scholarly journals Welfare Challenges Influence the Complexity of Movement: Fractal Analysis of Behaviour in Zebrafish

Fishes ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 8 ◽  
Author(s):  
Anthony G. Deakin ◽  
Joseph W. Spencer ◽  
Andrew R. Cossins ◽  
Iain S. Young ◽  
Lynne U. Sneddon
Keyword(s):  
Fractal Analysis ◽  
Good Condition ◽  
Control Fish ◽  
Dependent Manner ◽  
Fish Welfare ◽  
Treatment Groups ◽  
Before And After ◽  
Pain Test ◽  
Pit Tagging ◽  
The Impact

The ability to assess welfare is an important refinement that will ensure the good condition of animals used in experimentation. The present study investigated the impact of invasive procedures on the patterns of movement of zebrafish (Danio rerio). Recordings were made before and after fin clipping, PIT tagging and a standard pain test and these were compared with control and sham handled zebrafish. The fractal dimension (FD) from the 3D trajectories was calculated to determine the effect of these treatments on the complexity of movement patterns. While the FD of zebrafish trajectories did not differ over time in either the control or sham group, the FDs of the treatment groups reduced in complexity. The FD of fish injected with different strengths of acetic acid declined in a dose-dependent manner allowing us to develop an arbitrary scale of severity of the treatments. The 3D trajectory plots from some groups indicated the presence of repetitive swimming patterns akin to stereotypical movements. When administered with lidocaine, which has analgesic properties, the movement complexity of fin clipped fish reverted to a pattern that resembled that of control fish. Fractal analysis of zebrafish locomotion could potentially be adopted as a tool for fish welfare assessment.

Impact of Rituximab On the Treatment of Waldenström's Macroglobulinemia (WM).

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 2734-2734
Author(s):  
Sheeba K. Thomas ◽  
Kay B Delasalle ◽  
Jatin J. Shah ◽  
Luhua Wang ◽  
Robert Z. Orlowski ◽  
...  
Keyword(s):  
Conflicts Of Interest ◽  
Alkylating Agents ◽  
Single Agent ◽  
Nucleoside Analogs ◽  
Low Grade ◽  
Primary Therapy ◽  
Treatment Groups ◽  
Before And After ◽  
The Impact

Abstract Abstract 2734 Background: Rituximab was first approved by the FDA for use in relapsed and/or refractory low grade or follicular B cell non-Hodgkin's lymphoma in 11/1997. Since that time it has been widely used in WM, and is the backbone of drug combinations developed for treatment of this disease. Methods: To evaluate the impact of rituximab on overall survival (OS), we retrospectively evaluated patients (pts) treated at our center who received primary therapy for symptomatic WM with combinations of either alkylating agents (AA), nucleoside analogs (NA) +/− AA, or bortezomib (B), each with or without rituximab (R). The effect of primary therapy on OS was compared between patients receiving primary therapy before and after rituximab use for WM began at our center (11/11/1998). OS was calculated from the date of initial treatment until date of death or last follow-up. Due to small patient numbers, those who received vincristine-doxorubicin-dexamethasone (2 pts), single agent rituximab (3 pts), or rituximab-alkylating agent combinations (11 pts) as primary therapy, were excluded from the analysis. Results: Among 315 patients with previously untreated symptomatic WM treated since 3/1966, 118 received AA alone; 137 received NA +/− AA alone (85 pts) or with R (52 pts), and 44 received B + R. Median age, hemoglobin, platelet count and β2 microglobulin were comparable between all treatment groups (AA alone, NA +/− AA alone, NA +/− AA + R, B + R). Only median albumin differed significantly, with levels of 3.7 g/dL (AA alone), 4.1 g/dL (NA+/− AA alone), 4.3 g/dL (NA+/− AA + R) and 4.4 g/dL (B + R), respectively (p < 0.01). The median OS of pts treated with AA was 4.5 years, and 6.5 years with NA +/− AA, while the median OS of pts treated with NA+/− AA + R (median follow-up: 8 years) and B + R (median follow-up: 2.6 years) has not been reached. Comparing all patients treated with vs. without R, median OS is >13 years vs. 5.6 years (p<0.01). Conclusions: While pts with WM have most certainly benefitted from improvements in supportive care and the greater availability of salvage therapy options in the modern era, the addition of rituximab to available therapies appears to have significantly improved the OS of patients with WM compared with AA or NA +/− AA alone. Our data supports the role of rituximab as an indispensable component of modern therapy for this disease. Disclosures: No relevant conflicts of interest to declare.

