledge between different specialties can significantly improve diagnostic approaches and the management of ILD patients.

scholarly journals Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

2017 ◽  
Vol 26 (143) ◽  
pp. 160099 ◽  
Author(s):  
Matteo Bonini ◽  
Giuseppe Fiorenzano
Keyword(s):  
Gas Exchange ◽  
Lung Diseases ◽  
Clinical Utility ◽  
Pulmonary Inflammation ◽  
Cardiopulmonary Exercise Testing ◽  
Interstitial Lung Diseases ◽  
Respiratory Physiology ◽  
Exertional Dyspnoea ◽  
Cardiopulmonary Exercise ◽  
Peripheral Muscle

Interstitial lung diseases (ILDs) represent a heterogeneous group of pathologies characterised by alveolar and interstitial damage, pulmonary inflammation (usually associated with fibrosis), decreased lung function and impaired gas exchange, which can be attributed to either a known or an unknown aetiology. Dyspnoea is one of the most common and disabling symptoms in patients with ILD, significantly impacting quality of life. The mechanisms causing dyspnoea are complex and not yet fully understood. However, it is recognised that dyspnoea occurs when there is an imbalance between the central respiratory efferent drive and the response of the respiratory musculature. The respiratory derangement observed in ILD patients at rest is even more evident during exercise. Pathophysiological mechanisms responsible for exertional dyspnoea and reduced exercise tolerance include altered respiratory mechanics, impaired gas exchange, cardiovascular abnormalities and peripheral muscle dysfunction.This review describes the respiratory physiology of ILD, both at rest and during exercise, and aims to provide comprehensive and updated evidence on the clinical utility of the cardiopulmonary exercise test in the assessment and management of these pathological entities. In addition, the role of exercise training and pulmonary rehabilitation programmes in the ILD population is addressed.

scholarly journals Progressive Fibrosing Interstitial Lung Diseases: A Current Perspective

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1237
Author(s):  
Carlo Albera ◽  
Giulia Verri ◽  
Federico Sciarrone ◽  
Elena Sitia ◽  
Mauro Mangiapia ◽  
...  
Keyword(s):  
Lung Fibrosis ◽  
Lung Diseases ◽  
Current Knowledge ◽  
Relevant Literature ◽  
Interstitial Lung Diseases ◽  
Current Perspective ◽  
Similar Disease ◽  
Diagnostic Approaches ◽  
Disease Behavior ◽  
A Current

Interstitial lung diseases (ILDs) are a large and diverse group of rare and chronic respiratory disorders, with idiopathic pulmonary fibrosis (IPF) being the most common and best-studied member. Increasing interest in fibrosis as a therapeutic target and the appreciation that fibrotic mechanisms may be a treatable target of IPF prompted the development and subsequent approval of the antifibrotics, pirfenidone and nintedanib. The management of ILDs has changed considerably following an understanding that IPF and some ILDs share similar disease behavior of progressive fibrosis, termed “progressive fibrosing phenotype”. Indeed, antifibrotic treatment has shown to be beneficial in ILDs characterized by the progressive fibrosing phenotype. This narrative review summarizes current knowledge in the field of progressive fibrosing ILDs. Here, we discuss the clinical characteristics and pathogenesis of lung fibrosis and highlight relevant literature concerning the mechanisms underlying progressive fibrosing ILDs. We also summarize current diagnostic approaches and the available treatments of progressive fibrosing ILDs and address the optimization of treating progressive fibrosing ILDs with antifibrotics in clinical practice.

scholarly journals Special Issue Dedication to Stephen H. Schneider

1970 ◽  
Vol 8 (3) ◽  
Author(s):  
Paul Baer
Keyword(s):  
Public Service ◽  
Multidisciplinary Approach ◽  
Policy Design ◽  
Communication Policy ◽  
Special Issue ◽  
Special Report ◽  
Climate Change Issue ◽  
Level Of Activity ◽  
Hearts And Minds ◽  
Better Than

It is with both pleasure and sadness that we dedicate this special climate change issue of Portal to the late Dr. Stephen H. Schneider. Steve, as he was known to his friends and colleagues, was as rare a bird as any he sought out in his passion as a birdwatcher. A brilliant climate scientist, author of countless books and papers, path breaking inter-disciplinarian, eminent public communicator, mentor to dozens of young scholars; the list of roles and adulatory adjectives could fill an IPCC special report. Steve would have appreciated this special issue, with its multidisciplinary approach, and its quest for solutions based on analytical scholarship. He understood better than most the inseparability of normative and descriptive concerns, the need for academics and scientists of all kinds to be involved with public processes of communication, policy design and deliberation. While his last book was called “Science as a Contact Sport,” the unspoken title of his career might have been “Science as a Public Service.” He was endlessly testifying, consulting and giving interviews, and encouraged others to learn to do the same. Notwithstanding a battle with lymphoma in the last decade (chronicled in the wonderful book The Patient from Hell), Steve maintained a frenetic level of activity and was still going strong when he was felled by a pulmonary embolism in July of 2010 at age 65. He leaves behind a legacy embodied in his publications, institutions like the IPCC and the journal Climatic Change, and in the hearts and minds of the countless persons he interacted with, mentored, and loved. Exuberant, passionate, full of warmth and good humor, Steve was a mensch among mensches. He will be sorely missed. Paul Baer, with the assistance of Terry Root and Ian McGregor.

