scholarly journals The Dynamics of Beech Roundwood Prices in Selected Central European Markets

Forests ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 902
Author(s):  
Anna Kożuch ◽  
Jan Banaś
Keyword(s):  
Time Series ◽  
Large Diameter ◽  
The Other ◽  
Seasonal Effects ◽  
Type I ◽  
German Market ◽  
Price Series ◽  
Other Hand ◽  
Cointegration Tests

The European beech (Fagus sylvatica L.) is the most prevalent deciduous tree species in Central Europe. The implementation of sustainable, close-to-nature silvicultural practices increased the percentage share of beech in forest species composition, raising the economic significance of beech roundwood, especially in terms of revenues from timber sales. The elucidation of roundwood price mechanisms as well as long-term equilibrium relations between international markets may be helpful in calculating the profitability of beech roundwood production. The study material consists of quarterly time series of beech roundwood prices from Austria, Czechia, Germany, Poland, Slovakia, and Slovenia in the years 2005–2018. The price time series were described with a multiplicative model incorporating seasonal, cyclical, and irregular, as well as long-term trend components. The time series were decomposed using the Census X11 method. Stationarity was tested by means of the augmented Dickey–Fuller test (ADF) and the Kwiatkowski–Phillips–Schmidt–Shin test (KPSS). Cointegration was assessed using the Johansen and Engle–Granger methods. From 2005–2018, the highest mean beech roundwood prices were found for Austria (77.5 € m−3) and Germany, and the lowest for Poland and Slovakia. Roundwood prices were badly affected by the 2008/2009 financial crisis, which caused an approx. 27% decline. The prices of large-diameter beech logs exhibited seasonal fluctuations, typically reaching a maximum in Q1 and a minimum in Q3. The amplitude of those fluctuations was the highest in Slovenia in 2005 (10.1%), while in Czechia and Germany, seasonal effects increased over the period of study. The lowest seasonality was found in Slovakia and Austria (in the latter country it was not statistically significant). On an annual scale, cyclical changes generally accounted for the largest proportion of price variation, and were particularly pronounced in Poland (78.9%), Slovakia (78.6%), and Austria (69.2%). On the other hand, seasonal effects were predominant in the Slovenian (40.6%), German (34.1%), and Czech (33.3%) markets. In countries with price series of type I(0), simple correlation between stationary beech roundwood prices is positive and the strongest between Czechia–Poland and Czechia–Austria; on the other hand they are the weakest in the German market. In Slovakia and Slovenia with nonstationary price series, both Johansen’s and Engle-Granger’s cointegration tests indicated the absence of a long-term equilibrium between the analyzed beech timber markets. Results revealed integration between the prices of large-diameter beech logs in Czechia, Austria, and Poland. It should be mentioned that in this study, the time series of price used are rather short for long time cointegration analysis, which might prevent the proper detection of cointegration between all analyzed countries.

Radioimmunotherapy for treatment of acute myeloid leukaemia and myelodysplastic syndrome

2005 ◽  
Vol 44 (03) ◽  
pp. 107-117
Author(s):  
R. G. Meyer ◽  
W. Herr ◽  
A. Helisch ◽  
P. Bartenstein ◽  
I. Buchmann
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Primary Tumour ◽  
The Other ◽  
Haematopoietic Stem Cell ◽  
Other Hand ◽  
Primary Reduction ◽  
The One ◽  
Acute Myeloid

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.

scholarly journals A Game System for Cognitive Rehabilitation

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Azrulhizam Shapi’i ◽  
Nor Azan Mat Zin ◽  
Ahmed Mohammed Elaklouk
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Conceptual Framework ◽  
Cognitive Rehabilitation ◽  
The Other ◽  
Rehabilitation Treatment ◽  
Other Hand ◽  
Rehabilitation Exercises

Brain injury such as traumatic brain injury (TBI) and stroke is the major cause of long-term disabilities in many countries. The increasing rate of brain damaged victims and the heterogeneity of impairments decrease rehabilitation effectiveness and competence resulting in higher cost of rehabilitation treatment. On the other hand, traditional rehabilitation exercises are boring, thus leading patients to neglect the prescribed exercises required for recovery. Therefore, we propose game-based approach to address these problems. This paper presents a rehabilitation gaming system (RGS) for cognitive rehabilitation. The RGS is developed based on a proposed conceptual framework which has also been presented in this paper.