scholarly journals IS THE FASHION STORE, PT MATAHARI DEPARTMENT STORE TBK STILL PROFITABLE IN THE ERA OF DIGITAL INNOVATION? For the Period of 2008-2017

2020 ◽  
Vol 7 (1) ◽  
pp. 1-22
Author(s):  
Wiwiek Mardawiyah Daryanto ◽  
Fransiscus X John Brazer ◽  
Jodipati Alif
Keyword(s):  
Financial Performance ◽  
Technology Development ◽  
Good Condition ◽  
Department Store ◽  
Pilot Project ◽  
Retail Industry ◽  
Digital Innovation ◽  
Financial Ratio ◽  
Before And After ◽  
The Impact

Retail industry in Indonesia has grown rapidly alongside with the current growing of technology. By the ever-growing technology development, the behaviors of Indonesian people are also slightly changes to become more efficient and simple way of buying things. The study sought to observe the performance of PT Matahari Department Store Tbk (MDS) before and after the digital innovation that took place in the early 2010s. The aim of this study was to investigate whether the advent of E-commerce has affected PT MDS’s performance. Financial ratio such as profitability and overall measures were used to analyze PT MDS’s financial performance. Period taken in this study were in before (2008-2010) and after the appearance of E-Commerce in retail  industry (2011-2017). This study found that in 2008-2010 (E-commerce first pilot project) the profitability performance of PT MDS was not in good condition. However, in 2011 or E-Commerce Emergence & Transition, PT MDS began to improve its financial performance by successfully recording positive trends in all financial ratios except ROE. This has occurred due to the impact of reverse stock and corporate restructuring in 2009. Additionally, an increase in the shareholding of public ownership was also taken in action in 2013 to drive up the price of company’s shares and boost the company's ratio. Thus, it can be sum up that PT MDS’s financial performance was not affected by the presence of E-commerce, instead it influenced by company’s actions. However, with an objective to adapt in this era, PT MDS has launched Matahari.com for targeting other segments and other strategies to keep up the improvements.

scholarly journals The Impact of Project-Based Learning on Students’ Cultural Awareness

2021 ◽  
Vol 3 (2) ◽  
pp. 54-80
Author(s):  
Mohamed AKHARRAZ
Keyword(s):  
Cultural Awareness ◽  
Language Education ◽  
Radical Change ◽  
Project Based Learning ◽  
Control Group ◽  
Treatment Groups ◽  
Before And After ◽  
Culture Teaching ◽  
Teaching Learning ◽  
The Impact

While only a few studies have been conducted to explore the effectiveness of project-based learning (PjBL) in culture teaching/learning in second and foreign language education, no study known to the investigator has empirically measured the effect of PjBL together with the cultural  framework of the 3Ps (products, practices, and perspectives) in the teaching of culture in an EFL context. This study aimed to measure the effect of PjBL on students’ awareness of the English cultures. Two intact groups at a Moroccan public school were randomly assigned to control and treatment groups. A cultural awareness test was utilized to measure students’ cultural awareness levels before and after a 24-week treatment. The independent sample t-tests indicated that the PjBL group substantially outperformed the control group in cultural awareness. While the study concluded that PjBL is a useful tool for incorporating cultures in the EFL classes, its proper implementation entails a redistribution of power in the language classroom and a radical change in the culture of assessment.

Protein supplementation to enhance the performance of pregnant cows on rough fescue grasslands in winter

1998 ◽  
Vol 78 (1) ◽  
pp. 89-94 ◽  
Author(s):  
W. D. Willms ◽  
L. M. Rode ◽  
B. S. Freeze
Keyword(s):  
Block Design ◽  
Good Condition ◽  
Grazing Pressure ◽  
Protein Supplementation ◽  
Before And After ◽  
Acid Detergent Fibre ◽  
Winter Grazing ◽  
Four Levels ◽  
The Impact ◽  
Rough Fescue