scholarly journals Comment from the Editor of the Special Issue: “Lung Disease on COPD, Asthma, Bronchiectasis, Lung Cancer Screening, IPF”

2019 ◽  
Vol 8 (12) ◽  
pp. 2060
Author(s):  
Nazia Chaudhuri
Keyword(s):  
Lung Cancer ◽  
Lung Diseases ◽  
Respiratory Diseases ◽  
Lung Cancer Screening ◽  
Interstitial Lung Diseases ◽  
Original Research ◽  
Special Issue ◽  
General Physicians ◽  
Key Topics ◽  
Respiratory Specialist

This Special Issue on lung diseases is aimed at giving emergent researchers and clinicians an important forum to share their original research and expert reviews on key topics within respiratory diseases. This Special Issue will be of interest to general physicians and respiratory specialist and will equip the reader with up-to-date knowledge on a wide array of lung diseases, including interstitial lung diseases, COPD, and Asthma.

scholarly journals A contemporary practical approach to the multidisciplinary management of unclassifiable interstitial lung disease

2021 ◽  
pp. 2100276
Author(s):  
Christopher J. Ryerson ◽  
Tamera J. Corte ◽  
Jeffrey L. Myers ◽  
Simon L. F. Walsh ◽  
Sabina A. Guler
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Practical Approach ◽  
Multidisciplinary Management ◽  
Management Decisions ◽  
Histopathological Features ◽  
Radiological Features ◽  
Immunomodulatory Therapies

Fibrotic interstitial lung diseases (ILDs) frequently have nonspecific and overlapping clinical and radiological features, resulting in approximately 10–20% of patients with ILD lacking a clear diagnosis and thus being labelled with unclassifiable ILD. The objective of this review is to describe how patients with unclassifiable ILD should be evaluated and what impact specific clinical, radiological, and histopathological features may have on management decisions, focusing on patients with a predominantly fibrotic phenotype. We highlight recent data that have suggested an increasing role for antifibrotic medications in a variety of fibrotic ILDs, but justify the ongoing importance of making an accurate ILD diagnosis given the benefit of immunomodulatory therapies in many patient populations. We provide a practical approach to support management decisions that can be used by clinicians and tested by clinical researchers, and further identify the need for additional research to support a rational and standardised approach to the management of patients with unclassifiable ILD.

scholarly journals Idiopathic pulmonary fibrosis: possibilities of multidisciplinary diagnostic approach

2018 ◽  
Vol 28 (5) ◽  
pp. 622-625
Author(s):  
A. М. Kardangusheva ◽  
Н. A. Sabanchieva
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Biopsy ◽  
Poor Prognosis ◽  
Lung Diseases ◽  
Multidisciplinary Approach ◽  
Usual Interstitial Pneumonia ◽  
Interstitial Lung Diseases ◽  
High Resolution Computed Tomography ◽  
Antifibrotic Drugs

Idiopathic pulmonary fibrosis (IPF) is the commonest form of idiopathic interstitial pneumonias with very poor prognosis. Currently, diagnostic and treatment approaches to this disease have been revised. Confirmation of the diagnosis requires careful exclusion of other known causes of interstitial lung diseases and the presence of usual interstitial pneumonia (UIP) pattern on high-resolution computed tomography (HRTC) and/or on lung biopsy. Also, multidisciplinary discussion involving experts with experience in the diagnosis of interstitial lung diseases is recommended. Given recent knowledge on pathogenesis of IPF antifibrotic drugs are recommended for the therapy of this disease. A clinical case that demonstrates the multidisciplinary approach to diagnosis of IPF is reported in this article.

scholarly journals Monitoring and management of fibrosing interstitial lung diseases: a narrative review for practicing clinicians

2021 ◽  
Vol 15 ◽  
pp. 175346662110397
Author(s):  
Anoop M. Nambiar ◽  
Christopher M. Walker ◽  
Jeffrey A. Sparks
Keyword(s):  
Lung Diseases ◽  
Multidisciplinary Approach ◽  
Progressive Disease ◽  
Pulmonary Function Tests ◽  
Interstitial Lung Diseases ◽  
Narrative Review ◽  
Disease Monitoring ◽  
Close Monitoring ◽  
High Resolution Computed Tomography ◽  
Progression Risk

Close monitoring of patients with fibrosing interstitial lung diseases (ILDs) is important to enable prompt identification and management of progressive disease. Monitoring should involve regular assessment of physiology (including pulmonary function tests), symptoms, and, when appropriate, high-resolution computed tomography. The management of patients with fibrosing ILDs requires a multidisciplinary approach and should be individualized based on factors such as disease severity, evidence of progression, risk factors for progression, comorbidities, and the preferences of the patient. In this narrative review, we discuss how patients with fibrosing ILDs can be effectively monitored and managed in clinical practice.

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