scholarly journals The role of SMEs in innovation-oriented economic development

2017 ◽  
pp. 95-99
Author(s):  
Tamás Köpeczi-Bócz ◽  
Mónika Lőrincz
Keyword(s):  
Rural Areas ◽  
Tertiary Education ◽  
National Level ◽  
Business Environment ◽  
The Other ◽  
Sectoral Structure ◽  
Other Hand ◽  
Knowledge Intensive ◽  
The One

Both at European and national level tertiary and quaternary sectors are concentrated in the metropolitan centre. In the rural areas only the sites of such sectors can be found the premises of which temporarily transform the sectoral structure of these areas, but from the regional development aspect they did not prove to be an effective strategy.The European Commission is now focusing on growth from innovation, which could become the driving force behind productivity growth and the economy’s long-term trend. The innovation-oriented economic development’s key players are on the one hand the knowledge-intensive enterprises, on the other hand the universities. Tertiary education can play a role – among others – in shaping and creating the development of knowledge intensive business environment and conditions, on the other hand it can assist the development of network contacts – another precondition of employment growth.

scholarly journals Long-Term Outcome of Deferasirox Chelation in Patients with Thalassemia Major

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 3620-3620
Author(s):  
Sule Unal ◽  
Neslihan Kalkan ◽  
Mualla Cetin ◽  
Fatma Gumruk
Keyword(s):  
Serum Creatinine ◽  
Sample Size ◽  
Serum Ferritin ◽  
Thalassemia Major ◽  
Iron Chelator ◽  
The Other ◽  
Single Center ◽  
Other Hand

Abstract Introduction: Iron overload is one of themajor complicationsof transfusion treatment in patient with thalassemia major. Deferasirox is a once-daily orally active iron chelator and long-term efficacy and safety data are being published. Herein we report the long-term follow-up data of thalassemia major patients in a single center. Methods: Of the 67 patients with thalassemia major who were under follow-up in a single center, 42 who were on deferasirox chelation for at least three years were included in the study. Patients' initial serum ferritin, ALT, creatinine, cardiac T2* and hepatic T2* values were recorded at the time of deferasirox initiation and at last visit. Deferasirox was not initiated as an iron chelator to none of the patients with a cardiac T2* value below 8 ms. All of the patients had creatinine clearance above 40 ml/minute and had serum creatinine levels within age appropriate normals at deferasirox initiation. None of the patients received any other chelations during the follow-up period. Results: Mean age of the patients were 16±9.4 years (2-33.4 years) at initiation of deferasirox and 22 (52%) were females. Eighteen (43%) of the patients were splenectomized. Median follow-up time of deferasirox chelation was 7.9 years (3-10). The median deferasirox doses at initiation of chelation and at last visit were 20.5 mg/kg/day and 30.7 mg/kg/day (7-40), respectively. Serum ferritin levels decreased significantly with deferasirox chelation (median 1969 ng/ml (516-5404) vs 1113 ng/ml (339-4003), p<0,001). We did not find statistically significant difference between the inital cardiac T2* values and the values at the last visit (median 25 .3 ms((8.7-42) vs 32 ms (6.6-42), p=0.607), despite a dramatic increase. On the other hand, hepatic T2* values did not significantly change compared to initial values, as well (median 3.7 ms (1-13.6) vs 3.3 (1-16), p=0.865). However of the patients who had cardiac T2* value between 10-20 ms, 67% was found to have T2* value above 20 ms by the end of the follow-up duration. On the other hand 53% of the patients with hepatic T2* value below 3.5 ms, had T2* values above 3.5 ms by the end of the follow-up, indicating improvement in iron stores. None of the patients exibited an adverse event that requires cessation of the drug totally, but patients exibited transient hypertransaminasemia that required transient cessation and/or dose decrement. The changes in serum ALT and serum creatinine levels at the initiation and at last visit were not significant. Conclusions: This is a a study that includes patients with a relatively long duration of follow-up. Although the cardiac T2* values improved by the end of the follow-up, this change was not found statistically significant. This can be attributed to the sample size and in a larger sample size, the change might be found significant. Additionally, the patients included in the study were composed of not only naive patients to chelation but also of the patients who were imcomplant to previous chelation and who were highly iron loaded before initiation of deferasirox. Disclosures No relevant conflicts of interest to declare.