Rough fescue grasslands are readily damaged with heavy grazing pressure in the summer but tolerate grazing in winter. In addition, these grasslands have physical and nutritive properties that make them favourable for winter grazing by cattle, which reduces the cost of winter feeding while preserving the integrity of the grasslands. This study was conducted on the rough fescue grassland to determine the impact of protein supplementation on pregnant Hereford cows and the effect of supplementation on forage intake. A secondary objective was to determine the winter quality of forage from this grassland as measured by crude protein (CP), phosphorus (P), and acid detergent fibre (ADF) of selected species. The study site was in the rough fescue grasslands at the Agriculture and Agri-Food Canada Range Research Substation west of Stavely, AB. A canola based supplement (32% CP) with added minerals was fed to pregnant Hereford cows at four levels [0, 0.4, 0.8, and 1.2 kg d−1 per animal] from 1 November to 31 January over 3 yr. Two animals were used in each of 12 paddocks (1.67 ha each) arranged in a randomized complete block design with three blocks. Cow weight and backfat were recorded before and after each feeding period. Forage biomass and feed intake were estimated by harvesting plots before and after grazing, and with the use of a non-destructive method based on measurements of individual plants that allowed estimates for each forage species. Cow weights were affected (P = 0.002) by supplementation. Cows receiving 0.4 kg d−1 supplement lost the most weight while cows receiving 0.8 or 1.2 kg d−1 lost the least. Backfat was not responsive to supplementation (P > 0.05). Rough fescue grasslands must be in good condition to be able to support winter grazing because rough fescue provides most of the forage utilized by cattle in winter. Key words: Winter grazing, Festuca campestris, rough fescue, weight loss, backfat, digestibility, beef cattle

The Effect of Active Site-inhibited Factor VIIa on Tissue Factor-initiated Coagulation Using Platelets before and after Aspirin Administration

1997 ◽  
Vol 78 (04) ◽  
pp. 1202-1208 ◽  
Author(s):  
Marianne Kjalke ◽  
Julie A Oliver ◽  
Dougald M Monroe ◽  
Maureane Hoffman ◽  
Mirella Ezban ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Active Site ◽  
Large Scale ◽  
Thrombin Generation ◽  
Factor Viia ◽  
Dependent Manner ◽  
Antithrombotic Agent ◽  
Before And After ◽  
Ic50 Values

SummaryActive site-inactivated factor VIIa has potential as an antithrombotic agent. The effects of D-Phe-L-Phe-L-Arg-chloromethyl ketone-treated factor VIla (FFR-FVIIa) were evaluated in a cell-based system mimicking in vivo initiation of coagulation. FFR-FVIIa inhibited platelet activation (as measured by expression of P-selectin) and subsequent large-scale thrombin generation in a dose-dependent manner with IC50 values of 1.4 ± 0.8 nM (n = 8) and 0.9 ± 0.7 nM (n = 7), respectively. Kd for factor VIIa binding to monocytes ki for FFR-FVIIa competing with factor VIIa were similar (11.4 ± 0.8 pM and 10.6 ± 1.1 pM, respectively), showing that FFR-FVIIa binds to tissue factor in the tenase complex with the same affinity as factor VIIa. Using platelets from volunteers before and after ingestion of aspirin (1.3 g), there were no significant differences in the IC50 values of FFR-FVIIa [after aspirin ingestion, the IC50 values were 1.7 ± 0.9 nM (n = 8) for P-selectin expression, p = 0.37, and 1.4 ± 1.3 nM (n = 7) for thrombin generation, p = 0.38]. This shows that aspirin treatment of platelets does not influence the inhibition of tissue factor-initiated coagulation by FFR-FVIIa, probably because thrombin activation of platelets is not entirely dependent upon expression of thromboxane A2.

Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

2018 ◽  
Vol 15 (1) ◽  
pp. 55-72
Author(s):  
Herlin Hamimi ◽  
Abdul Ghafar Ismail ◽  
Muhammad Hasbi Zaenal
Keyword(s):  
Quality Of Life ◽  
Positive Impact ◽  
Wealth Distribution ◽  
Absolute Poverty ◽  
Before And After ◽  
The Status ◽  
Being There ◽  
The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

ANALISIS PENGARUH PEMBANGUNAN JALAN LAYANG JANTI TERHADAP PERKEMBANGAN TATA RUANG KAWASAN JANTI STUDI KASUS : KAWASAN JANTI, DESA CATURTUNGGAL, KABUPATEN SLEMAN, D. I. YOGYAKARTA

2017 ◽  
Vol 11 (3) ◽  
pp. 255
Author(s):  
Jeky El Boru
Keyword(s):  
Road Network ◽  
Open Space ◽  
Qualitative Description ◽  
Analysis Method ◽  
Open Spaces ◽  
The Road ◽  
Before And After ◽  
Linkage Method ◽  
The Impact ◽  
Parking Place