scholarly journals VENOUS CONDUITS IN CORONARY SURGERY: OLD PROBLEMS — NEW SOLUTIONS

2019 ◽  
Vol 34 (1) ◽  
pp. 24-32
Author(s):  
Y. Y. Vecherskiy ◽  
D. V. Manvelyan ◽  
V. V. Zatolokin ◽  
V. M. Shipulin
Keyword(s):  
Coronary Artery ◽  
Soft Tissues ◽  
The Other ◽  
Wound Complications ◽  
Coronary Surgery ◽  
Surgical Revascularization ◽  
Other Hand ◽  
Venous Shunt ◽  
High Incidence

The introduction of autovenous coronary artery bypass grafting (CABG) marked the era of surgical revascularization in patients with coronary artery disease. It provided effective treatment for angina and significantly improved the long-term prognosis. Venous transplants today remain the most popular conduits in coronary surgery due to their availability, ease of harvesting, and the absence of length restrictions. Despite the advantages of autovenous CABG, the main disadvantage is the high incidence of venous graft failure, which represents an important and unresolved problem in cardiac and cardiovascular surgery. On the other hand, the traditional allocation of a large saphenous vein implies the dissection of soft tissues throughout the length of the isolated conduit. Traumatic dissection causes a long-lasting persistent pain syndrome after surgery, frequent abnormalities in  skin sensitivity, and a high incidence of wound complications in the lower extremities. These complications lengthen the period of rehabilitation of patients and worsen the quality of life. There is an approach of isolating the vein in a block with surrounding tissues to optimize the long-term functioning of the venous shunt, however, this technique is even more traumatic than the traditional method, and therefore its use is limited in practice. On the other hand, the introduction of minimally invasive methods of isolation allowed to reduce the incidence of wound complications and to improve the cosmetic result, but there is no convincing data regarding the effect on the consistency of shunts in the long-term postoperative period. The problems associated with the use of venous conduits in CABG are multifaceted, and their solutions are necessary to improve the effectiveness of surgical revascularization.

scholarly journals Total ozone trends and variability during 1979–2012 from merged datasets of various satellites

2013 ◽  
Vol 13 (11) ◽  
pp. 30407-30452 ◽  
Author(s):  
W. Chehade ◽  
J. P. Burrows ◽  
M. Weber
Keyword(s):  
Heat Flux ◽  
Solar Cycle ◽  
Trend Analysis ◽  
Total Ozone ◽  
Montreal Protocol ◽  
The Other ◽  
The Arctic ◽  
Eddy Heat Flux ◽  
Other Hand