Abstract: This research aims to analyze the impact of Janti Flyover Construction toward the growth of layout at Janti Urban Area, including structured space, open space, and linkage. Method used for data collecting are observation, air photograph monitoring, and interview, whereas the analysis method is qualitative description, which is the superimposed method of two layers, that are the layout condition before and after flyover construction. The result shows that the impact of Janti Flyover construction can be seen on building mass (solid), the increasing number of open spaces, including the road network, parking place, and park, whereas the relation between spaces, visually and structurally, can be seen on the growth of buildings which have new shapes and styles, therefore the performance of the overall building does not have a proportional shape. Considering Janti Street at the collective relation, its role is getting stronger as the main frame road network.Keywords: Flyover construction, layout changing, Janti AreaAbstrak: Penelitian ini bertujuan untuk menganalisis pengaruh pembangunan Jalan Layang Janti terhadap perkembangan tata ruang Kawasan Janti, meliputi ruang terbangun, ruang terbuka, serta hubungan antar ruang (“linkage”). Metode pengumpulan data dilakukan melalui observasi, pengamatan foto udara, dan wawancara; sedangkan metode analisis melalui deskripsi secara kualitatif yang berupa “superimposed method” dari dua lapisan kondisi lahan, yakni kondisi tata ruang sebelum dan sesudah pembangunan jalan layang. Hasil penelitian menunjukkan bahwa pengaruh pembangunan Jalan Layang Janti terdapat pada massa bangunan (“solid”), pertambahan ruang terbuka yang berupa jaringan jalan, parkir, dan taman; sedangkan pada hubungan antar ruang ̶ secara visual dan struktural ̶ yakni tumbuhnya bangunan dengan bentuk dan gaya baru, sehingga bentuk tampilan bangunan secara keseluruhan tidak proporsional. Pada hubungan kolektif, Jalan Janti semakin kuat perannya sebagai kerangka utama jaringan jalan.Kata kunci : Pembangunan jalan layang, tata ruang, Kawasan Janti

Impact of merger on efficiency and productivity : a case study of commercial banks in Malaysia

1970 ◽  
Vol 5 (1) ◽  
pp. 77
Author(s):  
Mahadzir Ismail ◽  
Saliza Sulaiman ◽  
Hasni Abdul Rahim ◽  
Nordiana Nordin
Keyword(s):  
Efficiency Score ◽  
Malmquist Productivity Index ◽  
Productivity Index ◽  
Data Envelopment ◽  
Master Plan ◽  
Before And After ◽  
Domestic Banks ◽  
The Impact ◽  
Efficiency And Productivity

The Financial Master Plan (2001- 2010) aims to enhance the capacity of banking industry so that higher effic iency and productivity can be reaped in the future. This study seeks to determine the impact of merger on the efficiency and productivity ofcommercial banks in Malaysia for the period 1995 until 2005. The study uses a non-parametric approach, nam ely DEA (data envelopment analysis?) to estimate the efficiency scores and to construct the Malmquist productivity index. To enable this estimation, three bank inputs and outputs are used. Amongst the findings are those banks exhibit higher efficiency score after the merger and thefo reign banks are more efficient than the local banks. Productivity of the banks is calculated in both periods, before and after the merger: The results show that, it is the local banks that have improved the most after the merger. The main source of productivity is technical change or innovation. The findings support the existing policy of having larger domestic banks in term of size.

THE EFFECT OF METACOGNITIVE INSTRUCTION ON MAXIMIZING EFL LEARNERS’ METACOGNITIVE AWARENESS IN LISTENING

2018 ◽  
Vol 7 (1) ◽  
pp. 8-17
Author(s):  
Mahsa Assadi
Keyword(s):  
Experimental Research ◽  
Listening Comprehension ◽  
Intervention Program ◽  
Metacognitive Awareness ◽  
Listening Test ◽  
Efl Learners ◽  
Metacognitive Instruction ◽  
Before And After ◽  
Comprehension Ability ◽  
The Impact

This study reports a pre-experimental research on the impact of metacognitive instruction on EFL learners’ metacognitive awareness and their listening performance. To obtain the goal of the study, a group of 30 Iranian intermediate EFL learners, including 14 males and 16 females, were selected randomly. Their ages range from 20 to 24. The participants took part in 16 weeks’ intervention program based on metacognitive pedagogical sequence consisted of five stages. The metacognitive awareness listening questionnaire (MALQ), and a listening test were also used to find changes in metacognitive awareness and listening performance before and after the treatment. The results of comparing pre and posttests scores revealed that metacognitive instruction raised the learners’ metacognitive awareness and helped them improve their listening comprehension ability.

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