Abstract. The study presents a~long term statistical trend analysis of total ozone datasets obtained from various satellites. A multi-variate linear regression was applied to annual mean zonal mean data using various natural and anthropogenic explanatory variables that represent dynamical and chemical processes which modify global ozone distributions in a changing climate. The study investigated the magnitude and zonal distribution of the different atmospheric chemical and dynamical factors to long-term total ozone changes. The regression model included the equivalent effective stratospheric chlorine (EESC), the 11 yr solar cycle, the Quasi-Biennial Oscillation (QBO), stratospheric aerosol loading describing the effects from major volcanic eruptions, the El Niño/Southern Oscillation (ENSO), the Arctic and Antarctic Oscillation (AO/AAO), and accumulated eddy heat flux (EHF), the latter representing changes due to the Brewer–Dobson circulation. The total ozone column dataset used here comprises the SBUV/TOMS/OMI merged data (1979–2012) MOD V8.0, the SBUV/SBUV-2 merged V8.6 and the merged GOME/SCIAMACHY/GOME-2 (GSG) WFDOAS merged data (1995–2012). The trend analysis was performed for twenty six 5° wide latitude bands from 65° S to 65° N, the analysis explained most of the ozone variability. The results show that QBO dominates the ozone variability in the tropics (±7 DU) while at higher latitudes, the dynamical indices, AO/AAO and eddy heat flux, have substantial influence on total ozone variations by up to ±10 DU. Volcanic aerosols are only prominent during the eruption periods and these together with the ENSO signal are more evident in the Northern Hemisphere. The signature of the solar cycle is evident over all latitudes and contributes about 10 DU from solar maximum to solar minimum. EESC is found to be a main contributor to the long-term ozone decline and the trend changes after the end of 1990s. A positive significant trend in total ozone columns is found after 1997 (between 1 and 8.2 DU decade−1) which points at the slowing of ozone decline and the onset of ozone recovery. The EESC based trends are compared with the trends obtained from the statistical piecewise linear trend (PWLT or hockey stick) model with a turnaround in 1997 to examine the differences between both approaches. Similar and significant pre-turnaround trends are observed. On the other hand, our results do indicate that the positive PWLT turnaround trends are larger than indicated by the EESC trends, however, they agree within 2-sigma, thus demonstrating the success of the Montreal Protocol phasing out of the ozone depleting substances (ODS). A sensitivity study is carried out by comparing the regression results, using SBUV MOD 8.0 merged time series (1979–2012) and a merged dataset combining TOMS/SBUV (1979–June 1995) and GOME/SCIAMACHY/GOME-2 ("GSG") WFDOAS (Weighting Function DOAS) (July 1995–2012) as well as SBUV/SBUV-2 MOD 8.6 (1979–2012) in the regression analysis in order to investigate the uncertainty in the long-term trends due to different ozone datasets and data versions. Replacing the late SBUV merged data record with GSG data (unscaled and adjusted) leads to very similar results demonstrating the high consistency between satellite datasets. However, the comparison of the new SBUV merged Mod V8.6 with the V8.0 data showed somewhat smaller sensitivities with regard to several proxies, however, the EESC and PWLT trends are very similar. On the other hand, the new MOD 8.6 data in the PWLT model revealed a~reduced ODS related upward trend after 1997.

scholarly journals Degradation of a Short-lived Glycoprotein from the Lumen of the Endoplasmic Reticulum: The Role of N-linked Glycans and the Unfolded Protein Response

1999 ◽  
Vol 10 (12) ◽  
pp. 4059-4073 ◽  
Author(s):  
Maddalena de Virgilio ◽  
Claudia Kitzmüller ◽  
Eva Schwaiger ◽  
Michael Klein ◽  
Gert Kreibich ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Unfolded Protein Response ◽  
The Other ◽  
Slow Phase ◽  
Type I ◽  
Unfolded Protein ◽  
Other Hand ◽  
The Unfolded Protein Response ◽  
Protein Response

We are studying endoplasmic reticulum–associated degradation (ERAD) with the use of a truncated variant of the type I ER transmembrane glycoprotein ribophorin I (RI). The mutant protein, RI332, containing only the N-terminal 332 amino acids of the luminal domain of RI, has been shown to interact with calnexin and to be a substrate for the ubiquitin-proteasome pathway. When RI332 was expressed in HeLa cells, it was degraded with biphasic kinetics; an initial, slow phase of ∼45 min was followed by a second phase of threefold accelerated degradation. On the other hand, the kinetics of degradation of a form of RI332 in which the single used N-glycosylation consensus site had been removed (RI332-Thr) was monophasic and rapid, implying a role of the N-linked glycan in the first proteolytic phase. RI332degradation was enhanced when the binding of glycoproteins to calnexin was prevented. Moreover, the truncated glycoprotein interacted with calnexin preferentially during the first proteolytic phase, which strongly suggests that binding of RI332 to the lectin-like protein may result in the slow, initial phase of degradation. Additionally, mannose trimming appears to be required for efficient proteolysis of RI332. After treatment of cells with the inhibitor of N-glycosylation, tunicamycin, destruction of the truncated RI variants was severely inhibited; likewise, in cells preincubated with the calcium ionophore A23187, both RI332 and RI332-Thr were stabilized, despite the presence or absence of the N-linked glycan. On the other hand, both drugs are known to trigger the unfolded protein response (UPR), resulting in the induction of BiP and other ER-resident proteins. Indeed, only in drug-treated cells could an interaction between BiP and RI332 and RI332-Thr be detected. Induction of BiP was also evident after overexpression of murine Ire1, an ER transmembrane kinase known to play a central role in the UPR pathway; at the same time, stabilization of RI332 was observed. Together, these results suggest that binding of the substrate proteins to UPR-induced chaperones affects their half lives.

Economic complexity and price competitiveness dependence: empirical evidence using panel models

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Guilherme Magacho ◽  
Rafael Ribeiro ◽  
Igor Rocha
Keyword(s):  
Exchange Rate ◽  
Generalized Method Of Moments ◽  
Output Growth ◽  
The Other ◽  
Content Type ◽  
Price Competitiveness ◽  
Economic Complexity ◽  
Other Hand ◽  
The Impact

Purpose As economies with high economic complexity and productive capabilities may easily adapt their productive structure due to product differentiation and innovation, the central variable of competitiveness for these countries is the product quality, not price. On the other hand, the price can be an important determinant of less complex countries, and hence, real exchange rate (RER) misalignments may have long-term impacts. This paper aims to empirically assess variations in the magnitude of the impact in RER misalignments on output growth subject to countries’ economic complexity. Design/methodology/approach The estimation technique used is the generalized method of moments-System estimator as this method is robust to reverse causality. Heterogeneous regressions using interaction models are undertaken to analyze to what extend promoting economic complexity can reduce price competitiveness dependence and allow countries to grow faster without relying on cost competitiveness. Findings Estimates show that economic complexity (which measures technological and productive capabilities) determines cross-country differences regarding the effects of RER misalignments on countries’ long-term growth rates. The results suggest that exchange rate devaluations may not be effective for countries at the top end of the technological ladder while an overvalued RER may damage the long-term growth rate of countries with low levels of economic complexity. Originality/value This paper contributes to the literature by empirically investigating the impact of RER misalignments in countries with distinct technological and productive capabilities based on the recent developments of countries’ economic complexity analysis. It investigates whether more diversified and complex economies are less sensitive to RER misalignments as they can adapt their production, undertake other tasks, create new products and increase the quality of products they produce. Less complex economies, on the other hand, are less capable of innovating because it demands productive capabilities they do not have, and hence, they are more dependent on their current export basket.

The Qualitative Relationship Between Banks and SMEs in Wales

2017 ◽  
pp. 86-110
Author(s):  
Atsede Woldie ◽  
Hooman Hagshenas ◽  
Brychan Celfyn Thomas
Keyword(s):  
Asymmetric Information ◽  
Small Businesses ◽  
Order Theory ◽  
The Other ◽  
Pecking Order ◽  
Pecking Order Theory ◽  
External Finance ◽  
Other Hand ◽  
Qualitative Relationship

A long-term or close and intense relationship with banks could help overcome the main problems like asymmetric information. Using collateral is another way to overcome the effects of asymmetric information. The findings show that having collateral does not reduce loan costs, and on the other hand it will increase the availability of finance for small businesses. In general, small businesses use pecking order theory in choosing their formal sources of finance. Because of their lack of knowledge, they are not completely aware of available sources of finance. Banks are the first and most important external finance provider for small businesses, so having a good long-term relationship with banks can help them to overcome problems like asymmetric information, which would influence their access to more finance. Collateral is the other way to access more finance and it can help small businesses in their relationship with banks, especially in a period of unsustainability to reduce the risks for banks.

The Values of β-TG During the Anticoagulant Therapy in Patients with Venous Thrombosis and Myocardial Infarction

1979 ◽  
Author(s):  
A. Lucic ◽  
R. Borota ◽  
Z. Radujkov
Keyword(s):  
Myocardial Infarction ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Anticoagulant Therapy ◽  
The Other ◽  
Prothrombin Activity ◽  
Normal Concentration ◽  
Preliminary Results ◽  
Other Hand

In 38 patients with deep venous thrombosis and 52 patients with myocardial infarction who were on long term anticoagulant therapy, the estimations of β-TG have been done by radioimmunoassay using a kit developed by the Radiochemical Centre, Amersham, England. In the group of patients with deep venous thrombosis, the increased values of β-TG /values which were higher than 80 ng/ml /have been established in 47,3% of the cases and among the patients with myocardial infarction, in 73% of the cases. From the total of 56 patients with increased level of β-TG, in 50 patients the level of prothrombin activity was higher than 20%. On the other hand, in patients with normal concentration of β-TG, the level of prothrombin activity was usually lower than 20%. Our preliminary results suggest the possible use of estimation of β-TG as an important supplementary parameter for evaluation of a substantial efficasy of applied anticoagulant therapy.

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